检索结果-南通市图书馆

Role of N-form.l peptide receptor 2 in germ.nal m.trix hem.rrhage:an intrinsic review of a hem.tom. resolving pathway

引用

Neural Regeneration Research 2024年第2期19卷 350-354页

作者： Jerry flores Jiping Tang Departm.nt of Physiology&Pharm.cology Loma Linda University School of MedicineLoma LindaCAUSA

Germ.nal m.trix hem.rrhage is one of the leading causes of m.rbidity,m.rtality,and acquired infantile hydrocephalus in preterm.infants in the United States,with little progress m.de in its clinical m.nagem.nt.Blood clots have been shown to elicit secondary brain injury after germ.nal m.trix hem.rrhage,by disrupting norm.l cerebrospinal fluid circulation and absorption after germ.nal m.trix hem.rrhage causing post-hem.rrhagic hydrocephalus developm.nt.Current evidence suggests that rapid hem.tom. resolution is necessary to im.rove neurological outcom.s after hem.rrhagic stroke.Various articles have dem.nstrated the beneficial effects of stim.lating the polarization of m.croglia cells into the m. phenotype,as it has been suggested that they play an essential role in the rapid phagocytosis of the blood clot after hem.rrhagic m.dels of stroke.N-form.l peptide receptor 2(FPR2),a G-protein-coupled receptor,has been shown to be neuroprotective after stroke.FPR2 activation has been associated with the upregulation of phagocytic m.crophage clearance,yet its m.chanism.has not been fully explored.Recent literature suggests that FPR2 m.y play a role in the stim.lation of scavenger receptor CD36.Scavenger receptor CD36 plays a vital role in m.croglia phagocytic blood clot clearance after germ.nal m.trix hem.rrhage.FPR2 has been shown to phosphorylate extracellular-signal-regulated kinase 1/2(ERK1/2),which then prom.tes the transcription of the dual-specificity protein phosphatase 1(DUSP1)gene.In this review,we present an intrinsic outline of the m.in com.onents involved in FPR2 stim.lation and hem.tom. resolution after germ.nal m.trix hem.rrhage.

关键词： AnxA1 FPR2 Gm. hem.tom. resolution hem.rrhagic stroke m. m. m.croglia polarization m.croglia phagocytosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Did m.ize dom.stication and early spread m.diate the population genetics of corn leafhopper?

引用

Insect Science 2019年第3期26卷 569-586页

作者： Julio S. Bernal amanda m. davila-flores Raul F. m.dina Yolanda H. Chen Kyle E. Harrison Kim.erly A. Berrier Departm.nt of Entom.logy Texas A&M University College Station Texas USA Departm.nt of Plant and Soil Sciences University of Vermont Burlington Vermont USA

Investigating how crop dom.stication and early farm.ng m.diated crop attributes, distributions, and interactions with antagonists m.y shed light on today's agricultural pest problem.. Crop dom.stication generally involved artificial selection for traits desirable to early farm.rs, for exam.le, in creased productivity or yield, and enhanced qualities, though invariably it altered the interactions between crops and insects, and expanded the geographical ranges of crops. Thus, som. studies suggest that with crop dom.stication and spread, insect populations on wild crop ancestors gave rise to pestiferous insect populations on crops. Here, we addressed whether the em.rgence of corn leafhopper (Dalbulus m. id is) as an agricultural pest m.y be associated with dom.stication and early spread of m.ize (Zea m.ys m.ys). We used AFLP m.rkers and m.tochondrial COI sequences to assess population genetic structuring and haplotype relationships am.ng corn leafhopper sam.les from.m.ize and its wild relative Zea diploperennis from.m.ltiple locations in m.xico and Argentina. We uncovered seven corn leafhopper haplotypes contained within two haplogroups, one haplogroup containing haplotypes associated with m.ize and the other containing haplotypes associated with Z. diploperennis in a m.untainous habitat. Within the first haplogroup, one haplotype was predom.nant across m.xican locations, and another across Argentinean locations;both were considered pestiferous. We suggested that the divergence tim.s of the m.ize-associated haplogroup and of the "pestiferous" haplotypes are correlated with the chronology of m.ize spread following its dom.stication. Overall, our results support a hypothesis positing that m.ize dom.stication favored corn leafhopper genotypes preadapted for exploiting m.ize so that they becam. pestiferous, and that with the geographical expansi on of m.ize farm.ng, corn leafhopper colonized Z. diploperennis, a host exclusive to secluded habitats that serves as a refuge for archaic corn leafhopper genotypic diversity. B

关键词： Dalbulus m.idis haplotype network analysis perennial teosinte population genetic structuring Zea diploperennis Zea m.ys m.ys

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design,Synthesis,and Applications of m.soporous Covalent Organic Fram.works

引用

CCS Chem.stry 2024年第1期6卷 57-68页

作者： Niyati Arora Cassandra flores m.linda C.Senarathna Christina m.Thom.son Ronald A.Sm.ldone Departm.nt of Chem.stry and Biochem.stry University of TexasDallasRichardsonTexas 75080

Covalent organic fram.works(COFs)are highly ordered and perm.nently porous organic polym.rs that can be classified as two-dim.nsional or threedim.nsional.Their tunable design and crystalline order endow a range of pore sizes,shapes,functions,and applications that differentiate them.from.other polym.rs.The COF pore sizes and shapes rely on the geom.try of the m.nom.rs and dynam.c covalent chem.stry,while the stacking of the sheets relies on noncovalent interactions.Their tunability allows for post-m.dification or the incorporation of additional functional groups for the reinforcem.nt by various noncovalent interactions.The lim.ts of m.soporous COFs are still being investigated,with the design rules continuing to evolve.Here we report a com.rehensive review of m.soporous COFs,explore strategies for large pore reinforcem.nt,highlight structural design and features,elucidate their various functions and applications,discuss fundam.ntal challenges faced that need to be addressed,and predict future directions.

关键词： covalent organic fram.works m.soporous supram.lecular chem.stry polym.rs pore size

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pig Reproductive and Respiratory Syndrom. Virus (PRRSV) Does Not Attach to Boar Sperm.It Affects Only the Velocity Pattern and the m.bility Pattern

引用

Journal of Biosciences and m.dicines 2024年第4期12卷 216-228页

作者： Néstor m.ndez Palacios Netzi Naidí m.ndez Palacios Felicitas Vázquez flores José Alfredo Galicia Dom.nguez Edgar Guadalupe Beltrán Rosas m.xim.no m.ndez m.ndoza Facultad de m.dicina Veterinaria and Zootecnia-Benem.#233 rita Universidad Aut&#243noma de Puebla Puebla Mexico Independent Advisor in the Porcine Area Puebla Mexico

The purpose of the study was to evaluate the sperm.viability of sem.n infected with PRRSV viral particles, observing the effect of the Virus on the m.tility of boar sperm. The work was carried out at the Fm.Z-BUAP Genetics and Reproduction Laboratory. 5 stallions were used. Each sam.le contained 1 × 106 sperm. the PRRS virus strain was ATCC-VR-2332 (0, 102, 104 and 106 copies of RNA/m. in triplicate), it was observed daily at the CASA;Ham.lton Thorne®. Cells with m. (P m. between control and virus concentrations (P ≥ 0.05). The LCV on day 1 and 7 PI at 10X2 and 10X6 (P m.trix, where it is observed that there is a correlation between VSL and VAP, VSL and VCL, VCL and ALH, VAP with ALH. There is a correlation of VSL and ALH, STR and ALH. In this study there were (P ≤ 0.01) in the VCL, in the concentrations (102) 162.81 ± 10.65 and (106) 177.12 ± 5.77 vs 193.04 ± 4.62 of control. This indicates that altering these param.ters would be related to fertility and the PRRS virus affects the LCV. Regarding the VSL, it was observed that the sperm.infected with viruses 102, 104 and 106 of 48.00 ± 3.38, 49.88 ± 1.83 and 50.55 ± 2.24 Vs. 56.66 ± 1.68 of control respectively, the control would have greater possibilities of fertilizing the oocyte. In this study, it was found (P ≤ 0.01) in the VAP with 102 of 77.26 ± 5.16, 104 with 83.35 ± 2.41 and 106 with 81.29 ± 3.14 vs the control with 90.56 ± 2.07. Regarding the ALH there is (P 4 with 8.70 ± .26 and 106 with 9.64 ± 0.23 vs control 8.50 ± 0.27. The presence of different concentrations of PRRSV in boar sem.n induces changes in different types of sperm.m.tility. Infection of ejaculates with the PRRS virus affects sperm.m.til

关键词： PRRSV Boar Sperm. Velocity Pattern and m.bility Pattern

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Vegetation Response To Soil And m.rphological Properties In An Arid Region Alluvial Fan Landscape. Pre-Andes Of San Juan， Argentina

引用

Journal of Earth Science 2024年

作者： flores Daniel Germ.n OCA?A Raúl Em.anuel m.LIáN Edgardo ORTEG Andrés ESPER ANGILLIERI m.ría Yanina PITTALUGA m.ría Alejandra CIGEOBIO (CONICET-UNSJ) Av.José I.de la Roza y m.glioli Gabinete de Geología Am.iental INGEO Universidad Nacional de San Juan Av.José I.de la Roza y m.glioli

The m.nte Desert is characterized by a great diversity of landform. created with fluvial， alluvial which the vegetation patterns are related to. The present work has the following objectives: 1: determ.ne whether topographical attributes， surface characteristics， soil properties and vegetation patterns vary between alluvial landform.， and 2: define whether m.rphom.tric， soil and surface properties influence vegetation patterns along alluvial landscape. m.rphom.tric data were obtained by processing a 5 m.digital elevation m.del. The coverage of rock fragm.nts， fine sedim.nts and m.lch was quantified. Observations and descriptions of the soil profiles were restricted to the upperm.st 50 cm. Vegetation properties were calculated using a Point Quadrat m.thod. The relationship between variables was evaluated through m.ltivariate statistical analysis. The m.in results show the presence of 45 plant species distributed in 19 fam.lies， where shrubs are dom.nant. The wind effect， topographic wetness and dissection of the landscape are lim.ting factors of diversity. The coverage of superficial rock fragm.nts influence vegetation coverage through the distribution and availability of rainwater. Furtherm.re， the different soil textures reveal that the silt content favors an increase in vegetation coverage. The presence of V horizon could condition the installation and developm.nt of vegetation in the early stages of growth.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

C19m. m.RNA-520G induces SP100 antiviral gene transcription and inhibits m.lanin production in skin cutaneous m.lanom.

引用

Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh m.rian T.Sm.llin Nino m.chedlidze Isha Godwin m.rco Napoli Nicole Hackel m.nali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao m.chelle A.Reiser Keiran S.m.Sm.lley Elsa R.flores Andrew S.Brohl Departm.nt of m.lecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA m.lecular m.dicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha m.dical College ChennaiTamil Nadu 602105India Tum.r Biology Departm.nt H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcom. Departm.nt H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein that restricts the productive stage of hum.n papillom.virus(HPV)and m.ltiple other viruses,and viruses in turn block sUm.-1-m.diated stabilization of SP100 and prom.tes its degradation(Table S1).Interferon(IFN)signaling could still produce m.re SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts.

关键词： SP100 m.lanom. stabilization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dendritic spine degeneration:a prim.ry m.chanism.in the aging process

引用

Neural Regeneration Research 2025年第6期 1696-1698页

作者： Gonzalo flores Leonardo Aguilar-Hernández Fernado García-Dolores Hum.erto Nicolini Andrea Judith Vázquez-Hernández Hiram.Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla (BUAP) Instituto de Ciencias Forenses (INCIFO) Tribunal Superior de Justicia de la Ciudad de México (TSJCDMX) Instituto Nacional de m.dicina Genóm.ca (INm.GEN)

Recent reports suggest that aging is not solely a physiological process in living beings; instead, it should be considered a pathological process or disease(Am.rim.et al., 2022). Consequently, this process involves a wide range of factors, spanning from.genetic to environm.ntal factors, and even includes the gut m.crobiom.(Gm.(m.yer et al., 2022). All these processes coincide at som. point in the inflam.atory process, oxidative stress, and apoptosis, at different degrees in various organs and system. that constitute a living organism.m.yer et al., 2022; AguilarHernández et al., 2023).

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Com.etencies in Com.uter Security and Resolution of Technological Problem. in Higher Education Students

引用

Journal of Com.uter and Com.unications 2024年第4期12卷 171-185页

作者： Esteban Pérez flores Alejandra Aldrette m.lacara Sandra R. m.rillo Cano Vittorio Zanella Palacios Facultad de Ciencias Adm.nistrativas Universidad Aut&#243noma de Baja California Mexicali M&#233xico Decanato de Ingenierí as Universidad Popular Aut&#243noma Del Estado de Puebla Puebla M&#233xico

Starting from.the im.ortance of preserving our inform.tion and protecting our devices against attacks on their vulnerabilities, this article aim. to establish the level of knowledge in com.uter security and problem.solving of students at a university in northwest m.xico. This research has a quantitative approach where the European Fram.work of Digital Com.etencies for Citizenship was used as a reference to identify and establish the level of the com.etencies that were evaluated. The IKANOS Test was used as a data collection tool. The results show that students know the im.ortance of keeping their devices safe and how valuable the inform.tion found on them.is. On the other hand, the results also show a considerable percentage of students who do not have the knowledge and are at a basic level of knowledge to solve technical problem. with their devices.

关键词： Digital Literacy Cybersecurity DigCom. Digital Skills Data Protection

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Transperineal laser ablation of the prostate as a treatm.nt for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

引用

Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci m.rta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielm. m.nenti Gianluca m.to Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.m.Salam.nca m.tteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora m.rchiori Hugo davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo m.De Reijke Vito Ricapito Pierluca Pellegrini Andrea m.nervini Sergio Serni Francesco Sessa Departm.nt of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Departm.nt of Urology San Carlo di Nancy HospitalRomeItaly Departm.nt of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly Departm.nt of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departem.nt of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Hum.nitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly Departm.nt of Biom.dical Sciences Humanitas UniversityPieve EmanueleItaly Departm.nt of Biom.dicine and Prevention University of Rome“Tor Vergata”RomeItaly Departm.nt of Diagnostic Im.ging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly Departm.nt of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly Departm.nt of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland Departm.nt of Urology University of CataniaItaly Departm.nt of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain Departm.nt of m.dico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly Departm.nt of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Departm.nt of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatm.nt for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus m.thod.m.thods: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatm.nt of BPH and PCa answering online questionnaires on indications, m.thodology, and potential com.lications of this technology. Level of agreem.nt or disagreem.nt to reach consensus was set at 75%. If the consensus was not achieved, questions were m.dified after each round. A final round was perform.d during an online m.eting, in which results were discussed and finalized.Results: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreem.nt was achieved on recom.ending Echolaser® TPLA as a treatm.nt of BPH in patients with am.le range of prostate volum., from.m. (80%) to >80 m. (80%), com.rbidities (100%), antiplatelet or anticoagulant treatm.nt (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). m.jority of respondents agreed that Echolaser® TPLA is a potential option for the treatm.nt of localized PCa (78%) and recom.ended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for interm.diate-risk PCa and it should be proposed as an effective alternative to radical prostatectom. for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Alm.st all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreem.nt am.ng experts). Pre-procedural assessm.nt, technical aspects, post-procedural catheterization, pharm.cological therapy, and expected outcom.s were discussed, leading to statem.nts and recom.endations.Conclusion: Ech

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of Angiotensin II on α₁-Adrenergic Receptors Function in Rat Aorta and Expression in Vascular Sm.oth m.scle Cells

引用

Journal of Biosciences and m.dicines 2024年第4期12卷 123-134页

作者： Itzell Alejandrina Gallardo-Ortíz Juan Pablo de Jesús Benítez-Garrido Santiago C. Sigrist-flores Juan Javier López-Guerrero Enrique Hong Rafael Villalobos-m.lina Unidad de Biom.dicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Carrera de Enferm.rí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Departam.nto de Farm.cobiologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico Carrera de m.#233 dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

Angiotensin II (Ang II) is the m.in m.diator of the Renin-Angiotensin-System.acting on AT1 and other AT receptors. It is regarded as a pleiotropic agent that induces m.ny actions, including functioning as a growth factor, and as a contractile horm.ne, am.ng others. The aim.of this work was to exam.ne the im.act of Ang II on the expression and function of α1-adrenergic receptors (α1-ARs) in cultured rat aorta, and aorta-derived sm.oth m.scle cells. Isolated Wistar rat aorta was incubated for 24 h in Dm.m.at 37˚C, then subjected to isom.tric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10−5 m., and in som. experim.nts, 5-m.thylurapidil (α1A-AR antagonist), AH11110A (α1B-AR antagonist), or Bm.-7378 (α1D-AR antagonist), were used to identify the α1-AR involved in the response. Desensitization of the contractile response to norepinephrine was observed due to incubation tim., and by the Ang II action. α1D-AR was protected from.desensitization by Bm.-7378;while RS-100329 and prazosin partially m.tigated desensitization. In another set of experim.nts, isolated aorta-derived sm.oth m.scle cells were exposed to Ang II and α1-ARs proteins were evaluated. α1D-AR increased at 30 and 60 m.n post Ang II exposure, the α1A-AR dim.nished from.1 to 4 h, while α1B-AR rem.ined unchanged over 24 h of Ang II exposure. Ang II induced an increase of α1D-AR at short tim.s, and Bm.-7378 protected α1D-AR from.desensitization.

关键词： Angiotensin II α1D-AR α1-AR Expression Rat aorta Sm.oth m.scle Cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：