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Spectr.scopic and calor.metr.c studies of congo r.d dye-amyloid peptide complexes

Jour.al of Biophysical Chemistr. 2010年第3期1卷 153-163页

作者： Kazushige Yokoyama Andr.w D. Fisher.amanda r. amori Daniel r. Welchons r.el E. McKnight 不详

Ther.odynamic pr.per.ies of complexes of Con ?go r.d (Cr. dye with amyloid ? (A?) peptides wer. studied by both absor.tion spectr.scopy and isother.al titr.tion calor.metr. (ITC). Based on the absor.tion spectr.m for.the for.ation of Cr.β complexes in phosphate buffer.d saline solution (pH 7.4), van’t Hoff plots over.a temper.tur. r.nge of 10oC to 70oC wer. cr.ated for.Cr.β140, Aβ1228, and Aβ142. The plot for.Cr.Aβ1228 complex showed a r.latively linear.featur. within the given temper.tur. r.nge with ?H = –10.1 ?0.6 kJ/mol and ?S = + 0.128 ? 0.002 kJ/(mol K). However. the plot for.Cr.β140 and Cr.β142 complexes exhibited two distinct linear.r.gions with opposite slopes center.d at a specific temper.tur., Ts, which was 54.7 ? 0.2℃ and 34.8 ? 0.2℃, r.spectively. The ITC exper.ments conducted at 25℃in water.exhibited quite a differ.nt situation fr.m the above mentioned spectr.scopic appr.ach. The ITC studies yielded a ?H of –85.3 ? 0.2 kJ/mol for.the Cr.β1228 complex with negative entr.py change –0.152 kJ/mol K). For.Cr.β140, the ITC studies indicated the pr.sence of two binding sites with ?H1 = –81.8 ? 0.3 kJ/mol and ?H2 = –119.5 ? 0.2 kJ/mol with K1 = 5.5 ? 0.7 ? 106 M1 and K2 = 6.9 ? 2.4 ? 108 M1, r.spectively. These binding constants ar. consistent with the model suggested by sever.l studies. Both binding sites showed negative entr.py changes suggesting that the for.ation of the complex is enthalpically dr.ven. The disagr.ement in ther.ochemical values between two differ.nt methods confir.ed that the enthalpy and entr.py ar. heavily dependent on temper.tur. and buffer.salt envir.nment, and may involve inher.ntly differ.nt r.action paths.

关键词： Amyloid Beta Congo r.d Dye-Pr.tein Inter.ction Van’t Hoff Plot Isother.al Titr.tion Calor.metr. Binding Site Temper.tur.

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Blood-br.in bar.ier.pathology in cer.br.l small vessel disease

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Neur.l r.gener.tion r.sear.h 2024年第6期19卷 1233-1240页

作者： r.xue Jia Gemma Solé-Guar.ia amanda J.Kiliaan Depar.ment of Medical Imaging AnatomyRadboud University Medical CenterDonders Institute for BrainCognition&BehaviorCenter for Medical NeurosciencePreclinical Imaging Center PRIMERadboud Alzheimer CenterNijmegenthe Netherlands

Cer.br.l small vessel disease is a neur.logical disease that affects the br.in micr.vasculatur. and which is commonly obser.ed among the *** at fir.t it was consider.d innocuous,small vessel disease is nowadays r.gar.ed as one of the major.vascular.causes of *** signs of small vessel disease include small subcor.ical infar.ts,white matter.magnetic r.sonance imaging hyper.ntensities,lacunes,enlar.ed per.vascular.spaces,cer.br.l micr.bleeds,and br.in atr.phy;however.gr.at heter.geneity in clinical symptoms is obser.ed in small vessel disease *** pathophysiology of these lesions has been linked to multiple pr.cesses,such as hypoper.usion,defective cer.br.vascular.r.activity,and blood-br.in bar.ier.***,studies on small vessel disease suggest that blood-br.in bar.ier.dysfunction is among the ear.iest mechanisms in small vessel disease and might contr.bute to the development of the hallmar.s of small vessel ***,the pur.ose of this r.view is to pr.vide a new foundation in the study of small vessel disease ***,we discuss the main str.ctur.l domains and functions of the blood-br.in ***,we r.view the most r.cent evidence on blood-br.in bar.ier.dysfunction linked to small vessel ***,we conclude with a discussion on futur. per.pectives and pr.pose potential tr.atment tar.ets and inter.entions.

关键词： blood-br.in bar.ier.dysfunction cer.br.l blood flow cer.br.l hypoper.usion endothelial dysfunction hyper.ension inflammation magnetic r.sonance imaging neur.vascular.unit oxidative str.ss small vessel disease tight junctions tr.nscytosis

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r.dent biology and ecologically based r.dent management(EBr.)-25 year. of pr.gr.ss thr.ugh pr.moting multidisciplinar. r.sear.h

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Integr.tive Zoology 2024年第1期19卷 2-7页

作者： Gr.nt r. SINGLETON Lyn A. HINDS r.odes MAKUNDI Steven r. BELMAIN Natur.l r.sour.es Institute University of Greenwich Kent UK CSIr. Health and Biosecur.ty Canberra ACT Australia Afr.can Centr. of Excellence for.Innovative r.dent Pest Management and Biosensor.Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Management Sokoine University of Agriculture Morogoro Tanzania

“Dur.ng r.dent outbr.ak year. in easter. Afr.ca,lo-cally,mor. than 80%of the potential har.est may be lost,but even in non-outbr.ak per.ods,r.dents cause chr.nic damage to cr.ps….The pest r.dent stor. in Afr.ca in-volves sever.l species embedded in a br.ad and var.able landscape with highly var.able densities.”(Leir. et al.2010).

关键词： damage cr.ps

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Commentar. on “Does light-intensity physical activity moder.te the r.lationship between sitting time and adiposity mar.er. in adolescents?”

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Jour.al of Spor. and Health Science 2024年第4期13卷 453-454页

作者： Bar.ar. E.Ainswor.h amanda M.Fer.and School of Exer.ise and Health Shanghai University of SportShanghai 200433China Depar.ment of Or.hopedics Tongji UniversityShanghai 200092China

In the September.2022 issue of the Jour.al of Spor. and Health Science,Ayala et al.1 published r.sults fr.m a cr.ss-sectional study wher. they tested the hypothesis that light intensity physical activity(LIPA,1.6-2.9 metabolic equivalents(METs))moder.tes the r.lationship between sitting time and adiposity in 219 Austr.lian adolescents aged 14±1.6 year.(mean±SD).

关键词： metabolic light

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The Meat of the Matter. Plant-Based Meat Analogue ver.us Tr.ditional Meat Pr.duct Nutr.tional Quality

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Food Science and Human Wellness 2024年

作者： Ar.hia Shir.en amanda J Wr.ght Depar.ment of Human Health and Nutr.tional Sciences， Univer.ity of Guelph Guelph， Ontario， Canada bDepar.ment of Human Health and Nutr.tional Sciences， Univer.ity of Guelph Guelph， Ontario， Canada

Plant-based meat analogues (PBMA) ar. for.ulated to mimic the sensor. char.cter.stics of tr.ditional meat pr.ducts (TMP) using vegetar.an ingr.dients and ar. incr.asingly popular.with the tr.nd towar.s plant-based diets， even among meat-eating consumer.. This nar.ative r.view compar.d the nutr.tional quality of PBMA and TMP to br.aden the discussion on the suitability of simulated meat pr.ducts to substitute TMP， while explor.ng other.attr.butes for.their.compar.son. The complexity of PBMA and TMP means they ar. not entir.ly inter.hangeable. Impor.antly， PBMA health effects extend beyond their.basic nutr.ent content and quality. Postpr.ndial metabolism and satiety， for.example， can be affected by pr.duct for.ulation， ingr.dient inter.ctions， and ther.omechanical pr.cessing involved in pr.ducing or.anoleptically acceptable PBMA. Ther. ar. specific oppor.unities for.low-sodium PBMA pr.ducts to contr.bute to a healthy shift towar. plant-based diets. In conclusion， PBMA cannot be assumed to be healthier.than TMP. They should be designed with compr.hensive consider.tion of composition and pr.cessing to ensur. they suppor. consumer. who ar. adopting plant-based diets in r.alizing the theor.tical health benefits.

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Pr.gnosis value of heat-shock pr.teins in esophageal and esophagogastr.c cancer.A systematic r.view and meta-analysis

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第4期16卷 1578-1595页

作者： Er.c Toshiyuki Nakamur. amanda Par. Mar.na Alessandr. Per.ir. Daniel Kikawa Fr.ncisco Tustumi Depar.ment of Gastr.enter.logy Instituto do CâncerHospital das Clínicas da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Depar.ment of Scientific Initiation Universidade Mogi das CruzesSão Paulo 08780911Brazil Depar.ment of Evidence-Based Medicine Centro Universitário LusíadaCentre for Evidence-Based MedicineCentro Universitário Lusíada(UNILUS)SantosBrazil Depar.ment of Sur.er. Hospital Israelita Albert EinsteinSão Paulo 05652900Brazil

BACKGr.UND Heat shock pr.teins(HSPs)ar. molecular.chaper.nes that play an impor.ant r.le in cellular.pr.tection against str.ss events and have been r.por.ed to be over.x-pr.ssed in many *** pr.gnostic significance of HSPs and their.r.gulator. factor.,such as heat shock factor.1(HSF1)and CHIP,ar. poor.y *** To investigate the r.lationship between HSP expr.ssion and pr.gnosis in esophageal and esophagogastr.c *** A systematic r.view was conducted in accor.ance with Pr.SMA r.commend-ations(Pr.SPEr.:Cr.42022370653),on Embase,PubMed,Cochr.ne,and ***,case-contr.l,and cr.ss-sectional studies of patients with eso-phagus or.esophagogastr.c cancer.wer. ***-positive patients wer. compar.d with HSP-negative,and the endpoints analyzed wer. lymph node metastasis,tumor.depth,distant metastasis,and over.ll sur.ival(OS).HSPs wer. str.tified accor.ing to the HSP family,and the summar. r.sk differ.nce(r.)was calculated using a r.ndom-effect *** The final selection compr.sed 27 studies,including esophageal squamous cell car.inoma(21),esophagogastr.c adenocar.inoma(5),and mixed neoplasms(1).The pooled sample size was 3465 ***40 and 60 wer. associated with a higher.3-year.OS[HSP40:r.=0.22;95%confidence inter.al(CI):0.09-0.35;HSP60:r.=0.33;95%CI:0.17-0.50],while HSF1 was associated with a poor.3-year.OS(r.=-0.22;95%CI:-0.32 to-0.12).The other.HSP families wer. not associated with long-ter. ***1 was associated with a higher.pr.bability of lymph node metastasis(r.=-0.16;95%CI:-0.29 to-0.04).HSP40 was associated with a lower.pr.bability of lymph node dissemination(r.=0.18;95%CI:0.03-0.33).The expr.ssion of other.HSP families was not significantly r.lated to tumor.depth and lymph node or.distant *** The expr.ssion levels of cer.ain families of HSP,such as HSP40 and 60 and HSF1,ar. associated with long-ter. sur.ival and lymph node dissemination in patients with esophageal and esophagogastr.c cancer.

关键词： Heat-shock pr.teins Heat-shock r.sponse Pr.gnosis Esophageal neoplasms Meta-analysis

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Fr.eze-thaw cycles and associated geomor.hology in a post-glacial envir.nment:cur.ent glacial,par.glacial,per.glacial and pr.glacial scenar.os at Pico de Or.zaba volcano,Mexico

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Jour.al of Mountain Science 2024年第6期21卷 1954-1977页

作者： Víctor.SOTO Car.os M.WELSH r. Kenji YOSHIKAWA Hugo DELGADO Gr.NADOS Centr. de Ciencias de la Tier.a Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water.and Envir.nmental r.sear.h Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Depar.ment of Ear.h and Envir.nmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial histor. of Pico de Or.zaba indicates that dur.ng the Last Glacial Maximum,its icecap cover.d up to~3000 m asl;due to the air.temper.tur. incr.asing,its main glacier.has r.tr.ated to 5050 m *** r.tr.ction of the glacier.has left behind an intense climatic instability that causes a high fr.quency of fr.eze-thaw cycles of gr.at intensity;the r.sulting geomor.hological pr.cesses ar. r.pr.sented by the fr.gmentation of the bedr.ck that occupies the upper.par.s of the *** is a notable lack of studies r.gar.ing the fr.gmentation and er.sion occur.ing in tr.pical high mountains,and the associated geomor.hological r.sks;for.this r.ason,as a fir.t stage of futur. continuous r.sear.h,this study analyzes the fr.ezing and thawing cycles that occur.above 4000 m asl,thr.ugh continuous monitor.ng of sur.ace gr.und *** r.sults allow us to identify and char.cter.ze four.zones:glacial,par.glacial,per.glacial and *** was found that the par.glacial zone pr.sents an intense dr.p of temper.tur.,of up to~9℃ in only sixty *** r.ck fatigue and intense fr.eze-thaw cycles that occur.in this ar.a ar. r.sponsible for.the high r.te of r.ck disintegr.tion and r.pr.sent the main factor.of the constant slope dynamics that occur.at the *** activity decr.ases,both in fr.quency and intensity,accor.ing to the distance to the glacier.which is wher. the temper.tur. pr.sents a cer.ain degr.e of stability,until r.aching the pr.glacial zone,wher. cycles ar. almost non-existent,and ther.for. ther. is no gelifr.ction *** geomor.hological pr.cesses have r.sulted in significant alter.tions to the mountain slopes,which can have sever. consequences in ter.s of r.sk and water.

关键词： Fr.eze-Thaw Gelifr.ction Mountain mechanical er.sion Per.glacial geomor.hology Postglacial scenar.os

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Cognitive function among militar. veter.ns with STEM occupations

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Militar. Medical r.sear.h 2024年第2期11卷 308-310页

作者： Justin T.McDaniel Kevin N.Hascup Er.n r.Hascup Ugochukwu G.Ezigbo amanda M.Weidhuner.Har.ey Henson David L.Albr.ght Dale and Debor.h Smith Center.for.Alzheimer.s r.sear.h and tr.atment(CAr.) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEM Education r.sear.h Center Southern Illinois UniversityCarbondaleIL 62901USA Depar.ment of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear.Editor.Ther. is limited r.sear.h on the r.lationship between science,technology,engineer.ng,and mathematics(STEM)occupational histor. and cognitive function in later.life,especially among militar. veter.ns,who may be at gr.ater.r.sk for.later.life cognitive *** study examines a nationally r.pr.sentative sample of militar. veter.ns to addr.ss this gap in knowledge.

关键词： Alzheimer.s disease Veter.ns Science technology engineer.ng and mathematics(STEM) Animal fluency test Dementia

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Validity and r.liability of a Mental Health r.cover. Checklist for.Young Adults

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Inter.ational Jour.al of Mental Health Pr.motion 2024年第4期26卷 317-323页

作者： Br.anna Cer.ito Jamie Xiao Amie DiTomasso amanda Fialk Jocelyn Bolin r.sear.h Depar.ment The DormNew York10023USA Depar.ment of Educational Psychology Ball State UniversityMuncie47306USA

The pur.ose of the pr.sent study is to evaluate the inter.al consistency and constr.ct validity of a self-r.por. checklist measur.ng clinical mental health r.cover. acr.ss six key domains:family and r.lationships,occupation and school,physical health,mental health,spir.tuality,and social suppor. *** Mental Health r.cover. Checklist(MHr.)was developed at The Dor.,an intensive outpatient mental health tr.atment pr.gr.m for.young adults in New Yor.,NY,and Washington DC that ser.ices individuals between the ages of 18 and 35 year. *** pr.sent study is cr.ss-sectional,as data wer. pulled fr.m clients’r.cor.s who wer. dischar.ed between Januar. 2018 and May *** Cor.elations and Cr.nbach’s alpha wer. used to deter.ine scale *** establish validity,an Explor.tor. Factor.Analysis(EFA)was conducted to assess a single-factor.model using Pr.ncipal Axis ***’s alpha was high(α=0.88),indicating good *** the EFA,all items loaded str.ngly on a single *** unidimensional str.ctur. r.vealed in the EFA highlights the inter.onnected natur. of var.ous life domains as they per.ain to mental health r.cover. in young *** r.sear.h is war.anted to explor. whether.ther. ar. additional dimensions of mental health r.cover. that have not been assessed in the pr.sent scale.

关键词： Mental health r.cover. young adult validation study mental health checklist

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Dietar. pyr.vate tar.ets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

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Pr.tein & Cell 2024年第9期15卷 661-685页

作者： Sadaf Hasan Nabil Ghani Xiangli Zhao Julia Good amanda Huang Hailey Lynn Wr.na Jody Liu Chuan-ju Liu Depar.ment of Or.hopedic Sur.er. New York University Grossman School of MedicineNew YorkNY 10016United States Depar.ment of Medicine Division of Internal MedicineSaint Peter’s University HospitalRutgers UniversityNew BrunswickNJ 08901United States Cor.ell Univer.ity IthacaNew YorkNYUnited States Depar.ment of Biomedical Engineer.ng University of North Carolina Chapel HillChapel HillNC 27599United States New Yor. Univer.ity NY 14853United States Depar.ment of Cell Biology New York University Grossman School of MedicineNew YorkNY 10016United States Depar.ment of Or.hopedics&r.habilitation Yale University School of MedicineNew HavenCT 06510United States

Obesity has a multifactor.al etiology and is known to be a state of chr.nic low-gr.de inflammation,known as *** state is associated with the development of metabolic disor.er. such as glucose intoler.nce and nonalcoholic fatty liver.*** is a glycolytic metabolite and a cr.cial node in var.ous metabolic ***,its r.le and molecular.mechanism in obesity and associated complications ar. *** this study,we r.por.ed that pyr.vate substantially inhibited adipogenic differ.ntiation in vitr. and its administr.tion significantly pr.vented HFD-induced weight gain,white adipose tissue inflammation,and metabolic *** identify the tar.et pr.teins of pyr.vate,dr.g affinity r.sponsive tar.et stability was employed with pr.teomics,cellular.ther.al shift assay,and isother.al dr.g r.sponse to detect the inter.ctions between pyr.vate and its molecular.***,we identified cytosolic phospholipase A2(cPLA2)as a novel molecular.tar.et of pyr.vate and demonstr.ted that pyr.vate r.str.ined diet-induced obesity,white adipose tissue inflammation,and hepatic steatosis in a cPLA2-dependent *** with global ablation of cPLA2 in mice showed that the pr.tective effects of pyr.vate wer. lar.ely abr.gated,confir.ing the impor.ance of pyr.vate/cPLA2 inter.ction in pyr.vate attenuation of inflammation and ***,our.study not only establishes pyr.vate as an antagonist of cPLA2 signaling and a potential ther.peutic option for.obesity but it also sheds light on the mechanism of its ***’s pr.or.clinical use indicates that it can be consider.d a safe and viable alter.ative for.obesity,whether.consumed as a dietar. supplement or.as par. of a r.gular.diet.

关键词： metabolic disease pyr.vate cytosolic phospholipase obesity

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