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Quantitative &Qualitative Regulation of Peripheral Leukocyte Subsets plus Emotional Hormones by Floor Heating

Open Journal of Rheumatology and Autoimmune Diseases 2014年第2期4卷 97-105页

作者： Nobuo Yamaguchi amat nurmuhammad Jameas Zhao Xiufeng Jia Jiao Jian Rui Chen Tsugiya Murayama Deaprtment of Microbiology and Immunology Faculty of Pharmaceutical Sciences Hokuriku University Kanazawa Japan Ishikawa Natural Medicinal Products Research Center Kanazawa Japan Uighur Medicine Department of Xinjiang Medical University Urumqi City China Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

A floor heating system is a traditionary famous in Asian countries, especially in North East of China and Korea. In this report, we intended to clarify the effect of floor hating system for accessing a peripheral leukocyte regulation in winter season by evidence-based manner more than VAS. We set up two different office rooms heat-controlled by floor heating and air-conditioned by ceiling electric heater. Both qualitative and quantitative approaches determine which are better therapeutic effective recipes for this trial. The elements were evaluated by the total number of peripheral leukocyte, granulocyte and lymphocyte ratio and lymphocyte subsets. For 5 days of working in each conditioned room, the volunteers were changed the room after one-week interval for cooling down. Floor heating system regulated total number of peripheral leukocyte. The mode of the action for the high number of the volunteer was down-regulated. On the contrary, in lower numbers it was up-regulated after the trial. The number of leukocyte subsets, granulocyte and lymphocyte were also regulated by dose dependent manner. Emotional hormone, adrenalin, cortisone and nor-adrenaline were down regulated by floor heating but dopamine was up-regulated by this heating system. The reversal results were obtained by the group who worked in the conditioned room by the system heating from ceiling.

关键词： Room Temp Control Floor Heating Leukocyte Subsets Ratio Emotional Hormone

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Regulative effect for natural killer cell by hot spring hydrotherapy—Quantitative and qualitative discussion

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Open Journal of Immunology 2013年第4期3卷 201-209页

作者： Nobuo Yamaguchi Wenhan Wan Daisuke Sakamoto amat nurmuhammad Kengo Matsumoto Takafumi Takei Katsuko Okuzumi Tsugiya Murayama Takashi Takahashi Deaprtment of Microbiology and Immunology Faculty of Pharmaceutical Sciences Hokuriku University Japan Department of Heart Surgery Kanazawa Medical University Himi Municipal Hospital Himi City Japan Ishikawa Medicinal Products Research Center Kanazawa Japan Ishikawa Medicinal Products Research Center Kanazawa Japan Laboratory of Infectious Diseases Graduate School of Infection Control Sciences Kitasato University Tokyo Japan Uighur Medicine Department of Xinjiang Medical University Urumqi City China

Along with maintaining immune competent cells, one of the purposes of cancer patient is regulating the first line of defense for survival. Moreover, the factors that influence the acquired immune activity are systemic metabolic disorder in diabetes, malnutrition, extreme exhaustion, stresses, aging and medical side effect such as chemotherapy. So we have to select appropriate menu to regulate immune function through leukocyte storage. Especially, NK cell is first line of defense against virus infected cell and/or tumor cell. In order to recommend the effect of hot spring hydrotherapy on the peripheral white blood cells as a parameter for complementary and alternative medicine (CAM) within a short period, the granulocytes, lymphocytes, lymphocyte subsets in their peripheral blood were monitored. In the young group (35 or less), the number of granulocytes clearly decreased after hydrotherapy. In the older group (over 35 years old), the total number of leukocytes and lymphocytes significantly increased after the therapy. Using a FACScan, we investigated CD2, CD4, CD8, CD16, CD19 and CD56 positive cell as well as the cytokine containing cell, as direct assessment for immunological preparation (IFN-γ, IL-4 and IL-1β). After hydrotherapy, the CD16+ cells also increased outstandingly. However, the CD19+ cells clearly decreased. Moreover, there was a decrease in the cytokine-producing cell count of subjects whose blood cells had a higher number of the cell level before. All of the results indicated that hot spring hydrotherapy could regulate the immune system even in normal human. Like this, blood hormonal level was measured in order to know the mechanism of the quantitative and qualitative, adjustment of the leucocytes becomes possible within a short term. As a result of measuring, 7 kinds of hormone including mainly adrenocortical hormones, adrenalin level reduced in constitution dependent manner. From these results, it was suggested that the quantitative and qualitative

关键词： Hot Spring Hydrotherapy Leukocyte Regulation NK Cell Quantitative Regulation of Lymphocyte Qualitative Regulation of Lymphocyte

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