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Neural Regeneration Research 2023年第1期18卷 119-120页

作者： Sara Kelley Nelson perez-Urrutia Rodrigo Morales Department of Neurology University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Potential causes for the clinical and pathological variability observed in Alzheimer’s disease(AD):AD is an age-related neurodegenerative disorder characterized by the impairment of cognitive functions such as memory,learning,and *** commonly described clinical symptoms are due to particular pathological changes in the brain,including inflammation,synaptic loss,and neuronal *** changes are a consequence of the accumulation of abnormally folded amyloid-β(Aβ)and tau proteins in specific areas of the central nervous *** the progressive aging of the world’s population,the number of people affected by AD is expected to substantially and consistently increase in the coming *** positions AD as one of the main public health challenges in the near future.

关键词： clinical Alzheimer amyloid

Overcoming thermo-optical dynamics in broadband nanophotonic sensing

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Microsystems & Nanoengineering 2021年第4期7卷 47-57页

作者： Mingkang Wang Diego J.perez-Morelo Vladimir Aksyuk Microsystems and Nanotechnology Division National Institute of Standards and TechnologyGaithersburgMD 20899USA Institute for Research in Electronics and Applied Physics University of MarylandCollege ParkMD 20742USA

Advances in integrated photonics open up exciting opportunities for batch-fabricated optical sensors using high-quality-factor nanophotonic cavities to achieve ultrahigh sensitivities and *** sensitivity improves with increasing optical power;however,localized absorption and heating within a micrometer-scale mode volume prominently distorts the cavity resonances and strongly couples the sensor response to thermal dynamics,limiting the sensitivity and hindering the measurement of broadband time-dependent ***,we derive a frequency-dependent photonic sensor transfer function that accounts for thermo-optical dynamics and quantitatively describes the measured broadband optomechanical signal from an integrated photonic atomic force microscopy nanomechanical *** this transfer function,the probe can be operated in the high optical power,strongly thermo-optically nonlinear regime,accurately measuring low-and intermediate-frequency components of a dynamic signal while reaching a sensitivity of 0.7fm/Hz^(1/2) at high frequencies,an improvement of=10x relative to the best performance in the linear ***,we discover that a higher transduction gain and sensitivity are achieved with lower quality-factor optical modes for low signal *** limited to optomechanical transducers,the derived transfer function is generally valid for describing the small-signal dynamic responses of a broad range of technologically important photonic sensors subject to the thermo-optical effect.

关键词： dynamics regime hinder

Woodland Mediterranean birds can resist a dry extreme cold wave

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Current Zoology 2014年第4期60卷 429-437页

作者： Sara VILLEN-perez Luis M. CARRASCAL Department of Biogeography and Global Change Museo Nacional de Ciencias Naturales (CSIC) C/Jos6 Guti6rrez Abascal 228006 Madrid Spain

The ecological consequences of climate extreme events are still poorly understood, especially those related to cold episodes. Winter cold spells might imperil the energy balance of small passerines, thus compromising their survivorship. Here we analyze how the abundance and habitat use of three tree-gleaning passerine species wintering in a montane oakwood of central Spain at ca. 1,300 m a.s.1, was influenced by the cold wave that hit Europe in February 2012. We monitored temperature, wind and the relative abundance of great tit Parus major, blue tit Cyanistes caeruleus and long-tailed tit Aegithalos caudatus in 15 plots throughout three periods： before, during and after the cold wave. Our results clearly rule out widespread mortality and temporal migration of the studied passerine populations, as the abundance of these species did not diminish during the cold wave. Moreover, the species usually foraging higher in the tree canopy -and thus more exposed to windmoved to the less windy woodland plots （long-tailed tit） and reduced their foraging height above ground during the cold wave （long-tailed tit and blue tit）, probably to mitigate the deleterious effects of wind chill. Therefore, these forest birds were able to cope with a dry cold wave that was statistically extreme in terms of temperature and wind chill, according to the historic climate records of the region. It seems that, at least when foraging substrates are not heavily covered by snow or ice, Mediterranean birds can resist an extreme cold wave [Current Zoology 60 （4）： 429-437, 2014].

关键词： Cold wave Harsh weather Mediterranean oakwoods Temperature Tree-gleaning birds Wind chill

Oxidation and Coatings for Power Generation： New Super Ultra Critical Steam Turbines

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中国腐蚀与防护学报 2009年第4期29卷 318-319页

作者： F. J. perez Grupo de Investigacion de Ingenieria de Superficies y Materiales Nanoestructurados U. C. M. N°910627 Facultad de Ciencias Quimicas Universidad Complutense de Madrid. 28040 Madrid Spain

The steels with chromium contents between 9%and 12%wt are used for power plants with advanced steam oxidation *** present good creep properties as 9%Cr steels and good oxidation resistance,at the temperatures range between 500℃～600℃.In the last years numerous investigation in development of coatings has been realized with the aim the protected them against the oxidation in order to allow operation of steam turbines at 650℃.In this study,Al-Hf protective coatings were deposited by CVD-FBR on ferritic steel HCM-12A followed by a diffusion heat treatment,have shown to be protective at 650℃under steam for at least 3000 hours of laboratory steam exposure under atmospheric *** and composition of coatings were characterized by different techniques, such as scanning electron microscopy(SEM),electron probe microanalysis,and X-ray diffraction(XRD). On the other hand,volatile species by mass spectrometry(MS) and thermogravimetric measurements (TG) during the initial stages oxidation of the P92 ferritic steel without and of Al and Al/Si coating by chemical vapour deposition in fluidized bed reactors(CVD-FBR) at 650℃in Ar+20%H_2O for 150 h were *** order to go forward to coatings design the Thermocalc code is used as base for the MSdata. TG-MS experiments were conducted in a closed steam loop in order to obtain information about the oxyhydroxides formation as reaction between coatings and *** those results the role of the different coating element could be established and optimized for the coating *** oxidation mechanism based on the TG-MS results is *** morphology/composition and structure of the oxidized samples were also studied using SEM/EDS and XRD techniques.

关键词：氧化金属腐蚀防护

Driving Factors for Forest Fire Occurrence in Durango State of Mexico:A Geospatial Perspective

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Chinese Geographical Science 2010年第6期20卷 491-497页

作者： Diana Avila-Flores Marin Pompa-Garcia Xanat Antonio-Nemiga Dante A Rodriguez-Trejo Eduardo Vargas-perez Javier Santillan-perez Forestry Division University of Chapingo Faculty of Forestry Juarez University of the State of DurangoRio Papaloapan and Durango Blvd Faculty of Geography Autonomous University of Mexico StateCerro de Coatepec s/nCiudad Universitaria

Forest fire is one of the major causes of forest loss and therefore one of the main constraints for sustainable forest management *** the driving factors and understanding the contribution of each factor are essential for the management of forest fire *** objective of this study is to identify variables that are spatially related to the occurrence and incidence of the forest fire in the State of Durango,*** this purpose,data from forest fire records for a five-year period were *** spatial correlations between forest fire occurrence and intensity of land use,susceptibility of vegetation,temperature,precipitation and slope were tested by Geographically Weighted Regression(GWR) method,under an Ordinary Least Square *** show that the spatial pattern of the forest fire in the study area is closely correlated with the intensity of land use,and land use change is one of the main explanatory *** addition,vegetation type and precipitation are also the main driving *** fitting model indicates obvious link between the *** fire was found to be the consequence of a particular combination of the environmental factors,and when these factors coexist with human activities,there is high probability of forest fire *** regulation of human activities is a key strategy for forest fire prevention.

关键词： forest fire Geographically Weighted Regression(GWR) land use forest management Durango State Mexico

Glial kon/NG2 gene network for central nervous system repair

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Neural Regeneration Research 2017年第1期12卷 31-34页

作者： Maria Losada-perez Neale Harrison Alicia Hidalgo School of Biosciences University of BirminghamBirminghamEnglandUK Universidad Autonoma de Madrid MadridSpain

The glial regenerative response to central nervous system（CNS） injury,although limited,can be harnessed to promote regeneration and *** provokes the proliferation of ensheathing glial cells,which can differentiate to remyelinate axons,and partially restore *** response is evolutionarily conserved,strongly implying an underlying genetic *** mammals,it is elicited by NG2 glia,but most often newly generated cells fail to *** an important goal had been to find out how to promote glial differentiation following the proliferative response.A gene network involving Notch and prospero（pros） controls the balance between glial proliferation and differentiation in flies and mice,and promotes CNS repair at least in fruit-flies.A key missing link had been how to relate the function of NG2 to this gene *** findings by Losada-perez et al.,published in JCB,demonstrated that the Drosophila NG2 homologue kon-tiki（kon） is functionally linked to Notch and pros in *** engaging in two feedback loops with Notch and Pros,in response to injury,Kon can regulate both glial cell number and glial shape homeostasis,essential for *** offers powerful genetics to unravel the control of stem and progenitor cells for regeneration and repair.

关键词： NG2 kon-tiki glia Drosophila injury regeneration repair CNS

Egg CD9 protein tides correlated with sperm oscillations tune the gamete fusion ability in mammal

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Journal of Molecular Cell Biology 2018年第6期10卷 494-502页

作者： Benjamin Ravaux Sophie Favier Eric perez and Christine Gourier Laboratoire de Physique Statistique Ecole Normale Superieure/PSL Research UniversityUPMC Univ Paris 06Universite Paris DiderotCNRS75005 ParisFrance

Mammalian fertilization involves membrane events-adhesion,fusion,sperm engulfment,membrane block to polyspermy-whose causes remain largely ***,specific oscillations of the sperm in contact with the egg were shown to be necessary for *** a microfluidic chip to impose the venue for the encounter of two gametes allowed real-time observation of the membrane remodelling occurring at the sperm/egg *** spatiotemporal mapping of egg CD9 revealed that this protein concentrates at the egg/sperm interface as a result of sperm oscillations,until a CDg-rich platform is nucleated on which fusion immediately takes *** 2-5 min after fusion,most of the CD9 leaves the egg for the external aqueous *** an egg membrane wave engulfs the sperm head in^25 *** results show that sperm oscillations initiate the CD9 recruitment that causes gamete fusion after which CD9 and associated proteins leave the membrane in a process likely to contribute to block *** highlight that the gamete fusion story in mammals is an unexpected interplay between mechanical constraints and proteins.

关键词： mammalian fertilization membrane dynamics real-time imaging CDg sperm oscillations gamete fusion

Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review

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World Journal of Gastroenterology 2020年第37期26卷 5617-5628页

作者： Miguel Jimenez perez Rocio Gonzalez Grande UGC de Aparato Digestivo Unidad de Hepatologia-Trasplante HepaticoHospital Regional Universitario de MalagaMalaga 29010Spain

Although artificial intelligence(AI)was initially developed many years ago,it has experienced spectacular advances over the last 10 years for application in the field of medicine,and is now used for diagnostic,therapeutic and prognostic purposes in almost all *** application in the area of hepatology is especially relevant for the study of hepatocellular carcinoma(HCC),as this is a very common tumor,with particular radiological characteristics that allow its diagnosis without the need for a histological ***,the interpretation and analysis of the resulting images is not always easy,in addition to which the images vary during the course of the disease,and prognosis and treatment response can be conditioned by multiple *** vast amount of data available lend themselves to study and analysis by AI in its various branches,such as deeplearning(DL)and machine learning(ML),which play a fundamental role in decision-making as well as overcoming the constraints involved in human *** is a form of AI based on automated learning from a set of previously provided data and training in algorithms to organize and recognize *** is a more extensive form of learning that attempts to simulate the working of the human brain,using a lot more data and more complex *** review specifies the type of AI used by the various ***,welldesigned prospective studies are needed in order to avoid as far as possible any bias that may later affect the interpretability of the images and thereby limit the acceptance and application of these models in clinical *** addition,professionals now need to understand the true usefulness of these techniques,as well as their associated strengths and limitations.

关键词： Artificial intelligence Machine learning Hepatocellular carcinoma Diagnosis Treatment Prognosis

Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma

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Chinese Journal of Integrative Medicine 2018年第12期24卷 912-919页

作者： Rosa Martha perez Gutierrez Jose Maria Mota Flores Natural Products Research Laboratory Higher School of Chemical Engineering and Extractive IndustriesInstituto Politecnico Nacional (IPN) Professional Unit Adolfo Lopez Mateos Av. Instituto Politécnico NacionalS/N

Objective： To examine the effect of metanol extract of Petiveria alliacea （PM） on airway inflammation in a murine model of chronic asthma. Methods： Two-month-old male BALB/c mice （n=6-8/group） were sensitized on days 0 and 14 by intraperitoneal injection of 20μg ovalbumin （OVA）. On day 25, the mice received an airway challenge with OVA （3%, w/v, in phosphate buffered saline）. PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline （PBS） to induce a model of asthma. At the end of the test, respiratory reactivity was assayed, the total cell number, interleukin-4 （IL-4）, IL-5, IL-13, tumor necrosis factor-alpha （TNF-α） and reactive oxygen species （ROS） in the bronchoalveolar lavage fluid （BALF） were determined and the levels of serum IgE, intercellular cell adhesion molecule 1 （ICAM-1） and eotoxin were measured. In addition, lung tissue was used to qualify the IL-4, IL-5, IL-13, TNF-α and transforming growth factor beta 1 （TGF-β1）. Histologic examination was performed to observe inflammatory cellular infiltration. Results： The administration of PM in comparison with the OVA-only treated group significantly attenuated the infiltration of eosinophUs and other inflammatory cells （P〈0.01）. Airway resistance （RI） in the OVA-only induced group was significantly higher than that of the PBS control group （P〈0.01） when methacholine was added. TNF-α, IgE, TGF-β1 and cytokine levels IL-4, IL-5, IL-β in the BALF decreased compared to control mice （P〈0.01 or P〈0.05）. PM treatment also inhibited the production of chemokines, eotaxin and ICAM-1 in BALF （P〈0.01）, which improved lung function. Histopathological examination revealed that the sensitized treated PM groups had significant lower in inflammatory scores similar to dexamethasone treatments and the untreated group. Conclusion： Administration of PM could inhibit airway inflammation, regulate cyt

关键词： Petiveria alliacea allergy antiinflammation asthma

Hierarchical dispatch of multiple microgrids using nodal price:an approach from consensus and replicator dynamics

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Journal of Modern Power Systems and Clean Energy 2019年第6期7卷 1573-1584页

作者： Miguel A.VELASQUEZ Oscar TORRES-perez Nicanor QUIJANO Angela CADENA Department of Electrical and Electronics Engineering Universidad de los AndesBogotaColombia

A hierarchical approach for the energy management of geographically close microgrids connected through a dedicated AC power network is proposed in this *** proposed approach consists of a two-layer energy management system(EMS)for networked *** the lower layer,each micro grid solves its own economic dispatch problem through a distributed model predictive control approach that respects capacity limits and ramp-rate constraints of distributed *** the upper layer,the energy trading in the network of microgrids decides how to optimally trade the energy based on the marginal cost information from the lower layer in order to improve global optimization objectives,e.g.,social *** order to solve the trading problem,a consensusbased algorithm and a replicator dynamics algorithm are proposed assuming that the marginal cost function of the microgrid is known and *** is shown that both algorithms converge to the same solution,which is equivalent to the minimization of operation *** consensus-based algorithm is extended in order to tackle more general marginal cost functions and trading network ***,the effect of ramp constraints and network limits is *** show the effectiveness of the proposed algorithms for three interconnected microgrids with different characteristics.

关键词： Consensus Economic dispatch Hierarchical control Networked microgrids Ramp limits Replicator dynamics