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宝钢情报 1992年第1期 16-21页

作者： amano,s 蒋莉玲

Enhancing Erectile Function and Alleviating Andropause symptoms: Clinical Efficacy of a Human stem Cell Conditioned Medium Cream

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Health 2024年第7期16卷 626-634页

作者： Hoichi amano eHealth Clinic Shinjuku Tokyo Japan Graduate school of Public Health Teikyo University Tokyo Japan

Erectile dysfunction (ED) is increasingly prevalent in Japan, exceeding 30%, and increasing with age. Unhealthy lifestyle habits, obesity, insufficient exercise, and smoking have been implicated in its pathogenesis, along with endothelial dysfunction of the corpora cavernosa and impaired blood flow to the penis considered underlying factors. However, the current treatments are limited to Phosphodiesterase-5 (PDE5) inhibitors. ED is the primary symptom of andropathy. This study reports the clinical efficacy of human stem cell-conditioned medium cream for ED treatment. Ten men without underlying diseases suspected of andropause with ED (mean age 43.2 ± 4.4 y, Hb 15.2 ± 0.6 gm/dL, AsT/ALT 30.2/37.9 ± 12.4/14.0, eGFR 82.7 ± 12.4 mL/min/1.73 m2) were targeted. The cream was applied twice daily to the genital and scrotal areas. The erectile hardness score (EHs), International Index of Erectile Function-5 (IIEF-5), and Aging Male symptoms (AMs) scale were used to evaluate the participants before and 30 days after use, and the results were compared using paired t-tests. The post-use qualitative opinions were collected through interviews. significant improvements were observed compared to baseline in the IIEF-5 (11.8 ± 4.6→17.2 ± 5.1, P s (46.3 ± 6.7→37.6 ± 5.3, P scores post cream use. EHs did not show a statistically significant difference, but a trend towards improvement was observed. Qualitative feedback included increased morning erection, improved maintenance of erection during intercourse, and reduced post work fatigue. Human stem cell-conditioned medium contains endothelial growth factors that potentially contribute to the improvement of ED and andropause by enhancing corporal endothelial function. Future studies should include control groups to further investigate the efficacy of these treatments.

关键词： Erectile Dysfunction Andropause Human stem Cell Conditioned Medium Cream stem Cell

Evaluation of mitral chordae tendineae length using four-dimensional computed

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World Journal of Cardiology 2024年第5期16卷 274-281页

作者： Takuya Mori satoshi Matsushita Terumasa Morita Abulaiti Abudurezake Junji Mochizuki Atsushi amano Department of Cardiovascular surgery Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of Cardiovascular surgery JACCT Japan Animal Cardiovascular Care TeamOsaka 533-0033Japan Department of Radiology Minamino Cardiovascular HospitalTokyo 192-0918Japan

BACKGROUND Mitral valvuloplasty using artificial chordae tendineae represents an effective surgical approach for treating mitral *** precise measurements of artificial chordae tendineae length(CL)is an important factor in the procedure;however,no objective index currently exists to facilitate this ***,preoperative assessment of CL is critical for surgical planning and ***-dimensional x-ray micro-computed tomography(4D-CT)may be useful for accurate CL measurement considering that it allows for dynamic three-dimensional(3D)evaluation compared to that with transthoracic echocardiography,a conventional inspection *** To investigate the behavior and length of mitral chordae tendineae during systole using *** Eleven adults aged>70 years without mitral valve disease were evaluated.A 64-slice CT scanner was used to capture 20 phases in the cardiac cycle in electrocardiographic *** length of the primary chordae tendineae was measured from early systole to early diastole using the 3D *** primary chordae tendineae originating from the anterior papillary muscle and attached to the A1-2 region and those from the posterior papillary muscle and attached to the A2-3 region were designated as cA and cP,*** behavior and maximum lengths[cA(ma),cP(max)]were compared,and the correlation with body surface area(BsA)was *** In all cases,the mitral anterior leaflet chordae tendineae could be *** most cases,the cA and cP chordae tendineae could be measured *** mean cA(max)and cP(max)were 20.2 mm±1.95 mm and 23.5 mm±4.06 mm,***(max)was significantly *** correlation coefficients(r)with BsA were 0.60 and 0.78 for cA(max)and cP(max),*** cA and cP exhibited constant variation in CL during systole,with a maximum 1.16-fold increase in cA and a 1.23-fold increase in cP from early to *** cP,CL reached a plateau at 15%and remaine

关键词： Mitral valve Chordae tendineae Computed tomography Four-dimensional Cardiac cycle

采用高压CO_2气体灭活啤酒酵母的试验研究

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食品科学 2005年第10期26卷 43-45页

作者：柏冰周建军俞逾卢啸风邵春波杨卓 Ryo s.amano 重庆大学动力工程学院重庆啤酒股份有限公司 Department of Mechanical Engineering The University of Wisconsin-MilwaukeeMilwaukeeWI53201-0784USA

本文对啤酒酵母溶液采用高压CO2气体杀菌过程进行了试验研究。试验表明,向啤酒酵母溶液中通入高压CO2气体,对啤酒酵母有明显的杀灭作用。CO2气体压力、通气时间、酵母溶液浓度、微孔气体分配管孔径等参数对杀菌效果有明显影响。在1MPa的... 详细信息

本文对啤酒酵母溶液采用高压CO2气体杀菌过程进行了试验研究。试验表明,向啤酒酵母溶液中通入高压CO2气体,对啤酒酵母有明显的杀灭作用。CO2气体压力、通气时间、酵母溶液浓度、微孔气体分配管孔径等参数对杀菌效果有明显影响。在1MPa的CO2压力下,通气4min,即可达到37.2%的杀菌率。

关键词：杀菌高压 CO2 啤酒酵母

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日本秋季过敏性结膜炎患者过敏原的研究

世界核心医学期刊文摘(眼科学分册) 2006年第4期 40-41页

作者： Mimura T. Yamagami s. amano s. 王大江 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan

Purpose: The purpose of the current study is to evaluate the relation between various specific class E immunoglobulins (IgE) in the serum and allergic conjunctivitis in autumn. Methods: Total IgE and specific IgE to 12 inhalant allergens were measured using the CAP system in 32 patients with allergic conjunctivitis in spring (spring group), 27 patients with allergic conjunctivitis in autumn (autumn group), and 40 healthy volunteers (control group). Results: specific IgE levels caused by house dust, Derm atophagoides pteronyssinus, and orchard grass were higher in the autumn group than in the spring group. The highest positivity rate for a specific allergen was 51.9%for house dust, followed by D. pteronyssinus (48.1%) in the autumn group, while the highest rate was 68.8%for cedar pollen, followed by cypress pollen (59.4%) in the spring group. Correlation analysis showed that house dust was significantly correlated with animal epithelia, D. pteronys- sinus, acarus, and Alternaria tenuisin the autumn group (Psions: These results suggest that house dust is the main cause of allergic conjunctivitis during autumn. In spring, cypress pollen is the largest cause of allergic conjunctivitis, while indoor allergens such as house dust, animal epithelia, D. pteronyssinus, and acarus are not causative allergens in Japan.

关键词：结膜炎结膜疾病过敏性过敏原患者日本

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先天性痛觉迟钝和无汗症患者的眼部表现

世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 6-7页

作者： amano s. Fukuoka s. Usui T. 杨秀梅(译) 不详 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan

PURPOsE: To describe ocular manifestations in Japanese patients with congenital insensitivity to pain with anhidrosis (CIPA),focusing particularly on the status of the ocular surface. DEsIGN: Observational case series. METHODs: Eighteen patients with CIPA underwent applicable ophthalmologic examinations,including visual acuity,refraction,slit-lamp examination,fundus examination,tear breakup time,schirmer 1 test,corneal sensitivity,and corneal topography. REsULTs: superficial punctate keratopathy (sPK) was observed at the interpalpebral area in 23 (64% ) of 36 eyes. Corneal opacity was observed in three eyes (8.3% ). Tear breakup time was below the lower limit of the normal range in all examined eyes,and the value of schirmer 1 test was above the lower limit of the normal range in most of the examined eyes. CONCLUsIONs: superficial punctate keratopathy is observed in most cases of CIPA,which might predispose patients to corneal infection. Investigation of dry eye in patients with CIPA will provide unique opportunities to explore the critical roles of the autonomic sympathetic nervous system as well as the sensory nervous system in the physiology of tear production.

关键词：眼部表现痛觉迟钝无汗症先天性患者 schirmer 泪膜破裂时间自主神经系统眼科检查 CIPA

醛糖还原酶抑制剂CT-112治疗糖尿病患者角膜上皮病变:随机化安慰剂对照临床试验

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 37-38页

作者： Nakahara M. Miyata K. Otani s. s. amano 邢咏新 7-31 Hongo Bunkyo-ku Tokyo 113-8655 Japan

Aim: To evaluate the efficacy of topical aldose reductase inhibitor CT-112 (5 -[3-ethoxy-4-pentyloxyphenyl]2,4-thiazolidinedione) on corneal epitheli al barrier function in diabetic patients. Methods: This was a prospective, randomi sed, double masked placebo controlled study. 34 eyes of 34 diabetic patients wer e randomly assigned treatment with 0.25%eye drops of CT-112 (n=22) or a placeb o (n=12) four times a day for 8 weeks. Corneal fluorescein staining and corneal sensation were examined before treatment as well as 4 and 8 weeks after administ ration. Corneal epithelial permeability to fluorescence was measured with an ant erior fluorophotometer. Results: Average scores of superficial punctate keratopa thy and corneal sensitivity did not differ significantly between the two groups at any time. Whereas average fluorescein concentrations did not differ significa ntly for the CT-112 and placebo groups before treatment, they did differ signif icantly 4 and 8 weeks after treatment (4 weeks, p=0.0327; 8 weeks, p=0.0143). Co nclusion: The topical aldose reductase inhibitor, CT-112 improves the corneal e pithelial barrier function in diabetic patients.

关键词： CT-112 随机化角膜上皮通透性角膜荧光素染色安慰剂对照屏障功能荧光素荧光光度计平均分值

皮肤Fibulin-5沉积量随年龄及紫外线B暴露增加而减少,在日光性弹力组织变性中增加

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 49-50页

作者： Kadoya K. sasaki T. Kostka G. s. amano 王琼 skin Biology Research Laboratories Shiseido Life Science Research Centre 2- 12- 1 Fukuura Kanazawa- ku Yokohama- shi 236- 8643 Japan

Background: Fibulin- 5 was recently found as a secreted extracellular matrix protein that functions as a scaffold for elastic fibres. However, the distribution of fibulin- 5 in human skin and its changes during the ageing process are not known. Objectives: To explore the involvement of fibulin- 5 in skin ageing, the age- dependent changes in fibulin- 5 localization in human skin were examined compared with those of other elastic fibre components including elastin, fibrillin- 1 and fibulin- 2. Methods: The distribution of elastin, fibrillin- 1, fibrillin- 2, fibulin- 2 and fibulin- 5 was investigated by means of immunohistochemistry using their specific antibodies. skin samples were recovered from 12 healthy subjects undergoing plastic surgery. Ultraviolet (UV) B- irradiated or control nonirradiated buttock skin samples were obtained from two healthy volunteers at 2 days after the irradiation at 2 minimal erythemal doses. Results: In the reticular dermis of young sun- protected skin from the upper arm, fibulin- 5 colocalized with the other elastic fibre components, while in the papillary dermis fibulin- 5 showed candelabra- like structures perpendicular to the epidermiswith an unstained area just beneath the epidermis, which was similar to that of elastin but not fibrillin- 1. Fibulin- 5 in the reticular dermis decreased and disappeared with age even in sun- protected skin from the thigh, abdomen and upper arm. In sun- exposed skin, fibulin- 5 was extremely reduced in the dermis of cheek skin even from a 20- year- old man. UVB irradiation reduced fibulin- 5, fibulin- 2 and elastin markedly, moderately and weakly, respectively, compared with levels in control nontreated skin. Interestingly, the deposition of fibulin- 5 was increased in solar elastosis, like that of other elastic fibre components. Conclusions: These results suggest that fibulin- 5 is a good marker of skin ageing and that the earlier loss of fibulin- 5 may involve age- dependent changes in other elastic

关键词： Fibulin-5 组织变性光性力蛋白原纤维蛋白沉积量最小红斑量真皮网状层真皮乳头层整形外科

Effect of Eu3+,Bi3+,and Li+ doping on luminescent property of GdNbO4

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Journal of Rare Earths 2024年第1期42卷 66-75页

作者： s.W.Wi Y.s.Lee Department of Physics and Integrative Institute of Basic sciences Soongsil University

We investigated the emission properties of Eu3+-doped GdNbO4-based oxide phosphors,aiming at improving the Eu3+emission by codoping of Bi3+and Li+.Eu3+singly doped,Eu3+and Bi3+doubly doped,and Eu3+,Bi3+,and Li+triply doped GdNbO4were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu3+in the singly doped samples are significantly improved by the codoping of Bi3+,mainly due to the energy transfer from Bi3+to Eu3+.The additional codoping of Li+is found to increase the Eu3+emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu3+in GdNbO4does not change significantly with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO4phosphors.

关键词： Eu 3+ GdNbO 4 Codoping of Li + Photoluminescence sensitizer Rare earths

First evidence for chiral wobbling of triaxial nuclei

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Nuclear science and Techniques 2024年第7期35卷 4-7页

作者： s.Frauendorf Department of Physics and Astronomy University of Notre DameNotre DameIN 46556USA

Chirality(Greek“handiness”)is a property of many com-plex *** molecules exist in two forms,one being the mirror image of the *** for our hands,it is impossible to make the images identical by a suitable *** two forms are called left-handed and *** have the same binding energy,because the electro-magnetic interaction,which holds the molecule together,does not change under a *** properties that are insensitive to the geometry are also the *** different geometry is the reason why the left-handed form turns the polarization plane of transmitted light in one direction by some angle while the right-handed form turns it in the oppo-site direction by the same ***,the geometrical differences between the two species may have other *** two species of the carvon molecule shown in Fig.1 taste quite differently.

关键词： turns Chiral mirror