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Analytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines

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American Journal of Analytical Chemistry 2015年第13期6卷 977-994页

作者： Vé daste Habyalimana Jé ré mie Kindenge Mbinze Nicodè me Kalenda Tshilombo amandine dispas Achille Yemoa Loconon Pierre-Yves Sacré Joë lle Widart Pascal De Tullio Sté phane Counerotte Justin-Lé onard Kadima Ntokamunda Eric Ziemons Philippe Hubert Roland Marini Djang&rsquo eing&rsquo a Department of Pharmacy CIRM Laboratory of Analytical Chemistry Quartier H&ocirc pital University of Liege (ULg) Liège Belgium Rwanda Biomedical Center/Medical Procurement and Production Division Butare Rwanda Faculté des Sciences Pharmaceutiques Université de Kinshasa Kinshasa XI République Démocratique du Congo Ecole de Pharmacie Faculté des Sciences de la Santé Université d’Abomey Calavi Cotonou Bénin Department of Pharmacy CIRM Quartier H&ocirc pital University of Liege (ULg) Liège Belgium Department of Pharmacy CIRM Laboratory of Medicinal Chemistry Quartier H&ocirc pital University of Liege (ULg) Liège Belgium School of Medicine and Pharmacy University of Rwanda Butare Rwanda

Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in developing countries where drug quality assurance and regulatory systems for drug manufacturing, importation, distribution and sales are weak. A sustained vigilance on poor quality medicines that regroup counterfeit/falsified, substandard and degraded medicines is therefore required to ensure patient safety and genuine medicines integrity. A case situation is illustrated including a strategic approach and analytical tools that were found useful to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures against the spread of those harmful products. Several suspected medicines randomly sampled in several strategic Rwandan areas were firstly check-controlled by means of visual inspection and then applying several analytical techniques from simple to more complex ones. The following medicines were studied: quinine sulfate tablets, artemisinin-based combination tablets, and artesunate powders for injection. Taking into account the pharmaceutical forms and the chemical characteristics, the following tests were applied: uniformity of mass, friability, disintegration, fluorescence, identification and assay. They were followed by more complex analytical techniques that allowed more comprehension of abnormal findings among which the presence of a wrong active pharmaceutical ingredient in quinine sulfate tablets which is mainly discussed in this paper to illustrate a strategic approach and various analytical tools that can be used in detecting and identifying unknown component in poor quality medicines.

关键词： Poor Quality Medicines Antimalarial Medicines Visual Inspection Simple and Complex Analytical Tools

Identifying terrorist attack victims

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Forensic Sciences Research 2020年第3期5卷 236-241页

作者： Elvire Arrighi amandine Matricon Charlot National French Police Direction Centrale de la Police JudiciaireParisFrance French DVI Police Unit 31 avenue Franklin Rossevelt69130 EcullyLyonFrance

The terrorist attacks that occurred in France in 2015 and 2016,which had many victims,proved that it is essential to identify victims following the methodology developed by International Criminal Police Organization(INTERPOL)for such *** designed for natural disasters,this approach must be strictly respected should a terrorist attack *** includes the specific collection of bodies and body parts,as well as the setup of an antemortem unit,postmortem unit,and Identification *** commission is made up of specialists and will make decisions on the basis of primary identifying elements(fingerprints,DNA,dental records)and/or secondary identifying elements(other distinctive and particularly discriminating signs).A multidisciplinary team,combining specifically trained police officers and scientists,must provide a reliable and consolidated list of deceased people based on biometric elements cross checked with elements from the *** list of names generated on another basis should be *** of the deceased by relatives(visual recognition),even if the bodies do not appear mutilated and/or decayed,should be avoided to avert erroneous death announcements,body presentations,or even burials or ***,identifying victims only on the basis of their personal effects(such as an identity card)must be absolutely *** bodies,even those whose identities seem obvious to the first responders or to the relatives,must be registered as“X”during the crime scene search and properly identified according to the INTERPOL *** same protocol should be applied to unconscious injured *** the expectations of our modern society for rapid information circulation and quick responses from the authorities,the French team has made a few adjustments to speed up the identification process without compromising its *** and supported by both the French judicial and administrative authorities in t

关键词： Forensic sciences victims identification terrorist attacks mass killing INTERPOL Identification Commission antemortem unit postmortem unit

The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy

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Cancer Communications 2022年第12期42卷 1288-1313页

作者： amandine Crombé Mathtieu Roulleau-Dugage Antoine Italiano Department of Imaging Institut BergonieBordeauxNouvelle-Aquitaine F-33076France Faculty of Medicine University of BordeauxBordeauxNouvelle-Aquitaine F-33000France Department of Medicine Gustave RoussyVillejuifIle de France F-94800France Early Phase Trials and Sarcoma Unit Institut BergonieBordeauxNouvelle-Aquitaine F-33076France

Soft-tissue sarcomas(STS)represent a group of rare and heterogeneous tumors associated with several challenges,including incorrect or late diagnosis,the lack of clinical expertise,and limited therapeutic *** pathology and radiomics represent transformative technologies that appear promising for improving the accuracy of cancer diagnosis,characterization and ***,we review the potential role of the application of digital pathology and radiomics in managing patients with *** have particularly described the main results and the limits of the studies using radiomics to refine diagnosis or predict the outcome of patients with soft-tissue *** also discussed the current limitation of implementing radiomics in routine *** management approaches for STS have not improved since the early *** has revolutionized cancer treatment;nonetheless,immuno-oncology agents have not yet been approved for patients with ***,several lines of evidence indicate that immunotherapy may represent an efficient therapeutic strategy for this group of ***,we emphasized the remarkable potential of immunotherapy in sarcoma treatment by focusing on recent data regarding the immune landscape of these *** have particularly emphasized the fact that the development of immunotherapy for sarcomas is not an aspect of histology(except for alveolar soft-part sarcoma)but rather that of the tumor *** studies investigating immunotherapy strategies in sarcomas should incorporate at least the presence of tertiary lymphoid structures as a stratification factor in their design,besides including a strong translational program that will allow for a better understanding of the determinants involved in sensitivity and treatment resistance to immune-oncology agents.

关键词： artificial intelligence digital pathology immunotherapy radiomics sarcoma

Self-medication of achalasia with cannabis, complicated by a cannabis use disorder

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World Journal of Gastroenterology 2015年第20期21卷 6381-6383页

作者： amandine Luquiens Nelson Lourenco Amine Benyamina Henri-Jean Aubin Hopital Paul Brousse-Addictologie 94804 Villejuif cedex France Service d'hepatogastroenterologie Hopital Saint Louisuniversite Denis Diderot Paris Ⅶ 75010 ParisFrance

Achalasia is a rare esophagus motility disorder. Medical, endoscopic and surgical treatments are available, but all endorse high relapse rates. No data has been published to date reporting a therapeutic effect of cannabis use neither in achalasia nor on its influence on manometric measurements. We report the case of a patient diagnosed with achalasia. He could benefit from a large panel of therapeutic interventions, but none of them was effective over the time. He first used cannabis at age 20 and identified benefits regarding achalasia symptoms. He maintained regular moderate cannabis use for 9 years, with minimal digestive inconvenience. A manometry performed without cannabis premedication was realized at age 26 and still found a cardiospasm. Cannabis use could explain the gap between functional symptoms assessment and manometry measurement. Further investigations are warranted to explore a therapeutic effect of cannabis in achalasia and possible influence on outcome measurements.

关键词： Achalasia Cannabis Treatment Manometry Addiction

Effect of crosslinking by microbial transglutaminase of gelatin films on lysozyme kinetics of release in food simulants

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Food Bioscience 2022年第4期48卷 541-550页

作者： Moslem Sabaghi Catherine Joly Isabelle Adt Keziban Ozturk amandine Cottaz Pascal Degraeve Department of Food Science and Technology Gorgan University of Agricultural and Natural ResourcesGorganIran Univ Lyon Universit´e Claude Bernard Lyon 1ISARA LyonBioDyMIA Research UnitTechnopole Alimentec155 rue Henri de BoissieuF-01000Bourg en BresseFrance

The effect of enzymatic crosslinking by microbial transglutaminase on the physico-chemical properties of gelatin-based films incorporated with lysozyme were *** in the crosslinking degree of gelatin with microbial transglutaminase concentration in film-forming suspensions was correlated with a decrease of films ***,the enhancement in crosslinking resulted in a decrease of the solubility in water,as well as of the extent of swelling degree,and of the water vapor permeability of films and in an increase of films tensile *** kinetics of release at 4◦C of lysozyme from control non-reticulated films and reticulated films to either sodium acetate buffer,or 2%(w/v)agar gels in direct contact were ***,the kinetics of release of lysozyme were always slower from crosslinked films than from control *** difference was higher for lysozyme release to agar gels,which was dominated by Fickian *** crosslinking by microbial transglutaminase of gelatin-based films incorporated with lysozyme can thus effectively control the release of this food preservative.

关键词： Gelatin-based films Enzymatic crosslinking Microbial transglutaminase Lysozyme Controlled release

Essential tremor:A three-dimensional neurosphere in vitro model to assess the neurotoxicity of harmane

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 19-34页

作者： Rania Aro amandine Nachtergael Laurence Ris Mario Manto Pierre Duez Unit of Therapeutic Chemistry and Pharmacognosy University of Mons(UMONS)Mons 7000Belgium Department of Neuroscience Research Institute for BiosciencesUniversity of MonsMons 7000Belgium Department of Neurology CHU-CharleroiCharleroi 6000Belgium

Objectives: To use a novel in vitro model of three-dimensional(3D) neurosphere cultures to assess neurotoxic or neuroprotective effects with harmane as a model ***: A reproducible model of 3D spheroids was developed from embryonic mouse cortical neurons,using molded agarose micro-wells;this method seems particularly practical as it is customizable and widely available and does not require specific cell treatments or assay components different from 2D cultures, allowing for the easy transposition of routine protocols. To assess the neurotoxic effects of harmane, a resazurin assay was performed to measure cell viability, and a highly sensitive fluorometric method, based on the oxidation of dichlorodihydrofluorescein, was applied to measure eventually induced reactive oxygen species(ROS) after exposure to harmane at increasing concentrations of 50 100,and 250 μ***: Hydrogel microwells facilitated the assembly of spheroids containing neurons and glial cells into a complex 3D structure and prevented the agglomeration of spheroids. Exposure to harmane induced cytotoxicity in 3D neural spheroids, which was correlated with harmane concentrations, with a 27%reduction in viability at 250 μm. Harmane that did not induce significant levels of oxidative stress was detected for all tested ***: This 3D neurosphere model mimics a neuronal microenvironment, allowing a fine study of neurodegenerative disorders and the effects of chemicals on the brain. This model opens novel opportunities, not only from a pathogenetic point of view but also from a therapeutic perspective.

关键词： 3D spheroid Toxicity Neurotoxicity Harmane Essential tremor

What lessons can be learned from y T cell-based cancer immunotherapy trials？

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Cellular & Molecular Immunology 2013年第1期10卷 35-41页

作者： Jean-Jacques Fournie Helene Sicard Mary Poupot Christine Bezombes amandine Blanc Franqois-Romagne Loic Ysebaert Guy Laurent INSERM UMR1037-Cancer ResearchCenter of Toulouse Toulouse France University of Toulouse Toulouse France ERL 5294 CNRS BP3028 Hospital Purpan ToulouseFrAnce lnnate Pharma Marseilles France and Department of Hematology Hospital Purpan Toulouse France

During the last several years, research has produced a significant amount of knowledge concerning the characteristics of human 76 T lymphocytes. Findings regarding the immune functions of these cells, particularly their natural killer cell-like lyric activity against tumor cells, have raised expectations for the therapeutic applications of these cells for cancer. Pharmaceutical companies have produced selective agonists for these lymphocytes, and several teams have launched clinical trials of y8 T cell-based cancer therapies. The findings from these studies include hematological malignancies （follicular lymphoma, multiple myeloma, acute and chronic myeloid leukemia）, as well as solid tumors （renal cell, breast and prostate carcinomas）, consisting of samples from more than 250 patients from Europe, Japan and the United States. The results of these pioneering studies are now available, and this short review summarizes the lessons learned and the role of y6 T cell-based strategies in the current landscape of cancer immunotherapies.

关键词： cancer cell therapy gamma-delta lymphocytes immunotherapy lymphoma trials

Does the gap between health workers’expectations and the realities of implementing a performance-based financing project in Mali create frustration?

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Global Health Research and Policy 2021年第1期6卷 468-477页

作者： Tony Zitti amandine Fillol Julia Lohmann Abdourahmane Coulibaly Valéry Ridde Centre Population et Développement(Ceped) Institut de recherche pour le développement(IRD)et Universitéde ParisInserm ERL 124445 rue des Saints-Pères75006 ParisFrance École doctorale Pierre Louis de santépublique Universitéde ParisParisFrance ONG Miseli BamakoMali Ecole de santépublique de l’Universitéde Montréal MontréalCanada London School of Hygiene&Tropical Medicine LondonUK Heidelberg Institute of Global Health Medical Faculty and University HospitalHeidelberg UniversityHeidelbergGermany Facultéde Médicine et d’Odontostomatologie Universitédes Sciencesdes Techniques et des TechnologiesBamakoMali

Background:Performance-Based Financing(PBF),an innovative health financing initiative,was recently implemented in *** aims to improve quality of care by motivating health *** purpose of this research was to identify and understand how health workers’expectations related to their experiences of the first cycle of payment of PBF subsidies,and how this experience affected their motivation and sentiments towards the *** pose the research question,“how does the process of PBF subsidies impact the motivation of health workers in Mali?”Methods:We adopted a qualitative approach using multiple case *** chose three district hospitals(DH 1,2 and 3)in three health districts(district 1,2 and 3)among the ten in the Koulikoro *** cases correspond to the three *** followed the principle of data source triangulation;we used 53 semi-directive interviews conducted with health workers(to follow the principle of saturuation),field notes,and documents relating to the distribution grids of subsidies for each *** analyzed data in a mixed deductive and inductive ***:The results show that the PBF subsidies led to health workers feeling more motivated to perform their tasks *** financial motivation,this was primarily due to PBF allowing them to work more ***,respondents perceived a discrepancy between the efforts made and the subsidies *** fact that their expectations were not met led to a sense of frustration and ***,the way in which the subsidies were distributed and the lack of transparency in the distribution process led to feelings of unfairness among the vast majority of *** results show that frustrations can build up in the early days of the ***:The PBF implementation in Mali left health workers *** short overall implementation period did not allow actors to adjust their initial expectations and motivational responses,neither positiv

关键词： Motivation of health workers Performance-based financing District hospital expectations Frustration Mali

Antineoplastic Drug Handling:Higher Risk for Healthcare Workers in Tunisia than in France?

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Biomedical and Environmental Sciences 2020年第10期33卷 803-806页

作者： Kaouther Zribi Laetitia Minh Mai Le Asok Rajkumar Hail Aboudagga Mounir Frikha amandine Dietrich Emna Zribi Fathi Safta Eric Caudron Faculty of Pharmacy of Monastir-University of Monastir Rue Avicenne Monastic Tunisie Service de Pharmacie Hopital europeen Georges PompidouAssistance Publique-Hopitaux de Paris Centre Universite-Paris20 rue LeblancParis 75015France Universite Paris-Saclay LipidesSystemes Analytiques et BiologiquesChatenay-Malabry 92296France Oncolgy department Centre hospitalo-universitaire Habib BourguibaRue Ferdaous SfaxTunisie Oncology Department Hopital europeen Georges PompidouAssistance Publique-Hopitaux

In 2018,the World Health Organization(WHO)reported 9.6 million cancer deaths worldwide,in accordance with the data collected by the International Agency for Research on Cancer(IARC).The fight against cancer and other ... 详细信息

关键词： cancer Cancer diseases