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Better Selection Model for EML4-ALK Fusion Gene Test in Patients with Non-Small-Cell Lung Cancer

Journal of Cancer Therapy 2013年第8期4卷 54-58页

作者： Dekel Shlomi amir onn Maya Gottfried Jair Bar Haim Biran Maya Ilouze Addie Dvir Hovav Nechushtan Lior Soussan-Gutman Nir Peled Oncology Department Meir Medical Center Kfar Saba Israel Oncotest-TEVA Teva Pharmaceutical Industries LTD. Shoham Israel Pulmonary-Oncology Unit Chaim Sheba Medical Center Tel Hashomer Israel Sharett Institute of Oncology Hadassah He- brew University Medical Center Jerusalem Israel.

Background: In the last decade, the search for gene mutations in lung cancer has been constantly growing. EGFR, KRAS mutations and, recently, the EML4-ALK fusion can guide the selection of treatment for patients who carry a specific mutation. Methods: During 2010-2011, EML4-ALK fusion test has been performed in Israel, mostly for wild type EGFR non-squamous NSCLC patients based on fluorescent in-situ hybridization (FISH) technique to detect EML4-ALK rearrangements. Results: Between January 2010 and December 2011, 3341 patients were diagnosed with lung cancer in Israel. Of the 2997 patients with NSCLC 687 had squamous cell carcinoma and 2310 had non-squamous NSCLC. This study focused on available 125 non-squamous NSCLC cases in which analysis for EML4-ALK rearrangement was available. All were negative for EGFR mutation. Nineteen (15.2%) were found positive for the fusion, a figure 2 - 10 times higher compared with previously reported findings. The EML4-ALK fusion was significantly more prevalent in younger male patients (52.1 vs. 61.3 years, p = 0.049), in whom every additional year reduced the chance to find the fusion by 7% [CI = 0.93 (0.88 - 0.99), p = 0.03]. Conclusions: A stepwise approach based on histology and prior EGFR analysis to detect EML4-ALK fusion is highly efficient with a related increased yield of detection. We recommend testing patients with non-squamous cell lung carcinoma after ruling out an EGFR mutation. The chance to find the ALK fusion is significantly greater in younger men.

关键词： Lung Cancer EML4-ALK Gene Mutation EGFR Histology

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Workplace Wellness,Mental Health Literacy,and Usage Intention of E-Mental Health amongst Digital Workers during the COVID-19

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International Journal of Mental Health Promotion 2023年第1期25卷 99-126页

作者： Choon-Hong Tan Ah-Choo Koo Hawa Rahmat Wei-Fern Siew Alexius Weng-onn Cheang Elyna amir Sharji Faculty of Creative Multimedia Multimedia UniversityCyberjaya63000Malaysia Faculty of Applied Communication Multimedia UniversityCyberjaya63000Malaysia International Medical University(IMU) Bukit Jalil57000Malaysia

The prevalence of mental health problems in both Malaysian and global workplaces has signiﬁcantly increased due to the presence of the coronavirus disease(COVID-19)pandemic,globalization,technology advancement in Industry 4.0,and other contributing *** pervasiveness of the issue poses a huge challenge to improving the occupational safety and health(OSH)of workers in various industries,especially in the digital *** emergence of the innovative industry is evident mainly due to the rapid development of Industry 4.0 and the rele-vant demands of multiple businesses in the digital ***,limited studies and academic dis-cussions were conducted on the OSH topic of digital ***,the current study serves toﬁll the existing gap and provide academic contributions by scrutinising the perceptions of digital workers regarding their work-place well-being,mental health literacy,and the impression of employing e-mental *** objectives of this study are:1)To examine the mental health literacy and workplace wellness of digital workers,2)to explore the e-mental health usage intention and actual e-mental health utilization,and 3)to identify digital workers’feedback on e-mental *** the current context,e-mental health focuses on three dimensions,namely,1)“health in our hand(HIOH)”,2)“interacting for health(IFH)”,and 3)“data enabling health(DEH)”.The present study employed an online cross-sectional survey and received 326 digital workers’completed ***,such as“mental health literacy(MHL)”,“workplace wellness(WW)”,and e-mental health intention and usage were explicated by analysing the data through descriptive *** study results indicated a moderate to a high level of the MHL and the *** than half of the workers possessed a high intention level to employ e-mental health,with the HIOH dimension being the most prevalent ***,the actual e-mental health usage was very low,owing to the online r

关键词： E-mental health intention digital workers digital industry workplace wellness mental health literacy

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