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Immunoprophylaxis failure and vaccine response in infants born to mothers with chronic hepatitis B infection in Djibouti

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World Journal of Hepatology 2024年第7期16卷 1039-1050页

作者： Sahal Darar Dirir ambroise D Ahouidi Aboubacry Drame Warsama Osman Abdi Guelleh Youssouf Kayad Mohamed Houmed Aboubakar Makhtar Camara Coumba Toure Kane Halimatou Diop Ndiaye Laboratoire Medical de la Caisse National de SécuritéSocial de Djibouti Caisse National de SécuritéSocial de DjiboutiDjibouti BP 696Senegal Parasitology Institut de Recherche en santéde Surveillanceépidémiologique et de FormationDakar 7325Senegal Ecole Doctoral UniversitéAlioune Diop de BambeyDakar 7325Senegal Department of Des Soins Caisse National de Securite SocialDjibouti 696Senegal Centre de Soin Caisse National de Securite SocialDjibouti 696Senegal Laboratoire Medical Mer Rouge Djibouti 99399Senegal Centre Hospitalier Universitaire Aristide le Dantec Laboratoire Bactériologie-Virologie-Hôpital Aristide le DantecDakar 7325Senegal Department of Virology Institut de Recherche en Santéde Surveillanceépidémiologique et de FormationDakar 7325Senegal Bacteriology and Virology Laboratory Le Dantec University Teaching HospitalDakar BP 7325Senegal

BACKGROUND In endemic areas,vertical transmission of hepatitis B virus(HBV)remains a major source of the global reservoir of infected *** mother-to-child transmission(MTCT)of HBV is at the heart of World Health Organization’s goal of reducing the incidence of HBV in children to less than 0.1%by *** screening for hepatitis B during pregnancy and neonatal vaccination are the main preventive *** To evaluate the efficacy of HBV vaccination combined with one dose of immunoglobulin in children born to hepatitis B surface antigen(HBsAg)-positive mothers in Djibouti *** We conducted a study in a prospective cohort of HBsAg-positive pregnant women and their *** study ran from January 2021 to May 2022,and infants were followed up to 7 mo of *** serological markers and viral load in pregnant women were measured using aVidas microparticle enzyme-linked immunosorbent assay(Biomérieux,Paris,France)and the automated Amplix platform(Biosynex,Strasbourg,France).All infants received hepatitis B immunoglobulin and were vaccinated against HBV at *** infants were closely monitored to assess their seroprotective response and for failure of *** logistic regression was also used to identify risk factors associated with immunoprophylaxis failure and poor vaccine *** statistical analyses were performed with version 4.0.1 of the R *** Of the 50 pregnant women recruited,the median age was 31 years,ranging from 18 years to 41 *** MTCT rate in this cohort was 4%(2/50)in HBsAg-positive women and 67%(2/3)in hepatitis B e antigen-positive women with a viral load>200000 IU/*** the 48 infants who did not fail immunoprophylaxis,8(16%)became poor responders(anti-HB100 mIU/mL).Factors associated with this failure of immunoprophylaxis were maternal HBV DNA lev

关键词： Hepatitis B surface antigen Infants Hepatitis B immunoglobulin Hepatitis vaccine Djibouti

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Prognostic Role of Pulse Pressure in the Acute Phase of Myocardial Infarction

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World Journal of Cardiovascular Diseases 2015年第8期5卷 254-260页

作者： Justin Koffi Christoph Konin Yves N’goran Arnaud Ekou ambroise Gnaba Esaie Soya Marie Paul N’Cho Mottoh Bénédict Boka Michel Adoh Adoh Institute of Cardiology of Abidjan University of Cocody Abidjan Ivory Coast Hospital of the National Police Abidjan Ivory Coast

Objective: Pulse pressure is a cardiovascular risk factor. The aim of our study was to assess the short and medium term prognosis of myocardial infarction in the African black having a high pulse pressure. Methods: We performed a comparative retrospective study of 200 patients hospitalized in the Cardiology Institute of Abidjan. The first group (100 patients) had a high pulse pressure (≥60 mmHg). The second (100 patients) had normal pulse pressure (≤60 mmHg). The primary outcome was mortality. Secondary endpoints were represented by hemodynamic complications, rhythmic and conduction disturbances. Both groups of patients were matched. The matching is performed by socio-demographic criteria, the seat of necrosis and cardiovascular risk factors. The authors explained the choice of 60 mmHg as references because in all their studies they have realized that it is from 60 mmHg pulse pressure morbid events that occur in prospective studies and retrospective studies in stiffness of the great arteries is responsible for all these events. Pulse pressure is in itself, an independent cardiovascular risk factor in systolic blood pressure, diastolic blood pressure when associated with myocardial infarction, it becomes from 60 mmHg poor prognostic factor especially in the acute phase. Results: The mean age was 54.46 ± 10.10 years for patients with normal pulse pressure and 52.32 ± 10.89 years in patients with high pulse pressure. Patients with elevated pulse pressure were twice as left ventricular failure (Chi2 = 3.71;P = 0.048 = 2 OR 95% CI = 0.93 to 4.29). These patients had an ejection fraction and fractional shortening double bass (Chi2 = 31.23 P = 0.00001, OR = 2.2 95% CI 0.8 to 17.4) 10 mmHg for increased pulse pressure we observed an average growth of 18% mortality rate. Mortality was three times higher in patients with elevated pulse pressure (Khi2 = 15, 06 ddl = 1 P = 0.0001 OR = 3.34 95% CI 1.72 to 6.52). Conclusion: The high pulse pressure represented an independent poor

关键词： Myocardial Infarction Pulsed Pressure African

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Contribution of Ambulatory Pulsed Pressure in the Modification of the Left Ventricular Geometry of the African Black People

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World Journal of Cardiovascular Diseases 2020年第12期10卷 831-838页

作者： Gnaba Loa ambroise Adoubi Kassi Anicet Diby Kouakou Florent Ouattara Pinnin Diomandé Manga Ayegnon Kouakou Gregoire Abro Samuel Tro Keumian Gabin Dakoi Serge Coulibaly Abdoulaye Yangni-Angaté Koffi Hervé Department of Cardiovascular and Thoracic Diseases Teaching Hospital of Bouake Bouake Ivory Coast Alassane Ouattara University Bouake Ivory Coast

Introduction-Purpose: Pulsed pressure is recognized as an important predictor of cardiovascular risk. The purpose of this study was to identify a possible association between high ambulatory pulsed pressure and left ventricular geometry change in African black people. Material and methods: We conducted a bicentric, retrospective descriptive and analytical study that took place from 2010 to 2015 at the Abidjan Heart Institute and the Polyclinic Sainte Anne Marie in Abidjan. The people were selected from MAPA’s archive files. Those aged 18 years and over were included, all of whom had valid echocardiography and MAPA. The analyzed parameters concerned epidemiological data with age, gender and body surface area. The clinical data analyzed included systolic, diastolic, mean and 24-hours pulsed pressures. On the echocardiographic parameters, it was the evaluation of the ventricular mass indexed to the body surface. Results: A total of 177 patients records were selected. The mean age of the patients was 56.32 ± 10.51 years. There was a male predominance with a sex ratio of 1.15. The main cardiovascular risk factors found outside high blood pressure were dyslipidemia (06.87%) and obesity (13.7%). In clinical terms, hypertension was found in 75% of cases (n = 133) versus 25% (n = 44) of normotensive patients. These blood pressure profiles allowed us to classify our study population into two groups: hypertensives people and normotensives people. The hypertensives people had significantly higher mean pulsed pressure levels than the normotensives people. All normotensive patients had normal pulsed pressure. In the hypertensive population, the prevalence of high pulsed pressure was 31% (n = 41) versus 69% (n = 92) normal pulsed pressure. Concerning the relationship between 24 hour ambulatory pulsed pressure and left ventricular mass, hypertensives patients with a high ambulatory pulsed

关键词： Ambulatory Pulsed Pressure-Left Ventricular Mass Indexed -African Black People

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Optimization of Technical Parameters for Detecting Mycobacteria in Hospital Wastewater in Tropical Urban Areas: The Case of the City of Abidjan (Côte d’Ivoire)

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Open Journal of Medical Microbiology 2023年第3期13卷 195-206页

作者： Cissé Souleymane Coulibaly-Kalpy Julien Vakou N’dri Sabine Assohoiun Egomli Stanislas Ouattara Mohamed Baguy Kouamé Kintossou ambroise Diané Kouao Maxime Ettien Money Marcelle Nguessan Felix Kouassi Dosso Mireille Department of the Biological Resource Center Institut Pasteur Abidjan C&#244te d’Ivoire Department of Environment and Health Institut Pasteur Abidjan C&#244 te d’Ivoire Laboratory of Microbial Genomics and Metagenomics Institut Pasteur Abidjan C&#244 te d’Ivoire Laboratory of Environmental Sciences and Technology Jean Lorougnon Guédé University Daloa C&#244te d’Ivoire Input Preparation Unit Institut Pasteur Abidjan C&#244te d’Ivoire Institut Pasteur Abidjan C&#244te d’Ivoire

The loads of organic matter, microorganisms, detergents and antibiotics in liquid hospital effluents make them complex environments, raising numerous health and ecological questions. Investigations of mycobacteria in water lack adequate techniques. This study is the first part of a pilot project aimed at developing an optimized protocol for the isolation of mycobacteria from hospital effluents, as a prelude to more in-depth investigation in this matrix. The aim was to compare the performance of two decontamination methods, three culture media and two incubation temperatures generally proposed in the literature, in order to identify the most effective methods in each case, as well as possible areas for improvement in the isolation of these germs from this environmental matrix. The results show that liquid hospital effluent can be decontaminated using both the NaOH method (4%;for 30 min.) and the CPC method (0.05%;for 30 min.), with the same mycobacteria recovery efficiency. Despite the low concentration, decontamination with CPC killed more mycobacteria and sufficiently eliminated contaminating germs. In contrast, decontamination with NaOH was less harmful to mycobacteria, but did not remove many contaminating germs. On the other hand, LJG medium performed better than LJGF medium and LJGP medium for the growth of mycobacteria in hospital waters. Finally, there was no difference in performance between the two incubation temperatures of 30℃ and 37℃. The results of this study show that further evaluation of existing protocols is required in order to optimize methods for the pre-treatment of hospital effluent for the isolation of mycobacteria.

关键词： Hospital Wastewater Mycobacterium Decontamination Löwenstein Jensen Medium Growth Temperature

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气管插管脑损伤患者的早期神经唤醒试验:长期的单中心经验报告

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中国护理管理 2017年第10期30卷 1440-1440页

作者： Pierre Esnault ambroise Montcriol Erwan D'Aranda Julien Bordes Philippe Goutorbe Henry Boret Eric Meaudre 昆圣安妮军队医院重症监护室法国军队卫生服务学院 Ecole du Val-de-Grce

背景:入院前处理中,在初始影像学检查前,严重创伤性脑损伤（TBI）均需要气管插管、镇静和机械通气。初始影像评估后,随即以早期的神经唤醒试验（ENWT）给予快速的神经学复评。这一管理策略给予了早期的参考临床检查,将与后续检查对比。... 详细信息

背景:入院前处理中,在初始影像学检查前,严重创伤性脑损伤（TBI）均需要气管插管、镇静和机械通气。初始影像评估后,随即以早期的神经唤醒试验（ENWT）给予快速的神经学复评。这一管理策略给予了早期的参考临床检查,将与后续检查对比。目的 :本研究旨在描述经历过ENWT患者的临床特点,并明确ENWT失败的原因。方法 :我们进行了一项观察性的回顾性单中心研究,纳入创伤中心收治的所有TBI患者。ENWT是指在TBI后24小时内暂停镇静。研究数据涵盖了患者特点、CT扫描结果及患者转归,患者转归数据来自ICU收治的所有气管插管的TBI患者的预估。从患者档案中检索ENWT的特点和失败的原因。建立了多元Logistic回归模型,以确定ENWT失败的危险因素。结果 :7年中,所收治的242例气管插管TBI患者均纳入此研究。96例患者接受了ENWT,占患者总数的40%;其中38例（39.5%）患者中止了ENWT,主要原因是神经系统恶化（27例,71%）或呼吸窘迫（10例,26%）。ENWT失败的重要预测因子是:第1次影像检查显示硬膜下血肿厚度>5 mm（OR=3.2,95%CI为1.01;0.28）,以及初始GCS评分5 mm或初始GCS评分<5的患者,预期ENWT可能会失败。

关键词：创伤性脑损伤唤醒试验头部损伤镇静阻断

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Growth, Duplication and Lateral Mutual Compressive Deformation of Akouemma hemisphaeria on the Seafloor of Okondja Basin at 2.2 Ga (Gabon)

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International Journal of Geosciences 2017年第9期8卷 1172-1191页

作者： ambroise Edou-Minko Mathieu Moussavou Tomohiko Sato Yusuke Sawaki Simplice Ndong Ondo Richard Maire Guillaume Fleury Michel Mbina Mounguengui Anders Kaestner Richard Ortega Stéphane Roudeau Asuncion Carmona Makaya Mvoubou Benjamin Musavu Moussavou Osamu Sasaki Shigenori Maruyama Université des Sciences et Techniques de Masuku Franceville Gabon Earth-Life Science Institute (ELSI) Tokyo Institute of Technology Tokyo Japan Department of Earth Science and Astronomy Graduate School of Arts and Sciences The University of Tokyo Tokyo Japan UMR 5319 Passages Maison des Suds CNRS-Université Bordeaux-Montaigne Pessac France Muséum d’Histoire Naturelle de Toulouse Toulouse France Laboratory for Neutron Scattering and Imaging Paul Scherrer Institut Villigen Switzerland CENBG Univ. Bordeaux CNRS IN2P3 UMR 5797 Gradignan France Tohoku University Museum Université de Tohoku Sendai Japan

A colony of macro-fossils Akouemma hemisphaeria has been described in the Paleoproterozoic sedimentary basin of Okondja, Gabon. These fossils are classified into two groups according to their spheroidal or elongated forms. The spheroidal shapes are similar, have a tripartite structure with two hemispheres and a median disc and gradually pass to the elongated forms. These elongated forms have a pronounced bipartite tendency to two “hemispheres” separated by a median surface, and often have several ovoid “pieces” attached. The elongated specimens show both lateral growth marks and signs of fission. Growth marks are characterized by unidirectional homogeneous side elongations and lateral bud-like protuberances. The signs of fission are marked by circular furrows perpendicular to the direction of elongation, called “constriction furrows” with varying depths depending on the degree of fission of the specimen and internal vertical “division planes”. All of these ovoid and elongated specimens have undergone significant initial deformations due mainly to mutual lateral compressions in tabular beds. The Akouemma hemisphaeria macro-organisms, which were primitive probably sessile organisms, lived on the seafloor. They provide the oldest known record of macro-organisms on Earth having vegetative growth and asexual reproduction by budding, lateral elongation and fission. Their mutual lateral deformations would result from their growth.

关键词： Paleoproterozoic Francevillian Group Okondja Basin Akouemma hemisphaeria Growth Duplication

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皮下,静脉注射肝素与阿斯匹林治疗不稳定型心绞痛的随机对照研究

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金华医学 1996年第1期 F003-F003页

作者： seme,GGN

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Profile of Radiotherapy Side Effects in Patients Treated for Cervical Cancer in Cameroon: Case of the Douala General Hospital

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Journal of Cancer Therapy 2023年第1期14卷 59-71页

作者： Berthe Sabine Esson Mapoko Anne Marthe Maison Mayeh Ruth Rosine Meka’h Mapenya Orel Kelvin Ndouandju Saha Esther Dina Bell Etienne Atenguena Okobalemba Anne Sango Romeo Talla ambroise Ntama Sidonie Ananga Albertine Eloundou Martin Essomba Biwole Odette Samba Ngano Albert Mouelle Sone Emilienne Guegang Goudjo Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Science University of Dschang Dschang Cameroon

Background: Radiotherapy is one of the main therapeutic strategies used in cervical cancer. The first radiotherapy services in Cameroon have existed since 1987 and still treat by conventional radiation techniques. With the evolution of radiation techniques, acute, subacute, and late complications are minimized. Our study aimed to describe the profile of side effects in patients with uterine cervix cancer treated by conventional radiotherapy, still used in our services. Methods: This was a retrospective and descriptive study of the records of patients treated in the radiotherapy department of the Douala General Hospital from January 2015 to December 2019. Data concerning radiation-induced toxicities were collected using the CTCAE Version 4.0 classification. Data analysis was performed using SPSS version 20.0. Results: A total of 270 records were selected. The median age was 54 years. The mean total radiation dose was 55.9 ± 11.8 Gy and 71.1% of patients were treated for less than 8 weeks. We found a frequency of 66.7% of radio-induced lesions with 99% being acute. The main acute lesions encountered were radio dermatitis (40%), radiation cystitis (17.7%), and radiation proctitis (17.1%). As late lesions, we found one case of vaginal fibrosis (0.4%). Exclusive radiotherapy, classical fractionation, and total doses lower than 45 Gy seemed to decrease the toxicity linked to conventional radiotherapy. Conclusion: The frequency of side effects of radiotherapy for cervical cancer at the Douala General Hospital remains high. Early lesions are the most encountered but strategies should be put in place to better evaluate late lesions.

关键词： Cervical Cancer Radiotherapy Radiation-Induced Lesions Cameroon

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The Psychological Experience of the Nursing Staff of the Medical Oncology Department in Cameroon: Case of the YaoundéGeneral Hospital

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Journal of Cancer Therapy 2023年第1期14卷 50-58页

作者： Berthe Sabine Esson Mapoko Esther Dina Bell Mbassi Véronique Mboua Batoum Marie Josiane Ntsama Essomba Lionel Tabola Fossa Lionel Bala Etienne Atenguena Okobalemba Ruth Rosine Meka’h Mapenya Anne Juliette Flora Sango Anne Marthe Maison Mayeh Sidonie Ananga Noa ambroise Ntama Zacharie Sando Paul Ndom Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Faculty of Health Sciences University of Buea Buea Cameroon

Background: The world of cancer care is an emotional place, given the severity of the disease being treated, the heavy workload, the suffering of patients, and the high number of deaths. The nursing staff who work there may be exposed to constant stress from these factors. This study aimed to explore the psychological experience of the nursing staff of the Medical Oncology Department of the Yaoundé General Hospital. Methods: We carried out a cross-sectional study, in June 2017, involving the nursing staff of the Medical Oncology Department of the Yaoundé General Hospital. Results: Sixteen out of 18 nurses were interviewed. All had worked in at least one other department prior to Oncology. The number of years of experience in Oncology ranged from less than one year to 13 years. The choice of the Oncology department was involuntary for 100% of the staff;of these, 62% had intentions of changing departments. Twenty-five percent had applied for a change of department, which was unsuccessful. Stress was expressed by 94% of the staff;93% thought that there was a solution to the stress experienced on a daily basis in the Oncology department. The main solutions proposed to manage this stress were: support for the staff, provision of work materials, and staff training. Conclusion: The nursing staff of the Medical Oncology Department of the Yaoundé General Hospital experiences a high level of stress and are in need of solutions.

关键词： Psychological Experience Nursing Staff Medical Oncology Department Ya-oundé General Hospital

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行动战胜疾病

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环球科学 2024年第21期 74-75页

作者：安布鲁瓦兹·翁卡姆郭书萌(翻译) 约翰·霍普金斯大学医学院遗传医学系麦库西克-纳森斯研究所不详

镰状细胞病尚未获得足够的关注,而全球范围内对该疾病研究的投入和资助将使百万患者受益。镰状细胞病患者往往不甚富裕、生活在资源较少的地区,且多为深肤色人群。尽管该疾病的影响范围广泛,但它在政策优先级、医学研究投资、倡导活动... 详细信息

镰状细胞病尚未获得足够的关注,而全球范围内对该疾病研究的投入和资助将使百万患者受益。镰状细胞病患者往往不甚富裕、生活在资源较少的地区,且多为深肤色人群。尽管该疾病的影响范围广泛,但它在政策优先级、医学研究投资、倡导活动和临床护理资助方面却很少受到重视。相较于主要影响富裕国家中浅肤色人群的疾病(比如囊性纤维化),镰状细胞病获得的投资和关注相当有限,这可能源于过去几个世纪中众所周知的种族主义。

关键词：镰状细胞病囊性纤维化临床护理全球范围种族主义优先级肤色资助

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