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Blood-brain barrier pathology in cerebral small vessel disease

Neural Regeneration Research 2024年第6期19卷 1233-1240页

作者： Ruxue Jia Gemma solé-Guardia Amanda J.Kiliaan Department of Medical Imaging Anatomy Radboud University Medical Center Donders Institute for Brain Cognition & Behavior Center for Medical Neuroscience Preclinical Imaging Center PRIME Radboud Alzheimer Center

Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the elderly. Although at first it was considered innocuous, small vessel disease is nowadays regarded as one of the major vascular causes of dementia. Radiological signs of small vessel disease include small subcortical infarcts, white matter magnetic resonance imaging hyperintensities, lacunes, enlarged perivascular spaces, cerebral microbleeds, and brain atrophy; however, great heterogeneity in clinical symptoms is observed in small vessel disease patients. The pathophysiology of these lesions has been linked to multiple processes, such as hypoperfusion, defective cerebrovascular reactivity, and blood-brain barrier dysfunction. Notably, studies on small vessel disease suggest that blood-brain barrier dysfunction is among the earliest mechanisms in small vessel disease and might contribute to the development of the hallmarks of small vessel disease. Therefore, the purpose of this review is to provide a new foundation in the study of small vessel disease pathology. First, we discuss the main structural domains and functions of the blood-brain barrier. Secondly, we review the most recent evidence on blood-brain barrier dysfunction linked to small vessel disease. Finally, we conclude with a discussion on future perspectives and propose potential treatment targets and interventions.

关键词： blood-brain barrier dysfunction cerebral blood flow cerebral hypoperfusion endothelial dysfunction hypertension inflammation magnetic resonance imaging neurovascular unit oxidative stress small vessel disease tight junctions transcytosis

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Suboptimal Feature Selection Techniques for Effective Malicious Traffic Detection on Lightweight Devices

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1669-1687页

作者： So-Eun Jeon Ye-sol Oh Yeon-Ji Lee Il-Gu Lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering SungshinWomen’s UniversitySeoul02844Korea

With the advancement of wireless network technology,vast amounts of traffic have been generated,and malicious traffic attacks that threaten the network environment are becoming increasingly *** signature-based detection methods,static analysis,and dynamic analysis techniques have been previously explored for malicious traffic detection,they have limitations in identifying diversified malware traffic *** research has been focused on the application of machine learning to detect these ***,applying machine learning to lightweight devices like IoT devices is challenging because of the high computational demands and complexity involved in the learning *** this study,we examined methods for effectively utilizing machine learning-based malicious traffic detection approaches for lightweight *** introduced the suboptimal feature selection model(SFSM),a feature selection technique designed to reduce complexity while maintaining the effectiveness of malicious traffic *** performance was evaluated on various malicious traffic,benign,exploits,and generic,using the UNSW-NB15 dataset and SFSM sub-optimized hyperparameters for feature selection and narrowed the search scope to encompass all *** improved learning performance while minimizing complexity by considering feature selection and exhaustive search as two steps,a problem not considered in conventional *** experimental results showed that the detection accuracy was improved by approximately 20%compared to the random model,and the reduction in accuracy compared to the greedy model,which performs an exhaustive search on all features,was kept within 6%.Additionally,latency and complexity were reduced by approximately 96%and 99.78%,respectively,compared to the greedy *** study demonstrates that malicious traffic can be effectively detected even in lightweight device *** verified the possibility of detecting various attack

关键词： Feature selection lightweight device machine learning Internet of Things malicious traffic

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Al_(2)O_(3)掺杂无色聚酰亚胺/Ag柔性薄膜的辐射致冷性能

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硅酸盐学报 2024年第7期52卷 2175-2186页

作者：梁冬冬任杰刘欢杨映新 Atsha ambar 孙莹王聪北京航空航天大学能源与动力工程学院北京100191 北京航空航天大学集成电路科学与工程学院北京100191 北京航空航天大学物理学院北京100191

辐射致冷柔性薄膜作为冷却电子器件的候选材料受到广泛关注。然而材料和制备工艺的限制,很难同时具备优异的辐射致冷性能和热稳定性。通过溶胶凝胶法制备了Al_(2)O_(3)掺杂无色聚酰亚胺(CPI)薄膜,不仅利用Al_(2)O_(3)声子–增强共振增... 详细信息

辐射致冷柔性薄膜作为冷却电子器件的候选材料受到广泛关注。然而材料和制备工艺的限制,很难同时具备优异的辐射致冷性能和热稳定性。通过溶胶凝胶法制备了Al_(2)O_(3)掺杂无色聚酰亚胺(CPI)薄膜,不仅利用Al_(2)O_(3)声子–增强共振增强了红外辐射,而且超细Al_(2)O_(3)纳米粒子与分子链的相互作用提高了热稳定性。结果表明:Al_(2)O_(3)掺杂CPI/Ag复合膜随着Al_(2)O_(3)含量增加,中红外发射率逐渐增加而太阳光谱反射率逐渐减小,其中5%(质量分数)Al_(2)O_(3)掺杂CPI/Ag复合膜具有高的太阳光谱(0.4~2.5μm)反射率(91.12%)和中红外(5~20μm)发射率(92.15%)。在阳光直射下,其最大冷却温度比环境温度低7.7℃,可降低铝制器件表面温度最大11.1℃。此外,该复合膜表现出优异的热稳定性(玻璃化转化温度约为328℃和热分解温度约为554℃)。该研究结果为电子器件和航天器附件的高效辐射致冷提供了有效的策略。

关键词：柔性薄膜辐射致冷热稳定性电子器件

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On Isodual Double Toeplitz Codes

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Journal of Systems Science & Complexity 2024年第5期37卷 2196-2206页

作者： SHI Minjia XU Li solé Patrick Key Laboratory of Intelligent Computing and Signal Processing Ministry of Education School of Mathematical Sciences Anhui University State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of Sciences CNRS University of Aix Marseille Centrale Marseille

Double Toeplitz（shortly DT） codes are introduced here as a generalization of double circulant codes. The authors show that such a code is isodual, hence formally self-dual（FSD）. FSD codes form a far-reaching generalization of self-dual codes, the most important class of codes of rate one-half. Self-dual DT codes are characterized as double circulant or double negacirculant. Likewise, even binary DT codes are characterized as double circulant. Numerical examples obtained by exhaustive search show that the codes constructed have best-known minimum distance, up to one unit, amongst formally self-dual codes, and sometimes improve on the known values. For q = 2, the authors find four improvements on the best-known values of the minimum distance of FSD codes. Over F4an explicit construction of DT codes, based on quadratic residues in a prime field, performs equally well. The authors show that DT codes are asymptotically good over Fq. Specifically, the authors construct DT codes arbitrarily close to the asymptotic Varshamov-Gilbert bound for codes of rate one half.

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Designing for well-Being: Using facial micro-expression analysis and EEG biosensor to evaluate human responses to 2D biophilically-driven geometries

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Frontiers of Architectural Research 2024年第2期13卷 219-234页

作者： Andrea Macruz Ernesto Bueno Gustavo sol Jaime Vega Ricardo Palmieri Bing Zhao College of Architecture and Urban Planning Tongji UniversityShanghaiChina Universidade Presbiteriana Mackenzie Sao PauloBrazil Centro Universitario Belas Artes Sao PauloBrazil Universidade Anhembi Morumbi Sao PauloBrazil Universidade Federal do ABC Santo AndreBrazil

This research explores the capacity of emerging technologies to enhance well-being. It involves the generation of 2D biophilically-driven geometries to represent human-response-oriented built environments and conducts inter and intra-individual analyses to assess human responses using a range of technologies within the realms of facial micro-expression analysis and EEG biosensor use. The outcomes of this analysis allow for the grading of these geometries in terms of emotional valences, meditation levels, and subjective preferences. These graded geometries can subsequently be employed in specific architectural contexts, such as interior decor, wallpapers, furniture surfaces, or other architectural and interior components. It is an interdisciplinary effort that underscores the importance of incorporating emerging technological means with human-response-oriented design approaches to foster built environments that promote well-being.

关键词： Biophilic design Geometrical algorithmicmodeling Facial micro-expressionanalysis EEG biosensor Neuroscience

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Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo López-López Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al composition in the EBL from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SILVACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN DUV-LED EBL simulation

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Catalysts for electrochemical ammonia oxidation:Trend,challenge,and promise

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Science China Materials 2022年第12期65卷 3334-3352页

作者： sol A Lee Mi Gyoung Lee Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Electrical and Computer Engineering University of TorontoToronto M5S 3G4OntarioCanada Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea

Developing sustainable and clean energy technology is critial to address the current energy and environmental *** an energy carrier,hydrogen has been getting attention due to its abundance,high energy density,and zero carbon *** to the difficulty of hydrogen storage and transport,the electro-oxidation of ammonia shows great potential for renewable energy since it satisfies both energy supply and environmental protection as a carbon-free fuel with high hydrogen ***,ammonia electro-oxidation is a sluggish reaction and shows low *** the complicated mechanism and intermediates is conducive to developing efficient electrocatalysts with high catalytic activity and *** review begins with the ammonia oxidation technologies and their *** two typical mechanisms for ammonia electro-oxidation,Oswin-Salomon mechanism and Gerischer-Mauerer mechanism,are discussed,and attention to the poisoning species is ***,the electrocatalysts for ammonia reaction are classified into Pt-based catalysts and non-noble metal-based catalysts,and their performances are reviewed with various *** on the progress on the electrochemical ammonia oxidation catalysts,the challenges and future insight on ammonia oxidation reaction are discussed and proposed.

关键词： NH3 oxidation reaction electrocatalysts green hydrogen

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Influence of the molecular structure of metal-phthalocyanine on electrocatalytic reactions

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Science China Materials 2022年第12期65卷 3324-3333页

作者： Da sol Jeong Hyeon Suk Shin Jieun Yang Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)50 UNIST-gilUlsan 44919Republic of Korea Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoul 02447Republic of Korea

The demand for new catalysts for renewable energy production has become *** an alternative to metal catalysts for electrocatalysis to produce energy sources,metal-phthalocyanine(MPc)electrocatalysts have shown *** physicochemical and electrochemical properties depend on the chemical structure of the MPc and the central metal *** reviews of MPcs focused on their electrochemical performance in specific catalytic reactions,such as oxygen reduction reaction and CO_(2)reduction ***,understanding the structure of MPcs in depth is important,since their electrochemical catalytic activity is affected by structural modifications of ***,this minireview focuses on how the molecular structure of MPcs affects electrochemical catalysis.

关键词： metal-phthalocyanine oxygen reduction reaction carbon dioxide reduction reaction hydrogen evolution reaction oxygen evolution reaction electrocatalytic activities

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Cardiogenic shock:approaching the truth

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Journal of Geriatric Cardiology 2022年第2期19卷 95-97页

作者： Isaac Llaó Albert Ariza-solé Cardiology Department Intensive Cardiac Care UnitBellvitge University HospitalL’Hospitalet de LlobregatBarcelonaSpain

Cardiogenic shock(CS)is a severe clinical condition characterized initially by reduced cardiac output with abnormal organ perfusion which commonly leads to a multiorgan *** expansion of cardiac critical care units,development of reperfusion networks and progress of mechanical circulatory support(MCS),mortality of CS due to acute myocardial infarction(AMI)remains as high as 40%−50%.[1]Clinical outcomes in non-AMI patients are less established but remains similarly disappointing.

关键词： cardiac mortality acute

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Self-Dual Hadamard Bent Sequences

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Journal of Systems Science & Complexity 2023年第2期36卷 894-908页

作者： SHI Minjia LI Yaya CHENG Wei CRNKOVIC Dean KROTOV Denis soléPatrick Key Laboratory of Intelligent Computing Signal Processing Ministry of EducationSchool of Mathematical SciencesAnhui UniversityHefei 230601China State Key Laboratory of Information Security(Institute of Information Engineering) Chinese Academy of SciencesBeijing 100093China. LTCI Télécom ParisParis91120 PalaiseauFrance Secure-IC S.A.S. 104 Bd du Montparnasse75014 Paris Faculty of Mathematics University of RijekaNovosibirsk 630090Russia Sobolev Institute of Mathematics Novosibirsk 630090Russia Aix Marseille Univ CNRSCentrale MarseilleI2MMarseilleFrance

A new notion of bent sequence related to Hadamard matrices was introduced recently,motivated by a security application(solé,et al.,2021).The authors study the self-dual class in length at most *** authors use three competing methods of generation:Exhaustion,Linear Algebra and Gr?bner *** Hadamard matrices and Bush-type Hadamard matrices provide many *** authors conjecture that if v is an even perfect square,a self-dual bent sequence of length v always *** authors introduce the strong automorphism group of Hadamard matrices,which acts on their associated self-dual bent *** authors give an efficient algorithm to compute that group.

关键词： Bent sequences bush-type Hadamard matrices Hadanard matrices PUF functions regular Hadamard matrices

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