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Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta Fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

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Photoluminescence emissions of Ca_(1-x)WO_(4):xEu^(3+):Bridging between experiment and DFT calculations

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Journal of Rare Earths 2022年第10期40卷 1527-1534页

作者： amanda Fernandes Gouveia Marcelo Assis Lara Kelly ribeiro Aline Estefany Brandao Lima Eduardo de Oliveira Gomes Daniele Souza Yara Gobato Galvao Ieda Lucia Viana Rosa Geraldo Eduardo da Luz Jr Eva Guillamón Elson Longo Juan Andrés Miguel Angel San-Miguel Department of Physical and Analytical Chemistry University Jaume I(UJI)12071CastelloSpain Institute of Chemistry State University of Campinas(Unicamp)13083-970CampinasSPBrazil CDMF Federal University of S?o Carlos(UFSCar)P0.Box 67613565-905Sao CarlosSao PauloBrazil Departamento de Química Federal University of Piauí(UFPI)64049-550TeresinaPiautBrazil Physics Department Federal University of S?o Carlos(UFSCar)P.0.Box 67613565-905Sao CarlosSao PauloBrazil

In this work,the impact of the doping process on the photoluminescence emission of CaWO_(4) as a function of the concentration of Eu^(3+) cation(0.01 mol%,0.02 mol%,0.04 mol%,0.06 mol%,0.08 mol%,and 0.10 mol%) is discussed in ***_(1-x)WO~4:xEu^(3+) samples were successfully synthesized by a simple coprecipitation method followed by microwave *** blue shift in the absorption edge confirms the quantum confinement effect and the band gap energy covers the range from 3.91 to 4.18 eV,as the amount of Eu^(3+) cations *** experimental results are sustained by first-principles calculations,at the density functional theory level,to decipher the geometry and electronic properties,thereby enabling a more accurate and direct comparison between theory and experiment for the Ca_(1-x)WO_(4):xEu^(3+) structure.

关键词： Ca_(1-x)WO_(4):xEu^(3+) DFT calculations Photoluminescence emissions Rare earths

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A Use Case of Patent Classification Using Deep Learning with Transfer Learning

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Journal of Data and Information Science 2022年第3期7卷 49-70页

作者： Roberto Henriques Adria ferreira Mauro Castelli Campus de Campolide Lisboa 1070-312Portugal

Purpose:Patent classification is one of the areas in Intellectual Property Analytics(IPA),and a growing use case since the number of patent applications has been increasing *** propose using machine learning algorithms to classify Portuguese patents and evaluate the performance of transfer learning methodologies to solve this ***/methodology/approach:We applied three different approaches in this ***,we used a dataset available by INPI to explore traditional machine learning algorithms and ensemble *** preprocessing data by applying TF-IDF,FastText and Doc2Vec,the models were evaluated by cross-validation in 5 *** a second approach,we used two different Neural Networks architectures,a Convolutional Neural Network(CNN)and a bi-directional Long Short-Term Memory(BiLSTM).Finally,we used pre-trained BERT,DistilBERT,and ULMFiT models in the third ***:BERTTimbau,a BERT architecture model pre-trained on a large Portuguese corpus,presented the best results for the task,even though with a performance of only 4%superior to a LinearSVC model using TF-IDF feature *** limitations:The dataset was highly imbalanced,as usual in patent applications,so the classes with the lowest samples were expected to present the worst *** result happened in some cases,especially in classes with less than 60 training *** implications:Patent classification is challenging because of the hierarchical classification system,the context overlap,and the underrepresentation of the ***,the final model presented an acceptable performance given the size of the dataset and the task *** model can support the decision and improve the time by proposing a category in the second level of ICP,which is one of the critical phases of the grant patent ***/value:To our knowledge,the proposed models were never implemented for Portuguese patent classification.

关键词： Natural Language Processing(NLP) Patent classification Transfer Learning Bi-directional Encoder Representations for Transformers(BERT)

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Role of short chain fatty acids in gut health and possible therapeutic approaches in inflammatory bowel diseases

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World Journal of Clinical Cases 2022年第28期10卷 9985-10003页

作者： Marcos Antônio ferreira Caetano Patricia Castelucci Department of Anatomy Institute of Biomedical SciencesUniversity of São PauloSão Paulo 05508900SPBrazil

Inflammatory bowel diseases(IBDs) are characterized by inflammation in the gastrointestinal tract and include Ulcerative Colitis and Crohn’s *** diseases are costly to health services,substantially reduce patients’ quality of life,and can lead to complications such as cancer and even *** include abdominal pain,stool bleeding,diarrhea,and weight *** treatment of these diseases is symptomatic,seeking disease *** intestine is colonized by several microorganisms,such as fungi,viruses,and bacteria,which constitute the intestinal microbiota(IM).IM bacteria promotes dietary fibers fermentation and produces short-chain fatty acids(SCFAs) that exert several beneficial effects on intestinal *** can bind to G protein-coupled receptors,such as GPR41 and GPR43,promoting improvements in the intestinal barrier,anti-inflammatory,and antioxidant ***,SCFAs could be a therapeutic tool for ***,the mechanisms involved in these beneficial effects of SCFAs remain poorly ***,this paper aims to provide a review addressing the main aspects of IBDs,and a more detailed sight of SCFAs,focusing on the main effects on different aspects of the intestine with an emphasis on IBDs.

关键词： Ulcerative colitis Crohn’s disease Short-chain fatty acid Butyrate Inflammatory bowel diseases Free fatty acid receptor

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Prognosis of forest production using machine learning techniques

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Information Processing in Agriculture 2023年第1期10卷 71-84页

作者： Jeferson Pereira Martins Silva Mayra Luiza Marques da Silva Adriano ribeiro de Mendonca Gilson Fernandes da Silva Antoˆnio Almeida de Barros Junior Evandro ferreira da Silva Marcelo Otone Aguiar Jeangelis Silva Santos Nı´vea Maria Mafra Rodrigues Federal University of Espirito Santo UFESDepartment of Forestry and Wood ScienceAvenue Governor Lindemberg31629550-000 Jeroˆnimo MonteiroESBrasil b Departamento de Cieˆncias Agra´riasUniversidade Federal de Sa o Joa del-Rei Sete Lagoas CampusHighway MG 424-Km 47Sete LagoasMinas Gerais 35701-970Brazil Federal University of Para(UFPA) University Campus of AltamiraStreet Cel.Jose Porfırio2515Sa o Sebastiao68372-040 AltamiraPABrazil

Forest production and growth are obtained from statistical models that allow the generation of information at the tree or forest stand *** the use of regression models is common in forest measurement,there is a constant search for estimation procedures that provide greater ***,machine learning techniques have been used with satisfactory performance in measuring ***,methods such as Adaptive NeuroFuzzy Inference System(ANFIS)and Random Forest are relatively poorly studied for predicting the volume of wood in eucalyptus plantations in ***,it is essential to check whether these techniques can provide gains in terms of ***,this study aimed to evaluate the use of Random Forest and ANFIS techniques in the prognosis of forest *** data used come from continuous forest inventories carried out in stands of eucalyptus *** data were divided into 70%for training and 30%for *** algorithms used to generate rules in ANFIS were Subtractive Clustering and ***,training was done with the hybrid algorithm(descending gradient and least squares)with the number of seasons ranging from 1 to *** RFs were trained,varying the number of trees from 50 to 850 and the number of observations by five leaves to *** neural networks and decision trees were also trained to compare the feasibility of the *** evaluation of the estimates generated by the techniques for training and validation was calculated based on the following statistics:correlation coefficient(r),relative Bias(RB),and the relative root mean square error(RRMSE)in *** general,the techniques studied in this work showed excellent performance for the training and validation data set with RRMSE values*** RF presented inferior statistics about the ANFIS for the prognosis of forest *** Subtractive Clustering(SC)and Fuzzy-C-Means(FCM)algorithms provide accurate baseline

关键词： Artificial Intelligence Ensemble Learning Forest Measurement Forest inventory Artificial Neural Networks Regression

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Structural and optical properties of pillared Eu^(3+)-containing layered double hydroxides intercalated by 2-to 12-carbon aliphatic dicarboxylates

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Journal of Rare Earths 2022年第2期40卷 260-267,I0003页

作者： Alexandre Candido Teixeira Ivan Guide Nunes Silva Alysson ferreira Morais Danilo Mustafa Physics Institute.University of Sao Paulo 05508-090Sao PauloSPBrazil

While the versatile composition of layered double hydroxides(LDHs)allows the introduction of almost any polyvalent cation in their structure,the exchangeable negatively charged ions intercalated between the plates increase their vast range of *** we report on the preparation and optical properties of pillared Eu^(3+)-substituted ZnAl LDHs intercalated by aliphatic dicarboxylates:-OOC-(CH_(2))_(n-2)-COO-.The basal distance in these materials is dependent on the size and packing of the intercalated *** varying the number(n)of carbon atoms in the aliphatic chain from 2 to 12,the interlayer gallery of these ZnAlEu LDHs is considerably expanded from 0.9 to 2.1 *** the interlayer gallery,the aliphatic dicarboxylates form a monolayer,with the aliphatic chain inclined by an angleα≈63°with the hydroxide *** carbon atom in the COO-group is 0.43 nm far from the metal plane,showing that these carboxylates are not grafted in the brucite-like *** LDHs are thermally stable up to around 150℃,after which dehydroxylation of the hydroxide layers is *** Judd-Ofelt intensity parameters were obtained and compared to the Eu^(3+)-containing complexes with the same ligand series indicating a more symmetrical and less polarizable chemical environment around the rare earth ion.

关键词： Europium Layered double hydroxides Carboxylate ligands Luminescence Rare earths

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Traditional Chinese medicine wrist pulse-taking is associated with pulse waveform analysis and hemodynamics in hypertension

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Journal of Integrative Medicine 2016年第2期14卷 100-113页

作者： Nathalia Gomes ribeiro de Moura Ivan Cordovil Arthur de Sa ferreira Postgraduate Program of Rehabilitation Science Augusto Motta University Center21041-010Rio de JaneiroR JBrazil Division of Arterial Hypertension National Institute of Cardiology22240-002Rio de JaneiroR JBrazil Department of Physical Therapy Salgado de Oliveira University24030-060NiteroiR JBrazil

BACKGROUND： Pulse wave analysis（PWA） quantifies the phenomenon of pulse waveform propagation in patients with cardiovascular diseases, whereas pulse image analysis（PIA） is a subjective examination in traditional Chinese medicine. OBJECTIVE： This study evaluated the association of PIA with PWA and hemodynamics in patients with hypertension. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This observational, cross-sectional study enrolled 45 patients（26 men,（55.2± 10.3） years, systolic blood pressure（155± 28） mm Hg, diastolic blood pressure（93± 17） mm Hg） for assessment of clinical and laboratorial data. MAIN OUTCOME MEASURES： Primary outcomes comprised： pattern differentiation based on an automated method; PIA at the radial artery using the ‘simultaneous pressing＇ method for identification of factors such as strength（strong/weak）, depth（superficial/deep）, and speed（fast/moderate/slow）; and PWA at the same artery using a noninvasive system. RESULTS： Significant multivariate main effects were observed for depth（l=0.648, F_（5,29）=3.149, P=0.022, h^2 =0.352）, strength（l=0.608, F_（5,29） =3.736, P=0.010, h^2 =0.392）, and speed（l=0.535, F_（5,29） =5.302, P=0.002, h^2 =0.465）. General effects comprised high values of PWA and blood pressure for superficial, strong, and fast pulse images. A strong pulse was found for pulse pressure ≥ 62.5 mm Hg and systolic blood pressure ≥ 149.5 mm Hg, whereas a superficial pulse was found for heart rate ≥ 58.25 beats/min; a fast pulse was found for heart rate ≥ 69.6 beats/min and pulse wave velocity ≥ 9.185 m/s. CONCLUSION： Associations were explained by La Place＇s law, arterial remodeling in hypertension, alongside the traditional criterion for classifying speed in pulse images. PIA is associated with PWA and hemodynamics in patients with hypertension. Systolic and pulse pressures, heart rate, and pulse wave velocity are quantitative variables that have information to describe the qualitative pulse images such as strength, depth and speed.

关键词： medicine Chinese traditional hypertension syndrome differentiation rehabilitation

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Preoperative risk modelling for oesophagectomy: A systematic review

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 450-470页

作者： James Paul Grantham amanda Hii Jonathan Shenfine Department of General Surgery Modbury HospitalAdelaide 5092South AustraliaAustralia General Surgical Unit Jersey General HospitalSaint Helier JE13QSJerseyUnited Kingdom

BACKGROUND Oesophageal cancer is a frequently observed and lethal malignancy *** resection remains a realistic option for curative intent in the early stages of the ***,the decision to undertake oesophagectomy is significant as it exposes the patient to a substantial risk of morbidity and ***,appropriate patient selection,counselling and resource allocation is *** tools have been developed to aid surgeons in appropriate *** To examine all multivariate risk models that use preoperative and intraoperative information and establish which have the most clinical *** A systematic review of the MEDLINE,EMBASE and Cochrane databases was conducted from *** search terms applied were((Oesophagectomy)AND(Risk OR predict OR model OR score)AND(Outcomes OR complications OR morbidity OR mortality OR length of stay OR anastomotic leak)).The applied inclusion criteria were articles assessing multivariate based tools using exclusively preoperatively available data to predict perioperative patient outcomes following *** exclusion criteria were publications that described models requiring intra-operative or post-operative data and articles appraising only univariate predictors such as American Society of Anesthesiologists score,cardiopulmonary fitness or pre-operative *** that exclusively assessed distant outcomes such as long-term survival were excluded as were publications using cohorts mixed with other surgical *** articles generated from each search were collated,processed and then reported in accordance with PRISMA *** risk models were appraised for clinical credibility,methodological quality,performance,validation,and clinical *** The initial search of composite databases yielded 8715 articles which reduced to 5827 following the deduplication *** title and abstract screening,197 potentially relevant texts were

关键词： Oesophagectomy Risk model Oesophageal cancer Preoperative Morbidity Mortality

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Combined and intraoperative risk modelling for oesophagectomy:A systematic review

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1485-1500页

作者： James Paul Grantham amanda Hii Jonathan Shenfine Department of General Surgery Modbury HospitalModbury 5092South AustraliaAustralia Department of General Surgical Unit Jersey General HospitalSaint Helier JE13QSJerseyUnited Kingdom

BACKGROUND Oesophageal cancer is the eighth most common malignancy worldwide and is associated with a poor *** remains the best prospect for a cure if diagnosed in the early disease ***,the procedure is associated with significant morbidity and mortality and is undertaken only after careful *** patient selection,counselling and resource allocation is *** risk models have been devised to guide surgeons in making these *** To evaluate which multivariate risk models,using intraoperative information with or without preoperative information,best predict perioperative oesophagectomy *** A systematic review of the MEDLINE,EMBASE and Cochrane databases was undertaken from *** search terms used were[(Oesophagectomy)AND(Model OR Predict OR Risk OR score)AND(Mortality OR morbidity OR complications OR outcomes OR anastomotic leak OR length of stay)].Articles were included if they assessed multivariate based tools incorporating preoperative and intraoperative variables to forecast patient outcomes after *** were excluded if they only required preoperative or any post-operative *** appraising univariate risk predictors such as preoperative sarcopenia,cardiopulmonary fitness and American Society of Anesthesiologists score were also *** review was conducted following the preferred reporting items for systematic reviews and meta-analyses *** captured risk models were appraised for clinical credibility,methodological quality,performance,validation and clinical *** Twenty published studies were identified which examined eleven multivariate risk *** of these combined preoperative and intraoperative data and the remaining three used only intraoperative *** two risk models were identified as promising in predicting mortality,namely the Portsmouth physiological and operative severity score for the enumeration o

关键词： Oesophagectomy Risk model Oesophageal cancer Preoperative Intraoperative Morbidity Mortality

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Insights on in-office scar revision and resurfacing procedures

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第3期9卷 249-256页

作者： amanda Goslawski Eve Tranchito Cyrus C.Rabbani Department of Otolaryngology-Head&Neck Surgery University Hospitals Cleveland Medical CenterClevelandOhioUSA Case Western Reserve University School of Medicine ClevelandOhioUSA

Objective:Many facial plastic surgery procedures can be performed in an office-based setting,ranging from simple chemical peels to reconstructive surgeries to assist with scar *** aim of this review is to summarize the current state of facial plastics in-office surgical procedures,including scar revision,dermabrasion,lasers,and chemical ***:A literature review was conducted with the PubMed search engine with the following keywords:facial plastics,scar revision,dermabrasion,lasers,chemical peels,face,office,and *** literature was surveyed for relevance,with a focus on realistically which procedures were performed in a facial plastics surgery outpatient *** were then used to compile a review of the current state of this *** and Conclusions:There are various scar revision procedures that can be performed in the office setting,including z-plasty,w-plasty,and geometric broken line closure techniques,as well as various nonmedical treatment options to improve the appearance of a *** can also be performed to assist with elevated *** lasers are available to enhance cell turnover in the field of facial rejuvenation,scarring,and sun *** peels are also available to assist with facial *** the appropriate counseling of the patient and medical staff,these can be safely performed in the office.

关键词： chemical peel dermabrasion laser office scar revision

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