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clinical course and prognostic factors of hepatorenal syndrome:a retrospective single-center cohort study

World Journal of Hepatology 2013年第12期5卷 685-691页

作者： Anna Licata Marcello Maida ambra bonaccorso Fabio Salvatore Macaluso Maria Cappello Antonio Craxì Piero Luigi Almasio Section of Gastroenterology Dipartimento Biomedicodi Medicina Interna e SpecialisticaUniversity of Palermo

AIM: To investigate clinical and biochemical features of hepatorenal syndrome(HRS), to assess short and long- term survival evaluating potential predictors of early mortality. METHODS: Sixty-two patients with liver cirrhosis and renal failure, defined as a serum creatinine value > 1.5 mg/dL on at least two measurements within 48 h, admitted to our tertiary referral Unit from 2001 to 201, were retrospectively reviewed. Among them, 33 patients(53.2%) fulfilled the revised criteria of the International Ascites Club for the diagnosis of HRS. Twenty-eight patients were treated with combinations of terlipressin and albumin, two with dopamine and al- bumin, and three with albumin alone. No patients were suitable for liver transplantation. Complete response was defined as normalization of creatinine levels to less than 1.5 mg/dL, partial response as a decrease of at least 50% but not to less than 1.5 mg/dL, no response as no reduction in creatinine or a decrease of less 50% compared to pre-treatment values. All of the patients were followed up for at least 1 year until January 2013. RESULTS: HRS type 1 was diagnosed in 15 patients(45.5%). Hepatitis C virus infection was the primary etiology(69.6%), followed by alcohol(15.2%), and cryptogenesis(15.2%). Complete response to therapy was obtained in only 3 cases(9.1%) and partial re- sponse in 7 patients(21.2%). Median survival was 30 d(range: 10-274) without significant differences be- tween type 1 and type 2 HRS. By univariate analysis, Child-Pugh class C(P = 0.009), presence of hepatocel- lular carcinoma(P = 0.04), low serum sodium(P = 0.02), high bilirubin values(P = 0.009) and high Model for End-stage Liver Disease(MELD) score(P = 0.03) were predictive factors of 30-d mortality. By multivari- ate analysis, only serum sodium 27(OR = 18.72; P = 0.01) were independently associated with a survival of less than one month. CONCLUSION: HRS still has a poor prognosis, even when va

关键词： Hepatorenal syndrome Liver cirrhosis Hepatitis C virus vasoactive drugs Mortality

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Laparoscopic central pancreatectomy with gastro-pancreatic anastomosis for symptomatic serous cystadenoma:A case report and literature review

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 87-91页

作者： Giuseppe Frazzetta Antonino Picciurro Angela Maffongelli Irene Vitale Francesco Vitale Daniela Scimeca Michele Amata Anna Calì ambra bonaccorso Barbara Scrivo Vincenzo Di Martino Elisabetta Conte Filippo Mocciaro Roberto Di Mitri Pierenrico Marchesa Oncologic Surgery Unit ARNAS Civico HospitalPalermo 90100Italy Gastroenterology Unit ARNAS Civico HospitalPalermo 90100Italy

Surgery for lesions of the proximal part of the pancreatic body or neck can be challenging,and when enucleation is not possible,central pancreatectomy is an *** central pancreatic resection is rarely described worldwide;it is considered a difficult procedure mainly because of the risk of double pancreatic fistula developing at two sites of ***,it seems to be an excellent alternative to distal pancreatectomy or pancreaticoduodenectomy,with the advantages of preserving functioning parenchyma and reducing endocrine and exocrine ***,patients with pancreatic lesions requiring central resection are often managed with the open approach in many hospitals due to the complexity of total laparoscopic central pancreatectomy,which requires advanced laparoscopic skills,expertise and ***,we report a case of a 29-year-old female who underwent total laparoscopic central pancreatic resection with gastro-pancreatic anastomosis for symptomatic serous *** discuss the details of case management and review the relevant literature.

关键词： Laparoscopic Pancreatic surgery Central pancreatectomy Cystadenoma

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Current collectors based on multiwalled carbon-nanotubes and fewlayer graphene for enhancing the conversion process in scalable lithium-sulfur battery

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Nano Research 2023年第6期16卷 8433-8447页

作者： Vittorio Marangon Edoardo Barcaro Luca Minnetti Wolfgang Brehm Francesco bonaccorso Vittorio Pellegrini Jusef Hassoun Graphene Labs Istituto Italiano di TecnologiaGenoa 16163Italy Department of Chemical Pharmaceutical and Agricultural SciencesUniversity of FerraraFerrara 44121Italy BeDimensional S.p.A. Genoa 16163Italy National Interuniversity Consortium of Materials Science and Technology(INSTM) University of Ferrara Research UnitFerrara 44121Italy

We investigated herein the morphological,structural,and electrochemical features of electrodes using a sulfur(S)-super P carbon(SPC)composite(i.e.,S@SPC-73),and including few-layer graphene(FLG),multiwalled carbon nanotubes(MWCNTs),or a mixture of them within the current collector ***,we studied the effect of two different electron-conducting agents,that is,SPC and FLG,used in the slurry for the electrode *** supports have high structural crystallinity,while their morphologies are dependent on the type of material *** voltammetry(CV)shows a reversible and stable conversion reaction between Li and S with an activation process upon the first cycle leading to the decrease of cell *** activation process is verified by electrochemical impedance spectroscopy(EIS)with a decrease of the resistance after the first CV ***,CV at increasing scan rates indicates a Li+diffusion coefficient(D)ranging between 10^(−9) and 10^(−7) cm^(2)·s^(−1)in the various states of charge of the cell,and the highest D value for the electrodes using FLG as electron-conducting *** tests performed at constant current of C/5(1 C=1675 mA·g_(s)^(−1))show high initial specific capacity values,which decrease during the initial cycles due to a partial loss of the active material,and subsequently increase due to the activation *** the electrodes show a Coulombic efficiency higher than 97%upon the initial cycles,and a retention strongly dependent on the electrode ***,this study suggests a careful control of the electrode in terms of current collector design and slurry composition to achieve good electrode morphology,mechanical stability,and promising electrochemical performance in practical Li-S cells.

关键词： lithium-sulfur battery current collector few-layer graphene carbon nanotubes scalability sulfur loading

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Impact of Gender Inequality on Economic Growth of European Countries

Impact of Gender Inequality on Economic Growth of European C...

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作者： ambra THANA 山东大学

学位级别：硕士

Despite various progressive developments and policies nowadays,women and men do not share the same level of opportunities to take part in economic activity,and whenever they do manage to participate,they never receive the same level of comfort,recognition,pays,or support as men *** inequality in economic setting is a global *** study is exploring the impact of gender inequality on labor market on economic growth of European *** inequalities in labor market dampens economic *** study can provide the evidence that gender discrimination in employment is directly related to economic *** is significant to be assessed for the current variables in this scenario opposed to economic growth,since potential output growth in Europe has declined substantially in the aftermath of the global financial crisis（IMF,2015）.Still European females are found to be less active in the labor force participation than men.21 years（1998-2018）and 33 European countries from different sub-regions will be taken into consideration in this *** women understood and exercised their power,they could remake the world.

关键词： gender inequality labor force economic growth Solow model European countries

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Ticagrelor therapy and atrioventricular block:Do we need to worry?

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World Journal of Clinical Cases 2017年第5期5卷 178-182页

作者： Elia De Maria ambra Borghi Letizia Modonesi Stefano Cappelli Cardiology Unit Ramazzini Hospital

Ticagrelor is a potent,direct P2Y12 antagonist with rapid onset of action and intense platelet inhibition,indicated in patients with acute coronary syndromes(ACS).This drug is usually well tolerated,but some patients experience serious adverse effects:Major bleeding;gastrointestinal disturbances;dyspnoea;ventricular pauses > 3 *** the unexpected high incidence of bradyarrhythmias,a PLATO substudy monitored this side effect,showing that ticagrelor was associated with an increase in the rate of sinus bradycardia and sinus arrest compared to *** side effect was usually transient,asymptomatic and not associated with higher incidence of severe atrioventricular(AV) block or pacemaker needs.A panel of experts from Food and Drug Administration did not consider bradyarrhythmias a serious problem in clinical practice and,accordingly,current labeling of the drug does not give any precaution or contraindication regarding this ***,recently some articles have described ACS patients with high-degree,life-threatening,AV block requiring drug discontinuation and,in some cases,pacemaker *** this paper,we describe and discuss five published case reports of severe AV block following ticagrelor therapy and two other cases managed in our *** analysis of literature suggests that,although rarely,ticagrelor can be associated with lifethreatening AV *** and careful monitoring are required especially in patients with already compromised conduction system and/or treated with AV blocking *** studies,with long-term rhythm monitoring,would help to define the outcome of patients at higher risk of developing this complication.

关键词： Ticagrelor Atrioventricular block

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Karst caves and hydrology between geodesy and archeology:Field trip notes

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Geodesy and Geodynamics 2018年第3期9卷 262-269页

作者： Carla Braitenberg Tommaso Pivetta Giuliana Rossi Paola Ventura ambra Betic University of Trieste Department of Mathematics and GeosciencesItaly Istituto Nazionale di Oceanografia e di Geofisica Sperimentale-OGS.Centro di Ricerche Sismoloogiche.Italy Ministero dei beni e delle attivita culturali e del turismo Soprintendenza Archeologia.belle arti e paesaggio del Friuli Venezia GiuliaItaly

The Geodynamics-Earth-Tides-meeting-2016 was held in the Karst, the origin of geologic karst- formation. Surface-rivers are absent, and water flows in channels over distances of 30 km, forming subsurface caves. Geodetic observations allow detecting caves and sense hydrologic flow. The Karst water had been recognized before Romans as provision for man and livestock. Proto-historic remains near the mouth of the underground river suggest the water outpouring from the Karst was associated with deities to be worshiped. Here the geodetic and cultural aspects of the Karst are summarized, illustrating the field trip that had been offered to the participants.

关键词： Karst springs Archeology Hydrology Tiltmeter

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Externalized conductors and insulation failure in Biotronik defibrillator leads: History repeating or a false alarm?

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World Journal of Clinical Cases 2017年第2期5卷 27-34页

作者： Elia De Maria ambra Borghi Lorenzo Bonetti Pier Luigi Fontana Stefano Cappelli Cardiology Unit Ramazzini Hospital

Conductor externalization and insulation failure are frequent complications with the recalled St. Jude Medical Riata implantable cardioverter-defibrillator(ICD) leads. Conductor externalization is a "unique" failure mechanism: Cables externalize through the insulation("inside-out" abrasion) and appear outside the lead body. Recently, single reports described a similar failure also for Biotronik leads. Moreover, some studies reported a high rate of electrical dysfunction(not only insulation failure) with Biotronik Linox leads and a reduced survival rate in comparison with the competitors. In this paper we describe the case of a patient with a Biotronik Kentrox ICD lead presenting with signs of insulation failure and conductor externalization at fluoroscopy. Due to the high risk of extraction we decided to implant a new lead, abandoning the damaged one; lead reimplant was uneventful. Subsequently, we review currently available literature about Biotronik Kentrox and Linox ICD lead failure and in particular externalized conductors. Some single-center studies and a nonprospective registry reported a survival rate between 88% and 91% at 5 years for Linox leads, significantly worse than that of other manufacturers. However, the preliminary results of two ongoing multicenter, prospective registries(GALAXY and CELESTIAL) showed 96% survival rate at 5 years after implant, well within industry standards. Ongoing data collection is needed to confirm longer-term performance of this family of ICD leads.

关键词： Implantable cardioverter defibrillator Biotronik implantable cardioverter defibrillator lead Externalized conductors Insulation failure

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Multiscale Hybrid Modeling of Proteins in Solvent:SARS-CoV2 Spike Protein as Test Case for Lattice Boltzmann-All Atom Molecular Dynamics Coupling

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Communications in Computational Physics 2023年第1期33卷 57-76页

作者： Marco Lauricella Letizia Chiodo Fabio bonaccorso Mihir Durve Andrea Montessori Adriano Tiribocchi Alessandro Loppini Simonetta Filippi Sauro Succi Consiglio Nazionale delle Ricerche Istituto per le Applicazioni del Calcolo IAC-CNR00185Rome Italy Engineering Department Campus Bio-Medico University00128RomeItaly Physics Department and INFN University of Rome“Tor Vergata”00133 RomeItaly Istituto Italiano di Tecnologia Center for Life Nano-&Neuro-Science@Sapienza-IIT00161RomeItaly Engineering Department Universit´a degli Studi Roma TREvia Vito Volterra 62Rome00146Italy

Physiological solvent flows surround biological structures triggering therein collective *** examples are virus/host-cell interactions and solventmediated allosteric *** present work describes a multiscale approach joining the Lattice Boltzmann fluid dynamics(for solvent flows)with the all-atom atomistic molecular dynamics(for proteins)to model functional interactions between flows and *** present,as an applicative scenario,the study of the SARS-CoV-2 virus spike glycoprotein protein interacting with the surrounding solvent,modeled as a mesoscopic *** equilibriumproperties of the wild-type spike and of the Alpha variant in implicit solvent are described by suitable *** mesoscopic solvent description is critically compared to the all-atom solvent model,to quantify the advantages and limitations of the mesoscopic fluid description.

关键词： SARS-CoV-2 biophysics lattice Boltzmann molecular dynamics

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Assessment of sensory properties and in vitro antimicrobial activity of monofloral Sicilian honey

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Food Bioscience 2023年第2期52卷 791-801页

作者： Nunziatina Russo ambra Rita Di Rosa Alessandra Pino Gaetana Mazzeo Luigi Liotta Cinzia Caggia Cinzia Lucia Randazzo Department of Agriculture Food and Environment(Di3A)University of CataniaVia Santa Sofia 10095123CataniaItaly ProBioEtna srl Spin-off of University of CataniaVia S.Sofia10095123CataniaItaly Department of Veterinary Sciences University of MessinaPolo Universitario Annunziata98168MessinaItaly CERNUT(Interdepartmental Research Centre in Nutraceuticals and Health Products) University of CataniaVia le A.Doria 695125CataniaItaly

The antimicrobial and antioxidant properties of honey are well-established and recently the potential of honey for biotechnological and food preservative applications appeared *** to that,the present study evaluated the sensory profile and the antimicrobial potential of honey samples produced in different phytogeographical zones,in the Sicilian areas,and obtained from five different floral sources(chestnut,eucalyptus,sulla,thyme,and citrus).The specific sensory fingerprint of the analyzed samples was assessed by artificial senses(E-Eye,E-Nose,and E-Tongue).In addition,the antimicrobial activity against Staphylococcus aureus ATCC 29213,Listeria monocytogenes ATCC 19114,Bacillus subtilis DSM 10,Escherichia coli ATCC 25922,Enterococcus faecalis ATCC 29212,Pseudomonas aeruginosa ATCC 9027,Salmonella enterica Typhimurium ATCC 14026,and Candida albicans ATCC 10231 was *** senses allowed to confirm the impact of climate factors and genetic features on honey composition suggesting implications for antimicrobial activity.A broad spectrum of antagonistic activity was displayed by the analyzed honey samples in both undiluted and diluted *** particular,thyme honey showed interesting antagonistic *** addition,a greater inhibitory effect of amber-colored honey than light ones was observed.

关键词： Artificial senses Sensory properties Honeybees Antimicrobial potential Growth inhibition

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Laparoscopic distal pancreatectomy in Italy:a systematic review and meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 458-463页

作者： Claudio Ricci Riccardo Casadei Enrico Lazzarini Marielda D'ambra Salvatore Buscemi Carlo Alberto Pacilio Giovanni Taffurelli Francesco Minni Dipartimento di Scienze Mediche e Chirurgiche (DIMEC) Alma Mater Studiorum Università di Bologna

BACKGROUND： The use of laparoscopic distal pancreatectomy（LDP） increased in the past twenty years but the real diffusion of this technique is still unknown as well as the type of centers（high or low volume） in which this procedure is more frequently *** SOURCE： A systematic review was performed to evaluate the frequency of LDP in Italy and to compare indications and results in high volume centers（HVCs） and in low volume centers（LVCs）.RESULTS： From 95 potentially relevant citations identified, only5 studies were included. A total of 125 subjects were analyzed, of whom 95（76.0%） were from HVCs and 30（24.0%） from *** mean number of LDPs performed per year was 6.5. The mean number of patients who underwent LDP per year was 8.8in HVCs and 3.0 in LVCs（P0.001）. The most frequent lesions operated on in HVCs were cystic tumors（62.1%, P0.001） while,in LVCs, solid neoplasms（76.7%, P0.001）. In HVCs, malignant neoplasms were treated with LDP less frequently than in LVCs（17.9% vs 50.0%, P〈0.001）. Splenectomy was performed for non-oncologic reason frequenter in HVCs than in LVCs（70.2%vs 25.0%, P0.004）. The length of stay was shorter in HVCs than in LVCs（7.5 vs 11.3, P0.001）. No differences were found regarding age, gender, ductal adenocarcinoma treated, operative time, conversion, morbidity, postoperative pancreatic fistula,reoperation and margin ***： LDPs were frequently performed in *** ＂HVC approach＂ is characterized by a careful selection of patients undergoing LDP. The ＂LVC approach＂ is based on the hypothesis that LDPs are equivalent both in short-term and long-term results to laparotomic approach. These data are not conclusive and they point out the need for a national register of laparoscopic pancreatectomy.

关键词： pancreatic neoplasms laparoscopic distal pancreatectomy pancreatic surgery

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