检索结果-南通市图书馆

Many faces of neuronal activity manipulation in Drosophila

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： amber Krebs Steffen Kautzmann Christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

Therapeutic effect of hydrogen peroxide via altered expression of glutathione S-transferase and peroxiredoxin-2 in hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 258-265页

作者： Zehra Hashim amber Ilyas Shamshad Zarina Dr.Zafar H.Zaidi Center for Proteomics University of KarachiKarachi 75270Pakistan

Background:Hepatocellular carcinoma(HCC)has a high incidence and mortality that epitomizes one of the prominent causes of cancer-related death *** therapeutic approaches are therefore *** oxygen species(ROS)are necessary for maintaining cell *** ROS is involved in HCC progression,hydrogen peroxide(H2O2)has anti-proliferative effect on ***:HCC Huh-7 cells were cultured and incubated with various concentrations of *** activity,levels of malondialdehyde,glutathione and protein oxidation were measured in treated and untreated Huh-7 ***,untreated and treated Huh-7 cells were subjected to two dimensional gel electrophoresis and identified protein spots which were differentially expressed by LC-MS/MS analysis.q RT-PCR was performed to validate the identified ***:H2O2 depleted glutathione(GSH)with the concomitant up-regulation of GSTP1 and Prx2.H2O2 also increased malondialdehyde and protein oxidation,decreased the activity of paraoxonase in Huh-7 ***:H2O2 could be used as a novel therapeutic agent that might be beneficial in inducing cell cytotoxicity and hence suppress HCC proliferation.

关键词： Oxidative stress Hydrogen peroxide GSTP1 Prx2 Hepatocellular carcinoma

Eligibility of persons who inject drugs for treatment of hepatitis C virus infection

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第36期20卷 12722-12733页

作者： amber Arain Geert Robaeys Department of Gastroenterology and Hepatology Ziekenhuis Oost-Limburg 3600 Genk Belgium Faculty of Medicine and Life Sciences Hasselt University 3590 Diepenbeek Belgium Department of Hepatology UZ Leuven 3000 Leuven Belgium

In this decade, an increase is expected in end-stageliver disease and hepatocellular carcinoma, most commonly caused by hepatitis C virus(HCV) *** people who inject drugs(PWID) are the ma-jor source for HCV infection, they were excluded fromantiviral treatments until recently. Nowadays there isincontrovertible evidence in favor of treating these patients, and substitution therapy and active substanceuse are no longer contraindications for antiviral treatment. The viral clearance in PWID after HCV antiviraltreatment with interferon or pegylated interferon combined with ribavirin is comparable to the viral clearancein non-substance users. Furthermore, multidisciplinary approaches to delivering treatment to PWID are advised, and their treatment should be considered on anindividualized basis. To prevent the spread of HCV inthe PWID community, recent active PWID are eligiblefor treatment in combination with needle exchange programs and substitution therapy. As the rate of HCV reinfection is low after HCV antiviral treatment, there is no need to withhold HCV treatment due to concerns about reinfection alone. Despite the advances in treatment efficacies and data supporting their success, HCV assessment of PWID and initiation of antiviral treatment remains low. However, the proportion of PWID assessed and treated for HCV is increasing, which can be further enhanced by understanding the barriers to and facilitators of HCV care. Removing stigmatization and implementing peer support and group treatment strategies, in conjunction with greater involvement by nurse educators/practitioners, will promote greater treatment seeking and adherence by PWID. Moreover, screening can be facilitated by noninvasive methods for detecting HCV antibodies and assessing liver fibrosis stages. Recently, HCV clearance has become a major endpoint in the war against drugs for the Global Commission on Drug Policy. This review highlights the most recent evidence concerning HCV infection

关键词： Hepatitis C virus Persons who inject drugs Methadone Sustained viral response Adherence

Green Design Studio: A modular-based approach for high-performance building design

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2021年第2期14卷 241-268页

作者： Jialei Shen Bess Krietemeyer amber Bartosh Zhi Gao Jianshun Zhang Department of Mechanical and Aerospace Engineering Syracuse University263 Link HallSyracuseNY13244USA School of Architecture Syracuse UniversitySlocum HallSyracuseNY13244USA School of Architecture and Urban Planning Nanjing University22 Hankou RoadNanjingJiangsu Province210093China

A modular-based Green Design Studio(GDS)platform has been developed in this study for fast and accurate performance analysis for early stage green building *** GDS platform aims to simplify the design and analysis process by embedding performance parameters into design elements in modules and employing near-real-time model for whole building performance simulation as well as by providing an easy-to-use and intuitive user interface to assist users without extensive knowledge on building *** platform consists of building modules as fundamental building blocks,performance predicting models,and a user interface for visualization and interactive *** the platform,a whole building is composed of modules organized in a hierarchical structure,including spaces,enclosures,service systems,sustainable resource systems and *** physics-based and data-driven models can be used to simulate the building performance and optimize building systems.A simplified physics-based model,the Resistance–Capacitance(RC)model,has been proposed as a generic simulation model for the flows of heat,air,moisture and pollutants,which is significantly faster than conventional simulation tools such as EnergyPlus,and hence more practical for use in real-time design interaction and optimization.A pilot case study is conducted to illustrate the modular-based design approach using a section of an office *** to conventional building performance analysis tools,the GDS platform can provide fast and reliable feedback on performance prediction for early *** modular approach makes it easier to modify the building design and evaluate the potentials and contributions of various green design features and technologies.

关键词： modular-based building design building performance green building high-performance building building simulation energy efficiency

The Genetics of Speciation： Considering Early-Acting Isolation, Hybrid Evolution, and Epigenetic Mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2013年第5期59卷 654-657页

作者： amber M. RICE, Editor Lehigh University Department of Biological Sciences Bethlehem PA 18015 USA amber.rice@Lehigh.edu

Since Darwin＇s time, evolutionary biologists have sought to understand how species arise. The study of speciation remains a focus of evolutionary biology, and since the early 204 century, characterizing the genetics underlying this process has also become a central goal. Much research into the genetics of speciation has cen- tered on identifying the genes underlying reproductive isolating mechanisms, or ＇speciation genes＇（see Nosil and Schluter, 2011 for a discussion of this term）. With information about such genes available from many sys- tems, general questions about how speciation proceeds may be addressed： How many genes contribute to speciation？ Is reproductive isolation more commonly the result of divergence in protein-coding regions or regulatory regions？ Is reproductive isolation more fre- quently the result of natural selection or genetic drift？（Coyne and Orr, 2004; Nosil and Schluter, 2011）. Given recent advances in technology, such questions have be- come accessible in systems that were previously intrac- table for studying the genetics of speciation. Moreover, with this increase in the accessibility of genetic analyses for non-model systems, a broader set of questions about the genetics of speciation can now be addressed.

关键词：遗传学特性生物学形态进化遗传机制基因漂移物种形成混合表观

Alendronate and FTI-277 combination as a possible therapeutic approach for hepatocellular carcinoma:An in vitro study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 241-250页

作者： amber Ilyas Zehra Hashim Iffat Saeed Channa Shamshad Zarina National Center for Proteomics University of Karachi

Background： An important product of mevalonate pathway is downstream synthesis of isoprenoid unitsthat has long been implicated in development and progression of tumor. It has been speculated thatinhibition of protein prenylation might be therapeutically beneficial. The objective of current study wasto evaluate antitumor potential of a novel therapeutic combination of mevalonate pathway inhibitors, FTI-277 and alendronate. We also examined differentially expressed proteins in response to treatment usingproteomics approach.

关键词： Chemotherapy Hepatocellular carcinoma Gene expression Proteomics Therapeutic

Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani Vishal Jain Veenu Joshi Ravindra Kumar Pandey Shiv Shankar Shukla amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

Syzygium aromaticum ethanol extract reduces AlCl_3-induced neurotoxicity in mice brain through regulation of amyloid precursor protein and oxidative stress gene expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 123-130页

作者： Sanila amber Syed Adnan Ali Shah Touqeer Ahmed Saadia Zahid Neurobiology Research Laboratory Department of Healthcare BiotechnologyAtta-ur-Rahman School of Applied BiosciencesNational University of Sciences and Technology Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns)Universiti Teknologi MARA Puncak Alam Campus Faculty of Pharmacy Universiti Teknologi MARA Puncak Alam Campus

Objective: To investigate the neuroprotective effects of Syzygium aromaticum(***)extract(500 mg/kg) on AlCl_3(300 mg/kg)-induced mouse model of oxidative stress and ***: An ethanolic extract of *** seeds was prepared and the active compounds were identified using nuclear magnetic resonance ***/c mice were divided into five groups(negative control, AlCl_3-treated, self-recovery, AlCl_3 + ***, *** only; n=10) and treated with AlCl_3 and *** *** of oxidative markers [Superoxide dismutase 1(SOD1) and peroxiredoxin 6(Prdx6)] and amyloid precursor protein(APP) in the hippocampus and cortex was evaluated via *** assessment was performed to investigate the extent of ***: It was observed that AlCl_3 exposure increased the expression of APP770 while simultaneously down regulated the expression of ***_3 also induced a significant decrease(P<0.05) and an increase(P<0.05) in the expression level of SOD1 and Prdx6, respectively.A substantial decrease substantial(P<0.05) in the density of Nissl substance was also observed in cortex of the mice treated with AlCl_***, treatment with *** extract normalized the alterations in the expression level of SOD1, Prdx6 and APPisoforms and improved the neuronal structural ***: The results showed that *** is a promising antioxidant and a neuroprotective agent.

关键词： Amyloid precursor protein Oxidative stress Aluminum Neurodegeneration

Caffeine Exposure Causes Immune Dysfunction and Intrauterine Growth Restriction Retardation in Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2022年第2期35卷 170-173页

作者： ZHANG Wen Zhong SUN Na Na HU Yang CAO Yu amber Sheeks Department of Safety Engineering North China Institute of Science&TechnologySanhe 065201HebeiChina Key Laboratory of Food Risk Assessment Ministry of Health China National Center for Food Safety Risk AssessmentBeijing 100021China Center for Public Health Surveillance and Information Service Chinese Center for Disease Control and PreventionBeijing 102206China Muskingum University OH 43762USA

This study was conducted to assess the effects of caffeine on the dam and the physical development of rat *** Sprague-Dawley rats(20 per dose group)were administered caffeine by gavage at 0(control),5,20,and 80 mg/kg body weight(bw)daily from gestational day 6 through lactation using caffeine dissolved in *** developmental toxicity of caffeine was *** in the 80 mg/kg bw group exhibited splenic *** litter weights were significantly lower in the 20 and 80 mg/kg bw groups than the untreated control(P<0.05),with a greater reduction in the higher dose *** number of female offspring was reduced in the 20 and 80 mg/kg bw groups(P<0.05).Some of the offspring were eaten by the dam following birth,which accounted for half of the litters in the 80 mg/kg bw group(P<0.05).Offspring body weight in the 80 mg/kg bw group was lower than that in the control during the lactation period(P<0.05).Exposure to caffeine during pregnancy can cause maternal immune dysfunction and intrauterine growth restriction retardation(IUGR);the developmental toxicity of caffeine varied with gender,as females were more sensitive than *** no observed adverse effect level was 5 mg/kg bw based on the IUGR.

关键词： Immune weights offspring