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Chinese Medical Journal 2010年第12期123卷 1596-1602页

作者： FENG Jing CHEN Bao-yuan ambrose an-po chiang Department of Respiratory Medicine Tianjin Medical University General Hospital Tianjin 300052 China Division of Pulmonary and Critical Care Medicine Duke University Medical Center Durham NC 27710 USA

Obstructive sleep apnea （OSA）, which is the most common sleep-related breathing disorder and characterized by recurrent collapse of the upper airway, causes repeated arousals from sleep, decreased oxygen saturation of the blood, and excessive daytime sleepiness. Patients with OSA are at increased risk of cardiovascular and cerebrovascular disease,

关键词： obstructive sleep apnea depression continuous positive airway pressure prevalence treatment

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Chinese Medical Journal 2010年第17期123卷 2392-2399页

作者： FENG Jing ambrose an-po chiang WU Qi CHEN Bao-yuan CUI Lin-yang LIANG Dong-chun ZHANG Ze-li YAO Wo Department of Respiratory Disease Tianjin Medical University General Hospital Tianjin 300052 China Division of Pulmonary and Critical Care Medicine Duke University Medical Center Durham NC 27710 USA Tianjin Neurology Research Institute Tianjin 300052 China Tianjin Medical University Endocrinology Research Institute Tianjin 300052 China

Background Sleep disturbance is common in patients with emphysema. This study aimed to develop a novel model of sleep-related hypoxemia （SRH） in emphysema （SRHIE） with rats, and to explore the inflammatory status of SRHIE in lung, liver, pancreas, carotid artery and whole *** Seventy-five male Wistar rats were assigned to 5 groups with 15 per group according to the exposure conditions. The protocols varied with the degree of hypoxia exposure and severity of pre-existing emphysema caused by cigarette smoke exposure：（1） SRH control （SRHCtrl） group, sham smoke exposure （smoke exposure, exposed to smoke of 15 cigarettes twice everyday, 16 weeks） and SRH exposure （12.5% O2, 3 hours, SRH exposure, divide total hypoxia time （1.5 hours or 3 hours） into 4 periods evenly （22.5 minutes or 45 minutes） and distribute these hypoxia periods evenly into physiological sleep time of rats identified by electroencephalogram, week 9 to week 16）; （2） Emphysema control （ECtrl） group, smoke exposure and sham SRH exposure （21% O2, 3 hours）; （3） Short SRH in emphysema （SRHShort） group, smoke exposure and short SRH exposure （12.5% O2, 1.5 hours）; （4） Mild SRH in emphysema （SRHMild） group,smoke exposure and mild SRH exposure （15% O2, 3 hours）; （5） Standard SRH in emphysema （SRHStand） group, smoke exposure and SRH exposure （12.5% O2, 3 hours）. ECtrl, SRHShort, SRHMild and SRHStand groups were groups with emphysematous rats. Two days before the end of exposure, 5 rats in each group were randomly selected for arterial blood gas analysis. In the rest 10 rats in each group, we obtained blood samples and bronchoalveolar lavage fluid （BALF）for routine tests. We also obtained tissue blocks of lung, liver, pancreas, and right carotid artery for pathologic scoring and measurements of liver oxidative stress （measuring hepatic oxidative stress enzymes, superoxide dismutase （SOD） activity, catalase （CAT） activity and malondialdehyde （MDA） concentration）.Results Emphysematous groups had higher me

关键词： sleep-related hypoxemia emphysema inflammation oxidative stress bronchoalveolar lavage fluid superoxide dismutase catalase malondialdehyde

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慢性阻塞性肺疾病的睡眠相关低氧

国际呼吸杂志 2009年第23期29卷 1461-1464页

作者：冯靖姚我 ambroseAn—po chiang 吴琦陈宝元天津医科大学总医院呼吸科 300052 杜勒姆美国杜克大学医学中心呼吸与危重监护科 27710

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者的夜间低氧问题从50年以前就认识到了。在许多COPD患者的多导睡眠监测研究中，研究者发现患者的睡眠潜伏期延长，总睡眠时间减少，慢波睡眠减少，快速动眼睡眠减... 详细信息

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者的夜间低氧问题从50年以前就认识到了。在许多COPD患者的多导睡眠监测研究中，研究者发现患者的睡眠潜伏期延长，总睡眠时间减少，慢波睡眠减少，快速动眼睡眠减少，还有一个最为重要的问题就是睡眠相关低氧（SRH）。本文主要对COPD患者SRH的定义、原因、患病率、严重程度、意义以及治疗等相关问题作一综述。

关键词：肺疾病慢性阻塞性睡眠低氧

Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

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World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-po Li Zi-Shan Wang Hong-Xia Yu Shan-Shan Wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

Hybrid Silicon-Carbon Nanostructured Composites as Superior Anodes for Lithium Ion Batteries

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Nano Research 2011年第3期4卷 290-296页

作者： po-chiang Chen Jing Xu Haitian Chen Chongwu Zhou Mork Family Department of Chemical Engineering and Materials Science University of Southern Califomia Los Angeles CA 90089 USA Ming-Hsieh Department of Electrical Engineering University of Southern California Los Angeles CA 90089 USA

We have successfully fabricated a hybrid silicon-carbon nanostructured composite with large area （about 25.5 in^2） in a simple fashion using a conventional sputtering system. When used as the anode in lithium ion batteries, the uniformly deposited amorphous silicon （a-Si） works as the active material to store electrical energy, and the pre-coated carbon nanofibers （CNFs） serve as both the electron conducting pathway and a strain/stress relaxation layer for the sputtered a-Si layers during the intercalation process of lithium ions. As a result, the as-fabricated lithium ion batteries, with deposited a-Si thicknesses of 200 nm or 300 nm, not only exhibit a high specific capacity of 〉2000 mA.h/g, but also show a good capacity retention of over 80% and Coulombic efficiency of 〉98% after a large number of charge/discharge experiments. Our approach offers an efficient and scalable method to obtain silicon-carbon nanostructured composites for application in lithium ion batteries.

关键词： Amorphous silicon carbon nanofibers lithium ion batteries hybrid nanostructured composite

Distinguish models mimicking the SM Higgs

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Frontiers of physics 2013年第3期8卷 285-293页

作者： Jung Chang Kingman Cheung po-Yan Tseng Tzu-chiang Yuan Department of Physics Tsing Hua University Hsinchu 300 Taiwan China Division of Quantum Phases and Devices School of Physics Konkuk University Seoul 143-701 Republic of Korea Institute of Physics Academia Sinica Nangang Taipei 11529 Taiwan China

The new particle around 125 GeV observed at the LHC is almost consistent with the standard model Higgs boson, except that the diphoton decay mode may be excessive. We summarize a number of possibilities. We propose to use the vector-boson fusion to test the underlying model for electroweak symmetry breaking. Using the well known dijet-tagging technique to single out the vector-boson fusion mechanism, we investigate potential of vector-boson fusion to discriminate a number of models suggested to give an enhanced inclusive diphoton production rate.

关键词： Higgs boson vector-boson fusion diphoton electroweak svmmetrv breaking

Advection-Enhanced Gradient Vector Flow for Active-Contour Image Segmentation

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Communications in Computational Physics 2019年第6期26卷 206-232页

作者： po-Wen Hsieh Pei-chiang Shao Suh-Yuh Yang Department of Applied Mathematics National Chung Hsing UniversitySouth DistrictTaichung City 40227Taiwan Department of Mathematics National Central UniversityJhongli DistrictTaoyuan City 32001Taiwan National Center for Theoretical Sciences National Taiwan UniversityDa’an DistrictTaipei City 10617Taiwan

In this paper,we propose a new gradient vector flow model with advection enhancement,called advection-enhanced gradient vector flow,for calculating the external force employed in the active-contour image *** proposed model is mainly inspired by the functional derivative of an adaptive total variation regularizer whose minimizer is expected to be able to effectively preserve the desired object *** specifically,by incorporating an additional advection term into the usual gradient vector flow model,the resulting external force can much better help the active contour to recover missing edges,to converge to a narrow and deep concavity,and to preserve weak *** experiments are performed to demonstrate the high performance of the newly proposed model.

关键词： Image segmentation active contour gradient vector flow external force

EZ-Manipulator:Designing a mobile,fast,and ambiguity-free 3D manipulation interface using smartphones

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Computational Visual Media 2018年第2期4卷 139-147页

作者： po-Huan Wseng Shih-Hsuan Hung Pei-Ying chiang Chih-Yuan Yao Hung-Kuo Chu "National Tsing Hua University" Hsinchu 30013TaiwanChina. "National Taiwan University of Science and Technology" Taipei 10607TaiwanChina. "National Taipei University of Technology" Taipei 10607TaiwanChina.

Interacting with digital contents in 3 D is an essential task in various applications such as modeling packages, gaming, virtual reality, etc. Traditional interfaces using keyboard and mouse or trackball usually require a non-trivial amount of working space as well as a learning process. We present the design of EZ-Manipulator, a new 3 D manipulation interface using smartphones that supports mobile, fast, and ambiguity-free interaction with 3 D objects. Our system leverages the built-in multi-touch input and gyroscope sensor of smartphones to achieve 9 degrees-of-freedom axis-constrained manipulation and free-form *** EZ-Manipulator to manipulate objects in 3 D is easy. The user merely has to perform intuitive singleor two-finger gestures and rotate the hand-held device to perform manipulations at fine-grained and coarse levels respectively. We further investigate the ambiguity in manipulation introduced by indirect manipulations using a multi-touch interface, and propose a dynamic virtual camera adjustment to effectively resolve the ambiguity. A preliminary study shows that our system has significant lower task completion time compared to conventional use of a keyboard–mouse interface, and provides a positive user experience to both novices and experts.

关键词： 3D manipulation interface interaction technique multi-touch gyroscope sensorl mobile device input device

Antibodies against analogous heptad repeat peptide HR212 of Newcastle Disease Virus inhibit virus-cell membrane fusion

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Progress in Natural Science:Materials International 2007年第2期17卷 150-155页

作者： TIEN po Beijing 100080 China Chinese Academy of Sciences Molecular Virology Research Center Institute of Microbiology

Membrane fusion is a key step in enveloped virus entry. Highly conserved heptad repeat regions (HR1 and HR2) of Newcastle disease virus (NDV) fusion protein (F) are critical functional domains for viral membrane fusion. They display different conformations in the membrane fusion states and are viewed as candidate targets for neutralizing antibody responses. We previously reported that an analog of heptad repeat peptides HR2-HR1-HR2(HR212) and HR2 could inhibit NDV induced cell-cell membrane fusion. Here, we show that HR212 can induce the production of highly potent antibody in immunized rabbits, which could recognize full length peptides of both HR1 and HR2, and inhibit NDV hemagglutination and NDV entry. These suggest that either HR212 or its antibody could be an inhibitor of virus-induced cell-cell membrane fusion.

关键词： NDV heptad repeat domains immune response inhibition of viral entry.

Synergistic effect of fatty liver and smoking on metabolic syndrome

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World Journal of Gastroenterology 2009年第42期15卷 5334-5339页

作者： po-Hsin chiang Tsui-Yen Chang Jong-Dar Chen Department of Family Medicine Shin Kong Wu Ho-Su Memorial Hospital#95 Wen Chang RoadShih LinTaipei 111TaiwanChina School of Medicine Fu Jen Catholic University#510 Chung Cheng RoadHsinchuangTaipei 242TaiwanChina

AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its ***:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-Su Memorial Hospital from January to December 2005.A total of 3455(1981 men and 1474 women) subjects were included in final *** liver was diagnosed using abdominal ultrasonography by trained *** modified National Cholesterol Education Program Adult Treatment Panel Ⅲ was used to define metabolic *** associations between smoking,fatty liver and metabolic syndrome were analyzed using multiple logistic ***:Subjects with fatty liver,and who smoked tobacco,had the highest odds ratios(ORs) for high waist circumference [OR,4.5(95% CI:3.3-6.1) ,P poprotein cholesterol(HDL-C) [OR,8.3(95% CI:6.1-11.3) ,P ponents,especially for hypertriglyceridemia and low serum HDL-C.

关键词： Smoking Fatty liver Synergistic effect Metabolic syndrome