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Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus

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World Journal of Orthopedics 2012年第7期3卷 101-108页

作者： Niall A Smyth Christopher D murawski amgad m haleem Charles P Hannon Ian Savage-Elliott John G Kennedy Department of Orthopaedic Surgery Hospital for Special SurgeryNew YorkNY 10021United States

Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BmAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BmAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus.

关键词： Osteochondral lesion Cartilage repair Platelet-rich plasma Bone marrow aspirate concentrate

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Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model

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World Journal of Orthopedics 2015年第11期6卷 961-969页

作者： Lorraine A Boakye Keir A Ross John m Pinski Niall A Smyth amgad m haleem Charles P Hannon Lisa A Fortier John G Kennedy Department of Orthopaedic Surgery Hospital for Special Surgery Department of Orthopaedic Surgery Rush University Medical Center Department of Clinical Sciences Cornell University College of Veterinary Medicine

AIm: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect ***: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using meta morph. Percentage of chondrocytes positive for TGF-β1 was then ***: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo.

关键词： Platelet rich plasma Transforming growth factor-beta Autologous osteochondral transplantation

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Complex ankle arthrodesis: Review of the literature

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World Journal of Orthopedics 2015年第8期6卷 602-613页

作者： Remy V Rabinovich amgad m haleem S Robert Rozbruch Department of Orthopaedic Surgery Lenox Hill Hospital Department of Ortho-paedic Surgery Limb Lengthening and Complex Reconstruction Service Hospital for Special Surgery

Complex ankle arthrodesis is defined as an ankle fusion that is at high risk of delayed and nonunion secondary to patient comorbidities and/or local ankle/hindfoot factors. Risk factors that contribute to defining this group of patients can be divided into systemic factors and local factors pertaining to co-existing ankle or hindfoot pathology. Orthopaedic surgeons should be aware of these risk factors and their association with patients' outcomes after complex ankle fusions. Both external and internal fixations have demonstrated positive outcomes with regards to achieving stable fixation and minimizing infection. Recent innovations in the application of biophysical agents and devices have shown promising results as adjuncts for healing. Both osteoconductive and osteoinductive agents have been effectively utilized as biological adjuncts for bone healing with low complication rates. Devices such as pulsed electromagnetic field bone stimulators, internal direct current stimulators and low-intensity pulsed ultrasound bone stimulators have been associated with faster bone healing and improved outcomes scores when compared with controls. The aim of this review article is to present a comprehensive approach to the management of complex ankle fusions, including the use of biophysical adjuncts for healing and a proposed algorithm for their treatment.

关键词： Ankle Arthrodesis Ilizarov Reconstruction Salvage

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Future of the current anticoronaviral agents: A viewpoint on thevalidation for the next COVIDs and pandemics

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BIOCELL 2023年第10期47卷 2133-2139页

作者： amgad m.RABIE Drug Discovery&Clinical Research Department Dikernis General Hospital(DGH)Dikernis35744Egypt

Despite the global decline in the severity of the coronavirus disease 2019 (COVID-19) cases, the disease stillrepresents a major concern to the relevant scientific and medical communities. The primary concern of drug scientists,virologists, and other concerned specialists in this respect is to find ready-to-use suitable and potent anticoronaviraltherapies that are broadly effective against the different species/strains of the coronaviruses in general, not only againstthe current and previous coronaviruses (e.g., the recently-appeared severe acute respiratory syndrome coronavirus 2“SARS-CoV-2”), i.e., effective antiviral agents for treatment and/or prophylaxis of any coronaviral infections, includingthose of the coming ones from the next species and strains (if any). As an expert in this field, I tried, in this up-to-dateperspective “viewpoint” article, to evaluate the suitability and applicability of using the currently-availableanticoronaviral agents for the next coronavirus diseases (COVIDs) and coronaviral pandemics, highlighting the mostimportant general guidelines that should be considered in the next pandemics from the therapeutic points of view.

关键词： SARS-CoV-2/COVID-19 Spike(S)protein/main protease(mpro)/RNA-dependent RNA polymerase(RdRp) General anticoronaviral drug Specific anti-COVID-19 medication molnupiravir/Nirmatrelvir/Riboprine/Ensitrelvir Drug design and development

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Simulation of buoyancy-induced turbulent flow from a hot horizontal jet

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Journal of Hydrodynamics 2014年第1期26卷 104-113页

作者： El-AmIN m.F. SUN Shuyu SALAm amgad Computational Transport Phenomena Laboratory (CTPL) Division of Physical Sciences and EngineeringKing Abdullah University of Science and Technology

Experimental visualizations and numerical simulations of a horizontal hot water jet entering cold water into a rectangular storage tank are described. Three different temperature differences and their corresponding Reynolds numbers are considered. Both experimental visualization and numerical computations are carried out for the same flow and thermal conditions. The realizable k-e model is used for modeling the turbulent flow while the buoyancy is modeled using the Boussinesq approximation. Polynomial approximations of the water properties are used to compare with the Boussinesq approximation. Numerical solutions are obtained for unsteady flow while pressure, velocity, temperature and turbulence distributions inside the water tank as well as the Froude number are analyzed. The experimental visualizations are performed at intervals of five seconds for all different cases. The simulated results are compared with the visualized results, and both of them show the stratification phenomena and buoyancy force effects due to temperature difference and density variation. After certain times, depending on the case condition, the flow tends to reach a steady state.

关键词： turbulent flow realizablc k - e turbulence model heat transfer jet heat storage

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Application of new directional logic to improve DC side fault discrimination for high resistance faults in HVDC grids

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Journal of modern Power Systems and Clean Energy 2017年第4期5卷 560-573页

作者： Naushath m.haleem Athula D.RAJAPAKSE University of manitoba Winnipeg MB Canada

This paper proposes a simple and fast way to determine the direction of a fault in a multi-terminal high voltage direct current(HVDC) grid by comparing the rate of change of voltage(ROCOV) values at either side of the di/dt limiting inductors at the line terminals. A local measurement based secure and fast protection method is implemented by supervising a basic ROCOV relay with a directional element. This directional information is also used to develop a slower communication based DC line protection scheme for detecting high resistance faults. The proposed protection scheme is applied to a multi-level modular converter based three-terminal HVDC grid and its security and sensitivity are evaluated through electromagnetic transient simulations. A methodology to set the protection thresholds considering the constraints imposed by the breaker technology and communication delays is also presented. With properly designed di/dt limiting inductors,the ability of clearing any DC transmission system fault before fault currents exceeds a given breaker capacity is demonstrated.

关键词： Directional relay DC line protection multiterminal HVDC grid protection Rate of change of voltage(ROCOV)based HVDC transmission fault detection

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Computational Fluid Dynamics Approach for Predicting Pipeline Response to Various Blast Scenarios: A Numerical modeling Study

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Computer modeling in Engineering & Sciences 2024年第9期140卷 2747-2777页

作者： Farman Saifi mohd Javaid Abid haleem S.m.Anas Department of mechanical Engineering Jamia Millia Islamia(A Central University)New Delhi110025India Department of Civil Engineering Jamia Millia Islamia(A Central University)New Delhi110025India

Recent industrial explosions globally have intensified the focus in mechanical engineering on designing infras-tructure systems and networks capable of withstanding blast *** centered on high-profile facilities such as embassies and petrochemical plants,this concern now extends to a wider array of infrastructures and *** and scholars increasingly prioritize structural safety against explosions,particularly to prevent disproportionate collapse and damage to nearby *** has further amplified the reliance on oil and gas pipelines,making them vital for urban life and prime targets for terrorist ***,there is a growing imperative for computational engineering solutions to tackle blast loading on pipelines and mitigate associated risks to avert *** this study,an empty pipe model was successfully validated under contact blast conditions using Abaqus software,a powerful tool in mechanical engineering for simulating blast effects on buried *** a Eulerian-Lagrangian computational fluid dynamics approach,the investigation extended to above-surface and below-surface blasts at standoff distances of 25 and 50 *** descriptions in the numerical model relied on Abaqus’default mechanical *** analysis revealed varying pipe performance,with deformation decreasing as explosion-to-pipe distance *** explosion’s location relative to the pipe surface notably influenced deformation levels,a key finding highlighted in the ***,quantitative findings indicated varying ratios of plastic dissipation energy(PDE)for different blast scenarios compared to the contact blast(P0).Specifically,P1(25 mm subsurface blast)and P2(50 mm subsurface blast)showed approximately 24.07%and 14.77%of P0’s PDE,respectively,while P3(25 mm above-surface blast)and P4(50 mm above-surface blast)exhibited lower PDE values,accounting for about 18.08%and 9.67%of P0’s PDE,***

关键词： Blast loading computational fluid dynamics computer modeling pipe networks response prediction structural safety

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The Antibacterial Activities of Copper Oxide Nanoparticles Synthesized Using Laser Ablation in Different Surfactants against Streptococcus mutans

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Journal of Renewable materials 2023年第5期11卷 2109-2123页

作者： Ruaa H.Abbas A.Kadhim Azhar m.haleem Laser and Optoelectronics Engineering Department University of Technology-IraqBaghdadIraq Environmental Research Center University of Technology-IraqBaghdadIraq

Copper oxide nanoparticles(CuO NPs)were synthesised with laser ablation of a copper sheet immersed in deionized water(DW),cetrimonium bromide(CTAB),and sodium dodecyl sulphate(SDS),*** target was irradiated with a pulsed Nd:YAG laser at 1064 nm,600 mJ,a pulse duration of 10 ns,and a repetition rate of 5 *** CuO NPs colloidal were analyzed using UV–Vis spectroscopy,the Fourier transform infrared(FTIR)spectrometer,zeta potential(ZP),X-ray diffraction(XRD),transmission electron microscope(TEm)and field emission scanning electron microscopy(FESEm).The absorption spectra of CuO NPs colloidal showed peaks at 214,215 and 220 nm and low-intensity peaks at 645,650 and 680 nm for SDS,CTAB and DW,*** NPs’colloidal results are(−21.6,1.2,and 80 mV)for negatively,neutrally,and positively charged SDS,DW,and CTAB,*** XRD pattern of the NPs revealed the presence of CuO phase planes(110)(111),(20-2)and(11-1).The TEm images revealed nearly spherical NPs,with sizes ranging from 10–90,10–50,and 10–210 nm for CuO NPs mixed with DW,SDS and CTAB,*** images of all the synthesized samples illustrate the formation of spherical nanostructure and large particles are *** CuO NPs were tested for antibacterial activity against Streptococcus mutans by using the well diffusion *** this method,CuO NPs prepared in DW at a concentration of 200μg/mL showed a greater inhibition zone against Streptococcus mutans.

关键词： Copper oxide nanoparticles(CuO NPs) laser ablation Streptococcus mutans

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Development of new potentiometric sensors for the determination of proguanil hydrochloride in serum and urine

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Chinese Chemical Letters 2016年第6期27卷 857-863页

作者： Fatehy m.Abdel-haleem mohamed Saad mohamed S.Rizk Chemistry Department Faculty of Science Cairo University

Potentiometric electrodes were developed for the rapid determination of proguanil hydrochloride in pure samples, pharmaceutical preparations and spiked serum and urine samples using PVC membrane,screen printed（SPE）, coated wired（CWE）, carbon paste（CPE） and modified carbon paste（mCPE）electrodes based on the ion-exchanger of proguanil with phosphotungestic acid（Pr-PT） as a chemical modifier. The prepared electrodes showed Nernestian slopes of 59.7, 58.1, 58.5, 58.5 and 57.0 for the PVC,SPE, CWE, CPE and mCPE for the proguanil ions in a wide concentration range of 1.0 ＊ 10^-5–1.0 ＊ 10^-2mol L^-1 at 25°C with detection limits of 7.94 ＊ 10^-6, 1.0 ＊ 10^-5, 1.0 ＊ 10^-6, 7.07 ＊ 10^-6 and 2.5 ＊ 10^-6 mol L^-1, respectively. The prepared electrodes exhibited high proguanil selectivity in relation to several inorganic ions and sugars and they could be successfully utilized for its determination in pure solutions, pharmaceutical preparations and serum and urine samples using the direct potentiometry and standard addition methods with very good recovery values.

关键词： Proguanil hydrochloride PVC membrane electrode Carbon paste electrode Screen printed electrode mWCNTs Coated wire electrode

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Elemental analysis of some Egyptian ores and industrial iron samples by neutron activation analysis

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Journal of Environmental Sciences 2001年第1期13卷 115-118页

作者： A.Srror N.Abdel Basset A.S.Abdel haleem A.m.Hassan Nuclear Physics Lab. Physics DepartmentFaculty of GirlsAin Shams UniversityCairoEgypt Environmental Radioative Pollution Department Hot Laboratories CentreAEACairoEgypt

Elemental analysis of iron ore samples and first industrial iron production prepared by the Egyptian Iron and Steel Company of Helwan near Cairo were determined by instrumental neutron activation analysis technique. Five samples from each kind were irradiated for a 48 hours at a thermal neutron flux of 4×10 12 n/(cm 2.s) in the first Egyptian research reactor ET RR 1. Also the Pneumatic irradiation Rabbit system (PIRS) attached to the reactor in Inshass, was used to measure the elements of short life time. The gamma ray spectra were recorded by means of the hyper pure germanium detection system. The concentration percentage values of major, minor and trace elements are presented. The long and short lived isotopes were considered. A comparative study and a discussion on the elemental concentration values are given.

关键词： elemental analysis Egyptian iron samples neutron activation analysis

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