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Prediction of delayed graft function using different scoring algorithms: A single-center experience

World Journal of Transplantation 2017年第5期7卷 260-268页

作者： Magda Michalak Kristien Wouters Erik Fransen Rachel hellemans amaryllis h van craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans Department of Nephrology-hypertension Antwerp University Hospital Department of Medical Statistics Antwerp University Hospital StatUa Center for Statistics University of Antwerp Department of hepatobiliary Endocrine and Transplantation SurgeryAntwerp University Hospital histocompatibility and Immunogenetic Laboratory

AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each *** This single-center,retrospective study included 247 consecutive kidney transplants from a deceased *** kidney transplantations were performed at our institution between January 2003 and December *** compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under *** c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P however,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without *** sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations.

关键词： Delayed graft function Kidney transplantation Nomogram Receiver operating characteristic curve Risk calculation

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老龄小鼠模型内皮细胞衰老导致射血分数保留的心力衰竭

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中华高血压杂志 2017年第9期25卷 859-859页

作者：刘莉叶鹏 Gevaert AB Shakeri h Leloup AJ van hove CE De Meyer GRY Vrints CJ Lemmens K van craenenbroeck EM

由于全球老龄化,射血分数保留的心力衰竭（heart failure with preserved ejection fraction,hFpEF）发生率持续上升。虽然hFpEF的病理生理机制仍然不完全清楚,但通常认为内皮炎症发挥了核心作用。细胞衰老是一种与老化和炎症有关的细... 详细信息

由于全球老龄化,射血分数保留的心力衰竭（heart failure with preserved ejection fraction,hFpEF）发生率持续上升。虽然hFpEF的病理生理机制仍然不完全清楚,但通常认为内皮炎症发挥了核心作用。细胞衰老是一种与老化和炎症有关的细胞生长停滞过程。Gevaert等使用加速老化的小鼠（senescence-accelerated mice，SAM）模型探究细胞衰老在hFpEF发生发展中的作用。

关键词：细胞衰老射血分数心力衰竭老龄小鼠全球老龄化病理生理机制 ejection 内皮加速老化 preserved

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