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Bioactive compounds from mushrooms: Emerging bioresources of food and nutraceuticals

Food Bioscience 2022年第6期50卷 1349-1366页

作者： Harpreet Kour Divjot Kour Satvinder Kour Shaveta singh Syed Azhar Jawad Hashmi Ajar Nath Yadav Krishan Kumar Yash pal Sharma Amrik singh Ahluwalia Department of Botany University of JammuJammu180006India Department of Microbiology Akal College of Basic SciencesEternal UniversityBaru SahibSirmaur173101India Department of Biotechnology Dr.Khem Singh Gill Akal College of AgricultureEternal UniversityBaru SahibSirmaur173101India Department of Food Technology Dr.Khem Singh Gill Akal College of AgricultureEternal UniversityBaru SahibSirmaur173101India Department of Botany Akal College of Basic SciencesEternal UniversityBaru SahibSirmaur173101India

Mushrooms have been an indispensable element of the human culture since antiquity and are cherished all over the globe for their nutritive and therapeutic benefits. Being acknowledged as “the new superfood” of the future, they are a cardinal component of human diet for boosting health status and well being. Mushrooms are endowed with antioxidant, antimicrobial, anticancer, prebiotic, antidiabetic, and anti-inflammatory activities, upholding a great therapeutic potential and a huge spectrum of clinical applications. The wide ranges of bioactive compounds including polysaccharides, polysaccharides protein complexes, peptides and proteins, terpenoids and phenolic compounds have been reported from diverse groups of mushroom. Laden with a wealth of nutrients and innumerable biomolecules of therapeutic worth, they are internationally appreciated and envisaged as world's largest untapped resources of dietary supplements. In the recent years, owing to significant healthier lifestyle changes, dietary practices of people and consumers opting for immunity enhancing supplements especially during the COVID-19 pandemic, the yearning for mushroom based nutraceuticals and functional foods is on rise. This review gives comprehensive details on the biodiversity of mushrooms, its nutritional and medicinal importance, secondary metabolites especially of nutraceuticals and pharmaceutical potential, and their role as bioactive agents and application in preparing mushroom based value-added products.

关键词： Anti cancer compounds Bioactive compounds Biodiversity Food industry Mushrooms Nutraceuticals Nutritive value

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Dust-Holding Capacity and Bio-Chemical Changes of Plant Species Growing in an Around Opencast Mining Area of Bundelkhand Region of Uttar Pradesh, India

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American Journal of Plant Sciences 2024年第8期15卷 677-698页

作者： Priyanka singh Amit pal Institute of Environment and Development Studies Bundelkhand University Jhansi India

The present study has been carried out on a total of 50 available plant species to assess their dust-capturing capacity and biochemical performances in and around open cast granite mine areas of Jhansi district and Bundelkhand University campus treated as control site. Plant species existing under a polluted environment for a long time may be considered as potentially resistant species and recommended for green belt design in mining areas, especially to cope with dust pollution. Results showed the pollution level, especially of mining-originated dust particles holding capacity of leaves and effects of different biochemical parameters (Total Chlorophyll, Protein and Carotenoid) of existing plant species both from mining areas as well as from Bundelkhand University campus. Based on their performances, Tectona grandis L., Ficus hispida L., Calotropis procera Aiton., Butea monosperma Lam. and Ficus benghalensis L., etc. are highly tolerant species while Ficus infectoria L., Artocarpus heterophyllus Lam., Ipomoea purpurea L., Allianthus excelsa Roxb. and Bauhinia variegata L. are intermediate tolerant species. T. grandis had shown the highest dust-holding capacity (2.566 ± 0.0004 mg/cm2) whereas Albizia procera (0.018 ± 0.0002 mg/cm2) was found to be the lowest dust-holding capacity. Our findings also showed that the T. grandis and F. hispida have significant dust deposition with minimal effect of dust on their leaf chlorophyll (17.447 ± 0.019 mg/g and 14.703 ± 0.201 mg/g), protein (0.699 ± 0.001 mg/g and 0.604 ± 0.002 mg/g) and carotenoid (0.372 ± 0.003 mg/g and 0.354 ± 0.003 mg/g) content respectively among all selected plant species. Therefore, in the present investigation, plant species with high tolerance to high dust-holding capacity on their leaf surfaces are preferable for green corridors as open cast granite mines and their adjacent areas.

关键词： Bundelkhand Region Biochemical Changes Dust-Holding Capacity Chlorophyll Content Open Cast Granite Mining

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Fatty acid and amino acid profiling,antioxidant activity and other quality characteristics of vacuum packed cheddar style-yak milk cheese during ripening

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Food Bioscience 2023年第1期51卷 159-167页

作者： Tarun pal singh Shalini Arora Sanket G.Borad Joken Bam Vijay Paul Rajendran Thomas Mihir Sarkar ICAR-National Research Centre on Yak Dirang790101West KamengArunachal PradeshIndia Department of Dairy Technology College of Dairy Science and TechnologyLUVASHisar125004HaryanaIndia Flavi Dairy Solutions Ahmedabad380009GujaratIndia Food Quality Control Laboratory ICAR-National Research Centre on PigRani781129GuwahatiAssamIndia Goat Products Technology Laboratory ICAR-Central Institute for Research on GoatsMakhdoomFarah281122MathuraUttar PradeshIndia

This study aimed to formulate Cheddar-style cheese from standardised yak milk(casein-fat ratio:0.7)and examined different quality parameters during 5 months ripening at 7±1℃.The chemical components viz.,fat,protein,ash,and salt contents,increased significantly(p˂0.05),whereas the moisture content decreased considerably(p˂0.05)during ***,pH,titratable acidity[lactic acid(%by weight)],soluble protein(%),ripening index,tyrosine value(μg/g),total free fatty acids(μm/g),and peroxide value(mEq of O_(2)/kg)increased considerably(p˂0.05)during *** and mould count(logCFU/g)showed a significant(p˂0.05)increase,while the coliform count(logCFU/g)were undetectable at the end of ***,cheese textural attributes and colour value(L^(*),a^(*)and b^(*))also decreased significantly(p˂0.05).The protein hydrolysis pattern in cheese was detected using *** water-soluble extracts of cheese exhibited significant antioxidant ***(27.2%)and oleic acid(24.4%)were the prominent fatty acids detected in higher concentrations at the end of *** majority of amino acids such as glutamic acid and histidine,were also retained in the *** sensory ratings of cheese significantly increased as ripening proceeded,and the formulated product was acceptable for up to 120 days.

关键词： Yak milk Cheddar style-cheese Physicochemical property Antioxidant activity Ripening

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Anticancer efficacy of noble metal nanoparticles relies on reprogramming tumor-associated macrophages through redox pathways and pro-inflammatory cytokine cascades

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Cellular & Molecular Immunology 2018年第12期15卷 1088-1090页

作者： Mahuya Sengupta Ramkrishna pal Anupam Nath Biswajit Chakraborty Leichombam Mohindro singh Biswajit Das Sujit Kumar Ghosh Department of Biotechnology Assam UniversitySilcharAssam 788011India Department of Chemistry Assam UniversitySilcharAssam 788011India

The use of the optoelectronic properties of noble metal nanoparticles has given a new dimension to the realm of cancer diagnosis and therapy(theranostics).The multifunctional catalytic properties and surface plasmon resonance of noble metal nanoparticles(NPs)along with their facile surface chemistry gives them an edge in the field of biology,including for immunotherapeutic *** a previous study,we reported the anticancer efficacy of silver NPs coated with murine serum albumin against fibrosarcoma in an in vivo mouse model,highlighting their role in eliciting oxystress and immune *** addition to addressing the bioavailability and toxicity parameters,our study reported that there was a significant reduction in the size,as well as a delay in the incidence of tumors with AgNP-MSA *** electron micrographs revealed AgNP-MSA uptake by sentinel immune cells associated with the tumor along with the downregulation of pro-tumorigenic inflammatory cytokines,such as TNF-α,IL-6 and IL-1β.

关键词： inflammatory diagnosis cytokine

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Prognostic value of AKT isoforms in non-small cell lung adenocarcinoma

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The Journal of Biomedical Research 2023年第3期37卷 225-228页

作者： Sahil Khurana Ajay pal singh Ashok Kumar Rajeev Nema All India Institute of Medical Sciences Bhopal BhopalMadhya Pradesh 462021India Department of Medicine All India Institute of Medical Sciences RishikeshRishikeshUttarakhand 249201India Department of Biochemistry All India Institute of Medical Sciences BhopalBhopalMadhya Pradesh 462021India Department of Oncology 3B Blackbio Biotech India Ltd.BhopalMadhya Pradesh 462023India

Dear Editor,Lung cancer is one of the most prevalent cancers in the world and has a high mortality *** cancer patients often have a poor prognosis,with a five-year survival rate of only about 16%.The International Agency for Research on Cancer reports that lung cancer was the main cause of cancer deaths in 2020,accounting for 1.80 million deaths.

关键词： Lung lung cancer

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Surface Wave Propagation in a Generalized Thermoelastic Material with Voids

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Applied Mathematics 2011年第5期2卷 521-526页

作者： Baljeet singh Raj pal 不详

In the present paper, the propagation of surface wave in a generalized thermoelastic solid with voids is considered. The governing equations are solved to obtain the general solution in x-z plane. The appropriate boundary conditions at an interface between two dissimilar half-spaces are satisfied by appropriate particular solutions to obtain the frequency equation of the surface wave in the medium. Some special cases are also discussed.

关键词： Thermoelasticity Surface Waves Boundary Conditions Voids

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Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians

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World Journal of Diabetes 2017年第2期8卷 66-73页

作者： amar Gautam Stuti Gupta Mohit Mehndiratta Mohini Sharma Kalpana singh Om P Kalra Sunil Agarwal Jasvinder K Gambhir Department of Medicine University College of Medical Sciences (University of Delhi) and G.T.B. Hospital Molecular Diagnostic Laboratory Department of Biochemistry University College of Medical Sciences (University of Delhi) and G.T.B. Hospital

AIM To investigate the association of NFKB1 gene-94 ATTG insertion/deletion(rs28362491) polymorphism with inflammatory markers and risk of diabetic nephropathy in Asian *** A total of 300 subjects were recruited(100 each), normoglycemic,(NG); type 2 diabetes mellitus(T2DM) without any complications(DM) and T2 DM with diabetic nephropathy [DM-chronic renal disease(CRD)]. Analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism and ELISA. Pearson's correlation, analysis of variance and logistic regression wereused for statistical *** The allelic frequencies of-94 ATTG insertion/deletion were 0.655/0.345(NG), 0.62/0.38(DM) and 0.775/0.225(DM-CRD). The-94 ATTG ins allele was associated with significantly increased levels of urinary monocyte chemoattractant protein-1(u MCP-1); u MCP-1(P = 0.026) and plasma tumor necrosis factor-alpha(TNF-α); TNF-α(P = 0.030) and almost doubled the risk of diabetic nephropathy(OR = 1.91, 95%CI: 1.080-3.386, P = 0.025).CONCLUSION-94 ATTG ins/ins polymorphism might be associated with increased risk of developing nephropathy in Asian Indian subjects with diabetes mellitus.

关键词： Diabetic nephropathy Inflammation NFKB1 -94 ATTG ins/del polymorphism Urinary monocyte chemoattractant protein-1 Tumor necrosis factor-alpha

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Traumatic bilateral hip dislocation with bilateral sciatic nerve palsy

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Chinese Journal of Traumatology 2010年第2期13卷 126-128页

作者： Ajay pal singh amarjit singh Sidhu Arun pal singh Department of Orthopaedics Guru Teg Bahadur Hospital University College of Medical Sciences University of Delhi Delhi 110095 India Department of Orthopaedics Rajindra Hospital Government Medical College Punjab 147001 India

Bilateral hip dislocation rarely occurs. In this paper, a case of bilateral hip dislocation associated with bilateral sciatic nerve palsy resulted from a road traffic accident is reported. Both hips were emergently reduced under general anaesthesia. Acetabular reconstruction was done bilaterally due to the unstable hips. The patient subsequently developed heterotopic ossification and avascular necrosis on the left hip and underwent total hip arthroplasty. The sciatic nerve on the right side achieved complete recovery but that on the left side only partly recovered and was augmented by tendon transfer. Such injuries are serious and one should be aware of the complications because they can resurface and so patients should be followed up for a long time. To the best of our knowledge, this kind of injury has not been reported in the English .language literature.

关键词： Hip dislocation Sciatic nerve Paralysis Accident, traffic

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A Study of Determinants of Sensorineural Hearing Loss in Chronic Suppurative Otitis Media with or without Cholesteatoma

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第4期7卷 148-159页

作者： Rajwant Kaur Satinder pal singh Jagdeepak singh Department of ENT & Head Neck Surgery GMC Amritsar India Department of ENT & Head Neck Surgery Swift Hospital Amritsar India

Aim: This study was carried out to assess association between Sensorineural hearing loss (SNHL) and Chronic Suppurative Otitis Media (CSOM), to identify possible risk factors and determine correlation of duration of CSOM and incidence of SNHL. Material and Method: The study consisted of 100 patients of either sex between 15 and 40 years of age, suffering from unilateral CSOM for the past three months or more, the normal ear served as control. Results: This study showed duration of symptoms is 18% patients for 5 - 10 years and below 5 years in 73% patients. It was found that mean BC thresholds were significantly higher in the diseased ears as compared to the control ears. Though the higher frequencies are more affected than the lower frequencies, in subtotal and attic perforations the speech frequencies seemed to be maximally affected. Conclusion: CSOM should be diagnosed early and should be managed effectively so as to prevent the chances of developing SNHL.

关键词： CSOM Cholesteatoma Sensorineural Hearing Loss (SNHL)

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A New Model for the Etching Characteristics of Corners Formed by Si<sub>{111}</sub>Planes on Si<sub>{110}</sub>Wafer Surface

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Engineering（科研） 2013年第11期5卷 1-8页

作者： Prem pal Sajal Sagar singh MEMS and Micro/Nano Systems Laboratory Department of Physics Indian Institute of Technology Hyderabad India

The etching characteristics of concave and convex corners formed in a microstructure by the intersection of {111} planes in wet anisotropic etchant are exactly opposite to each other. The convex corners are severely attacked by anisotropic Fetchant, while the concave corners remain unaffected. In this paper, we present a new model which explains the root cause of the initiation and advancement of undercutting phenomenon at convex corners and its absence at concave corners on {110} silicon wafers. This contrary etching characteristics of convex and concave corners is explained by utilizing the role of dangling bond in etching process and the etching behavior of the tangent plane at the convex corner. The silicon atoms at the convex edge/ridge belong to a high etch rate tangent plane as compared to {111} sidewalls, which leads to the initiation of undercutting at the convex corner. On the other hand, all the bonds of silicon atoms pertaining to concave edges/ridge are engaged with neighboring atoms and consequently contain no dangling bond, thus resulting in no-undercutting at concave edges/corners.

关键词： MEMS Silicon Anisotropic Etching Micromachining KOH TMAH Convex Corner Concave Corner

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