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Looking at sound: optoacoustics with all-optical ultrasound detection

Light(Science & Applications) 2018年第1期7卷 556-571页

作者： Georg Wissmeyer Miguel A.Pleitez amir rosenthal Vasilis Ntziachristos Institute of Biological and Medical Imaging Helmholtz Zentrum MunchenNeuherbergGermany Chair of Biological Imaging Technische Universitat MunchenMunichGermany Andrew and Erna Viterbi Faculty of Electrical Engineering Technion-Israel Institute of TechnologyHaifaIsrael

Originally developed for diagnostic ultrasound imaging,piezoelectric transducers are the most widespread technology employed in optoacoustic(photoacoustic)signal ***,the detection requirements of optoacoustic sensing and imaging differ from those of conventional ultrasonography and lead to specifications not sufficiently addressed by piezoelectric ***,interest has shifted to utilizing entirely optical methods for measuring optoacoustic ***-optical sound detectors yield a higher signal-to-noise ratio per unit area than piezoelectric detectors and feature wide detection bandwidths that may be more appropriate for optoacoustic applications,enabling several biomedical or industrial ***,optical sensing of sound is less sensitive to electromagnetic noise,making it appropriate for a greater spectrum of *** this review,we categorize different methods of optical ultrasound detection and discuss key technology trends geared towards the development of all-optical optoacoustic *** also review application areas that are enabled by all-optical sound detectors,including interventional imaging,non-contact measurements,magnetoacoustics,and nondestructive testing.

关键词： sound acoustics piezoelectric

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Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content

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eLight 2022年第1期2卷 68-74页

作者： Jiawei Shi Mingsheng Li Huajun Tang Jiqiang Kang Najia Sharmin amir rosenthal Kenneth K.Y.Wong Department of Electrical and Electronic Engineering The University of Hong Kong Pokfulam RoadHong KongChina.2 Department of Electrical EngineeringTechnion–Israel Institute of TechnologyTechnion City32000 HaifaIsrael Advanced Biomedical Instrumentation Centre Hong Kong Science ParkShatinNew TerritoriesHong KongChina

Water plays a vital role in biological metabolism and it would be essential to trace the water content non-invasively,such as leveraging the vibrational absorption peak of the O-H ***,due to the lack of an efficient laser source,it was challenging to image the water content in the deep tissue with micron-level spatial *** address this problem,we develop a high-power hybrid optical parametrically-oscillating emitter(HOPE)at 1930 nm,at which the vibrational absorption peak of the O-H bond *** maximum pulse energy is over 1.74μJ with a pulse repetition rate of 50 kHz and a pulse width of 15 *** employ this laser source in the optical-resolution photoacoustic microscopy(OR-PAM)system to image the water content in the phantom and the biological tissue in *** 1930-nm OR-PAM could map the water content in the complex tissue environment at high spatial resolution,deep penetration depth,improved sensitivity,and suppressed artifact signal of the lipid.

关键词： Fiber optical parametric oscillator Thulium-doped fiber laser Photoacoustic microscopy

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Transient Expression of Virally Delivered Meganuclease In Planta Generates Inherited Genomic Deletions

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Molecular Plant 2015年第8期8卷 1292-1294页

作者： Arik Honig Ira Marton Michal rosenthal J. Jeff Smith Michael G. Nicholson Derek Jantz amir Zuker Alexander Vainstein Danziger Innovations Ltd. Mishmar Hashiva Village Beit Dagan 50297 Israel Precision Biosciences 302 East Pettigrew Street Dibrell Building Suite A-100 Durham NC 27701 USA Institute of Plant Sciences and Genetics in Agriculture Robert H. Smith Faculty of Agriculture Food and Environment Hebrew University of Jerusalem Rehovot 76100 Israel

Dear Editor The use of sequence-specific nucleases for plant genomic DNA mutagenesis is an exciting and rapidly developing tech- nology （Voytas and Merchant, 2013; Baltes and Voytas, 2014）. To date, most mutated plants have been recovered from transgenic plants stably expressing nucleases. However, transient nuclease delivery by plant DNA- and RNA-based viral vectors followed by regeneration of plantlets from modi- fied tissues has emerged as an alternative, efficient strategy in some plant species （Marton et al., 2010; Baltes et al., 2014）. Delivery of nucleases by plant RNA viruses is particularly attractive because they typically do not integrate into the plant genome, and therefore the mutated plants are not classified as transgenic （Marton et al., 2013; Voytas and Gao, 2014）.

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