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Psychological Experience of Mothers of Children with sickle Cell Disease Followed at the Pediatric Department of Bouaké University Teaching Hospital

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Open Journal of Pediatrics 2024年第1期14卷 149-163页

作者： Akanji Iburaima Alamun Aka-Tanoh Koko Aude Hélène Yao Kouassi Christian Adou Leioh Romeo sahi Gnantin Josette Landryse amani Ehi Alexise Eleonore Boune Aboulaye Asse Kouadio Vincent Paediatrics Department Bouaké University Teaching Hospital Bouaké C&#244te d’Ivoire

Introduction: sickle cell disease has physical and emotional repercussions on the child and his family. The aim of this study was to describe the psychosocial experiences of mothers of children with sickle cell disease in order to improve the overall care of the child. Methods: This was a descriptive cross-sectional study carried out in the pediatrics department of Bouaké University Teaching Hospital from June to september 2023. It focused on mothers of major sickle-cell-affected children followed up in the pediatrics department of the Bouaké University Teaching Hospital. The variables studied were sociodemographic, psychological, social and economic. Results: Of the 40 mothers surveyed, 15% were not in school and 32.5% were unemployed. For them, sickle cell disease was of natural (genetic) origin in 90% and supernatural in 10%. They stated that the child had an average age of 36 months (extremes 7 and 108 months) when the disease was discovered. And 52% of them were satisfied with the way the disease was clearly and completely announced. Following the announcement, the questioned mothers said they had felt shock (35%), sadness (31.7%), guilt (23.3%) and discouragement (10%). Anxiety and depression were experienced by 77.5% and 22.5% respectively. In 60% of cases, they stated that the disease was incurable, and the outcome was fatal in 2.5% of cases. The child’s illness was a source of problems in the home in 25% of cases, represented by arguments in 92% and divorce in 8%. In 97.5% of cases, the mother told her family and friends about the child’s illness. In 90% of cases, the mother and child benefited from psychological support from family and friends. Conclusion: sickle cell disease is a serious illness with a psychological and social impact on mothers. We recommend psychological support for mothers from the moment of diagnosis and throughout follow-up.

关键词： Psychosocial Experience sickle Cell Disease Côte d’Ivoire

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Knowledge, Attitudes and Practices of Mothers Regarding Exclusive Breastfeeding in Rural Areas of Brobo (Côte d’Ivoire)

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Open Journal of Pediatrics 2021年第4期11卷 694-705页

作者： Aka-Tanoh Koko Aude-Hélène Avi-siallou Christelle Honorine Yeboua Kossonou Roland Yao Kouassi Christian Akandji Iburaima Adou Leioh Roméo sahi Gnantin Landryse amani Ehi Alexise Asse Kouadio Vincent Department of the University Hospital of Bouaké Bouaké C&ocirc te d'Ivoire

Introduction:In C?te d’Ivoire, despite awareness raising among mothers by health authorities and health care providers, the exclusive breastfeeding rate is still low, 23%. This rate seems even lower in rural areas. The objective of the study was to evaluate the knowledge, attitudes and practices of mothers regarding exclusive breastfeeding for the reduction of malnutrition in rural areasspan>. Methods: This was a descriptive and analytical cross-sectional study conducted in Brobo from July to September 2020. It included consenting mothers of infants aged 0 to 24 months. Mothers’ knowledge, attitudes and practice were assessed by an anonymous structured questionnaire with a performance threshold set at 75%. Factors associated with exclusive breastfeeding were investigated by the Chi-square test at the 5% level of significance. span>Results: span style="font-family:Verdana;">The average age of the 183 mothers was 25 years (extremes 13 and 49 years). They were primigravida (33%) and had a low socioeconomic level (84%). The mothers knew the definition of exclusive breastfeeding (33%). They knew that breastfeeding promoted ideal infant growth (64%) and protected against diarrhea and infection (18%). They also knew that breastfeeding reduced the mother’s risk of cancer (16%) and strengthened the mother-infant bond (7%). The mothers interviewed stated that they had put the baby to the breast within the first hour after delivery in 2% and 63% of them gave the baby colostrum. Mothers were confident about breastfeeding (91%) and exclusive breastfeeding until 6 months of age represented 9%. The factor associated with lack of knowledge of exclusive b

关键词： Exclusive Breastfeeding Rural Environment Infant Brobo

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Knowledge, Attitudes and Practices of the Health Personnel of the Pediatric and Gynecology-Obstetrics Departments of the BouakéUniversity Hospital Center (CHU) regarding the Intestinal Microbiota and the First 1000 Days of Life

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Open Journal of Pediatrics 2021年第1期11卷 19-34页

作者： Azagoh-Kouadio Richard Yao Kouassi Christian Aka-Tanoh Aude Hélène siallou-Avi Christelle Yeboua Kossonou Roland Gnantin Josette Landryse sahi Adou Léioh Roméo Akanji Iburaima amani Alexise Asse Kouadio Vincent Pediatrics Department of the University Hospital Center of Angré Abidjan C&ocirc te d’Ivoire Pediatrics Department of the University Hospital Center of Bouaké Bouaké C&ocirc te d’Ivoire

Introduction: The harmonious development of the intestinal microbiota during the first 1000 days of life promotes the child’s immediate and future good health. The objective of the study was to evaluate the knowledge... 详细信息

strong>Introduction:strong> The harmonious development of the intestinal microbiotaspan>span> during the first 1000 days of life promotes the childspan>span>’span>span>s immediate and future good health. The objective of the study was to evaluate the knowledge and practices of health personnel on the intestinal microbiota and the first 1000 days of life for the improvement of child health.span>span>span> span>span>Methods:span>span> Knowledge, attitudes andspan>span> practices (KAP) type survey conducted among health personnel of the pediatric and gynecology-obstetrics departments of the Bouaké University Hospital from July 1 to 31, 2017. All consenting agents working in the said services andspan style="font-family:Verdana;"> present at the time of the study were included. The parameters studied concerned socio-professional characteristics, knowledge of the intestinal microbiota, and knowledge and practice of the first 1000 days. The data analysis was descriptive and analytical with a signi

关键词： Intestinal Microbiota First 1000 Days staff Knowledge Côte d’Ivoire

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Postpartum Hemorrhage: Incidence, Causes and Maternal Outcomes at Muhimbili National Hospital, Tanzania—A Retrospective Descriptive Hospital-Based study

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Open Journal of Obstetrics and Gynecology 2023年第7期13卷 1244-1258页

作者： Rafiki Nickson Mjema amani Idris Kikula Furaha August Fadhlun Alwy Al-Beity Ali said Phineas F. sospeter Nasra Batchu Benjamin shayo Damian Jeremiah Ponsian P. Kunambi John somi Patricia swai Department of Obstetrics and Gynecology Muhimbili University of Health and Allied Sciences MUHAS Dar es Salaam Tanzania Department of Reproductive Maternal and Child Health Ministry of Health Dodoma Tanzania Department of Obstetrics and Gynecology Kilimanjaro Christian Medical Centre Moshi Kilimanjaro Tanzania Department of Obstetrics and Gynecology Baylor’s College Lilongwe Malawi Kilimanjaro Christian Medical University College Moshi Kilimanjaro Tanzania

Worldwide obstetric hemorrhage remains the leading cause of maternal mortality, accounting for over one quarter of maternal deaths. Over half of these deaths occur in sub-saharan Africa with mortality rates of 500 - 1000 per 100,000 births, compared to approximately 5 - 10 in developed countries. Over decades in sub saharan Africa preventive measures and treatment protocols have been made to reduce maternal mortality caused by PPH. While rates of postpartum hemorrhage have continued to rise, there is a need to evaluate if its etiology and patterns have changed over time. Broad Objective: This study aims at describing trends in incidence, causes and maternal outcomes of Postpartum Hemorrhage at Muhimbili National Hospital for a period of 7 years. Methodology: This is a retrospective descriptive hospital-based study that has included all cases of postpartum hemorrhage at Muhimbili National Hospital, a tertiary hospital in Tanzania from 2014 to 2020. The data was analyzed using sPss Version 26 and presented using frequency tables, figures and percentages. The trends of postpartum hemorrhage over time were determined using chi-square test and P-value where less than 0.05 was considered statistically significant. Results: Overall, the incidence of postpartum hemorrhage has been fluctuating over the years with minimum of 1.78% and maximum of 2.87% with no statistical significance. Out of 1113 enrolled cases of PPH, 422 (37.9%) were attributed to genital tears followed by uterine atony 285 (25.6%). A statistically significant increase in linear trend was observed in the postpartum hemorrhage cases due to uterine atony, uterine rupture and sub analysis on genital tears (cervical tear). Overall, there was a statistically significant change in trend of maternal outcomes throughout the years, with a P-value s increasing over time. Conclusion: The trend in the incidence of postpartum hemorrhage has been fluctuating over the years during the

关键词： Postpartum Hemorrhage Incidence Causes Maternal Outcomes and Tanzania

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Astragalus kahiricus根提取物对乙醇诱导的大鼠肝细胞凋亡的肝保护作用(英文)

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中国天然药物 2013年第4期11卷 354-361页

作者： Rasha M.Allam Dina A.selim Asser I.Ghoneim Mohamed M.Radwan salwa M.Nofal amani E.Khalifa Ola A.sharaf soad M.Toaima Aya M.Asaad Nadia A.El-sebakhy Pharmacology Department Medical DivisionNational Research CenterGizaEgypt Department of Pharmacognosy Faculty of PharmacyThe University of AlexandriaAlexandria 21521Egypt Department of Pharmacology and Toxicology Faculty of PharmacyDamanhour UniversityDamanhourEgypt Department of Pharmacology & Therapeutics Faculty of PharmacyBeirut Arab UniversityBeirutLebanon National Center for Natural Products Research School of PharmacyThe University of MississippiUniversity 38677 MSUSA Department of Pharmacology and Toxicology Faculty of PharmacyAin Shams UniversityCairoEgypt

The hepatoprotective activity of the ethanol extract of Astragalus kahiricus(Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very promising hepatoprotective actions through different *** extract counteracted the ethanol-induced liver enzymes leakage and glutathione *** addition,it demonstrated anti-apoptotic effects against caspase-3 activation and DNA fragmentation that were confirmed by liver histopathological ***,the phytochemical study of this extract led to the isolation of four cycloartane-type triterpenes identified as astrasieversianin II(1),astramembrannin II(2),astrasieversianin XIV(3),and cycloastragenol(4).The structures of these isolates were established by HREsI-Ms and 1D and 2D NMR *** antimicrobial,antimalarial,and cytotoxic activities of the isolates were further evaluated,but none of them showed any activity.

关键词：实验药理学药理病理作用天然药物

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Type VI Aplasia Cutis Congenita: About a Case Report at University Teaching Hospital of Bouaké

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Open Journal of Pediatrics 2023年第1期13卷 146-152页

作者： Yao Kouassi Christian Yeboua Yao Kossonou Roland Yenan John Patrick Akanji Iburaima Alamun Adou Leioh Romeo sahi Gnantin Josette Landryse amani Ehi Alexise Eleonore Avi-siallou Christelle Honorine Aka-Tanoh Koko Aude Hélène Asse Kouadio Vincent Department of Pediatrics Universiy Teaching Hospital of Bouaké Bouaké Ivory Coast

Introduction: Aplasia cutis congenita is a rare congenital dermatosis of which type VI represents the Bart’s syndrome. The aim of this case is to describe the epidemiological, clinical, therapeutic and prognostic characteristics of this condition in a country with limited resources, for the improvement of prognosis and professional practice. Observation: This is a eutrophic newborn, born at term by vaginal delivery, who presented at birth with a unilateral absence of skin on the anteromedial aspect of the right leg starting from the knee and extending to the medial aspect of the right foot, with a dystrophy of the nail of the right big toe without any other visible physical malformation. The evolution was marked at D3 of life by the appearance of bullae on the right hand and elbow as well as on the posterior aspect of the neck, making epidermolysis bullosa suspect. The mother was 38 years old, 8sup>thsup> gesture, 7sup>thsup> pare with history of consanguinity and collodion baby. The association of a localized congenital absence of skin on the lower limbs, epidermolysis bullosa and a nail anomaly led to the diagnosis of congenital cutaneous aplasia of type VI of Frieden’s classification or Bart’s syndrome. The evolution was satisfactory on the 7sup>thsup> day of life with the beginning of scarring. The management was medical. The outcome was unfavorable with the appearance of sepsis and hemorrhage leading to death. Conclusion: Although rare, the clinical diagnosis of Bart’s syndrome is simple. However, the management is complex and the prognosis is reserved. To improve this prognosis, the treatment must guarantee excellent control of the infectious and hemorrhagic risks, an adhesion and good therapeutic compliance by the parents and a rigorous monitoring.

关键词： Aplasia Cutis Congenita Bart’s syndrome Newborn Prognosis Côte d’Ivoire

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豹皮菌中2-Amino-3-(1,2-dicarboxyethylthio)propanoic acid非对映异构体的绝对构型

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药学学报 1998年第1期33卷 64-66页

作者：顾谦群伏谷真二野副重男青岛海洋大学海洋药物与食品研究所东北大学药学部

豹皮菌中２Ａｍｉｎｏ３（１，２ｄｉｃａｒｂｏｘｙｅｔｈｙｌｔｈｉｏ）ｐｒｏｐａｎｏｉｃａｃｉｄ非对映异构体的绝对构型顾谦群伏谷真二野副重男（青岛海洋大学海洋药物与食品研究所，青岛２６６００３；东北大学药... 详细信息

豹皮菌中２Ａｍｉｎｏ３（１，２ｄｉｃａｒｂｏｘｙｅｔｈｙｌｔｈｉｏ）ｐｒｏｐａｎｏｉｃａｃｉｄ非对映异构体的绝对构型顾谦群伏谷真二野副重男（青岛海洋大学海洋药物与食品研究所，青岛２６６００３；东北大学药学部，日本仙台）豹皮菌（Ａｍａｎｉ...

关键词：豹皮菌非对映异构体构型担子菌神经毒物质

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