检索结果-南通市图书馆

Blood-brain barrier pathology in cerebral small vessel disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1233-1240页

作者： Ruxue Jia Gemma Solé-Guardia amanda J.Kiliaan Department of Medical Imaging AnatomyRadboud University Medical CenterDonders Institute for BrainCognition&BehaviorCenter for Medical NeurosciencePreclinical Imaging Center PRIMERadboud Alzheimer CenterNijmegenthe Netherlands

Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the *** at first it was considered innocuous,small vessel disease is nowadays regarded as one of the major vascular causes of *** signs of small vessel disease include small subcortical infarcts,white matter magnetic resonance imaging hyperintensities,lacunes,enlarged perivascular spaces,cerebral microbleeds,and brain atrophy;however,great heterogeneity in clinical symptoms is observed in small vessel disease *** pathophysiology of these lesions has been linked to multiple processes,such as hypoperfusion,defective cerebrovascular reactivity,and blood-brain barrier ***,studies on small vessel disease suggest that blood-brain barrier dysfunction is among the earliest mechanisms in small vessel disease and might contribute to the development of the hallmarks of small vessel ***,the purpose of this review is to provide a new foundation in the study of small vessel disease ***,we discuss the main structural domains and functions of the blood-brain ***,we review the most recent evidence on blood-brain barrier dysfunction linked to small vessel ***,we conclude with a discussion on future perspectives and propose potential treatment targets and interventions.

关键词： blood-brain barrier dysfunction cerebral blood flow cerebral hypoperfusion endothelial dysfunction hypertension inflammation magnetic resonance imaging neurovascular unit oxidative stress small vessel disease tight junctions transcytosis

Commentary on “Does light-intensity physical activity moderate the relationship between sitting time and adiposity markers in adolescents?”

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第4期13卷 453-454页

作者： Barbara E.Ainsworth amanda M.Ferland School of Exercise and Health Shanghai University of SportShanghai 200433China Department of Orthopedics Tongji UniversityShanghai 200092China

In the September 2022 issue of the Journal of Sport and Health Science,Ayala et al.1 published results from a cross-sectional study where they tested the hypothesis that light intensity physical activity(LIPA,1.6-2.9 metabolic equivalents(METs))moderates the relationship between sitting time and adiposity in 219 Australian adolescents aged 14±1.6 years(mean±SD).

关键词： metabolic light

The Meat of the Matter: Plant-Based Meat Analogue versus Traditional Meat Product Nutritional Quality

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Arshia Shireen amanda J Wright Department of Human Health and Nutritional Sciences， University of Guelph Guelph， Ontario， Canada bDepartment of Human Health and Nutritional Sciences， University of Guelph Guelph， Ontario， Canada

Plant-based meat analogues (PBMA) are formulated to mimic the sensory characteristics of traditional meat products (TMP) using vegetarian ingredients and are increasingly popular with the trend towards plant-based diets， even among meat-eating consumers. This narrative review compared the nutritional quality of PBMA and TMP to broaden the discussion on the suitability of simulated meat products to substitute TMP， while exploring other attributes for their comparison. The complexity of PBMA and TMP means they are not entirely interchangeable. Importantly， PBMA health effects extend beyond their basic nutrient content and quality. Postprandial metabolism and satiety， for example， can be affected by product formulation， ingredient interactions， and thermomechanical processing involved in producing organoleptically acceptable PBMA. There are specific opportunities for low-sodium PBMA products to contribute to a healthy shift toward plant-based diets. In conclusion， PBMA cannot be assumed to be healthier than TMP. They should be designed with comprehensive consideration of composition and processing to ensure they support consumers who are adopting plant-based diets in realizing the theoretical health benefits.

关键词：

Prognosis value of heat-shock proteins in esophageal and esophagogastric cancer:A systematic review and meta-analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1578-1595页

作者： Eric Toshiyuki Nakamura amanda Park Marina Alessandra Pereira Daniel Kikawa Francisco Tustumi Department of Gastroenterology Instituto do CâncerHospital das Clínicas da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Scientific Initiation Universidade Mogi das CruzesSão Paulo 08780911Brazil Department of Evidence-Based Medicine Centro Universitário LusíadaCentre for Evidence-Based MedicineCentro Universitário Lusíada(UNILUS)SantosBrazil Department of Surgery Hospital Israelita Albert EinsteinSão Paulo 05652900Brazil

BACKGROUND Heat shock proteins(HSPs)are molecular chaperones that play an important role in cellular protection against stress events and have been reported to be overex-pressed in many *** prognostic significance of HSPs and their regulatory factors,such as heat shock factor 1(HSF1)and CHIP,are poorly *** To investigate the relationship between HSP expression and prognosis in esophageal and esophagogastric *** A systematic review was conducted in accordance with PRISMA recommend-ations(PROSPERO:CRD42022370653),on Embase,PubMed,Cochrane,and ***,case-control,and cross-sectional studies of patients with eso-phagus or esophagogastric cancer were ***-positive patients were compared with HSP-negative,and the endpoints analyzed were lymph node metastasis,tumor depth,distant metastasis,and overall survival(OS).HSPs were stratified according to the HSP family,and the summary risk difference(RD)was calculated using a random-effect *** The final selection comprised 27 studies,including esophageal squamous cell carcinoma(21),esophagogastric adenocarcinoma(5),and mixed neoplasms(1).The pooled sample size was 3465 ***40 and 60 were associated with a higher 3-year OS[HSP40:RD=0.22;95%confidence interval(CI):0.09-0.35;HSP60:RD=0.33;95%CI:0.17-0.50],while HSF1 was associated with a poor 3-year OS(RD=-0.22;95%CI:-0.32 to-0.12).The other HSP families were not associated with long-term ***1 was associated with a higher probability of lymph node metastasis(RD=-0.16;95%CI:-0.29 to-0.04).HSP40 was associated with a lower probability of lymph node dissemination(RD=0.18;95%CI:0.03-0.33).The expression of other HSP families was not significantly related to tumor depth and lymph node or distant *** The expression levels of certain families of HSP,such as HSP40 and 60 and HSF1,are associated with long-term survival and lymph node dissemination in patients with esophageal and esophagogastric cancer.

关键词： Heat-shock proteins Heat-shock response Prognosis Esophageal neoplasms Meta-analysis

Validity and Reliability of a Mental Health Recovery Checklist for Young Adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mental Health Promotion 2024年第4期26卷 317-323页

作者： Brianna Cerrito Jamie Xiao Amie DiTomasso amanda Fialk Jocelyn Bolin Research Department The DormNew York10023USA Department of Educational Psychology Ball State UniversityMuncie47306USA

The purpose of the present study is to evaluate the internal consistency and construct validity of a self-report checklist measuring clinical mental health recovery across six key domains:family and relationships,occupation and school,physical health,mental health,spirituality,and social support *** Mental Health Recovery Checklist(MHRC)was developed at The Dorm,an intensive outpatient mental health treatment program for young adults in New York,NY,and Washington DC that services individuals between the ages of 18 and 35 years *** present study is cross-sectional,as data were pulled from clients’records who were discharged between January 2018 and May *** Correlations and Cronbach’s alpha were used to determine scale *** establish validity,an Exploratory Factor Analysis(EFA)was conducted to assess a single-factor model using Principal Axis ***’s alpha was high(α=0.88),indicating good *** the EFA,all items loaded strongly on a single *** unidimensional structure revealed in the EFA highlights the interconnected nature of various life domains as they pertain to mental health recovery in young *** research is warranted to explore whether there are additional dimensions of mental health recovery that have not been assessed in the present scale.

关键词： Mental health recovery young adult validation study mental health checklist

Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2024年第9期15卷 661-685页

作者： Sadaf Hasan Nabil Ghani Xiangli Zhao Julia Good amanda Huang Hailey Lynn Wrona Jody Liu Chuan-ju Liu Department of Orthopedic Surgery New York University Grossman School of MedicineNew YorkNY 10016United States Department of Medicine Division of Internal MedicineSaint Peter’s University HospitalRutgers UniversityNew BrunswickNJ 08901United States Cornell University IthacaNew YorkNYUnited States Department of Biomedical Engineering University of North Carolina Chapel HillChapel HillNC 27599United States New York University NY 14853United States Department of Cell Biology New York University Grossman School of MedicineNew YorkNY 10016United States Department of Orthopedics&Rehabilitation Yale University School of MedicineNew HavenCT 06510United States

Obesity has a multifactorial etiology and is known to be a state of chronic low-grade inflammation,known as *** state is associated with the development of metabolic disorders such as glucose intolerance and nonalcoholic fatty liver *** is a glycolytic metabolite and a crucial node in various metabolic ***,its role and molecular mechanism in obesity and associated complications are *** this study,we reported that pyruvate substantially inhibited adipogenic differentiation in vitro and its administration significantly prevented HFD-induced weight gain,white adipose tissue inflammation,and metabolic *** identify the target proteins of pyruvate,drug affinity responsive target stability was employed with proteomics,cellular thermal shift assay,and isothermal drug response to detect the interactions between pyruvate and its molecular ***,we identified cytosolic phospholipase A2(cPLA2)as a novel molecular target of pyruvate and demonstrated that pyruvate restrained diet-induced obesity,white adipose tissue inflammation,and hepatic steatosis in a cPLA2-dependent *** with global ablation of cPLA2 in mice showed that the protective effects of pyruvate were largely abrogated,confirming the importance of pyruvate/cPLA2 interaction in pyruvate attenuation of inflammation and ***,our study not only establishes pyruvate as an antagonist of cPLA2 signaling and a potential therapeutic option for obesity but it also sheds light on the mechanism of its ***’s prior clinical use indicates that it can be considered a safe and viable alternative for obesity,whether consumed as a dietary supplement or as part of a regular diet.

关键词： metabolic disease pyruvate cytosolic phospholipase obesity

Metal-Halide Perovskite Submicrometer-Thick Films for Ultra-Stable Self-Powered Direct X-Ray Detectors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第9期16卷 410-431页

作者： Marco Girolami Fabio Matteocci Sara Pettinato Valerio Serpente Eleonora Bolli Barbara Paci amanda Generosi Stefano Salvatori Aldo Di Carlo Daniele M.Trucchi CNR‑ISM Consiglio Nazionale delle RicercheIstituto di Struttura della MateriaSede Secondaria di MontelibrettiDiaTHEMA LabStrada Provinciale 35D900010 MontelibrettiRomeItaly CHOSE–Centre for Hybrid and Organic Solar Energy Department of Electronic EngineeringUniversity of Rome“Tor Vergata”Via del Politecnico 100133 RomeItaly Faculty of Engineering Universita degli Studi Niccolo CusanoVia don Carlo Gnocchi 300166 RomeItaly SpecXLab CNR‑ISMConsiglio Nazionale Delle RicercheIstituto di Struttura Della MateriaArea della Ricerca di Tor VergataVia del Fosso del Cavaliere 10000133 RomeItaly

Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective ***-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin ***,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection *** it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent *** structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin *** addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”***,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

关键词： Metal-halide perovskite thin films Direct X-ray detectors Self-powered devices Operational stability Medical linear accelerator

The use of Vis-NIR-SWIR spectroscopy in the prediction of soil available ions after application of rock powder

在线全文

学校读者我要写书评

暂无评论

Information Processing in Agriculture 2024年第1期11卷 26-44页

作者： Marlon Rodrigues Josiane Carla Argenta Everson Cezar Glaucio Leboso Alemparte Abrantes dos Santos ÖnderÖzal amanda Silveira Reis Marcos Rafael Nanni Department of Agronomy State University of MaringáColombo AvenueMaringá87020900Brazil Department of Plant and Soil Sciences Mississippi State UniversityMS 39762USA International Agricultural Research and Training Center Izmir 35660Turkey

Some of the problems attributed to traditional laboratory analyses that limit the correct assessment of the nutrient contents in the soil are time requirements and high cost of the soil nutrient *** solve these problems,a study was carried out to evaluate the use of visible,near-infrared,and short-wave infrared(Vis-NIR-SWIR)spectroscopy in the prediction of soil available ions submitted to the application of rock *** study was carried out on an Arenosol in ParanavaíCity/***(rock powders)were arranged within a split-plot system designed in randomized blocks with four *** was cultivated for 14 months after the application of rock ***,96 soil samples were collected for measuring the pH and available ions P,K^(+),Ca^(2+),Mg^(2+),S-SO_(4)^(2-),Si,Cu^(2+),Fe^(2+),Mn^(2+),and Zn^(2+)as well as spectral reading through a Vis-NIR-SWIR spectroradiometer to predict the soil chemical attributes through the partial least square regression(PLS)*** results showed that the elements K^(+),Ca^(2+),Mg^(2+),Cu^(2+),and Fe^(2+)could be predicted with a reasonable rightness degree(R^(2)_(p)>0.50,RPDp>1.40)from spectral ***,for the attributes pH,P,S-SO_(4)^(2-),Si,Mn^(2+),and Zn^(2+),there were no satisfactory models(R^(2)_(p)<0.50,RPDp<1.40).Thus,the application of rock powder changed the spectral curves and,because of that,allows the building of PLS models to predict the elements K^(+),Ca^(2+),Mg^(2+),Cu^(2+),and Fe^(2+).Therefore,Vis-NIR-SWIR spectroscopy is a promising alternative to the routine analyses of soil fertility since it has advantages such as fast analytical speed,low cost,easy to operate,non-destructive,and environmentally friendly,because it does not use harmful chemicals.

关键词： Alternative inputs Available Ions Multivariate analysis Soil Spectroscopy

Importance of Stewards and Other Protection Efforts for Conservation of Red Knots (Calidris canutus rufa) and Other Shorebirds on Delaware Bay, New Jersey

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2024年第9期16卷 162-182页

作者： Joanna Burger amanda Dey Larry Niles Division of Life Sciences Rutgers University Piscataway NJ USA Wildlife Restoration Partnerships 109 Market Lane Greenwich NJ USA

Understanding the factors that contribute to population stability in long-distance migrant birds is increasingly important, particularly given global climate change, sea level rise, and loss or disturbance at essential habitats. While the populations of most shorebirds are declining worldwide, those that migrate through Delaware Bay, New Jersey and Delaware, are declining at the most rapid rate despite conservation efforts. In this paper, we 1) provide background information on population declines of red knots (Calidris canutus rufa) using Delaware Bay, threats to their foraging, and efforts to reduce threats, 2) summarize briefly our studies of the effects of human activities on knots and other shorebirds, 3) present data on management efforts to protect knots and other shorebirds from the activities of people, and 4) discuss the efficacy of such efforts (usually referred to as “decreasing the effect of human disturbances”). The Shorebird Project on Delaware Bay is over 25 years old and provides long-term data to help assess the status of shorebird numbers, particularly for red knot, as well as the density of horseshoe crabs (Limulus polyphemus) and their eggs. Red knots have continued to decline even more precipitously in the last few years, presenting cause for concern. Protective efforts have been successful in reducing human disruption on the N.J. Delaware Bay beaches, but the lack of uniformity in implementation across the New Jersey side, and across the whole Bay have hampered further improvements. Implementation of signs, fencing, and stewards on some beaches significantly enhanced the use of these beaches by red knots, determined by examining the use of beaches pre- and post-implementation. Implementation of fencing and stewards had the greatest effect. From 1986 to 2018, there was a significant shift in the percent of Delaware Bay red knots using the NJ side, where protection efforts had been implemented on many of the beaches. Merely restricting access (w

关键词： Red Knot Calidris canutus rufa Conservation Beach Monitors Human Disturbance Habitat Restoration Management Stewards Education Population Declines Coastal