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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi Mohammad-Mahdi Salarabedi Syed Azizur rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M Abdel-rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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Expression of a Rice Chitinase Gene Enhances Antifungal Response in Transgenic Litchi (cv. Bedana)

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American Journal of Plant Sciences 2018年第11期9卷 2256-2275页

作者： Dilip Kumar Das amir rahman Post Graduate Department of Biotechnology Tilka Manjhi Bhagalpur University Bhagalpur India

To enhance the antifungal response of litchi, transferring rice chitinase gene under a maize-ubiquitin promoter along with its first intron into the zygotic embryos via Agrobacterium tumefaciens-mediated transformation generated transgenic plants. After co-cultivation for 2 days with recombinant Agrobacterium, zygotic embryos were transferred onto Murashige and Skoog (MS) medium consisted of MS salts and Gamborg (B5) vitamins with 2 mgl-1 2, 4-dichlorophenoxyacetic acid (2, 4-D), 50 gl-1 sucrose and 8 gl-1 agar supplemented with 25 mgl-1 hygromycin and 400 mgl-1 cefotaxime. Embryos were selected passing through a series of MS modified media and the antibiotic resistant transgenic plantlets were analyzed. The integration and stability of the transgene was confirmed by PCR, RT-PCR, Southern blotting and by Western blot analyses. The transgenic plants exhibited higher chitinase activity than the non-transformed plants. The chitinase activity was also examined using the native polyacrylamide in-gel assay. These analyses indicated that the foreign gene was translated into the protein of expected molecular weight that showed chitinase activity. Following in-vitro inoculation of die-back, leaf spots and blight pathogen (Phomopsis sp.), the transgenic plants showed delayed onset of the disease and smaller lesions. The transgenic plants were adapted to the greenhouse and did not show any phenotypic alterations.

关键词： Transgenic Litchi Agrobacterium Tumefaciens Blight Die Back and Leaf Spots Phomopsis sp. Somatic Embryogenesis Transformation

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Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model

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World Journal of Experimental Medicine 2024年第1期14卷 113-123页

作者： Suriati Mohd Nasir Anis Farihan Ismail Tuan Salwani Tuan Ismail Wan Faiziah Wan Abdul rahman Wan amir Nizam Wan Ahmad Tengku Ahmad Damitri Al-Astani Tengku Din Kuttulebbai Nainamohammed Salam Sirajudeen Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Endocrinology Laboratory Department of Chemical PathologySchool of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Biomedicine Program School of Health SciencesHealth CampusUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Basic Medical Sciences Kuliyyah of MedicineInternational Islamic University MalaysiaBandar Indera MahkotaKuantan 25200PahangMalaysia

BACKGROUND Diabetes is known damage the liver and kidney,leading to hepatic dysfunction and kidney *** is believed to help in lowering the blood glucose levels of diabetic patients and reducing diabetic ***,the effect of stingless bee honey(SBH)administration in relieving liver and kidney damage in diabetes has not been *** To investigate the effect of SBH administration on the kidney and liver of streptozotocin-induced(STZ;55 mg/kg)diabetic Sprague Dawley *** The rats were grouped as follows(n=6 per group):non-diabetic(ND),untreated diabetic(UNT),metformin-treated(MET),and SBH+metformin-treated(SBME)*** successful diabetic induction,ND and UNT rats were given normal saline,whereas the treatment groups received SBH(2.0 g/kg and/or metformin(250 mg/kg)for 12 *** biochemical parameters and histological changes using hematoxylin and eosin(H&E)and periodic acid–Schiff(PAS)staining were *** On H&E and PAS staining,the ND group showed normal architecture and cellularity of Bowman’s capsule and tubules,whereas the UNT and MET groups had an increased glomerular cellularity and thickened basement *** SBH-treated group showed a decrease in hydropic changes and mild cellularity of the glomerulus vs the ND group based on H&E staining,but the two were similar on PAS ***,the SBME-treated group had an increase in cellularity of the glomerulus on H&E staining,but it was comparable to the SBH and ND groups on PAS *** diabetic rats had tubular hydropic tubules,which were smaller than other *** fatty vacuole formation and dilated blood sinusoids in liver tissue were seen in the SBH ***,the UNT group had high glucose levels,which subsequently increased MDA levels,ultimately leading to liver *** treatment reduced this damage,as evidenced by having the lowest fasting glucose,serum alanine transaminase,aspartate transaminase,and alkaline phosphatase l

关键词： Diabetes Streptozotocin Stingless bee honey Hematoxylin and eosin Periodic acid-Schiff Liver Kidney

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Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia *** against alloxan-induced in vivo hyperglycemia model

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Journal of Traditional Chinese Medicine 2022年第1期42卷 17-22页

作者： Fazle Rabbi amir Zada Amna Nisar Achyut Adhikari Irfan Ullah Shafiq Ur rahman Department of Pharmacy Abasyn University PeshawarPeshawar 25000Khyber PakhtunkhwaPakistan Department of Pharmacy University of PeshawarPeshawar 25120Khyber PakhtunkhwaPakistan Central Department of Chemistry Tribhuvan UniversityKritipur 44613KathmanduNepal Department of Pharmacy Sarhad University of Science and Information TechnologyPeshawar25000Khyber PakhtunkhwaPakistan Department of Pharmacy Shaheed Benazir Bhutto UniversitySheringalDir(Upper)18000Khyber PakhtunkhwaPakistan

OBJECTIVE:To investigate Sterculia diversifolia *** for potential anti-diabetic activity in the in vivo mouse model of alloxan-induced ***:Sterculia diversifolia(***)was subjected to extraction and isolation techniques and structural characterization of the isolated compounds were performed using spectroscopic *** acute toxicity test was performed by orally administering *** in doses of 500-2000 mg/*** the assessment of anti-hyperglycemic activity,*** bark and leaves extracts were administered orally in doses of 50,100,and 200 mg/kg,along with metformin(150 mg/kg,i.p)as positive control,after confirmation of alloxan(150 mg/kg,i.p.)induced hyperglycemia in BALB/c *** biochemical parameters were monitored for the period of ***:The phytochemical studies showed the presence of quercetin and kaempferol in *** IC50 values in the in vivo acute toxicity study revealed the safety margin of *** bark(1166.66 mg/kg)and leaves(683.34 mg/kg)extracts.A significant attenuation of alloxan induced hyperglycemia was produced by *** extracts at 50 mg/kg(P<0.05),100 mg/kg(P<0.05,<0.01),and 150 mg/kg(P<0.05,<0.01,<0.001)during 1-4 h,which was comparable to metformin(P<0.001).Significant(P<0.001)improvement appeared in blood hemoglobin,protein,cholesterol,triglycerides,urea,creatinine,HDL,and LDL of the stem bark and leaves extracts treated diabetic ***:These findings connote the usefulness of *** as an anti-diabetic in traditional medicine and this might be attributed to the presence of quercetin and kaempferol,among other phytochemicals.

关键词： Sterculia hypoglycemic agents quercetin Kaempferols biochemical parameters

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A Fused Machine Learning Approach for Intrusion Detection System

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Computers, Materials & Continua 2023年第2期74卷 2607-2623页

作者： Muhammad Sajid Farooq Sagheer Abbas Atta-ur-rahman Kiran Sultan Muhammad Adnan Khan amir Mosavi School of Computer Science National College of Business Administration and EconomicsLahore54000Pakistan Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia Department of CIT The Applied CollegeKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Software Gachon UniversitySeongnam13120Korea John von Neumann Faculty of Informatics Obuda UniversityBudapest1034Hungary Institute of Information Engineering Automation and MathematicsSlovak University of Technology in BratislavaBratislava81107Slovakia Faculty of Civil Engineering TU-DresdenDresden01062Germany

The rapid growth in data generation and increased use of computer network devices has amplified the infrastructures of *** interconnectivity of networks has brought various complexities in maintaining network availability,consistency,and *** learning based intrusion detection systems have become essential to monitor network traffic for malicious and illicit *** intrusion detection system controls the flow of network traffic with the help of computer *** deep learning algorithms in intrusion detection systems have played a prominent role in identifying and analyzing intrusions in network *** this purpose,when the network traffic encounters known or unknown intrusions in the network,a machine-learning framework is needed to identify and/or verify network *** Intrusion detection scheme empowered with a fused machine learning technique(IDS-FMLT)is proposed to detect intrusion in a heterogeneous network that consists of different source networks and to protect the network from malicious *** proposed IDS-FMLT system model obtained 95.18%validation accuracy and a 4.82%miss rate in intrusion detection.

关键词： Fused machine learning heterogeneous network intrusion detection

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Automated File Labeling for Heterogeneous Files Organization Using Machine Learning

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Computers, Materials & Continua 2023年第2期74卷 3263-3278页

作者： Sagheer Abbas Syed Ali Raza MAKhan Muhammad Adnan Khan Atta-ur-rahman Kiran Sultan amir Mosavi School of Computer Science National College of Business Administration&EconomicsLahore54000Pakistan Department of Computer Science GC University LahorePakistan Riphah School of Computing&Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Department of Software Pattern Recognition and Machine Learning LabGachon UniversitySeongnam13120Korea Department of Computer Science College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal University(IAU)P.O.Box 1982Dammam31441Saudi Arabia Department of CIT The Applied CollegeKing Abdulaziz UniversityJeddah31261Saudi Arabia John von Neumann Faculty of Informatics Obuda UniversityBudapest1034Hungary Institute of Information Engineering Automation and MathematicsSlovak University of Technology in BratislavaBratislava81107Slovakia Faculty of Civil Engineering TU-DresdenDresden01062Germany

File labeling techniques have a long history in analyzing the anthological trends in computational *** situation becomes worse in the case of files downloaded into systems from the ***,most users either have to change file names manually or leave a meaningless name of the files,which increases the time to search required files and results in redundancy and duplications of user ***,no significant work is done on automated file labeling during the organization of heterogeneous user files.A few attempts have been made in topic ***,one major drawback of current topic modeling approaches is better *** rely on specific language types and domain similarity of the *** this research,machine learning approaches have been employed to analyze and extract the information from heterogeneous corpus.A different file labeling technique has also been used to get the meaningful and`cohesive topic of the *** results show that the proposed methodology can generate relevant and context-sensitive names for heterogeneous data files and provide additional insight into automated file labeling in operating systems.

关键词： Automated file labeling file organization machine learning topic modeling

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Aspect Level Songs Rating Based Upon Reviews in English

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Computers, Materials & Continua 2023年第2期74卷 2589-2605页

作者： Muhammad Aasim Qureshi Muhammad Asif Saira Anwar Umar Shaukat Atta-ur-rahman Muhammad Adnan Khan amir Mosavi Department of Computer Science Bahria University Lahore54000Pakistan Lahore Institute of Science and Technology Lahore 54792Pakistan Department of Multidisciplinary Engineering Texas A&M UniversityCollege Station77843USA Department of Computer Science College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal University(IAU)P.O.Box 1982Dammam 31441Saudi Arabia Department of Software Gachon UniversitySeongnam13120Korea John von Neumann Faculty of Informatics Obuda UniversityBudapest1034Hungary Institute of Information Engineering Automation and MathematicsSlovak University of Technology in BratislavaBratislava81107Slovakia Faculty of Civil Engineering TU-DresdenDresden01062Germany

With the advancements in internet facilities,people are more inclined towards the use of online *** service providers shelve their items for *** users post their feedbacks,reviews,ratings,*** the use of the *** enormous increase in these reviews has raised the need for an automated system to analyze these reviews to rate these *** Analysis(SA)is a technique that performs such decision *** research targets the ranking and rating through sentiment analysis of these reviews,on different *** a case study,Songs are opted to design and test the decision *** aspects of songs namely music,lyrics,song,voice and video are *** the reason,reviews of 20 songs are scraped from YouTube,pre-processed and formed a *** machine learning algorithms—Naïve Bayes(NB),Gradient Boost Tree,Logistic Regression LR,K-Nearest Neighbors(KNN)and Artificial Neural Network(ANN)are *** performed the best with 74.99%*** are validated using K-Fold.

关键词： Machine learning natural language processing songs reviews:sentiment analysis songs rating aspect level sentiment analysis reviews analysis text classification music

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Fast Intra Mode Selection in HEVC Using Statistical Model

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Computers, Materials & Continua 2022年第2期70卷 3903-3918页

作者： Junaid Tariq Ayman Alfalou amir Ijaz Hashim Ali Imran Ashraf Hameedur rahman Ammar Armghan Inzamam Mashood Saad Rehman Department of Computer Science&Engineering HITEC UniversityTaxilaPakistan L@BISEN Equipe LSLYncrea Oust20 rue Cuirasse BretagneBrest29200France Department of IT and CS Pak-Austria FachhochschuleHaripurPakistan Department of Electrical Engineering Jouf UniversitySakakaKSA

Comprehension algorithms like High Efficiency Video Coding(HEVC)facilitates fast and efficient handling of multimedia *** algorithms involve various computation modules that help to reduce the size of content but preserve the same subjective viewing ***,the brute-force behavior of HEVC is the biggest hurdle in the communication of multimedia ***,a novel method will be presented here to accelerate the encoding process of HEVC by making early intra mode decisions for the ***,the HEVC applies 35 intra modes to every block of the frame and selects the best among them based on the RD-cost(rate-distortion).Firstly,the proposed work utilizes neighboring blocks to extract available information for the current *** this information is converted to the probability that tells which intra mode might be best in the current *** proposed model has a strong foundation as it is based on the probability rule-2 which says that the sum of probabilities of all outcomes should be ***,it is also based on optimal stopping theory(OST).Therefore,the proposed model performs better than many existing OST and classical *** proposed algorithms expedited the encoding process by 30.22%of the HEVC with 1.35%Bjontegaard Delta Bit Rate(BD-BR).

关键词： Statistical HEVC angular mode reduce time

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Multi-Gigabit CO-OFDM System over SMF and MMF Links for 5G URLLC Backhaul Network

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Computers, Materials & Continua 2021年第5期67卷 1747-1758页

作者： amir Haider MuhibUr rahman Tayyaba Khan Muhammad Tabish Niaz Hyung Seok Kim Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea Department of Electrical Engineering Polytechnique MontrealMontrealCanada Department of Telecommunication Engineering University of Engineering and TechnologyTaxila47050Pakistan

The 5G cellular network aims at providing three major services:Massive machine-type communication(mMTC),ultra-reliable low-latency communications(URLLC),and enhanced-mobile-broadband(eMBB).Among these services,the URLLC and eMBB require strict end-to-end latency of 1 ms while maintaining 99.999%reliability,and availability of extremely high data rates for the users,*** of the critical challenges in meeting these requirements is to upgrade the existing optical fiber backhaul network interconnecting the base stations with a multigigabit capacity,low latency and very high reliability *** address this issue,we have numerically analyzed 100 Gbit/s coherent optical orthogonal frequency division multiplexing(CO-OFDM)transmission performance over 400 km single-mode fiber(SMF)and 100 km of multi-mode fiber(MMF)*** system is simulated over optically repeated and non-repeated SMF and MMF *** transmission is used,and the system is analyzed in a linear and non-linear *** system performance is quantified by bit error ratio(BER).Spectrally efficient and optimal transmission performance is achieved for 400 km SMF and 100 km MMF *** results designate thatMMF links can be employed beyond short reach applications by using them in the existing SMF infrastructure for long haul *** particular,the proposed CO-OFDM system can be efficiently employed in 5G backhaul *** multi-gigabit capacity and lower BER of the proposed system makes it a suitable candidate especially for the eMBB and URLLC requirements for 5G backhaul network.

关键词： CO-OFDM coherent transmission spectrally efficient optical communication optical networks dispersion eMBB URLLC 5G backhaul

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Quintuple Band Antenna for Wireless Applications with Small Form Factor

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Computers, Materials & Continua 2021年第3期66卷 2241-2251页

作者： amir Haider Tayyaba Khan MuhibUr rahman Byung Moo Lee Hyung Seok Kim Department of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006Korea Department of Telecommunication Engineering University of Engineering and TechnologyTaxila47050Pakistan Department of Electrical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada

A coplanar waveguide-fed quintuple band antenna with a slotted circular-shaped radiator for wireless applications with a high isolation between adjacent bands is presented in this *** proposed antenna resonates at multiple frequencies with corresponding center frequencies of 2.35,4.92,5.75,6.52,and 8.46 *** intended functionality is achieved by introducing a circular disc radiator with five slots and a U-shaped slot in the *** proposed antenna exhibits coverage of the maximum set of wireless applications,such as satellite communication,worldwide interoperability for microwave access,wireless local area network(WLAN),long-distance radio telecommunications,and X-band/Satcom wireless *** simulation and measurement results of the proposed fabricated antenna demonstrate the high isolation between adjacent bands.A stable realized gain with an advantageous radiation pattern is achieved at the operating frequency *** proposed simple design,compact structure,and simple feeding technique make this antenna suitable for integration in several wireless communication applications,where the portability of devices is a significant *** proposed antenna is anticipated to be an appropriate candidate for WLAN,long-term evolution,and fifth-generation mobile communication because of its multi-operational bands and compact size for handheld devices.

关键词： Coplanar waveguide isolated adjacent bands satellite WiMAX WLAN 5G communication

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