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Acceptance and Experience of HIV-Infected Adolescents in Two Hospitals in Yaoundé

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Open Journal of Pediatrics 2024年第2期14卷 435-443页

作者： Isabelle Mekone Nkwele Nelly Kamgaing Pierrette amanda Emah Manga Jeannette Épée Ngoué Hélène Kamo Sélangai Claude Audrey Meguieze Nsoh Ndeh-Fofang Serge Tchoukoua Jean-Baptiste Fotso Djemo Paul Koki Ndombo Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Institut Supérieur des Sciences de la Santé de Bangangté Université des Montagnes Bangangté Cameroon Faculty of Medicine and Biomedical Sciences University of Garoua Garoua Cameroon

Introduction: Access to antiretroviral drugs has improved the survival of children infected with the Human Immunodeficiency Virus (HIV). As they reach adolescence, they are confronted with various constraints related to the infection and its treatment, in addition to those of the growth period they are going through. The main aim of the study was to assess the acceptance and describe the experience of HIV infection by infected adolescents but also to investigate the factors associated with good acceptance and a positive experience. Methodology: The cross-sectional analytic study concerned HIV-infected adolescents aged 15 to 19 followed up at the Chantal Biya Foundation-Mother and Child Centre (CME-FCB) and the Yaoundé University Hospital Centre (CHUY) between February 2020 and June 2020. The study saw participants complete a questionnaire containing socio-demographic data and assessing acceptance and experience with the infection. Data analysis was accomplished using Epi info software version 7.***.2.6. Results: One hundred and thirteen HIV-infected adolescents were included in the study. The sex ratio was 0.68 and the mean age was 17 years. More than half of the adolescents had a good acceptance and positive experience with the infection. Related factors were the adolescent’s perception of good health and participation in an association with other infected adolescents. Conclusion: Emphasizing the psychological and educational follow-up of infected adolescents and encouraging their participation in associations for adolescents living with HIV could reduce the consequences of poor acceptance and ensure a better transition to adulthood. .

关键词： HIV Adolescent Acceptance Experience

Polycomb repressive complex 2 in embryonic stem cells:an overview

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Protein & Cell 2010年第12期1卷 1056-1062页

作者： amanda Jones Hengbin Wang Department of Biochemistry and Molecular Genetics University of Alabama at BirminghamKaul Human Genetics Building 402A720 South 20th StreetBirminghamAL 35294USA

Polycomb Group Proteins(PcG)are a family of epigenetic regulators responsible for the repression of an array of genes important in development and cell fate *** proteins complex to form two types of epigenetic regulators:Polycomb Repressive Complex 1 and 2(PRC1 and PRC2).Although the mechanisms regulating PRC2 recruitment and activity in mammals remain poorly understood,recent work has identified a non-canonical PRC2 in mouse embryonic stem cells(mESC)with unique activities required for repression of PRC2 target genes and necessary for mESC differentiation and somatic cell *** we review the functions of PRC2 in embryonic stem cells and explore the role of the newly identified mESC specific PRC2 regulatory subunits Jarid2(jumonji,AT rich interactive domain 2),Mtf2(metal response element binding transcription factor 2)and esPRC2p48.

关键词： polycomb repressive complex 2 histone modification epigenetic regulation

Cathepsins in neuronal plasticity

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Neural Regeneration Research 2021年第1期16卷 26-35页

作者： amanda Phuong Tran Jerry Silver Center for Integrative Brain Research Seattle Children’s Research InstituteSeattleWAUSA Department of Neurosciences Case Western Reserve UniversityClevelandOHUSA

Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other proteins,resulting in protein ***,specifically,encompass a class of at least twenty proteases with potent endopeptidase *** are located subcellularly in lysosomes,organelles responsible for the cell’s degradative and autophagic processes,and are vital for normal lysosomal *** cathepsins are involved in a multitude of cell signaling activities,this chapter will focus on the role of cathepsins(with a special emphasis on Cathepsin B)in neuronal *** will broadly define what is known about regulation of cathepsins in the central nervous system and compare this with their dysregulation after injury or ***,we will delineate what is currently known about the role of cathepsins in axon regeneration and plasticity after spinal cord *** is well established that normal cathepsin activity is integral to the function of *** normal lysosomal function,autophagy and other homeostatic cellular processes become dysregulated resulting in axon ***,controlled activation of cathepsins at specialized neuronal structures such as axonal growth cones and dendritic spines have been positively implicated in their *** chapter will end with a perspective on the consequences of cathepsin dysregulation versus controlled,localized regulation to clarify how cathepsins can contribute to both neuronal plasticity and neurodegeneration.

关键词： axon regeneration cathepsin CSPGs extracellular matrix growth cone lysosomes neuronal plasticity protease remodeling spinal cord injury synaptogenesis

Characterization of seawater and aerosol particle surfactants using solid phase extraction and mass spectrometry

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Journal of Environmental Sciences 2021年第10期33卷 164-174页

作者： Tret C.Burdette amanda A.Frossard Department of Chemistry University of Georgia140 Cedar StreetAthensGA30606USA

Surface-active organic molecules(surfactants)may influence the ability of an aerosol particle to act as a cloud condensation nuclei by reducing its surface *** source of organic mass in aerosol particles,which may also contain surfactants,is bubble bursting on the sea *** order to directly compare these molecules in the ocean and aerosol particles,we developed a method using multiple solid phase extractions and high resolution mass spectrometry to characterize surface active organic molecules in *** method has extraction efficiencies greater than 85%,75%,and 60%for anionic,cationic,and nonionic surfactant standards,*** this study,we demonstrate the presence of three ionic classes of surface active organics in atmospheric aerosol particles and estuarine water from Skidaway Island,*** this extraction method,organic molecules from both estuarine water and atmospheric aerosol particles significantly reduced surface tension of pure water(surface tension depression of~18 m N/m)and had high ratios of hydrogen to carbon(H/C)and low ratios of oxygen to carbon(O/C),indicative of *** previous work has observed a larger fraction of anionic surface active organics in seawater and marine aerosol particles,here we show cationic surface active organics may make up a large fraction of the total surface active molecules in estuarine water(43%–47%).

关键词： Solid phase extraction Organic aerosol particles Marine organics Mass spectrometry Surfactants

A review of modern treeline migration, the factors controlling it and the implications for carbon storage

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Journal of Mountain Science 2021年第2期18卷 291-306页

作者： HANSSON amanda DARGUSCH Paul SHULMEISTER Jamie School of Earth and Environmental Science University of QueenslandBrisbane QLD 4072Australia School of Earth and Environment University of CanterburyChristchurch 8140New Zealand

Numerous studies have reported that treelines are moving to higher elevations and higher *** treelines are temperature limited and warmer climate expands the area in which trees are capable of ***,climate change has been assumed to be the main driver behind this treeline *** latest review of treeline studies was published in 2009 by Harsch et *** then,a plethora of papers have been published studying local treeline *** we bring together this knowledge through a review of 142 treeline related publications,including 477 study *** summarize the information known about factors limiting tree-growth at and near *** migration is not only dependent on favorable growing conditions but also requires seedling establishment and survival above the current *** conditions appear to have become favorable at many locations,particularly so in recent *** review revealed that at 66%of these treeline sites forest cover had increased in elevational or latitudinal *** physical form of treelines influences how likely they are to migrate and can be used as an indicator when predicting future treeline *** analysis also revealed that while a greater percentage of elevational treelines are moving,the latitudinal treelines are capable of moving at greater horizontal *** can potentially have substantial impacts on ecosystem carbon *** conclude the review,we present the three main hypotheses as to whether ecosystem carbon budgets will be reduced,increased or remain the same due to treeline *** the answer still remains under debate,we believe that all three hypotheses are likely to apply depending on the encroached ***,evidence is emerging on how treeline migration may turn tundra landscapes from net sinks to net sources of carbon dioxide in the future.

关键词： Treeline advance Treeline migration Forest dynamics Alpine forests Ecosystem carbon storage Carbon sequestration Global meta-analysis

Effect of β -Glucan (Angel Yeast) Compared to a Placebo on Cold and Flu Incidence and Symptoms in an Adult Population—A Double Blind, Randomised Controlled Trial

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Wild Nutrition’s Food-Grown® Magnesium Supplementation Increases Sleep Quality and Sleep Duration and Reduces Stress in a Healthy Adult Population: A Double-Blind,Randomised, Placebo-Controlled Study

Food and Nutrition Sciences（食品与营养科学） 2024年第6期 484页

作者： David Briskey Haibo Zhang Zhixian Chen amanda Rao

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Factorial design analytics on effects of material parameter uncertainties in multiphysics modeling of additive manufacturing

Food and Nutrition Sciences（食品与营养科学） 2024年第7期 509页

作者： David Briskey Jane Erickson Chelsie Smith amanda Rao

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npj Computational Materials 2023年第1期9卷 1848-1865页

作者： amanda Giam Fan Chen Jiaxiang Cai Wentao Yan Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore 119077Singapore Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore Department of Industrial Systems Engineering and Management National University of SingaporeSingapore 117576Singapore

A bottleneck in Laser Powder Bed Fusion(L-PBF)metal additive manufacturing(AM)is the quality inconsistency of its *** address this issue without costly experimentation,computational multi-physics modeling has been used,but the effectiveness is limited by parameter uncertainties and their *** propose a full factorial design and variable selection approach for the analytics of main and interaction effects arising from material parameter uncertainties in multi-physics *** is collected from high-fidelity thermal-fluid simulations based on a 2-level full factorial design for 5 selected material *** physical phenomena of the L-PBF process are analyzed to extract physics-based domain knowledge,which are used to establish a validation checkpoint for our *** data visualization with half-normal probability plots,interaction plots and standard deviation plots,is used to assess if the checkpoint is being *** then apply the combination of best subset selection and the LASSO method on multiple linear regression models for comprehensive variable *** yield statistically and phyiscally validated findings with practical implications,emphasizing the importance of parameter interactions under uncertainty,and their relation to the underlying physics of L-PBF.

关键词： parameter additive analytic

Classifying Metarational Stabilities in Conflicts

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Journal of Systems Science and Systems Engineering 2019年第3期28卷 265-284页

作者： amanda Garcia Keith W.Hipel Amer Obeidi Department of Systems Design Engineering University of WaterlooWaterloo OntarioCanada Department of Management Sciences University of WaterlooWaterloo OntarioCanada

New solution concepts for n-decision maker conflicts based on generalized metarationalities for modelling possible human behaviour under conflict are proposed.A classification of these solution concepts,also called stability definitions,is presented both to simplify understanding and to illustrate important differences among different stability *** relationships among solution concepts are explored and new,more specific results are obtained in the comparison among existing stability concepts and the newly proposed *** informative example is used to demonstrate the applicability and insights of these solution concepts.

关键词： Graph model for conflict resolution generalized metarationalities stability criteria decisionmaking