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I-DCGAN and TOPSIS-IFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images

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China Foundry 2024年第3期21卷 239-247页

作者： Ming-jun Hou Hao Dong Xiao-yuan Ji Wen-bing zou Xiang-sheng Xia Meng Li Ya-jun Yin Bao-hui Li Qiang Chen Jian-xin Zhou State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Xinjiang Technology(Jiangsu)Co. Ltd.Nantong 226100JiangsuChina Southwest Technique and Engineering Research Institute Chongqing 400039China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy ***,the efficacy of deep learning models hinges upon a substantial abundance of flaw *** existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality *** this end,a novel approach was put forward,which involves the creation of the Interpolation-Deep Convolutional Generative Adversarial Network(I-DCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSIS-IFP.I-DCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational ***-IFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion *** results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,*** TOPSIS-IFP value reaches 78.7%and 73.8%similarity to the ideal solution,*** to single index evaluation,the TOPSIS-IFP algorithm achieves higher-quality simulated images at the optimal training *** approach successfully mitigates the issue of unreliable quality associated with single index *** image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks.

关键词： light alloy casting flaw detection image generator discriminator comprehensive evaluation index

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一种基于最小二乘的不完整椭圆拟合算法

仪器仪表学报 2006年第7期27卷 808-812页

作者：邹益民汪渤北京理工大学信息技术学院自动控制系北京100081

研究了一种基于最小二乘的不完整椭圆拟合算法。基于几何距离的拟合算法可达到较高的拟合精度,但迭代过程敏感于初始条件;由于不完整的椭圆样本点及噪声的存在,简单线性拟合方法可能使拟合结果退化为开放的双曲线,引起拟合失败,基于椭... 详细信息

研究了一种基于最小二乘的不完整椭圆拟合算法。基于几何距离的拟合算法可达到较高的拟合精度,但迭代过程敏感于初始条件;由于不完整的椭圆样本点及噪声的存在,简单线性拟合方法可能使拟合结果退化为开放的双曲线,引起拟合失败,基于椭圆约束的代数距离拟合方法可保证拟合结果一定是椭圆,从而为迭代提供适当的初值;利用多个待估计椭圆参数之间的相互约束,即使非常短的椭圆弧也可得到稳定的拟合结果。仿真结果与实际图像应用验证了算法的有效性。

关键词：最小二乘拟合曲线拟合椭圆拟合

Association of visceral adipose tissue with gout: Observational and Mendelian randomization analyses

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中华医学杂志(英文版) 2024年第19期137卷 2351页

作者： Xiao Wenze Wang Qi Liu Yining Zhang Hui zou Hejian Department of Rheumatology Shanghai Pudong Hospital Fudan University Pudong Medical Center Shanghai China Department of Nephrology Shanghai Pudong Hospital Fudan University Pudong Medical Center Shanghai China Human Phenome Institute Zhangjiang Fudan International Innovation Centre Fudan University Shanghai China Department of Rheumatology Huashan Hospital Fudan University Shanghai China

Background: The causal relationship between visceral adipose tissue (VAT) and gout is still unclear. We aimed to examine the potential association between them using observational and Mendelian randomization (MR) ***: In the observational analyses, a total of 11,967 participants (aged 39.5 ± 11.5 years) were included from the National Health and Nutrition Examination Survey. Logistic regression models were used to investigate the association between VAT mass and the risk of gout. In two-sample MR analyses, 211 VAT mass-related independent genetic variants (derived from genome-wide association studies in 325,153 UK biobank participants) were used as instrumental variables. The random-effects inverse-variance weighted (IVW) method was used as the primary analysis. Additional sensitivity analyses were also performed to validate our ***: Observational analyses found that an increase in VAT mass (per standard deviation) was associated with a higher risk of gout after controlling for confounding factors (odds ratio [OR] = 1.27, 95% confidence intervals [CI] = 1.11–1.45). The two-sample MR analyses demonstrated a causal relationship between increased VAT mass and the risk of gout in primary analyses (OR = 1.78, 95% CI = 1.57–2.03). Sensitivity analyses also showed similar findings, including MR-Egger, weighted median, simple mode, weighted mode, and leave-one-out ***: Observational analyses showed a robust association of VAT mass with the risk of gout. Meanwhile, MR analyses also provided evidence of a causal relationship between them. In summary, our findings suggested that targeted interventions for VAT mass may be beneficial to prevent gout.

关键词： Visceral adipose tissue Gout Observational analyses Mendelian randomization Causal relationship Epidemiology

A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis

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Journal of Integrative Plant Biology 2016年第6期58卷 600-609页

作者： Yan zou Satya Chintamanani Ping He Hirotada Fukushige Liping Yu Meiyu Shao Lihuang Zhu David F.Hildebrand Xiaoyan Tang Jian-Min Zhou School of Life Science and Technology Shanghai Tech University Syngenta Biotechnology Inc.Slater Department of Biochemistry and Biophysics Institute for Plant Genomics and Biotechnology Texas A&M University Department of Agronomy Agricultural Sciences Center-Noth University of Kentucky State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences School of Life Sciences Capital Normal University

Jasmonates（JAs） are rapidly induced after wounding and act as key regulators for wound induced signaling pathway. However, what perceives the wound signal and how that triggers JA biosynthesis remains poorly understood. To identify components involved in Arabidopsis wound and JA signaling pathway, we screened for mutants with abnormal expression of a luciferase reporter, which is under the control of a wound-responsive promoter of an ethylene response factor（ERF） transcription factor gene, RAP2.6（Related to APetala 2.6）.The rea1（RAP2.6 expresser in shoot apex） mutant constitutively expressed the RAP2.6-LUC reporter gene in young *** with the typical JA phenotypes including shorter petioles,loss of apical dominance, accumulation of anthocyanin pigments and constitutive expression of JA response gene, rea1 plants also displayed cell death and accumulated high levels of JA in response to wounding. The phenotype of rea1 mutant is caused by a gain-of-function mutation in the C-terminus of a mechanosensitive ion channel MscS-like 10（MSL10）. MSL10 is localized in the plasma membrane and is expressed predominantly in root tip, shoot apex and vascular tissues. These results suggest that MSL10 is involved in the wound-triggered early signal transduction pathway and possibly in regulating the positive feedback synthesis of JA.

关键词： Arabidopsis cell death jasmonates mechanosensitive ion channel wound

SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/b-catenin signaling

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Genes & Diseases 2021年第5期8卷 677-688页

作者： Daopei zou Yangmei Chen Lingzhao Zhang Xiaohui Yuan Yujie Zhang Adelina Inggawati Pham Thi Kieu Nguyet Tianwen Gao Jin Chen Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Key Laboratory of Clinical Laboratory Diagnostics Ministry of EducationChongqing Medical UniversityChongqing400016PR China Department of Dermatology Xijing HospitalFourth Military Medical UniversityXi’anShanxi Province710032PR China

Secreted frizzled-related protein 5(SFRP5)plays a pivotal role in regulating the development of many tissues and organs,however,as an inhibitor of Wnt signaling,the role of SFRP5 in vitiligo remains ***,we speculated that SFRP5 might be associated with melanogenesis in melanocytes by regulating Wnt signaling in *** this study,we found that SFRP5 was overexpressed in the skin lesions of patients with *** with that in normal epidermal melanocytes(PIG1),the expression of SFRP5 was increased in vitiligo melanocytes(PIG3V).To investigate the effect of SFRP5 on melanin synthesis,PIG1 cells were infected with recombinant SFRP5 adenovirus(AdSFRP5),and PIG3V cells were infected with recombinant siSFRP5 adenovirus(AdsiSFRP5).The results showed that SFRP5 overexpression inhibited melanin synthesis in PIG1 cells through downregulation of microphthalmia-associated transcription factor(MITF)and its target proteins via suppression of the Wnt/b-catenin signaling ***,SFRP5 silencing increased melanin synthesis and activated the Wnt signaling pathway in PIG3V ***,SFRP5 overexpression also downregulated the transcriptional activity of T cell factor/lymphoid enhancer factor(TCF/LEF)in PIG1 ***,this inhibitory effect of SFRP5 on melanin synthesis was reversed by treatment with the b-catenin agonist,*** inhibitory action of SFRP5 in pigmentation was further confirmed in vivo using a nude mouse ***,our results indicate that SFRP5 can inhibit melanogenesis in ***,our findings showed that SFRP5 plays a vital role in the development of vitiligo,and thus may serve as a potential therapeutic target for vitiligo.

关键词： Melanin synthesis Melanocytes MITF SFRP5 Vitiligo Wnt signaling

Cellulose fibers-reinforced self-expanding porous composite with multiple hemostatic efficacy and shape adaptability for uncontrollable massive hemorrhage treatment

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Bioactive Materials 2021年第7期6卷 2089-2104页

作者： Yansen Wang Yifan Zhao Longxue Qiao Faxing zou Yajie Xie Yudong Zheng Yong Chao Ying Yang Wei He Siming Yang School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083PR China Department of Anesthesiology Medical College of Chinese PLABeijing100853PR China Department of Medical Engineering The First Affiliated Hospital of the PLA General HospitalBeijing100048PR China First Affiliated Hospital of Medical College Zhejiang UniversityHangzhou310003PR China Key Laboratory of Wound Repair and Regeneration of PLA Chinese PLA General HospitalMedical College of PLABeijing100853PR China

Uncontrollable hemorrhage leads to high mortality and thus effective bleeding control becomes increasingly important in the military field and civilian trauma ***,current hemostats not only present limitation when treating major bleeding,but also have various side *** we report a self-expanding porous composites(CMCP)based on novel carboxymethyl cellulose(CMC)fibers and acetalized polyvinyl alcohol(PVA)for lethal hemorrhage *** CMC fibers with uniform fibrous structure,high liquid absorption and procoagulant ability,are evenly interspersed inside the composite *** obtained composites possess unique fiber-porous network,excellent absorption capacity,fast liquid-triggered self-expanding ability and robust fatigue resistance,and their physicochemical performance can be fine-tuned through varying the CMC *** vitro tests show that the porous composite exhibits strong blood clotting ability,high adhesion to blood cells and protein,and the ability to activate platelet and the coagulation *** vivo hemostatic evaluation further confirms that the CMCP presents high hemostatic efficacy and multiple hemostatic effects in swine femoral artery major hemorrhage ***,the CMCP will not fall off from the injury site,and is also easy to surgically remove from the wound cavity after the ***,results of CT tomography and 3D reconstruction indicate that CMCP can achieve shape adaptation to the surrounding tissues and the wound cavities with different depths and shapes,to accelerate hemostasis while protecting wound tissue and preventing infection.

关键词： Porous materials Cellulose fibers Self-expanding ability Shape-adaptive Hemostasis

Radiotherapy-induced heart disease:a review of the literature

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Precision Clinical Medicine 2019年第4期2卷 270-282页

作者： Bingwen zou Julius Philipp Schuster Kerun Niu Qianyi Huang Alexander Rühle Peter Ernst Huber Department of Radiation Oncology Heidelberg University HospitalIm Neuenheimer Feld 400Heidelberg 69120Germany Department of Molecular Radiation Oncology German Cancer Research CenterIm Neuenheimer Feld 280Heidelberg 69120Germany Heidelberg Institute for Radiation Oncology(HIRO)and National Center for Radiation Oncology(NCRO) Im Neuenheimer Feld 280Heidelberg 69120Germany

Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the multimodal treatment of thoracic *** to significant improvements in overall cancer survival,radiotherapy-induced heart disease(RIHD)has become an increasingly recognized adverse reaction which contributes to major radiationassociated toxicities including non-malignant *** is especially relevant for patients suffering from diseases with excellent prognosis such as breast cancer or Hodgkin’s lymphoma,since RIHD may occur decades after *** studies have enriched our knowledge of many potential mechanisms by which thoracic radiotherapy induces heart *** findings in humans reveal that irradiation might increase the risk of cardiac disease at even lower doses than previously *** preclinical studies have identified non-invasive methods for evaluation of ***,potential options preventing or at least attenuating RIHD have been *** research may enrich our limited knowledge about biological mechanisms of RIHD,identify non-invasive early detection biomarkers and investigate potential treatment options that might attenuate or prevent these unwanted side ***,we present a comprehensive review about the published literature regarding clinical manifestation and pathological alterations in *** mechanisms and treatment options are outlined,and challenges in RIHD treatment are summarized.

关键词： Radiotherapy heart injury thoracic cancer radiation-induced heart injury cancer treatment

Effects of Alcohol Addition on the Deposition of Diamond Thick Films by dc Plasma Chemical Vapor Deposition Method

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Chinese Physics Letters 1998年第3期15卷 228-229页

作者： BAI Yi-zhen JIANG Zhi-gang WANG Chun-lei JIN Zeng-sun LÜXian-yi zou Guang-tian National Laboratory of Superhard Materials Jilin UniversityChangchun 130023

Diamond films have been deposited by dc plasma chemical vapor deposition *** addition of alcohol in the resource gas largely increases the deposition *** effects of alcohol addition on deposition rate and film quality... 详细信息

关键词： Diamond alcohol film

Nonlinear optical response of niobium telluride and its application for demonstrating pulsed fiber lasers

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Journal of Materiomics 2024年第2期10卷 355-365页

作者： Xinxin Shang Yule Zhang Tuo Li Huanian Zhang Xiaofeng zou S.Wageh Ahmed A.Al-Ghamdi Han Zhang Shuhao Si Dengwang Li Shandong Province Key Laboratory of Medical Physics and Image Processing Technology Shandong Provincial Key Laboratory of Optics and Photonic DeviceSchool of Physics and ElectronicsShandong Normal UniversityJinan250014China Institute of Microscale Optoelectronics College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China Shandong Yunhai Guochuang Cloud Computing Equipment Industry Innovation Co. Ltd.JinanShandongChina School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo255049China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia

Niobium telluride(NbTe_(2)),a kind of few-layer two-dimensional(2D)transition metal dichalcogenides(TMDs)material,has been theoretically predicted with nonlinear absorption properties and excellent optical ***,we experimentally demonstrated an Er-doped fiber(EDF)laser based NbTe_(2)as saturable absorber(SA).Few-layer NbTe_(2)nanosheets were successfully prepared by adopting the commonly used liquid-phase exfoliation(LPE)*** nonlinear optical response of highly stable few-layer NbTe_(2)was investigated through an open-aperture Z-scan laser measurement,the nonlinear absorption coefficient was 2.45×10^(-11)m/*** Q-switched and mode-locked operation centered at 1559 nm were recorded based on NbTe_(2)*** pulse duration was varied from 4.88 ms to 1.75 ms,and the adjustable range of repetition frequency is changed from 44.01 kHz to 64.12 kHz in passively Q-switched ***,a constant repetition rate of 5.33 MHz and pulse width of 2.67 ps were observed in mode-locked *** experimental results fully reveal the nonlinear optical prop-erties of NbTe_(2)used in pulsed fiber lasers and broaden its ultrafast applications in the optics field.

关键词： Niobium telluride Saturable absorber Z-scan Mode-locked pulse Fiber laser