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Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

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World Journal of Gastrointestinal Surgery 2021年第1期13卷 50-75页

作者： Filippo Melli Ilenia Bartolini Matteo Risaliti Rosaria Tucci Maria Novella Ringressi Paolo Muiesan Antonio Taddei amedeo Amedei Department of Clinical and Experimental Medicine University of FlorenceAzienda Ospedaliero-Universitaria CareggiFlorence 50134Italy

BACKGROUND Colorectal cancer is a common tumor with a quite high-related *** the used curative treatments,patients will develop cancer recurrence in up to 50%of the cases and/or other primary *** most of the recurrences are discovered within 3 years from the first treatment,a small percentage is found after 5 *** early detection of recurrence is crucial to allow further therapies improving patients’*** follow-up programs have been developed but the optimal one is far from being *** To evaluation of potential prognostic factors for timing and patterns of recurrence in order to plan tailored follow-up *** Perioperative and long-term data of all consecutive patients surgically treated with curative intent,from January 2006 to June 2009,for colorectal adenocarcinoma,were retrospectively reviewed to find potential prognostic factors associated with:(1)Recurrence incidence;(2)Incidence of an early(within 3 years from surgery)or late recurrence;and(3)Different sites of *** addition,the incidence of other primary neoplasms has been evaluated in a cohort of patients with a minimum potential follow-up of 10 *** Our study included 234 *** median follow-up period has been 119±46.2 *** recurrence rate has been 25.6%.Patients with a higher chance to develop recurrence had also the following characteristics:Higher levels of preoperative glycemia and carcinoembryonic antigen,highest anaesthesiologists Score score,occlusion,received a complex operation performed with an open technique,after a longer hospital stay,and showed advanced *** independent prognostic factors for recurrence were the hospital stay,N stage 2,and M stage 1(multivariate analysis).Younger ages were significantly associated with an early recurrence *** that received intermediate colectomies or segmental resections,having an N stage 2 or American Joint Committee on Cancer stage 3 tumors were al

关键词： Prognostic factors Recurrence Recurrence patterns Colorectal cancer Longterm follow-up Follow-up programs

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Fecal metabolomic profiles: A comparative study of patients with colorectal cancer vs adenomatous polyps

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World Journal of Gastroenterology 2021年第38期27卷 6430-6441页

作者： Giulia Nannini Gaia Meoni Leonardo Tenori Maria Novella Ringressi Antonio Taddei Elena Niccolai Simone Baldi Edda Russo Claudio Luchinat amedeo Amedei Department of Clinical and Experimental Medicine University of FlorenceFlorence 50134Italy Department of Chemistry“Ugo Schiff” University of FlorenceFlorence 50134Italy Department of Chemistry&Magnetic Resonance Center(CERM) University of FlorenceFlorence 50134Italy

BACKGROUND Colorectal cancer(CRC),the third most common cause of death in both males and females worldwide,shows a positive response to therapy and usually a better prognosis when detected at an early ***,the survival rate declines when the diagnosis is late and the tumor spreads to other ***,the measures widely used in the clinic are fecal occult blood test and evaluation of serum tumor markers,but the lack of sensitivity and specificity of these markers restricts their use for CRC *** to its high sensitivity and precision,colonoscopy is currently the gold-standard screening technique for CRC,but it is a costly and invasive ***,the implementation of custom-made methodologies including those with minimal invasiveness,protection,and reproducibility is highly *** regard to other screening methods,the screening of fecal samples has several benefits,and metabolomics is a successful method to classify the metabolite shift in living systems as a reaction to pathophysiological influences,genetic modifications,and environmental *** To characterize the variation groups and potentially recognize some diagnostic markers,we compared with healthy controls(HCs)the fecal nuclear magnetic resonance(NMR)metabolomic profiles of patients with CRC or adenomatous polyposis(AP).METHODS Proton nuclear magnetic resonance spectroscopy was used in combination with multivariate and univariate statistical approaches,to define the fecal metabolic profiles of 32 CRC patients,16 AP patients,and 38 HCs well matched in age,sex,and body mass *** NMR metabolomic analyses revealed that fecal sample profiles differed among CRC patients,AP patients,and HCs,and some discriminatory metabolites including acetate,butyrate,propionate,3-hydroxyphenylacetic acid,valine,tyrosine and leucine were *** In conclusion,we are confident that our data can be a forerunner for future studies on CRC management,especially the di

关键词： Colorectal cancer Adenomatous polyps Nuclear magnetic resonance metabolomics Fecal samples Fecal metabolomics

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Usefulness and Effectiveness of Related Party Transactions （RPTs） Disclosure： Empirical Evidence From Italy

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Journal of Modern Accounting and Auditing 2014年第11期10卷 1105-1118页

作者： amedeo De Cesari Oscar Domenichelli Martina Vallesi University of Manchester Manchester United Kingdom Universita Politecnica delle Marche Ancona Italy

Related party transactions （RPTs） can be used by corporate insiders （e.g., managers, controlling shareholders） to expropriate corporate outsiders （e.g., minority shareholders）. We argue that effective disclosure of RPTs can eliminate or at least reduce expropriation phenomena by letting corporate outsiders assess the fairness of the transactions and identify the underlying conflicts of interest. We consider a sample of large RPTs carried out by listed corporations in Italy, a country that has been affected by significant corporate scandals in recent years. In particular, we analyse the content of several compulsory informative documents, required by CONSOB （the Italian Securities and Exchange Commission）, concerning large RPTs. The focus of our content analysis is on the ＂warnings＂ sections of these documents that should convey clear and comprehensive information on potential risks and conflicts of interest. Our empirical results show that, while the ＂warnings＂ sections of the studied documents generally contain all the information required by existing rules, the depth of the information provided is often unlikely to be sufficient to communicate the implications of the RPTs. Thus, readers may not find the disclosed information adequate to evaluate the fairness of the transactions. Moreover, visual representations are rarely used in the informative documents. The use of such representations could allow companies to convey the structures and features of complex RPTs in a simpler and more direct way.

关键词： related party related party transactions (RPTs) conflicts of interest disclosure

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Application of a Machine Learning Algorithm for the Structural Optimization of Circular Arches with Different Cross-Sections

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Journal of Applied Mathematics and Physics 2021年第5期9卷 1159-1170页

作者： Jonathan Melchiorre amedeo Manuello Bertetto Giuseppe Carlo Marano Department of Structural Building and Geotechnics Politecnico di Torino. Corso Duca degli Abruzzi Torino Italy

Arches are employed for bridges. This particular type of structures, characterized by a very old use tradition, is nowadays, widely exploited because of its strength, resilience, cost-effectiveness and charm. In recent years, a more conscious design approach that focuses on a more proper use of the building materials combined with the increasing of the computational capability of the modern computers, has led the research in the civil engineering field to the study of optimization algorithms applications aimed at the definition of the best design parameters. In this paper, a differential formulation and a MATLAB code for the calculation of the internal stresses in the arch structure are proposed. Then, the application of a machine learning algorithm, the genetic algorithm, for the calculation of the geometrical parameters, that allows to minimize the quantity of material that constitute the arch structures, is implemented. In this phase, the method used to calculate the stresses has been considered as a constraint function to reduce the range of the solutions to the only ones able to bear the design loads with the smallest volume. In particular, some case studies with different cross-sections are reported to prove the validity of the method and to compare the obtained results in terms of optimization effectiveness.

关键词： Structural Optimization Genetic Algorithm Boundary Value Problem Arch Volume Minimization

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Evaluating the best treatment for multifocal hepatocellular carcinoma:A propensity score-matched analysis

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World Journal of Gastroenterology 2022年第29期28卷 3981-3993页

作者： Matteo Risaliti Ilenia Bartolini Claudia Campani Umberto Arena Carlotta Xodo Valentina Adotti Martina Rosi Antonio Taddei Paolo Muiesan amedeo Amedei Giacomo Batignani Fabio Marra Department of Experimental and Clinical Medicine AOU CareggiFlorence 50134Italy

BACKGROUND Hepatocellular carcinoma(HCC)is a common tumour often diagnosed with a multifocal *** with multifocal HCC represent a heterogeneous *** Trans-Arterial ChemoEmbolization(TACE)is the most frequently employed treatment for these patients,previous data suggested that liver resection(LR)could be a safe and effective *** To compare LR and TACE in patients with multifocal HCC in terms of procedurerelated morbidity and oncologic *** All patients with multifocal HCC who underwent LR or TACE as the first procedure between May 2011 and March 2021 were *** decision to perform surgery or TACE was made after a multidisciplinary team *** patients in Child-Pugh class A or B7 and stage B(according to the Barcelona Clinic Liver Cancer staging system,without severe portal hypertension,vascular invasion,or extrahepatic spread)were included in the final *** score matching was used to adjust the baseline differences between patients undergoing LR and the TACE group[number and diameter of lesions,presence of cirrhosis,alpha-fetoprotein(AFP)levels,and Model for End-Stage Liver Disease score].The Kaplan-Meier method was used to estimate overall survival(OS)and disease-free survival(DFS).The outcomes of LR and TACE were compared using the log-rank *** After matching,30 patients were eligible for the final analysis,15 in each *** rates were 42.9% and 40% for LR and TACE,respectively(P=0.876).Median OS was not different in the LR and TACE groups(53 mo vs 18 mo,P=0.312),while DFS was significantly longer with LR(19 mo vs 0 mo,P=0.0001).Subgroup analysis showed that patients in the Italian Liver Cancer(***)B2 stage,with AFP levels lower than 400 ng/mL,less than 3 lesions,and lesions bigger than 41 mm,benefited more from LR in terms of *** classified as *** B3,with AFP levels higher than 400 ng/mL and with more than 3 lesions,appeared to receive more benefi

关键词： Hepatocellular carcinoma Multifocal hepatocellular carcinoma Liver resection Trans-arterial chemoembolization Guidelines Liver tumour management

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基于Morris、Sobol和EFAST的LID设施模型参数全局敏感性分析

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中国农村水利水电 2022年第6期 104-110页

作者：金梦潇田勇 Michele lancia 于江郑春苗哈尔滨工业大学环境学院哈尔滨150090 南方科技大学环境科学与工程学院地表水-地下水污染综合治理国家环境保护重点实验室广东深圳518055 北京大学工学院水科学中心北京100871

SWMM低影响开发模块可模拟暴雨情景下LID设施的水文效应,已在我国城市雨洪管理中得到广泛应用。研究以深圳市宝安区新桥河流域为例,选用Morris法、Sobol法和EFAST法分析了SWMM模型输出变量中的蒸发量、雨水下渗、地表径流量和峰值流量对... 详细信息

SWMM低影响开发模块可模拟暴雨情景下LID设施的水文效应,已在我国城市雨洪管理中得到广泛应用。研究以深圳市宝安区新桥河流域为例,选用Morris法、Sobol法和EFAST法分析了SWMM模型输出变量中的蒸发量、雨水下渗、地表径流量和峰值流量对4种LID设施(植被草沟、绿色屋顶、生物滞留池和透水铺装)模型参数的全局敏感性响应,并对比了3种方法的分析结果。研究表明:生物滞留池导水率对蒸发量、雨水下渗和地表径流量影响最显著,生物滞留池植物覆盖率和导水率对峰值流量影响最显著。Morris法、Sobol法和EFAST法计算的参数敏感性有较高的一致性。通过3种方法的对比分析,可有效地提高LID设施参数的敏感性分析的可靠性和准确性,从而为海绵城市优化设计提供技术支撑。

关键词： LID设施 SWMM Morris法 Sobol法 EFAST法全局敏感性海绵城市

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极端降水条件下海绵设施空间配置策略研究

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水利水电技术（中英文） 2022年第S2期53卷 100-106页

作者：金梦潇田勇 MICHELE lancia 郑权一郑春苗哈尔滨工业大学环境学院黑龙江哈尔滨150090 南方科技大学环境科学与工程学院地表水-地下水污染综合治理国家环境保护重点实验室广东深圳518055 暨南大学深圳旅游学院广东深圳518053

气候变化导致极端天气频发,城市亟需提高韧性来适应极端天气的影响。本研究通过极端降水和普通降水事件的对比,研究不同海绵设施的空间配置(分散式、组团式、集中式)对雨水径流及入渗的影响。通过建立SWMM理想模型,模拟不同海绵设施空... 详细信息

气候变化导致极端天气频发,城市亟需提高韧性来适应极端天气的影响。本研究通过极端降水和普通降水事件的对比,研究不同海绵设施的空间配置(分散式、组团式、集中式)对雨水径流及入渗的影响。通过建立SWMM理想模型,模拟不同海绵设施空间配置的径流总量、入渗总量、入渗峰值和径流总量控制率的情况。结果表明:在海绵设施类型选择相同、面积相同时,分散式会随着降水量的增加,入渗总量和入渗延迟时间增加。组团式和集中式的入渗总量和入渗延迟时间基本不会因为雨量的增加而变化,但是两者的入渗时间会随着雨量的增加而延长。根据不同的地质条件和地下水的高低,能够对海绵城市规划中海绵设施类型的选择和空间配置方式提出一种科学的策略。

关键词：极端降水海绵城市 LID设施 SWMM 雨水入渗空间配置

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Evaluation and comparison of short chain fatty acids composition in gut diseases

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World Journal of Gastroenterology 2019年第36期25卷 5543-5558页

作者： Elena Niccolai Simone Baldi Federica Ricci Edda Russo Giulia Nannini Marta Menicatti Giovanni Poli Antonio Taddei Gianluca Bartolucci Antonino Salvatore Calabrò Francesco Claudio Stingo amedeo Amedei Department of Experimental and Clinical Medicine University of Florence Florence 50134 Italy Department of Biomedical Experimental and Clinical Sciences “Mario Serio” University of Florence Florence 50134 Italy Department of Neurosciences Psychology Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences University of Florence Florence 50134 Italy Department of Statistics Computer Science Applications “G.Parenti” Florence 50134 Italy Department of Biomedicine Azienda Ospedaliera Universitaria Careggi Florence 50134 Italy

BACKGROUND An altered (dysbiosis) and unhealthy status of the gut microbiota is usually responsible for a reduction of short chain fatty acids (SCFAs) concentration. SCFAs obtained from the carbohydrate fermentation processes are crucial in maintaining gut homeostasis and their determination in stool samples could provide a faster, reliable and cheaper method to highlight the presence of an intestinal dysbiosis and a biomarker for various gut diseases. We hypothesize that different intestinal diseases, such as celiac disease (CD), adenomatous polyposis (AP) and colorectal cancer (CRC) could display a particular fecal SCFAs’ signature. AIM To compare the fecal SCFAs’ profiles of CD, AP, CRC patients and healthy controls, using the same analytical method. METHODS In this cross-sectional study, we defined and compared the SCFAs’ concentration in fecal samples of 9 AP, 16 CD, 19 CRC patients and 16 healthy controls (HC). The SCFAs’ analysis were performed using a gas-chromatography coupled with mass spectrometry method. Data analysis was carried out using Wilcoxon ranksum test to assess pairwise differences of SCFAs’ profiles, partial least squaresdiscriminate analysis (PLS-DA) to determine the status membership based on distinct SCFAs’ profiles, and Dirichlet regression to determine factors influencing concentration levels of SCFAs. RESULTS We have not observed any difference in the SCFAs’ amount and composition between CD and healthy control. On the contrary, the total amount of SCFAs was significantly lower in CRC patients compared to HC (P = 0.044) and CD (P = 0.005). Moreover, the SCFAs’ percentage composition was different in CRC and AP compared to HC. In detail, HC displayed higher percentage of acetic acid (P value = 1.3 × 10-6) and a lower amount of butyric (P value = 0.02192), isobutyric (P value = 7.4 × 10-5), isovaleric (P value = 0.00012) and valeric (P value = 0.00014) acids compared to CRC patients. AP showed a lower abundance of acetic acid (P value = 0.

关键词： Short chain fatty acids Microbiota Colorectal cancer Adenoma Celiac disease

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Gastric cancer and the epoch of immunotherapy approaches

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World Journal of Gastroenterology 2015年第19期21卷 5778-5793页

作者： Elena Niccolai Antonio Taddei Domenico Prisco amedeo Amedei Department of Experimental and Clinical Medicine University of Florence Department of Surgery and Translational Medicine University of Florence Department of Biomedicine Azienda Ospedaliera Universitaria Careggi SOD Medicina Interna Interdisciplinare-DAI Neuromuscoloscheletrico e degli organi di senso Azienda Ospedaliera Universitaria Careggi

The incidence of gastric cancer(GC) fell dramatically over the last 50 years, but according to IARC-Globocan 2008, it is the third most frequent cause of cancerrelated deaths with a case fatality GC ratio higher than other common malignancies. Surgical resection is the primary curative treatment for GC though the overall 5-year survival rate remains poor(approximately 20%-25%). To improve the outcome of resectable gastric cancer, different treatment strategies have been evaluated such as adjuvant or perioperative chemotherapy. In resected gastric cancer, the addition of radiotherapy to chemotherapy does not appear to provide any additional benefit. Moreover, in metastatic patients, chemotherapy is the mainstay of palliative therapy with a median overall survival of 8-10 mo and objective response rates of merely 20%-40%. Therefore, the potential for making key beneficial progress is to investigate the GC molecular biology to realize innovative therapeutic strategies, such as specific immunotherapy. In this review, we provide a panoramic view of the different immune-based strategies used for gastric cancer treatment and the results obtained in the most significant clinical trials. In detail, firstly we describe the therapeutic approaches that utilize the monoclonal antibodies while in the second part we analyze the cell-based immunotherapies.

关键词： Gastric cancer Immunotherapy Monoclonalantibodies T cells Dendritic cells NK cells

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Application of a Machine Learning Algorithm for the Structural Optimization of Circular Arches with Different Cross-Sections

Application of a Machine Learning Algorithm for the Structur...

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作者： Jonathan Melchiorre amedeo Manuello Bertetto Giuseppe Carlo Marano Department of Structural Building and Geotechnics Politecnico di Torino.Corso Duca degli Abruzzi

关键词： Structural Optimization Genetic Algorithm Boundary Value Problem Arch Volume Minimization

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