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Impact of sarcopenia on mortality in patients undergoing liver retransplantation

World Journal of Hepatology 2020年第10期12卷 807-815页

作者： amaninder dhal.wal.diana l.rson Molly Hiat lyudmila M Muinov William l Harrison Harlan Sayles Tomoki Sempokuya Marco A Olivera Fedja A Rochling Timothy M McCashland Department of Gastroenterology and Hepatology University of South Florida and Moffitt Cancer CenterTampaFL 33612United States Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Internal Medicine University of Nebraska Medical CenterOmahaNE 68198United States Department of Radiology University of Nebraska Medical CenterOmahaNE 68198United States Division of Abdominal Imaging Department of RadiologyUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Biostatistics College of Public HealthUniversity of Nebraska Medical CenterOmahaNE 68198United States

BACKGROUND Sarcopenia,which is a loss of skeletal muscle mass,has been reported to increase post-transplant mortality and morbidity in patients undergoing the first liver ***-sectional imaging modalities typically determine sarcopenia in patients with cirrhosis by measuring core abdominal ***,there is limited evidence for sarcopenia related outcomes in patients undergoing liver re-transplantation(re-OlT).AIM To evaluate the risk of mortality in patients with pre-existing sarcopenia following liver *** This is a retrospective study of all adult patients who had undergone a liver re-OlT at the University of Nebraska Medical Center from January 1,2007 to January 1,*** divided patients into sarcopenia and no sarcopenia groups.“TeraRecon AquariusNet 4.***.12.194”software was used to evaluate computed tomography or magnetic resonance imaging of the patients done within one year prior to their re-OlT,to calculate the Psoas muscle area at l3-l4 intervertebral *** defined cutoffs for sarcopenia asles andl *** also compared complications after re-OlT,length of stay,and readmission within 30 *** analysis was performed with Kaplan-Meier survival *** variables were evaluated with Wilcoxon rank-sum *** variables were evaluated with Fisher’s exact *** Fifty-seven patients were included,32 males:25 females,median age 50 *** patients were excluded due to incomplete ***,47%(26)of patients who underwent re-OlT had *** were found to have significantly more sarcopenia than males(73%vs 17%,Pl for end stage liver disease at re-OlT was 28 in both sarcopenia and no sarcopenia *** in the no sarcopenia group had a trend of longer median time between the first and second transplant(36.5 mo vs 16.7 mo).Biological markers,outcome par

关键词： Sarcopenia liver transplantation Mortality Re-transplantation Psoas muscle index

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