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Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani Vishal Jain Veenu Joshi Ravindra Kumar Pandey Shiv Shankar Shukla amber Vyas columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BcS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

The influence of resistance exercise training prescription variables on skeletal muscle mass,strength,and physical function in healthy adults:An umbrella review

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Journal of Sport and Health Science 2024年第1期13卷 47-60页

作者： Jonathan c.Mcleod Brad S.currier caroline V.Lowisz stuart M.Phillips Department of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy ***:Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,we systematically searched and screened eligible systematic reviews reporting the effects of differing RT prescription variables on muscle mass(or its proxies),strength,and/or physical function in healthy adults aged>18 ***:We identified 44 systematic reviews that met our inclusion *** methodological quality of these reviews was assessed using A Measurement Tool to Assess Systematic Reviews;standardized effectiveness statements were *** found that RT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),strength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).RT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted RT-induced increases in muscular *** discovered that 2/3 reviews provided some or sufficient evidence that RT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of RT load impacting skeletal muscle *** was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of RT prescription variables on physical ***:Overall,RT increased muscle mass,strength,and physical function compared to no ***

关键词： Hypertrophy Resistance training Resistance training prescription variables Strength Umbrella review

Taking care of volunteers in a stroke trial: a new assisted-management strategy

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Stroke & Vascular Neurology 2016年第3期1卷 108-114页

作者： amber c stuart Jason J Sico catherine M Viscoli Ashis H Tayal Silvio E Inzucchi Gary A Ford Karen L Furie Robert cote J David Spence David Tanne Walter N Kernan on behalf of the IRIS Trial Investigators Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology Service Veterans Affairs Connecticut Healthcare SystemWest HavenConnecticutUSA Neuroscience Institute Allegheny Health NetworkPittsburghPennsylvaniaUSA Lewis Katz School of Medicine at Temple University PhiladelphiaPennsylvaniaUSA Division of Medical Sciences Oxford UniversityOxfordUK The Warren Alpert Medical School of Brown University ProvidenceRhode IslandUSA Department of Neurology Neurosurgery and MedicineMcGill UniversityMontrealQuebecCanada University of Western Ontario LondonOntarioCanada 10Sheba Medical CenterTel Aviv UniversityTel AvivIsrael 不详

Background and purpose:Providing participants with evidence-based care for secondary prevention is an ethical and scientific priority for trials in stroke *** optimal strategy,however,is *** report the performance of a new approach for delivering preventive care to trial ***:Participants were enrolled in the Insulin Resistance Intervention after Stroke trial,which examined the insulin sensitiser,pioglitazone versus placebo for prevention of stroke and myocardial infarction after ischaemic stroke or transient ischaemic *** care was the responsibility of the participants’personal healthcare providers,but investigators monitored care and provided feedback *** studied achievement of 8 prevention goals at baseline and 3 annual visits,with a focus on 3 priority goals:blood pressurecholesterolc ***:The proportion of participants achieving the priority goals was highest for antithrombotic use(96–99%in each year)and similar for blood pressure(66–72%in each year)and LDL(68–70%in each year).All 3 priority goals were achieved by 47–52%of participants in any given ***,only 22%of participants achieved all 3 goals in each ***:A strategy of monitoring care and providing feedback was associated with high average yearly achievement of 3 priority secondary prevention goals,but the majority of trial participants did not persist in being at goal over *** registration number:NcT00091949.

关键词： prevention annually goals

Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca cidonio Richard O.c.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK center for Life Nano-and Neuro-Science(cLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-EcM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMScs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-EcM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMScs viability upon *** composite of human bone-EcM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(cAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMScs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-EcM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

The outcomes and safety of patients undergoing endoscopic retrograde cholangiopancreatography combining a single-use cholangioscope and a single-use duodenoscope:A multicenter retrospective international study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 71-76页

作者： Alessandro Fugazza Matteo colombo Michel Kahaleh V.Raman Muthusamy Bick Benjamin Wim Laleman carmelo Barbera carlo Fabbri Jose Nieto Abed Al-Lehibi Mohan Ramchandani Amy Tyberg Haroon Shahid Avik Sarkar Dean Ehrlich stuart Shermand cecilia Binda Marco Spadaccini Andrea Iannone Kareem Khalaf Nageshwar Reddy Andrea Anderloni Alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSVia Manzoni 5620089RozzanoMilanoItaly Gastroenterology Rutgers Robert Wood JohnsonNew BrunswickNew JerseyUSA Vatche and Tamar Manoukian Division of Digestive Diseases University of CaliforniaLos Angeles School of Medicine at UCLALos AngelesCaliforniaUSA Division of Digestive and Liver Disorders Indiana University School of MedicineIndianapolisINUSA Department of Gastroenterology and Hepatology University Hospitals LeuvenKU Leuven3000 LeuvenBelgium U.O.c.di Gastroenterologia ed Endoscopia Digestiva Ospedale Giuseppe MazziniASL TeramoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsAUSL RomagnaForlì-CesenaItaly Borland Groover clinic JacksonvilleFloridaUSA Department of Gastroenterology and Hepatology King Fahad Medical CityRiyadhSaudi Arabia Asian Institute of Gastroenterology HyderabadIndia Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly

Background: Duodenoscope-related multidrug-resistant organism(MDRO) infections raise concerns. Disposable duodenoscopes have been recently introduced in the market and approved by regulatory agencies with the aim to reduce the risk of endoscopic retrograde cholangiopancreatography(ERcP) associated infections. The aim of this study was to evaluate the outcome of procedures performed with single-use duodenoscopes in patients with clinical indications to single-operator cholangiopancreatoscopy. Methods: This is a multicenter international, retrospective study combining all patients who underwent complex biliopancreatic interventions using the combination of a single-use duodenoscope and a single-use cholangioscope. The primary outcome was technical success defined as ERcP completion for the intended clinical indication. Secondary outcomes were procedural duration, rate of cross-over to reusable duodenoscope, operator-reported satisfaction score(1 to 10) on performance rating of the single-use duodenoscope, and adverse event(AE) rate. Results: A total of 66 patients(26, 39.4% female) were included in the study. ERcP was categorized according to ASGE ERcP grading system as 47(71.2%) grade 3 and 19(28.8%) grade 4. The technical success rate was 98.5%(65/66). Procedural duration was 64(interquartile range 15-189) min, cross-over rate to reusable duodenoscope was 1/66(1.5%). The satisfaction score of the single-use duodenoscope classified by the operators was 8.6 ± 1.3 points. Four patients(6.1%) experienced AEs not directly related to the single-use duodenoscope, namely 2 post-ERcP pancreatitis(PEP), 1 cholangitis and 1 ***: Single-use duodenoscope is effective, reliable and safe even in technically challenging procedures with a non-inferiority to reusable duodenoscope, making these devices a viable alternative to standard reusable equipment.

关键词： Single-operator cholangioscopy Single-use duodenoscope Endoscopic retrograde cholangiopancreatography Indeterminate biliary stricture Difficult biliary stones

Viral hepatitis in 2021:The challenges remaining and how we should tackle them

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World Journal of Gastroenterology 2022年第1期28卷 76-95页

作者： Rebecca Dunn Aaron Wetten stuart McPherson Mhairi c Donnelly Gastroenterology University Hospital of North TeesStockton on Tees TS198PEUnited Kingdom Liver Unit Freeman HospitalNewcastle NE77DNUnited Kingdom Translational and clinical Research Institute Newcastle UniversityNewcastle NE17RUUnited Kingdom

Viral hepatitis results in 1.4 million deaths *** World Health Organization(WHO)set an ambitious target to eliminate viral hepatitis by 2030,but significant challenges *** include inequalities in access to healthcare,reaching at risk populations and providing access to screening and effective *** around viral hepatitis persists and must be *** WHO goal of global elimination by 2030 is a worthy aim,but remains ambitious and the coronavirus 2019 pandemic undoubtedly has set back *** review article will focus on hepatitis A to E,highlighting problems that have been resolved in the field over the past decade,those that remain to be resolved and suggest directions for future problem solving and research.

关键词： Hepatitis A Hepatitis B Hepatitis c Hepatitis D Hepatitis E cOVID-19

State of Science:Why Does Rework Occur in construction?What Are Its consequences?And What can be Done to Mitigate Its Occurrence?

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Engineering 2022年第11期18卷 246-258页

作者： Peter E.D.Love Jane Matthews Michael c.P.Sing stuart R.Porter Weili Fang School of civil and Mechanical Engineering Curtin UniversityPerthWA 6845Australia School of Architecture and Built Environment Deakin University Geelong Waterfront CampusGeelongVIC 3220Australia School of Architecture and Built Environment The University of NewcastleCallaghanNSW 2308Australia Department of civil and Building Systems Technische Universität BerlinBerlin 13156Germany

There has been a wealth of research that has examined the nature of rework in *** toward addressing the rework problem has been limited-it still plagues practice,adversely impacting a project’s *** all rework studies have focused on determining its proximal or root causes and therefore have overlooked the conditions that result from its *** filling this void,this paper draws upon our previous empirical studies,amongst others,to provide a much-needed theoretical framing to understand better why rework occurs,what its consequences are,and how it can be mitigated during *** theoretical framing we derive from our review provides construction organizations and their projects with a realization that the journey to mitigating rework begins with creating an error-mastery culture comprising authentic leadership,psychological safety,an errormanagement orientation,and *** suggest that,once an error-mastery culture is established within construction organizations and their projects,they will be better positioned to realize the benefits of the techniques,tools,and technologies espoused to address rework,such as the Last Planner® and building information *** also provide directions for future research and identify implications for practice so that strides toward rework mitigation in construction can be made.

关键词： construction Errors Error-mastery culture Pathogens Rework Violations

Mechanistic Insight into Supramolecular Polymerization in Water Tunable by Molecular Geometry

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ccS chemistry 2022年第7期4卷 2212-2220页

作者： Fan Xu Stefano crespi Lukas Pfeifer Marc c.A.stuart Ben L.Feringa Stratingh Institute for chemistry University of GroningenGroningen 9747 AG Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237 Angstrom Laboratory Department of ChemistryUppsala UniversityUppsala 75120 Laboratory of Photonics and Interfaces Department of Chemistry and Chemical EngineeringÉcole Polytechnique Fédérale de LausanneLausanne CH-1015

Supramolecular self-assembly in water based on non-covalent bonding is attracting major attention due to the potential of hydrogels and aqueous polymers in biomedical *** supramolecular polymerization in organic solvents is well established,the key design features,the assembly mechanisms in water and achieving control over the aggregate structures remain ***,we present the assembly and disassembly of geometrical isomers of a stiff-stilbene bis-urea amphiphile(SA)in pure water.A remarkable feature of this system is that the(E)-isomer forms supramolecular polymers in both pure water and organic *** advantage of this unique property,the hydrophobic effect was studied by comparing the supramolecular assembly in both *** assembly process inwater follows an enthalpy-driven nucleation-elongation(cooperative)supramolecular polymerization mechanism with a standard Gibbs free energy(ΔG°=−53 kJ mol^(−1))double the value of the one found in *** attributed this distinctive feature to the hydrophobic effect in ***,we discovered an isomer-dependent assembly process,which can be used to control aggregation in aqueous *** to the substantial geometric difference between(E)-SA and(Z)-SA,we compared their assembly in water to study the influence of different driving forces involved in the *** supramolecular polymerization of(E)-SA was cooperatively influenced by hydrogen bonding,π-stacking,and hydrophobic effects,whereas the assembly of(Z)-SAwasmainly driven by hydrophobic *** a result,the fiber length of(E)-SA in water is much longer than that of(Z)-SA,presenting opportunities for geometrical control of aggregation in aqueousmedia.

关键词： supramolecular polymerization stiff-stil-bene bis-urea hydrogen bonding π-stacking hydro-phobic effects

Onset temperature of intrinsic pinning in a REBcO coated conductor from critical current anisotropy

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Superconductivity 2022年第4期4卷 1-6页

作者： Nicholas M.Strickland Arya Ambadiyil Soman Martin W.Rupich stuart c.Wimbush Robinson Research Institute Victoria University of WellingtonWellingtonNew Zealand American Superconductor corporation AyerMA 01432USA

The field‐angle dependence of the critical current in a REBa_(2)cu_(3)O_(7) coated conductor has been measured over a fine range of temperatures from 15 K to 80 *** particular sample is demonstrated to have a very low fraction of extrinsic planar defects by its near‐isotropic critical current at 77 *** a representative magnetic field of 3 T we are able to track the emergence of the ab‐plane peak usually associated with intrinsic pinning and quantify its evolution with temperature by fitting to a maximum‐entropy *** are also able to observe the evolution of dip and peak features in the angle dependence of the power‐law index n with decreasing temperature and show that a dip appearing at 65 K is supplanted by a sharper positive peak from 50 *** combination of critical current and power‐law index temperature dependences shows the onset of intrinsic pinning at 50 K.

关键词： Intrinsic pinning REBcO coated conductors Maximum entropy N value

Effects of amyloid precursor protein peptide APP96-110,alone or with human mesenchymal stromal cells,on recovery after spinal cord injury

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Neural Regeneration Research 2022年第6期17卷 1376-1386页

作者： stuart I.Hodgetts Sarah J.Lovett D.Baron-Heeris A.Fogliani Marian Sturm c.Van den Heuvel Alan R.Harvey School of Human Sciences The University of Western Australia(UWA)PerthWAAustralia Perron Institute for Neurological and Translational Science PerthWAAustralia cell and Tissue Therapies WA(cTTWA) Royal Perth HospitalPerthWAAustralia Adelaide Medical School Faculty of Health and Medical SciencesThe University of AdelaideAdelaideSAAustralia

Delivery of a peptide(APP96-110),derived from amyloid precursor protein(APP),has been shown to elicit neuroprotective effects following cerebral stroke and traumatic brain *** this study,the effect of APP96-110 or a mutant version of this peptide(mAPP96-110)was assessed following moderate(200 kdyn,(2 N))thoracic contusive spinal cord injury(ScI)in adult Nude *** received a single tail vein injection of APP96-110 or mAPP96-110 at 30 minutes post-ScI and were then assessed for functional improvements over the next 8 weeks.A cohort of animals also received transplants of either viable or non-viable human mesenchymal stromal cells(hMScs)into the Sc lesion site at one week post-injury to assess the effect of combining intravenous APP96-110 delivery with hMSc *** were perfused 8 weeks post-ScI and longitudinal sections of spinal cord analyzed for a number of factors including hMSc viability,cyst size,axonal regrowth,glial reactivity and macrophage *** of sensorimotor function revealed occasional significant differences between groups using Ladderwalk or Ratwalk tests,however there were no consistent improvements in functional outcome after any of the ***96-110 alone,and APP96-110 in combination with both viable and non-viable hMScs significantly reduced cyst size compared to ScI *** treatments with donor hMScs also significantly increased βIII tubulin^(+),glial fibrillary acidic protein(GFAP^(+))and laminin+expression,and decreased ED1^(+)expression in *** preliminary study demonstrates that intravenous delivery of APP96-110 peptide has selective,modest neuroprotective effects following ScI,which may be enhanced when combined with hMSc ***,the effects are less pronounced and less consistent compared to the protective morphological and cognitive impact that this same peptide has on neuronal survival and behaviour after stroke and traumatic brain *** while the efficacy of a

关键词： amyloid precursor protein cell transplantation combination contusion functional recovery mesenchymal stromal cells neuroprotection regeneration spinal cord injury tissue sparing