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点击化学和生物正交化学中的化学基础概念和前沿思想——2022年诺贝尔化学奖浅析

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大学化学 2023年第1期38卷 1-7页

作者：李恒宇赖铖阳黄思齐陈兴北京大学化学与分子工程学院北京100871 北京大学附属中学道尔顿学院北京100190

2022年诺贝尔化学奖授予了Carolyn ***、Morten Meldal和*** Sharpless三位科学家,以表彰他们开创了点击化学和生物正交化学。点击化学源于对有机合成方法学的改进,提供了一种在温和条件下高效快速地偶联化学分子的新方法。生物正交化... 详细信息

2022年诺贝尔化学奖授予了Carolyn ***、Morten Meldal和*** Sharpless三位科学家,以表彰他们开创了点击化学和生物正交化学。点击化学源于对有机合成方法学的改进,提供了一种在温和条件下高效快速地偶联化学分子的新方法。生物正交化学的开发则起始于生命体系中糖质生物大分子的特异性标记和成像,发展出一类不干扰生命体系且不受生命体系干扰的连接反应。二者殊途同归、异曲同工,成为了在化学、生物医药和材料科学等领域中应用最为广泛的一类化学反应。本文从点击化学与生物正交化学开发中所涉及的化学基础概念出发,对这两种方法的前沿思想进行简要探讨。

关键词：诺贝尔化学奖点击化学生物正交化学

Prenatal diagnosis of a particular limb body wall complex

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Open Journal of Obstetrics and Gynecology 2014年第3期4卷 109-111页

作者： b. Fakhir I. Jadid A. Aboulfalah H. Asmouki A. Soummani Department of Obstetrics and Gynecology Mohamed VI University Hospital Cadi Ayyad University Marakesh Morocco

Limb body Wall Complex (LbWC) is a rare heterogenic group of fetal malformations including major defects of the ventral body (thoracoabdominal) wall associated with other anomalies including those of the limbs that may range from amelia to mild positional deformations, unusual craniofacial malformations, and a variety of visceral abnormalities that include the heart, lungs, genitourinary system. Tow phenotypes are described according to the feto-placental attachment. We report a particular case and iconography of LbWC associated with a giant sacral meningocele never described before. The patient was 26 years old, primigravida, with no illnesses or recent infections. She had no history of prenatal exposure to teratogenic agents, nor any family history of congenital malformations. She was referred for polymalformatif syndrome at 30 gestation weeks. Advanced sonography showed giant omphalocel with eviscerated liver, stomac and kidney, club feet, kyphoscoliosis and giant sacral fluid cyst. A 2100 g fetus was delivered, post natal examination confirmed LbWC with abdominoplacental attachment and the particularity of the presence of giant sacral meningocele, two bilateral hemi-genital tubercles and anal atresia.

关键词： Fetal Malformation Laparoscisis Feto-Placental Attachment Kyphoscolisis

Effects of 12 weeks of power-oriented resistance training plus high-intensity interval training on metabolic syndrome factors in older people with COPD

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Translational Exercise Biomedicine

Translational Exercise biomedicine 2024年第1期1卷 23-31页

作者： Lucia Romero-Valia Ivan baltasar-Fernandez Carlos Rodriguez-Lopez Jose Losa-Reyna Ana Alfaro-Acha amelia Guadalupe-Grau Ignacio Ara Luis M.Alegre Francisco J.García-García Julian Alcazar GENUD Toledo Research Group Faculty of Sports SciencesUniversidad de Castilla-La ManchaToledoSpainCarlos III S/N-45071 CIbER on Frailty and Healthy Ageing(CIbERFES) Instituto de Salud Carlos IIIMadridSpain28029 Instituto de Investigación Sanitaria de Castilla-La Mancha(IDISCAM) Junta de Comunidades de Castilla-La Mancha(JCCM)ToledoSpain45071 Geriatric Department Hospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)MadridSpain Valoración del Rendimiento Deportivo Actividad Física y Salud y Lesiones Deportivas(REDAFLED)Universidad de ValladolidSoriaSpain Department of Geriatrics Hospital Virgen del ValleComplejo Hospitalario Universitario de ToledoToledoSpain

Objectives To assess the effects of an exercise training program combining power-oriented resistance training(RT)and high-intensity interval training(HIIT)on metabolic syndrome(MetS)markers in older people with *** Twenty-nine older people(66–90 years old)with COPD were randomly assigned to 12 weeks of exercise training(ET;power-oriented RT+HIIT)or a control group(CON).Waist circumference,diastolic(DbP)and systolic blood pressure(SbP),and serum fasting glucose,triglycerides and HDL cholesterol levels were assessed at baseline and after 12 *** mixed-effects models were used to assess the effects of the intervention,and data were reported as mean and 95%confidence interval *** Waist circumference increased in the CT group,but not in the ET group(2.0[0.2,3.7]vs.1.0[−1.3,3.2]cm,respectively).No changes in fasting glucose(−4.1[−10.3,2.1]vs.−1.0[−8.7,6.7]mg dL−1),triglycerides(3.9[−13.4,21.3]vs.−13.9[−35.6,7.7]mg dL−1)or HDL cholesterol(1.0[−3.4,5.4]vs.2.9[−2.6,8.4]mg dL−1)were found in the CT or ET group,*** ET group exhibited decreased DbP(−5.2[−9.5,−0.8]mmHg)and SbP(−2.7[−22.7,−2.7]mmHg),while no changes were found in the CT group(0.3[−3.2,3.7]and−3.5[−11.4,4.5]mmHg).MetS z-score declined in ET but remained unchanged in CT(−0.88[−1.74,−0.03]vs.0.07[−0.62,0.76],respectively).Conclusions A 12-week exercise training program led to a reduction in blood pressure and MetS z-score in older people with COPD.

关键词： chronic obstructive pulmonary disease lung disease pulmonary rehabilitation concurrent training randomized controlled trial

2020年第六届“创艺杯”全国少儿书画创意大赛优秀作品选登

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小艺术家 2020年第4期 6-9页

作者：潘睿铭罗家璇(指导) 周蔚霖冼钻弟(指导) 谭晶刘赛春(指导) 王淙薇王心刚(指导) 李钜涂迎(指导) 王颖王伙平(指导) 蔡雨瑄董俊男(指导) [新加坡]陈艺郡陈镜淳王婉明(指导) 方婉鑫张蔚欣李秋瑶詹桂林(指导) 夏汝岚汤晶惠(指导) 潘彦诉凌立欣(指导) 蔡敬森刘婉秋(指导) 邓汶欣陈成拔(指导) 黄希璇卢韬文杨逸(指导) 天龙林余艳琪(指导) 孙一诺 [美国]amelia 马月雅李绍渲(指导) 李芷萱全承志(指导) 陈珈毅滕楠(指导) 江子琳王习雯杨莹杨叶滢李欣曈苏子墨云静堂不详广州市东堤幼儿园广东省东莞乐艺美术培训中心跟我学在线美术工作室广东省东莞市燃点艺术书画培训中心新风书画华南师范大学附属天河实验学校广州市海珠区少年宫广州市芳邻书画培训中心湖南省常德市郡德学校爱学教育广川市点墨书画艺术培训中心广州书画园培训中心广州市社会福利院重庆市南渝中学

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio bosco barón-Franco Lydia barrera-Pulido Rafael bellido-Alba Máximo bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of biomedicine of Seville(IbiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID