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Association of promoter polymorphism of the CD14 C (-159) T endotoxin receptor gene with chronic hepatitis B

World Journal of Gastroenterology 2006年第35期12卷 5717-5720页

作者： amir Houshang mohammad Alizadeh Mitra Ranjbar Mehrdad Hajilooi Farahnaz Fallahian Research Center for Gastroenterology and Liver Disease ShaheedBeheshti University of Medical Sciences Tehran Iran Hamedan University ofMedical Sciences Hamedan Iran

AIM: To investigate whether single-nucleotide polymor- phisms in the promoter regions of endotoxin-responsive genes CD14 C (-159) T is associated with chronic hepatitis B. METHODS: We obtained genomic DNA from 80 patients with established diagnosis of chronic hepatitis B and 126 healthy subjects served as a control population. The CD 14 C (-159) T polymorphism was investigated using an allele specific PCR method. RESULTS: Twenty seven percent of chronic hepatitis B patients and 75% of controls were heterozygous for CT genotype. The difference between the chronic hepatitis B and control groups was statistically significant [P < 0.0001; Odds ratio (OR) = 2.887; 95% CI: 1.609-5.178]. Twenty four point six percent of chronic hepatitis B and patients 12.3% of the control group were heterozygous for TT genotype. The difference between groups was not statistically significant (P = 0.256; OR = 0.658; 95% CI: 0.319-1.358). Forty eight point four percent of chronic hepatitis B patients and 12.7% of control were homozy- gote for CC genotype (P < 0.004; OR = 0.416; 95% CI: 0.229-0.755). The frequency of allele C was 61.9% and allele T was 38.1% in hepatitis B patients group. The frequency of allele C was 55.2% and allele T was 44.8% for the control group (P = 0.179; OR = 1.319; 95% CI: 0.881-1.977). CONCLUSION: The TT heterozygous genotype was not a risk factor for chronic hepatitis B. CC homozygote genotype is protective for hepatitis B. Lack of heterozy- gosis of genotype CT is a risk factor for chronic hepatitis B. Alleles C or T were not risk factors for chronic hepatitis B. These findings show the role of a single-nucleotide polymorphism at CD14/-159 on the development ofchronic hepatitis B. Endotoxin susceptibility may play a role in the pathogenesis of chronic hepatitis B.

关键词： CD14 C (-159) T gene Single nucleotide polymorphism Chronic hepatitis B Endotoxin susceptibility

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Benzene removal by nano magnetic particles under continuous condition from aqueous solutions

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Frontiers of Environmental Science & Engineering 2014年第3期8卷 345-356页

作者： mohammad Mehdi Amin Bijan Bina amir Masoud Samani Majd Hamidreza Pourzamani Environment Research Center lsfahan University of Medical Sciences Isfahan *** Iran BAEN Department Texas A&M University TX 77843 USA

Benzene removal evaluated using Fe304 nano continuous condition. A 44 initial benzene concentration, from aqueous solutions was magnetic particles （NM） in factorial design including NM dose, contact time and pH was investigated in 16 experiments （Taguchi OA design）. The results indicated that all factors were significant and the optimum condition was： pH 8, NM dose of 2000 mg.L-1, benzene concentrations of 100 mg.L-1 and contact time of 14min. The maximum benzene uptake and distribution ratio in the optimum situation were 49.4mg.g-1 and 38.4L.g-1, respectively. The nano particles were shown to capture 98.7% of the benzene in optimum batch condition and 94.5% in continuous condition. The isotherm data proved that the Bmnauer-Emmett-Teller model fit more closely and produced an isotherm constant （b） less than one, indicating favorable adsorption. Regeneration studies verified that the benzene adsorbed by the NM could be easily desorbed by temperature, and thereby, NM can be employed repeatedly in water and wastewater management.

关键词： benzene experimental design Fe304 continues condition thermal recycling

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Case study of hydraulic fracturing in an offshore carbonate oil reservoir

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Petroleum Research 2022年第4期7卷 419-429页

作者： mohammad Azad Mojtaba Ghaedi amir Farasat Hadi Parvizi Hamed Aghaei Department of Petroleum Engineering School of Chemical and Petroleum EngineeringShiraz UniversityIran Iranian Offshore Oil Company TehranIran Petroxin Ltd LondonUnited Kingdom

Maximizing petroleum production while efficiently managing the operational costs is the oil and gas industry's primary goal which requires innovative engineering approaches and production-enhancing treatments such as hydraulic fracturing(HF).During the HF process,the injected fluid mixed with sands or proppants will create permanent fluid channels to drain more of the reservoir *** level of complexity and various constraints involved in real field treatments have made HF even more chal-lenging in layered carbonate reservoirs with the water drive mechanism.A prominent concern is the downward fracture growth to the oil/water contact zone that may cause unfavorable water cut *** fracture height confinement criterion necessitates optimization of fracture dimension *** height development is mainly a function of in-situ stress conditions and stress magnitude differences between geologic *** cases with a water table at the proximity of the wellbore,fracture height directly affects the operational *** paper demonstrates a practical step-by-step approach towards the design of hydraulic fracturing treatment in an offshore carbonate oil *** modeling process involves optimization of the location,number,and conductivity of the proposed ***-jection of high viscosity fluid causes a bi-wing vertical planar fracture to propagate perpendicular to the direction of minimum horizontal stress in the strike-slip faulting *** of the induced hydraulic fractures are also impacted by the amount and type of ***,as with this case study,the magnitude of vertical stress is in the same range as the maximum horizontal stress;the fracture height growth is the limiting *** LGR method is used to define fractures in the dynamic reservoir model which has been built based on a complete set of data ranging from the analyses of logs,core samples,and seismic details,to perform production forecasts and economic ev

关键词： Hydraulic fracture design Carbonate reservoirs Proppant selection Economic analysis Reservoir modeling

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Leech therapy in treatment of cutaneous leishmaniasis:a case report

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Journal of Integrative Medicine 2017年第5期15卷 407-410页

作者： Nasrin Hamidizadeh amir Azizi mohammad M.Zarshenas Sara Ranjbar Molecular Dermatology Research Center Shiraz University of Medical SciencesShirazIran Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences ShirazIran Departments of Phytopharmaceuticals(Traditional)Pharmacy School of PharmacyShiraz University of Medical SciencesShirazIran Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShirazIran

1 IntroductionApplication of leeches has been a common treatment measure since ancient times and descriptions can be found in the works of Pliny,Galen,Avicenna and Themison.

关键词： leeching leishmaniasis, cutaneous medicine, traditional

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Numerical study of influence of hydraulic fracturing on fluid flow in natural fractures

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Petroleum 2019年第3期5卷 321-328页

作者： Jaber Taheri-Shakib amir Ghaderi mohammad Amin Sharif Nik Research Institute of Petroleum Industry Department of Research and Technology of the Rock and Fluid ReservoirsIran National Iranian South Oil Company Iran Research Institute of Petroleum Industry Department of Research and Technology of the Geomechanic ReservoirsIran

The hydraulic fracturing operation is highly complex in fractured *** fundamental key to a successful operation is processing and analysis of the propagation of hydraulic fracturing in a natural fracture *** this paper,the hydraulic fracturing process is evaluated in a fractured reservoir in southwest *** developing process of induced fracture in a natural fracture network is analysed by the Distinct Element Method(DEM).After determining the fluid flow regime in the natural fractures of the reservoir,hydraulic fracturing is applied along different lengths of the reservoir and in each range,the production rate is *** flow in natural fractures after the hydraulic fracturing operation is shown and evaluated in order to evaluate the induced fracture effectiveness in enhancing fluid flow regimes in the *** reverse suction phenomenon which causes changes in the fluid flow pattern in fractures and will thus affect the production rate is also studied in this *** coalescence will cause the induction of natural fractures to hydraulically fracture without their intersection;this is one of the significant parameters in hydraulic fracturing in naturally fractured reservoirs which is also discussed in *** paper can present valuable information on fluid flow analysis before and after applying hydraulic fracturing in a fractured reservoir and solve some essential ambiguities in this area.

关键词： Hydraulic fracture Fractured reservoirs Production Coalescence Fluid flow

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Biochemical response to lamivudine treatment in HBeAg negative chronic hepatitis B patients in Iran

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World Journal of Gastroenterology 2006年第26期12卷 4203-4205页

作者： amir Houshang mohammad Alizadeh Mitra Ranjbar Babak Karimi Saeed Hatami Research Center for Gastroenterology and Liver Disease Shaheed Beheshti University of Medical Sciences TehranIran Infectious Disease Specialist Hamadan University of Medical Sciences and Health Services Iran General Practitioner Hamadan University of Medical Sciences and Health Services Iran

AIM： To study the effect of a one-year lamivudine regimen in patients with chronic hepatitis B. METHODS： Medical records of HBeAg negative hepatitis B patients who attended a hepatitis clinic in Tehran between March 2002-March 2004 were evaluated. The patients received 100 mg lamivudine tablets once daily for at least 12 mo. Liver enzymes and complete blood count were checked at baseline and the end of treatment （12th mo） and 6 mo after discontinuation of treatment. RESULTS： Of all patients, 24 were excluded. Of 71 patients left, 58 （81.7%） were men. Mean age of the patients was 38 ± 14 years. Mean level of ALT in serum was 1437 ± 205 nkat/L at baseline with a significant reduction at the end of treatment to a mean level of 723 ± 92 nkat/L （P = 0.002）. In 38 patients （53.5%）, the ALT level was normal after one-year treatment. Five patients （7.3%） relapsed （biochemically） within 6 mo after discontinuing lamivudine therapy （the patients with good end of treatment response）. Mean level of AST in serum was 1060 ± 105 nkat/L at baseline which decreased significantly to 652 ± 75 nkat/L at the end of treatment （P = 0.002）. CONCLUSION： Over half （53.5%） of chronic hepatitis B patients with HBeAg negative have normal liver enzyme level at 12-mo lamivudine therapy.

关键词： Chronic hepatitis B Lamivudine HBeAg

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RFID Network Planning Optimization Using a Genetic-Simulated Annealing Combined Algorithm

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China Communications 2023年第8期20卷 234-253页

作者： Ali Sanagooy Aghdam Abbas Toloie Eshlaghy mohammad Ali Afshar Kazemi amir Danehsvar Department of Information Technology Management Central Tehran BranchIslamic Azad UniversityTehranIran Department of Industrial Management Science and Research BranchIslamic Azad UniversityTehranIran Department of Industrial Management Central Tehran BranchIslamic Azad UniversityTehranIran

The main purpose of this paper is to present and apply a genetic and simulated annealing combined algorithm to solve an optimization problem of Radio Frequency Identification(RFID)network planning in an emergency department of a ***,though genetic algorithm(GA)and simulated annealing(SA)have advantages and disadvantages,but they are also ***,the combined algorithm not only takes advantages of the two methods,but also avoids their *** simulation results in an emergency department of a hospital present that the proposed method provides minimum total cost and maximum RFID network coverage in a simultaneous way with the efficient use of multi-antenna RFID ***,the results of comparison of two scenarios of the model with the results of other existing models in the relevant literature show that the proposed model has better outcomes.

关键词： multi-objective problem multi-antenna readers healthcare simulation

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AFAR:adaptive fuzzy ant-based routing for communication networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1666-1675页

作者： Seyed Javad MIRABEDINI mohammad TESHNEHLAB M.H.SHENASA Ali MOVAGHAR amir Masoud RAHMANI Engineering Department Science and Research BranchIslamic Azad UniversityTehranIran Control Department K.N.Toosi Technology UniversityTehranIran Computer Department Sharif UniversitTehranIran

We propose a novel approach called adaptive fuzzy ant-based routing (AFAR), where a group of intelligent agents (or ants) builds paths between a pair of nodes, exploring the network concurrently and exchanging obtained information to up-date the routing tables. Routing decisions can be made by the fuzzy logic technique based on local information about the current network state and the knowledge constructed by a previous set of behaviors of other agents. The fuzzy logic technique allows multiple constraints such as path delay and path utilization to be considered in a simple and intuitive way. Simulation tests show that AFAR outperforms OSPF, AntNet and ASR, three of the currently most important state-of-the-art algorithms, in terms of end-to-end delay, packet delivery, and packet drop ratio. AFAR is a promising alternative for routing of data in next generation networks.

关键词： Adaptive fuzzy routing algorithm Swarm intelligence Routing table Communication network Packet delay,Throughput

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Polymorphisms of interleukin-1R receptor antagonist genes in patients with chronic hepatitis B in Iran

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World Journal of Gastroenterology 2006年第31期12卷 5044-5047页

作者： Mitra Ranjbar amir Houshang mohammad Alizadeh Mehrdad Hajiloi Seyed Mohsen Mousavi Hamadan University of Medical Sciences and Health ServicesSina Hospital Infectious wardHamedanIran Research Center for Gastroenterology and Liver DiseasesShaheed Beheshti University of Medical Sciences TehranIran

AIM： To investigate the relationships between polymorphisms of interleukin-1R receptor antagonist genes and susceptibility to chronic hepatitis B in Iran population. METHODS： Genomic DNA was extracted from the peripheral blood of 80 patients with chronic hepatitis B （57 males, 23 females） aged 12-77 years （mean 36.1 ± 13.8 years） and 147 normal controls （96 males, 51 females） aged 6-75 years （mean 41 ± 18.7 years） who referred to a liver clinic of Tehran and then subjected to polymerase chain reaction （PCR） amplification. PCR products were resolved on a 3% agarose gel and stained with ethidium bromide. RESULTS： Only three of the five kinds of polymorphism （2/2, 2/4, and 4/4） were found in this study. The frequencies of 2/2, 2/4, and 4/4 were 12.5%, 17.5%, 70% respectively in chronic hepatitis B patients and 6.8%, 24.5%, and 68.7% respectively in controls. IL-1 R allele 2 was detected in 30% of chronic hepatitis B patients and in 31.3% of controls, while IL-1 R allele 4 was detected in 87.5% of chronic hepatitis B patients and in 93.2% of controls. The frequency of IL-1R alleles 2 and 4 was detected in 21.25% and 78.75% of the patients and 19.04% and 80.96% of the controls, respectively. CONCLUSION： Our results suggest that the carriage of IL-1R receptor antagonist alleles 2, 4, 6 may not play any role in the development of HBV infection. Large population-based studies are needed to investigate the role of IL-1 polymorphisms in the pathogenesis of developing chronic hepatitis B.

关键词： Polymorphism Interleukin-1R receptorantagonist Chronic hepatitis B

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Numerical study of the melting of nano-enhanced phase change material in a square cavity

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第5期14卷 307-316页

作者： Seyed Sahand SEBTI mohammad MASTIANI Hooshyar MIRZAEI Abdolrahman DADVAND Sina KASHANI Seyed amir HOSSEINI Department of Mechanical Engineering Urmia University of TechnologyUrmiaIran Department of Research and Development Delvar Afzar Industrial Gases Co.Ltd.TehranIran Department of Mechanical Engineering Islamic Azad UniversityGorgan BranchKordkoy CenterGolestanIran

A comprehensive numerical study was conducted to investigate heat transfer enhancement during the melting process in a 2D square cavity through dispersion of nanoparticles.A paraffin-based nanofluid containing various volume fractions of Cu was *** governing equations were solved on a non-uniform mesh using a pressure-based finite volume method with an enthalpy porosity technique to trace the solid-liquid *** effects of nanoparticle dispersion in a pure fluid and of some significant parameters,namely nanoparticle volume fraction,cavity size and hot wall temperature,on the fluid flow,heat transfer features and melting time were *** results are presented in terms of temperature and velocity profiles,streamlines,isotherms,moving interface position,solid fraction and dimensionless heat *** suspended nanoparticles caused an increase in thermal conductivity of nano-enhanced phase change material(NEPCM)compared to conventional PCM,resulting in heat transfer enhancement and a higher melting *** addition,the nanofluid heat transfer rate increased and the melting time decreased as the volume fraction of nanoparticles *** higher temperature difference between the melting temperature and the hot wall temperature expedited the melting process of NEPCM.

关键词： Nanofluid Phase change material(PCM) Melting Thermal energy storage Square cavity

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