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Incidence, clinical features and para-clinical findings of achalasia in Algeria: Experience of 25 years

World Journal of Gastroenterology 2016年第38期22卷 8615-8623页

作者： amar tebaibia Mohammed Amine Boudjella Djamel Boutarene Farouk Benmediouni Hakim Brahimi Nadia Oumnia Internal Medicine Department Kouba HospitalUniversity of Algiers 1 Department of Epidemiology National Public Health InstituteEl BiarUniversity of Algiers 1

AIM To investigate the incidence of achalasia in Algeria and to determine its clinical and para-clinical profile. To evaluate the impact of continuing medical education(CME) on the incidence of this *** From 1990 to 2014, 1256 patients with achalasia were enrolled in this prospective study. A campaign of CME on diagnosis involving different regions of the country was conducted between 1999 and 2003. Annual incidence and prevalence were calculated by relating the number of diagnosed cases to 105 inhabitants. Each patient completed a standardized questionnaire, and underwent upper endoscopy, barium swallow and esophageal manometry. We systematically looked for Allgrove syndrome and familial *** The mean annual incidence raised from 0.04(95%CI: 0.028-0.052) during the 1990 s to 0.27/105 inhabitants/year(95%CI: 0.215-0.321) during the 2000 s. The incidence of the disease was two and half times higher in the north and the center compared to the south of the country. One-hundred-and-twenty-nine(10%) were children and 97(7.7%) had Allgrove syndrome. Familial achalasia was noted in 18 different families. Patients had dysphagia(99%), regurgitation(83%), chest pain(51%), heartburn 24.5% and weight loss(70%). The lower esophageal sphincter was hypertensive in 53% and hypotensive in 0.6%.CONCLUSION The mean incidence of achalasia in Algeria is at least 0.27/105 inhabitants. A good impact on the incidence of CME was noted. A gradient of incidence between different regions of the country was found. This variability is probably related to genetic and environmental factors. The discovery of an infantile achalasia must lead to looking for Allgrove syndrome and similar cases in the family.

关键词： Achalasia Incidence Allgrove syndrome Manometry Continuing medical education

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