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HLA-DQB1~* alleles and genetic susceptibility to type 1 diabetes mellitus

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World Journal of Diabetes 2012年第8期3卷 149-155页

作者： Youssef M Mosaad Fatma A Auf Shereen S Metwally Ashraf A elsharkawy amany k el-hawary Rasha H Hassan Ziyad E Tawhid Farha A el-Chennawi Unit of Clinical Immunology Department of Clinical Pathology Mansoura Faculty of Medi-cine Mansoura 35111 Egypt Unit of Pediatric Endocrinology and Diabetes Mansoura Faculty of Medicine Children’s Hospital Mansoura 35111 Egypt Unit of Pediatric Infectious Disease and Mal-nutrition Mansoura Faculty of Medicine Children’s Hospital Mansoura 35111 Egypt

AIM: To determine human leukocyte antigen (HLA)-DQB1 allele association with susceptibility to type 1 diabetes (T1D) and to clinical and laboratory findings. METHODS: This study was conducted on 85 unrelated Egyptian children with T1D recruited consecutively from the Pediatric Diabetes Endocrinology outpatients Clinic; Mansoura University Children’s Hospital, Egypt. Patient mean follow up period was 2.5 years. Patients were subdivided according to level of HbA1c (optimal/suboptimal control elated age- and sex-matched healthy subjects without T1D or other autoimmune diseases. Genomic DNA extraction was done for all subjects using a DNA isolation kit. HLA-Class II-DQB1 allele typing was carried out with a polymerase chain reaction-sequence-specific oligonucleotide probe using a INNO-LiPA HLA-DQB1 update kit. RESULTS: Significant differences were detected between Egyptian patients with T1D and control groups in the frequencies of DQB1*02 [44.4% vs 18.6%, corrected P value (Pc) ely associated with T1D (Pc = 0.014, Pc ely), while HLA-DQB1*060101 was negatively associated (Pc eles 030101 and 050101 were significantly higher in controls (P = 0.016, P = 0.025 respectively), both of them lost statistical significance after correction of P value. The frequency of the HLA-DQB1 genotypes 02/02, 02/03, and 03/03 was higher in T1D patients, and the frequency of the genotypes 03/06, 05/06, and 06/06 was higher in controls,

关键词： HLA-DQB1 Type 1 diabetes Egyptian Genetic susceptibility Children, Complication

Bayesian belief-based model for reliability improvement of the digital reactor protection system

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Nuclear Science and Techniques 2020年第10期31卷 55-73页

作者： Hanaa Torkey amany S.Saber Mohamed k.Shaat Ayman el-Sayed Marwa A.Shouman Faculty of electronic Engineering Menoufia UniversityCairoEgypt Nuclear Research Center Egyptian Atomic Energy AuthorityCairoEgypt

The digital reactor protection system(RPS)is one of the most important digital instrumentation and control(I&C)systems utilized in nuclear power plants(NPPs).It ensures a safe reactor trip when the safety-related parameters violate the operational limits and conditions of the *** high reliability and availability of digital RPS is essential to maintaining a high degree of reactor safety and cost *** main objective of this study is to develop a general methodology for improving the reliability of the RPS in NPP,based on a Bayesian Belief Network(BBN)*** structure of BBN models is based on the incorporation of failure probability and downtime of the RPS I&C *** architectures with dual-state nodes for the I&C components were developed for reliability-sensitive analysis and availability optimization of the RPS and to demonstrate the effect of I&C components on the failure of the entire system.A reliability framework clarified as a reliability block diagram transformed into a BBN representation was constructed for each architecture to identify which one will fit the required *** results showed that the highest availability obtained using the proposed method was *** are 120 experiments using two common component importance measures that are applied to define the impact of I&C modules,which revealed that some modules are more risky than others and have a larger effect on the failure of the digital RPS.

关键词： Nuclear power plants Reactor protection system Bayesian belief network

Promotive action of 2-acetylaminofluorene on hepatic precancerous lesions initiated by diethylnitrosamine in rats:Molecular study

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World Journal of Hepatology 2021年第3期13卷 328-342页

作者： amany Helmy Hasanin Eman k Habib Nesreen el Gayar Marwa Matboli Clinical Pharmacology Department Faculty of MedicineAin Shams UniversityCairo 11318Egypt Anatomy and Embryology Department Faculty of MedicineAin Shams UniversityCairo 11318Egypt Medical Biochemistry and Molecular Biology Department Faculty of MedicineAin Shams UniversityCairo 11381Egypt

BACkGROUND Diethylnitrosamine(DEN)induces hepatic neoplastic lesions over a prolonged *** To investigate the promotive action of 2-acetylaminofluorene(2-AAF)when combined with DEN in order to develop a rat model for induction of precancerous lesion and investigate the molecular mechanism underlying the activity of *** The pre-precancerous lesions were initiated by intraperitoneal injection of DEN for three weeks consecutively,followed by one intraperitoneal injection of 2-AAF at three different doses(100,200 and 300 mg/kg).Rats were separated into naïve,DEN,DEN+100 mg 2-AAF,DEN+200 mg 2-AAF,and DEN+300 mg 2-AAF *** were sacrificed after 10 wk and 16 *** functions,level of alpha-fetoprotein,glutathione S-transferase-P and proliferating cell nuclear antigen staining of liver tissues were *** mRNA level of RAB11A,BAX,p53,and Cyclin E and epigenetic regulation by long-noncoding RNA(lncRNA)RP11-513I15.6,miR-1262(microRNA),and miR-1298 were assessed in the sera and liver tissues of the *** 2-AAF administration significantly increased the percent area of the precancerous foci and cell proliferation along with a significant decrease in RAB11A,BAX,and p53 mRNA,and the increase in Cyclin E mRNA was associated with a marked decrease in lncRNA RP11-513I15.6 expression with a significant increase in both miR-1262 and *** 2-AFF promoted hepatic precancerous lesions initiated through DEN by decreasing autophagy,apoptosis,and tumor suppression genes,along with increased cell proliferation,in a time-and dose-dependent *** actions were mediated under the epigenetic regulation of lncRNA RP11-513I15.6/miR-1262/miR-1298.

关键词： Acetylaminofluorene Hepatic precancerous lesion Diethylnitrosamine Autophagy Apoptosis MicroRNA

Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion,in vivo study

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World Journal of Gastroenterology 2021年第14期27卷 1435-1450页

作者： Marwa Matboli amany H Hasanin Reham Hussein Sarah el-Nakeep Eman k Habib Rawan ellackany Lobna A Saleh Department of Biochemistry Ain Shams Faculty of MedicineCairo 11318Egypt Department of Clinical Pharmacology Ain Shams Faculty of MedicineCairo 11381Egypt Department of General Internal Medicine Ain Shams Faculty of MedicineCairo 11381Egypt Department of Anatomy&Embryology Ain Shams Faculty of MedicineCairo 11318Egypt Department of Undergraduate Faculty of MedicineModern University for Technology and InformationCairo 11381Egypt

BACkGROUND Cyanidin-3-O-glucoside(cyan)exhibits antioxidant and anticancer *** cell cycle proteins and antimitotic drugs might be promising therapeutic targets in hepatocellular *** To investigate the effect of cyan administration on cell cycle in hepatic precancerous lesion(PCL)induced by diethylnitrosamine/2-acetylaminofluorene(DEN/2-AAF)in Wistar *** In vivo,DEN/2-AAF-induced hepatic PCL,rats were treated with three doses of cyan(10,15,and 20 mg/kg/d,for four consecutive days per week for 16 wk).Blood and liver tissue samples were collected for measurement of the followings;alpha fetoprotein(AFP)liver function and RNA panel differential expression was evaluated via real time polymerase chain *** examination of liver sections stained with H&E and immunohistochemical study using glutathione S-transferase placental(GSTP)and proliferating cell nuclear antigen(PCNA)antibodies were *** Cyan administration mitigated the effect of DEN/2-AFF induced PCL,decreased AFP levels,and improved liver ***,treatment with cyan dose dependently decreased the long non-coding RNA MALAT1 and tubulin gamma 1 mRNA expressions and increased the levels of miR-125b,all of which are involved in cell cycle and mitotic spindle *** note,cyan decreased GSTP foci percent area and PCNA positively stained *** Our results indicated that cyan could be used as a potential therapeutic agent to inhibit liver carcinogenesis in rat model via modulation of cell cycle.

关键词： Hepatocellular carcinoma therapy Hepatocellular-carcinoma growth Hepatocellular-carcinoma model Hepatocellular-carcinoma size

Inhibitory effects of methanolic Olea europaea and acetonic Acacia laeta on growth of Babesia and Theileria

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Asian Pacific Journal of Tropical Medicine 2019年第9期12卷 425-434页

作者： amany Magdy Beshbishy Gaber el-Saber Batiha Oluyomi Stephen Adeyemi Naoaki Yokoyama Ikuo Igarashi Natonal Research Certer for Protocron Diseases Obihiro Uninersity of Agricnuture and Veterinary MedicineNishi 2-13Inada-choObihiroHolkkaido 080-8555Japan Department of Pharmacology and Therapeutics Faculy of Velerinary MedicineDamanhour UniersitDamonhour 22511Al BeheiraEgpt Medicinal Biochemistry Infectious DiseasesNanomedicine and Toricology LaboratoryDepurtment of BiochenmistryLandmarks UniversityOmu Aran 251101Kiuarc StateNigeria

Objective:To evaluate the antipiroplasmic activities of methanolic extract of Olea europaea(MOE)and acetonic extract of Acacia laeta(AAL)against Babesia and Theileria parasites in vitro and evaluate the chemotherapeutic effects of these extracts against Babesia(B.)microti in ***:Fluorescence assay using SYBR Green 1 nucleic acid stain was used to detect inhibitory effects of the two extracts as well as the combination effects of the two extracts with diminazene aceturate and atovaquone on four Babesia species and Theileria equi in vitro while for in vivo experiments,8-weekold female BALB/c mice were injected intraperitoneally with 1× 107 ***-iRBCs and treated orally at a dose of 150 mg/kg of both ***:The half maximal inhibitory concentration(IC50)values of AAL against ***,***,***,***,and Theileria equi were lower than those of MOE *** assay on Madin-Darby bovine kidney,mouse embryonic fibroblast(NIH/3T3),and human foreskin fibroblast cell lines showed that MOE and AAL affected only the viability of Madin-Darby bovine kidney cell line with half maximal effective concentrations(EC50)of(794.7±41.9)and(873.9±17.5)μg/mL,*** oral treatments of MOE and AAL at 150 mg/kg inhibited the growth of *** in mice by 80.4% and 64.4%,*** MOE and diminazene aceturate combination showed a higher chemotherapeutic effect than that of ***:MOE and AAL have the potential to be an alternative remedy for treating ***,the combination therapy of MOE + DA was more potent against *** infection in mice than their monotherapies.

关键词： Olea europaea Acacia laeta Babesia Theileria In vitro In vivo Inhibition

The combined effects of farm yard manure and boron application on growth,and oil quality of Canola grown under newly reclaimed soils

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Oil Crop Science 2024年第1期9卷 53-59页

作者： Farid Hellal Saied el Sayed amany Abdel Mohsen Ramadan Doaa M.Abobasha Plant Nutrition Department National Research Centre33 El-Behouth St12622DokkiCairoEgypt Botany Department National Research Centre33 El-Behouth St12622DokkiCairoEgypt

Two field experiments were conducted during the main seasons of 2021/2022 at the Research and Production Station of National Research Centre in Egypt to investigate the effects of farmyard manure(FYM)and boron on Canola growth,yield,oil yield,and *** results unequivocally demonstrated that the combined application of FYM at a rate of 14.4 ton ha^(-1)with a foliar spray of boron at 100 ppm positively influenced plant characteristics,leading to enhanced growth rates and higher yields compared to the control ***,this integrated approach significantly improved nutrient content by enhancing levels of oil content,carbohydrates,proteins,phenolics,flavonoids,and total soluble *** findings provide compelling evidence that utilizing farm manure along with boron can effectively enhance Canola properties in newly reclaimed soils while promoting sustainable agricultural practices.

关键词： Oil quality Farmyard manure Phytochemical content Canola Yield production

Environmental pollution and diabetes mellitus

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World Journal of Meta-Analysis 2021年第3期9卷 234-256页

作者： amany el-Sikaily Mohamed Helal National Institute of Oceanography and Fisheries(NIOF) Cairo 21513Egypt

Diabetes mellitus(DM)is a chromic metabolic disease that affects a large segment of the population *** inactivity,poor nutrition,and genetic predisposition are main risk factors for disease *** the last decade,it was clear to the scientific community that DM development is linked to a novel disease inducer that was later defined as diabetogenic factors of pollution and endocrine disrupting *** pollution is exponentially increasing in uncontrolled manner in several *** pollutants are of diverse nature and toxicities,including polyaromatic hydrocarbons(PAHs),pesticides,and heavy *** the current review,we shed light on the impact of each class of these pollutants and the underlined molecular mechanism of diabetes induction and biological ***,a brief overview about the connection between coronavirus disease 2019 and diabetes pandemics is presented.

关键词： Diabetes mellitus Glucose Heavy metals Polyaromatic hydrocarbons Pesticide COVID-19

Fault Diagnosis in Distribution Networks with Distributed Generation

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Smart Grid and Renewable Energy 2011年第1期2卷 1-11页

作者： amany M. el-Zonkoly 不详

The penetration of distributed generation (DG) in distribution power system would affect the traditional fault current level and characteristics. Consequently, the traditional protection arrangements developed in distribution utilities are difficult in coordination. Also, the reclosing scheme would be affected. With the rapid developments in distribution system automation and communication technology, the protection coordination and reclosing scheme based on information exchange for distribution power system can be realized flexibly. This paper proposes a multi-agent based scheme for fault diagnosis in power distribution networks with distributed generators. The relay agents are located such that the distribution network is divided into several sections. The relay agents measure the bus currents at which they are located such that it can detect and classify the fault, and determine the fault location. The proposed technique uses the entropy of wavelet coefficients of the measured bus currents. The performance of the proposed protection scheme is tested through simulation of two systems. The first system is a benchmark medium voltage (MV) distribution system and the second system is practical 66 kV system of the city of Alexandria.

关键词： Cooperative Systems Relay Agent Fault Diagnosis Distributed Generation Wavelet Transform Entropy Calculation

Treatment responses in Asians and Caucasians with chronic hepatitis C infection

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World Journal of Gastroenterology 2008年第21期14卷 3416-3420页

作者： kenneth k Yan Marianne Guirgis amany Zekry Thuy Dinh Anouk Dev Jacob George Alice Lee Department of Hepatology St George HospitalKogarahSydney 2217NSWAustralia Department of Gastroenterology Monash Medical CentreMelbourne 3168VictoriaAustralia Storr Liver Unit Westmead Millennium InstituteUniversity of Sydney and Westmead HospitalSydney 2217NSWAustralia Department of Gastroenterology and Hepatology Concord Repatriation HospitalConcordSydney 2217NSWAustralia

AIM：To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C（CHC） treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.METHODS：Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital *** demographic characteristics,biochemical,virological and histological data and details of treatment were *** virological responses（SVR） in this cohort were then compared to that in Caucasian subjects,matched by genotype,age,gender and the stage of hepatic fibrosis.RESULTS：A total of 108 Asians with genotype 1 CHC were *** end of treatment response（ETR） for the cohort was 79% while the SVR was 67%.Due to the relatively advanced age of the Asian cohort,only sixty-four subjects could be matched with *** ETR among matched Asians and Caucasians was 81% and 56% respectively（P=0.003）,while the SVR rates were 73% and 36%（P 〈0.001） *** difference remained significant after adjusting for other predictive variables. CONCLUSION： Genotype 1 CHC in Asian subjects is associated with higher rates of virological response compared to that in Caucasians.

关键词： Hepatitis C Treatment Asians Retro-spective studies Comparative study Interferon Ribavirin Statistical data analysis