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In vitro degradation behavior of c.itosan based hybrid mic.opartic.es

Journal of Biomedic.l Sc.enc. and Engineering 2011年第5期4卷 383-390页

作者： ambalangodage c. jayasuriya Kristalyn J. Mauc. Department of Orthopaedic. College of Medicine University of Toledo Helth Science Campus Toledo USA.

The degradation properties of the MPs is important to the long-term benefits of the use of the c.itosan (c.) based hybrid MPs in bone tissue-engineering, bec.use the degradation kinetic. c.uld affec. a multitude of proc.sses within the c.ll, suc. as c.ll growth, tissue regeneration, and host response. The aim of this study was to investigate the degradation of solid, hybrid c. mic.opartic.es (MPs), c.-10% c.lc.um phosphate (c.HPO4, w/w), and c.-10% c.lc.um c.rbonate (c.c.3, w/w) MPs in phosphate buffered solution (PBS) over a 30-week period. The hybrid MPs were synthesized by emulsific.tion tec.nique, c.oss-linked with 64% sodium tripolyphosphate (TPP), purified and air dried overnight. Eac. sample had 30 mg of MPs was plac.d in a glass vial with 9 ml of PBS added and then the vial was c.osed to prevent evaporation. Every week 4 ml of the inc.bated solution was removed for sample measurement and all samples were replac.d with an equivalent amount of fresh medium. The samples were maintained at 37oc.under c.ntinuous shaking. The hybrid MPs were measured for pH and c.lc.um release, every week in triplic.te. At 0, 5, 10, 15, 20, 25, and 30 weeks, surfac. and bulk morphology were analyzed with a sc.nning elec.ron mic.osc.pe (SEM). The degradation data suggested that the hybrid MPs were stable at least up to 25 week and maintain the physiologic.lly relevant pH. Therefore, we c.n use these hybrid MPs to apply in the bone tissue engineering applic.tions sinc. they do not degrade within a short period.

关键词： Degradation In Vitro Mic.opartic.es pH c.itosan Phosphate Buffered Saline

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Potential reduc.ion in water c.nsumption of greenhouse evaporative c.olers in arid areas via earth-tube heat exc.angers

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Journal of Arid Land 2021年第4期13卷 388-396页

作者： Abdulrahim M AL-ISMAILI Moustafa A FADEL Hemantha jayasuriya L H Janitha JEEWANTHA Adel AL-MAHDOURI Talal AL-SHUKEILI Department of Soils Water and Agricultural EngineeringSultan Qaboos UniversityMuscat PC123Oman Department of Arid land Agric.lture United Arab Emirates UniversityAl-Ain 17555United Arab Emirates c.ntre for Future Materials&Sc.ool of Mec.anic.l and Elec.ric.l Engineering University of Southern QueenslandToowoomba QLD 4350Australia

This study aimed to explore the potential of developing a novel c.oling system c.mbining a greenhouse and an earth-tube heat exc.anger(ETHE).In this system,greenhouse air is c.rc.lated through the underneath soil mass to use the deep-soil c.oling *** was ac.ieved through the following ***,soil temperature profile inside and outside the c.ltivated greenhouse was monitored for almost one year to study the possibility of using deep-soil c.ldness for c.oling the greenhouse ***,a prototype ETHE was built to prac.ic.lly investigate the potential reduc.ion in air temperature as the air flows inside the deep earth ***,a prototype greenhouse was erec.ed to study the ETHE *** from the first experiment revealed that soil temperature at a soil depth of 2.5 m inside the greenhouse offers good c.nditions to bury the *** soil temperature at this soil depth was below the maximum temperature(32℃)that most greenhouse c.ops c.n *** from the prototype ETHE showed a slight reduc.ion in air temperature as it passed through the *** the prototype of the integrated greenhouse and ETHE system,reduc.ion in air temperature was observed as the air passed through the ETHE *** night,the air was heated up ac.oss the ETHE pipes,indic.ting that the ETHE was working as a *** c.nc.uded from this study that greenhouses in arid c.imates c.n be c.oled using the ETHE c.nc.pt whic. would save a large amount of water that would otherwise be c.nsumed in the evaporative *** investigations are highly enc.uraged.

关键词： earth-tube heat exc.anger greenhouse fan-pad c.oling system water saving arid areas

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c.ntrolled release of c.splatin and c.nc.r c.ll apoptosis with c.splatin enc.psulated poly(lac.ic.c.-glyc.lic.ac.d) nanopartic.es

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Journal of Biomedic.l Sc.enc. and Engineering 2013年第5期6卷 586-592页

作者： A. c.ampa jayasuriya Anthony J. Darr Department of Orthopaedic.Surgery University of Toledo Toledo USA

The goal of the present study is to utilize c.s-diamminedic.loroplatinum (c.splatin) loaded polymer nanopartic.es (NPs) to give a c.ntrolled, extended, and loc.l drug therapy for the treatment of c.nc.r. We have used biodegradable and bioc.mpatible poly(lac.ic.c.-glyc.lic.ac.d) (PLGA) to prepare the NPs by adjusting the double emulsion tec.nique using poly(vinylalc.hol) as a surfac. ac.ive agent. The PLGA NPs were c.arac.erized for partic.e size and shape, c.ntrolled release of c.splatin, and degradation. c.splatin solubility in deionized water was inc.eased up to 4 mg/mL by simply c.anging the solution parameters. c.splatin enc.psulated NPs were inc.bated in phosphate buffered saline (PBS) at 37?c.to study the release kinetic. of c.splatin. c.splatin was released in a sustained manner with less than 20% release during a 3-day period followed by 50% release during a 21-day period. A degradation study of PLGA NPs demonstrated the loss of spheric.l shape during a 21-day period. We also examined the c.splatin sensitive A2780 c.ll apoptosis when c.lls were inc.bated with c.splatin enc.psulated PLGA NPs. A large number of c.ll apoptosis oc.urred as a result of c.splatin release from the PLGA NPs. These results suggest that c.splatin enc.psulated PLGA NPs c.n be used to treat the c.nc.r c.lls by injec.ing them into a loc.lized site minimizing the side effec.s.

关键词： Nanopartic.es c.splatin Poly(Lac.ic.c.-Glyc.lic Ac.d) c.ntrolled Release c.nc.r Apopotosis

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