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Evaluation of sheep sinonasal endoscopic anatomy as a model for rhinologic research

World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第4期4卷 268-272页

作者： Luis Macias-Valle Andres Finkelstein-Kulka Jamil Manji Christopher Okpaleke Salahuddin Al-Salihi amin r.javer St.Paul’s Sinus Centre VancouverBritish ColumbiaCanada Hospital Espan˜ol de Me´xico Facultad Mexicana de Medicina Universidad La Salle Mexico CityMexico Clínica Alemana de Santiago Facultad De Medicina Clínica AlemanaUniversidad Del DesarrolloChile Faculty of Medicine University of MelbourneMelbourneVictoriaAustralia

Objectives:Despite many publications describing sheep models for functional endoscopic sinus surgery(FESS)procedures,accurate endoscopic anatomical studies are *** are no publications correlating computed tomography(CT)and 3D models with endoscopic anatomical *** study evaluates and describes the endoscopic anatomy of a sheep ***:Ten live sheep(20-sides)were *** cadaveric specimens,imaged using thin slice CT for 3D reconstruction correlation were also *** endoscopy,anatomical structures were measured and *** of the same structures was carried out using the 3D imaging ***:Three sets of turbinates were identified at 2.3,5.1 and 8.5 cm from the anterior nasal *** recess and uncinate process were identified at 12.7 *** septum has a bony and cartilaginous component and measures 10.5 *** sphenopalatine foramen was measured at 12.1 *** anatomical measurements were correlated with the measurements on the CT scan 3D volume-rendering model,thereby allowing for an accurate description of the sheep sinonasal ***:This study describes the endoscopic sinonasal anatomical measurements of the adult *** is the first study to evaluate the sheep CT and endoscopic anatomy in order to determine its feasibility as an animal model for research in FESS.

关键词： Sinus anatomy Animal model Sinus endoscopy Sinus research Sinus surgery

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The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 19-25页

作者： Jamil Manji Andrew Thamboo Vishnu Sunkaraneni Amrit Singh Scott Tebbutt Cathie Garnis amin javer St.Paul's Sinus Centre Division of OtolaryngologyDepartment of SurgerySt.Paul's Sinus CentreVancouverBCCanada BC Cancer research Centre Division of OtolaryngologyDepartment of SurgeryVancouverBCCanada royal Surrey County Hospital Eserton RoadGuildfordUK PrOOF Centre of Excellence St.Paul’s HospitalVancouverBCCanada James Hogs research Centre St.Paul’s HospitalUniversity of British ColumbiaVancouverBCCanada

Objective:To identify the differences in cytokine expression between sinonasal tissue from patients treated with Leptospermum (Manuka) honey (LH) irrigation versus normal saline irrigation twice-daily for twelve weeks following sinus surgery (FESS).Methods:Forty-six CrS patients were *** tissue biopsies were collected during FESS and then at 5 and 12 weeks postoperatively during the course of treatment.A multiplex cytokine assay quantified the abundance of 17 cytokines in biopsied *** expression fold-change was analyzed between each time point using a robust linear regression model and compared between the two treatment ***:Compared to the saline irrigation group,five cytokines were differently expressed (CI =95%) in sinonasal tissue obtained from subjects in the LH irrigation group during the 12-week treatment *** IL-6 (P =0.0400),IL-8 (P =0.0398),MCP-1 (P =0.0284),and MIP-1β (P =0.016) were significantly increased in the LH irrigation group compared to the saline irrigation ***-13 was significantly increased in the saline irrigation group compared to the LH group (P =0.0086).Conclusion:LH may potentially act to modulate the expression of IL-6,IL-8,IL-13,MCP-1 and MIP-1β in sinonasal tissue.

关键词： Leptospermum honey Sinusitis Inflammation Postoperative care Irrigation

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