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Chinese Journal of Structural Chemistry 2015年第12期34卷 1830-1840页

作者： MUHAMMAD naeem Ahmed KHAWAJA Ansar Yasin TARIQ Mahmood FATIMA Wasim MUHAMMAD Haleem Khan M.NAWAZ Tahir SAFEENA Zafar SHAISTA Anjum Department of Chemistry The University of Azad Jammu and Kashmir Department of Chemistry COMSATS Institute of Information Technology Department of Chemistry Women University Bagh Azad Kashmir Department of Physics University of Sargodha

The title compound, 4-hexyl-1-（4-nitrophenyl）-1-H-1,2,3-triazole （CI4HIsN402）, was synthesized using one-pot strategy via click reaction and the structure was characterized mainly by single-crystal X-ray diffraction, NMR, FT-IR and MS. C14H18N4O2 was crystallized from an EtOH/EtOAc solution in triclinic system, space group PI, with a = 5.3679（3）, b = 7.5499（5）, c = 17.5534（11） A, a = 92.360（4）, β = 90.359（4）, γ = 98.864（4）°, V （A3） = 702.24（8）, Z = 2, crystal size （mm） = 0.42 × 0.26 × 0.18, Rint = 0.096. Packing diagram indicates that there is dimeric interaction between two units via N（3）...H（6）. The crystal structure of the title compound （1） is stabifized by intermolecular interactions. In addition, X-ray analys!s also reveals C-H…π and π-π interactions in the molecule. Theoretical investigations were performed by using Gaussian 09 software at the B3LYP/6, 31G （d,p）level of density,finctional theory （DFT）.to compare the theoretical results with the experimental and to probe structural properties. The molecular electrostatic potential （MEP） mapped over the entire stabilized geometry of the molecule indicated their chemical reactivities. Furthermore, frontier molecular orbital （electronic properties） was computed at the same level of DFT as used. forenergy minima structure.

关键词： click chemistry disubstituted triazole X-ray DFT MEP frontier molecurar orbital

Novel drug delivery systems for inflammatory bowel disease

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World Journal of Gastroenterology 2022年第18期28卷 1922-1933页

作者： Farah Yasmin Hala Najeeb Shehryar Shaikh Muhammad Hasanain Unaiza naeem Abdul Moeed Thoyaja Koritala Syedadeel Hasan Salim Surani Department of Medicine Dow University of Health ScienceKarachi 74200Pakistan Department of Medicine Dow OJha University HospitalKarachi 74200Pakistan Department of Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine University of LouisvilleLouisvilleKY 40292United States Department of Medicine Texas A&M UniversityCollege StationTX 77843United States Department of Anesthesiology Mayo ClinicRochesterMN 55901United States

Inflammatory bowel disease(IBD)is a chronic illness characterized by relapsing inflammation of the *** disorder is stratified according to the severity and is marked by its two main phenotypical representations:Ulcerative colitis and Crohn’s *** of the disease is ambiguous and is expected to have interactivity between genetic disposition,environmental factors such as bacterial agents,and dysregulated immune *** for IBD aims to reduce symptom extent and severity and halt disease *** mainstay drugs have been 5-aminosalicylates(5-ASAs),corticosteroids,and immunosuppressive ***,oral and rectal routes are the conventional methods of drug delivery,and among all,oral administration is most widely ***,problems of systematic drug reactions and low specificity in delivering drugs to the inflamed sites have emerged with these regular routes of *** drug delivery systems have been introduced to overcome several therapeutic obstacles and for localized drug delivery to target ***-coated microneedle pills,various nano-drug delivery techniques,prodrug systems,lipid-based vesicular systems,hybrid drug delivery systems,and biologic drug delivery systems constitute some of these novel *** are painless,they dislodge their content at the affected site,and their release can be *** bacteria such as genetically engineered Lactococcus Lactis and eukaryotic cells,including GM immune cells and red blood cells as nanoparticle carriers,can be plausible delivery methods when evaluating biologic ***-particle drug delivery systems consisting of various techniques are also employed as nanoparticles can penetrate through inflamed regions and adhere to the thick mucus of the diseased *** systems such as 5-ASAs formulations or their derivatives are effective in reducing colonic *** can be modified with both hydrophilic and lipophilic p

关键词： Inflammation Inflammatory bowel diseases Colitis Ulcerative Crohn’s disease Drug delivery systems Drug carrier

Ablative techniques in hepatocellular carcinoma treatment

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Hepatoma Research 2018年第6期4卷 1-10页

作者： Ehsun naeem Shahab Abid Section of Gastroenterology Department of MedicineAga Khan UniversityKarachi 74800Pakistan

Hepatocellular carcinoma has been known to arise commonly in the setting of chronic liver disease. Due to its association with cirrhosis, patients with hepatocellular carcinoma often present with markedly diminished hepatic functional reserve, making them poor surgical candidates. For such patients, image-guided percutaneous ablative modalities have provided a viable alternate curative therapy. Although treatment allocation is a decision based on a number of factors, patients eligible for percutaneous ablation generally include those with early stage disease, hepatocellular carcinoma with disease limited to the liver and no extra-hepatic metastases. While percutaneous ethanol injection is the seminal technique, newer developments have led to it being replaced by percutaneous radiofrequency ablation as the most commonly employed procedure, due to a better efficacy as well as safety profile. Other ablative modalities including microwave ablation, laser ablation and cryotherapy are not as widely available. Furthermore, data comparing their effectiveness with well-established procedures like radiofrequency ablation is limited.

关键词： Barcelona Clinic liver Cancer staging chronic liver disease hepatocellular carcinoma Milan Criteria percutaneous ethanol injection radiofrequency ablation surgical resection

PLC指令表程序的一种语法分析方法及其在代码静态测试上的应用

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清华大学学报（自然科学版） 2021年第10期61卷 1159-1165页

作者：李学良赵千川杨文 Syed naeem HAIDER 清华大学自动化系北京信息科学与技术国家研究中心智能与网络化系统研究中心北京100084

可编程逻辑控制器(PLC)是工业控制领域中广泛使用的自动控制装置。由于PLC程序缺乏具有普适性的测试工具,开发人员往往只能采用人工方式排查代码错误,导致测试效率低下。工业用户亟需一种标准化PLC代码检测方法,自动完成PLC程序语法检... 详细信息

可编程逻辑控制器(PLC)是工业控制领域中广泛使用的自动控制装置。由于PLC程序缺乏具有普适性的测试工具,开发人员往往只能采用人工方式排查代码错误,导致测试效率低下。工业用户亟需一种标准化PLC代码检测方法,自动完成PLC程序语法检测与分析。该文以IEC61131-3标准为基础,建立基于Backus-Naur范式(BNF)的指令表语法模型。基于该模型构造抽象语法树,进而设计出一种具有线性复杂度的PLC指令表代码语法检测算法。利用2段控制工程中的PLC指令表代码对所提出的算法与商用软件CODESYS Static Analysis进行对比测试,验证了所提算法的可用性。

关键词：可编程逻辑控制器(PLC) 指令表(IL) 静态分析 IEC61131-3

Effect of different catalysts and growth temperature on the photoluminescence properties of zinc silicate nanostructures grown via vapor-liquid-solid method

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Chinese Physics B 2022年第5期31卷 657-665页

作者： Ghfoor Muhammad Imran Murtaza Rehan Abid naeem Ahmad Department of Physics International Islamic UniversityIslamabad 44000Pakistan

We explore the photoluminescence properties of zinc silicate(Zn_(2)SiO_(4)) nanostructures synthesized by vapor-liquidsolid(VLS)mode of growth using three different catalysts(Sn,Ag,and Mn).Different catalysts significantly influence the growth rate which in turn has an impact on the structure and hence the photoluminescence of the prepared zinc silicate ***_(2)SiO_(4) has a wide bandgap of about 5.5 eV and in its pure form,it does not emit in visible region due to its inner shell electronic transitions between the 3 d5 energy ***,the incorporation of different catalysts(Sn,Ag and Mn)at different growth temperatures into the Zn_(2)SiO_(4) crystal growth kinetics provides wide visible spectral range of photoluminescence(PL)*** analysis shows broad multi-band spectrum in the visible region and distinct colors(red,yellow,green,blue,cyan and violet)are obtained depending on the crystalline structure of the prepared *** allowed transitions due to the effect of different catalysts on zinc silicate lattice offer a huge cross-section of absorption that generates strong *** correlation between the structural and optical properties of the synthesized nanostructures is discussed in *** synthesized photoluminescent nanostructures have potential applications in solidstate lighting and display devices.

关键词： nanostructures vapor-liquid-solid growth mode photoluminescence spectra fluorescence microscopy

Liquidity connectedness in cryptocurrency market

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Financial Innovation 2022年第1期8卷 81-105页

作者： Mudassar Hasan Muhammad Abubakr naeem Muhammad Arif Syed Jawad Hussain Shahzad Xuan Vinh Vo Lahore Business School The University of LahoreLahorePakistan Smurfit Graduate School of Business University Col-lege DublinDublinIreland Institute of Business Research University of Economics Ho Chi Minh CityHo Chi Minh CityVietnam Department of Business Administration Shaheed Benazir Bhutto UniversityShaheed BenazirabadPakistan Montpellier Business School MontpellierFrance South Ural State University ChelyabinskRussian Federation Institute of Business Research and CFVG University of Economics Ho Chi Minh CityHo Chi Minh CityVietnam

We examine the dynamics of liquidity connectedness in the cryptocurrency *** use the connectedness models of Diebold and Yilmaz(Int J Forecast 28(1):57–66,2012)and Baruník and Křehlík(J Financ Econom 16(2):271–296,2018)on a sample of six major cryptocurrencies,namely,Bitcoin(BTC),Litecoin(LTC),Ethereum(ETH),Ripple(XRP),Monero(XMR),and *** static analysis reveals a moderate liquidity connectedness among our sample cryptocurrencies,whereas BTC and LTC play a significant role in connectedness magnitude.A distinct liquidity cluster is observed for BTC,LTC,and XRP,and ETH,XMR,and Dash also form another distinct liquidity *** frequency domain analysis reveals that liquidity connectedness is more pronounced in the short-run time horizon than the medium-and long-run time *** the short run,BTC,LTC,and XRP are the leading contributor to liquidity shocks,whereas,in the long run,ETH assumes this *** with the medium term,a tight liquidity clustering is found in the short and long *** time-varying analysis indicates that liquidity connectedness in the cryptocurrency market increases over time,pointing to the possible effect of rising demand and higher acceptability for this unique ***,more pronounced liquidity connectedness patterns are observed over the short and long run,reinforcing that liquidity connectedness in the cryptocurrency market is a phenomenon dependent on the time–frequency connectedness.

关键词： Liquidity Time-frequency connectedness Cryptocurrencies

An improved technique for global daily sunshine duration estimation using satellite imagery

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第9期13卷 717-722页

作者： Muhammad Ali SHAMIM Renji REMESAN Da-wei HAN naeem EJAZ Ayub ELAHI Department of Civil Engineering University of Engineering and Technology Taxila 47050 Pakistan Department of Geography University of Hull HU6 7RX UK Department of Civil Engineering University of Bristol BS8 ITR UK

This paper presems an improved model for global sunshine duration estimation. The methodology incorporates geostationary satellite images by including snow cover information, sun and satellite angles and a trend correction factor for seasons, for the determination of cloud cover index. The effectiveness of the proposed methodology has been tested using Meteosat geostationary satellite images in the visible band with a temporal resolution of 1 h and spatial resolution of 2.5 km×2.5 km, for the Brue Catchment in the southwest of England. Validation results show a significant improvement in the estimation of global sunshine duration by the proposed method as compared to its predecessor （R2 is improved from 0.68 to 0.83, root mean squared error （RMSE） from 2.37 h/d to 1.19 h/d and the mean biased error （MBE） from 0.21 h/d to 0.08 h/d）. Further studies are needed to test this method in other parts of the world with different climate and geographical conditions.

关键词： Sunshine duration Geostationary satellite Evapotranspiration Solar radiation Remote sensing

Culture-positive urinary tract infection following micturating cystourethrogram in children

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Asian Journal of Urology 2022年第3期9卷 329-333页

作者： Simeon Ngweso Munyaradzi Nyandoro Tatenda Nzenza Ting Yi Cheow Fiona Bettenay Andrew Barker Japinder Khosa naeem Samnakay Fiona Stanley Hospital.Murdoch Western AustraliaAustralia Young Urology Researchers Organisation MelbourneAustralia Austin Hospital HeidelbergVictoriaAustralia Royal Perth Hospital PerthWestern AustraliaAustralia Princess Margaret Hospital SubiacoWestern AustraliaAustralia School of Medicine University of Western AustraliaDalkeithWestern AustraliaAustralia

Objective:To determine the incidence of culture-positive urinary tract infection(UTI)after micturating cystourethrogram(MCUG).We further wanted to identify risk factors for developing a culture-positive UTI following ***:A retrospective review of the available medical records of 500 paediatric patients who underwent MCUG in Perth,Western Australia was ***:Seven(1.4%)patients comprised of four females and three males developed a febrile,culture-positive UTI within 14 days following *** association was found for female patients,patients with neurogenic bladder,and patients with previous culture-positive UTI as developing a culture-positive UTI following *** logistic regression determined that patients were more likely to develop culture-positive UTI within 14 days following MCUG if they had a known history of UTI(odds ratio:5.0,95%confidence interval:1.5-17.3,p=0.010)or had a neurogenic bladder(odds ratio:4.2,95%confidence interval:1.0-17.9,p=0.049).Conclusion:The incidence of patients who developed a febrile,culture-positive UTI following MCUG was low at 1.4%.Statistically significant and independent associations for the development of culture positive UTI were found in patients with neurogenic bladder and patients with previous culture-positive *** prospective studies are necessary to determine necessity of prophylactic antibiotics for high-risk patients,e.g.,patients with neurogenic bladder or previous culture-positive UTI.

关键词： Micturating cystourethrogram Voiding cystourethrogram Paediatric urology Functional urology

Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model

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World Journal of Stem Cells 2022年第8期14卷 633-657页

作者： Rida-e-Maria Qazi Irfan Khan Kanwal Haneef Tuba Shakil Malick Nadia naeem Waqas Ahmad Asmat Salim Sadia Mohsin Stem Cell Laboratory Dr.Panjwani Center for Molecular Medicine and Drug ResearchICCBSUniversity of KarachiKarachi 75270SindhPakistan Dr.Zafar H.Zaidi Center for Proteomics University of KarachiKarachi 75270SindhPakistan Dow Research Institute of Biotechnology and Biomedical Sciences(DRIBBS) Dow University of Health and SciencesOjha CampusKarachi 74200SindhPakistan Cardiovascular Research Center Lewis Katz School of MedicineTemple UniversityPhiladelphiaPA 19140United States

BACKGROUND Cardiovascular diseases are the major cause of mortality *** of the damaged myocardium remains a challenge due to mechanical constraints and limited healing ability of the adult heart *** tissue engineering using biomaterial scaffolds combined with stem cells and bioactive molecules could be a highly promising approach for cardiac *** of biomaterials can provide suitable microenvironment to the cells and can solve cell engraftment problems associated with cell transplantation *** stem cells(MSCs)are potential candidates in cardiac tissue engineering because of their multilineage differentiation potential and ease of *** of DNA methyl transferase inhibitor,such as zebularine,in combination with three-dimensional(3D)scaffold can promote efficient MSC differentiation into cardiac lineage,as epigenetic modifications play a fundamental role in determining cell fate and lineage specific gene *** To investigate the role of collagen scaffold and zebularine in the differentiation of rat bone marrow(BM)-MSCs and their subsequent in vivo *** MSCs were isolated from rat BM and characterized morphologically,immunophenotypically and by multilineage differentiation *** were seeded in collagen scaffold and treated with 3μmol/L zebularine in three different *** analysis was done and cardiac differentiation was analyzed at the gene and protein *** and untreated MSC-seeded scaffolds were transplanted in the rat myocardial infarction(MI)model and cardiac function was assessed by *** tracking was performed by DiI dye labeling,while regeneration and neovascularization were evaluated by histological and immunohistochemical analysis,*** MSCs were successfully isolated and seeded in collagen *** analysis revealed that zebularine was not cytotoxic in any of the treatment *** differentiation analysis

关键词： Mesenchymal stem cells Myocardial infarction Cardiac tissue engineering Demethylating agent Collagen scaffold Zebularine

Comparative Analysis of Various Strains of Plant Growth Promoting Rhizobacteria on the Physiology of Garlic (Allium sativum)

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Natural Science 2023年第3期15卷 79-90页

作者： Shiza Tariq Asghari Bano naeem Khan Department of Biosciences University of Wah Wah Cantt Pakistan Department of Agronomy University of Florida Gainesville USA

Garlic is a most important medicinal herb belonging to the family Liliaceae. Both its leaves and bulb are edible. The current study was based on evaluating the growth promoting potential of plant growth promoting rhizobacteria (PGPR) on garlic (Allium sativum L.) growth and biochemical contents. Garlic cloves were inoculated with 3 kinds of PGPRs, Pseudomonas putida (KX574857), Pseudomonas stutzeri (Kx574858) and Bacillus cereus (ATCC14579) at 108 cells/mL prior to sowing. Under natural conditions, plants were grown in the net house. The PGPR significantly enhanced % germination, leaf and root growth and their biomass also increased the diameter of bulb and fresh and dry weight. The flavonoids, phenolics, chlorophyll, protein and sugar content were also significantly increased due to PGPR inoculation. The Pseudomonas stutzeri was found most effective for producing longer leaves with moderate sugar, high flavonoids (129%) and phenolics (263%) in bulb over control (Tap). The Pseudomonas putida exhibited a maximum increase in bulb diameter and bulb biomass with maximum phenolics and flavonoid contents.

关键词： Garlic Plant Microbe Interaction Rhizobacteria PGPR Plant Physiology Pseudomonas putida Pseudomonas stutzeri and Bacillus cereus