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Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens

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Plant Communications 2024年第1期5卷 55-68页

作者： Antoni garcia-Molina Victoria Pastor Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB C/Vall MorontaEdifici CRAG08193 Bellaterra(Cerdanyola del Valles)BarcelonaSpain Department of Biology Biochemistryand Natural SciencesSchool of Technology and Experimental SciencesUniversitat Jaume I12006 Castellode la PlanaSpain

Understanding plant immune responses is complex because of the high interdependence among biological processes in homeostatic ***,the integration of environmental cues causes network rewiring that interferes with defense ***,plants retain molecular signatures configured under abiotic stress periods to rapidly respond to recurrent stress,and these can alter *** changes imposed by abiotic stressors are persistent,although their impact on defense remains to be *** this study,we profiled metabolomes of Arabidopsis plants under several abiotic stress treatments applied individually or simultaneously to capture temporal trajectories in metabolite composition during adverse conditions and *** systemic analysis was performed to address the relevance of me-tabolome changes and extract central features to be tested in *** results demonstrate irreversibility in major fractions of metabolome changes as a general pattern in response to abiotic stress ***-tionalanalysisofmetabolomesandco-abundancenetworkspoints toconvergence inthereconfigurationof organic acid and secondary metabolite *** mutant lines for components related to these metabolic pathways showed altered defense capacities against different ***,our data suggest that sustained metabolome changes configured in adverse environments can act as mod-ulators of immune responses and provide evidence for a new layer of regulation in plant defense.

关键词： abiotic stress Arabidopsis biotic stress combinatorial stress metabolomics systems biology

Empagliflozin reduces brain pathology in Alzheimer's disease and type 2 diabetes

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Neural Regeneration Research 2024年第6期19卷 1189-1190页

作者： Carmen Hierro-Bujalance Monica garcia-Alloza Division of Physiology School of MedicineUniversidad de CadizCadizSpain Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz(INIBICA) CadizSpain Salus Infirmorum-Universidad de Cadiz CadizSpain

Alzheimer's disease(AD)and type 2 diabetes(T2D):More than 55 million people suffer from dementia,and it is expected that over 150 million people will suffer from this disease by *** is the most common type of dementia and while aging remains the main risk factor to suffer it,previous studies have also shown that metabolic disorders,and T2D specifically,are also major contributors(Wang et al.,2012).

关键词： Alzheimer diabetes

Oxidative dissolution of Cr(OH)_(3) and mixed Fe-Cr(Ⅲ)phases by aqueous Mn(Ⅲ)-pyrophosphate complex

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Journal of Environmental Sciences 2024年第5期139卷 105-113页

作者： Mismel Ruiz-garcia Jordan Stanberry Giovanna Ballerini Ribeiro Vasileios Anagnostopoulos Department of Chemistry University of Central FloridaOrlando FL 32816USA

The key role of manganese(Mn)in the biogeochemical cycle of trace elements has been of great interest in recent ***,the redox properties of aqueous Mn(Ⅲ)have been studied to a lesser ***(Ⅲ)is not stable in solution by ***,when complexed with inorganic ligands,it has shown potential to oxidize and reduce trace *** the present study,we are exploring the redox characteristics of the complex Mn(Ⅲ)-Pyrophosphate(Mn(Ⅲ)-PP).This complex is stable over a wide range of pH values but requires the ratio of Mn:PP to be less than 1:***,the redox reaction of chromium(Cr(Ⅲ))and Mn(Ⅲ)-PP is investigated.A solid,Cr(OH)_(3),is used as a source of Cr(Ⅲ).For this reaction,environmentally relevant parameters,such as pH,ionic strength,ratio Mn(Ⅲ)/Cr(Ⅲ),and excess of ligand,were *** showed that Mn(Ⅲ)can effectively oxidize Cr(Ⅲ)to Cr(Ⅵ),taking about 15 days for the reaction to *** reaction occurs only under acidic conditions(pH4),and with a low excess of *** initial Mn(Ⅲ)concentration decreases as the Cr(Ⅵ)is produced,and Cr(Ⅵ)can be adsorbed back into the Cr(OH)_(3)surface,limiting the mobility of this toxic *** this adsorption,significant amounts of Cr(VI)are release in the aqueous *** study shows the importance of a mobile species(Mn-PP complex)in the oxidation of Cr(Ⅲ)and the release of Cr(Ⅵ)to the environment.

关键词： Chromium Manganese Pyrophosphate complex Sorption Ionic strength Redox

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina Lam Carlos garcia-Esperon Yash Gawarikar Ronak Patel Matthew Lee-Archer Andrew Wong Michael Roizman amanda Gilligan Andrew Lee Kee Meng Tan Susan Day Christopher Levi Stephen M Davis Mark Parsons Bernard Yan Melbourne Brain Centre at Royal Melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of Medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1month in patients commenced on early(5mL,regardless of anticoagulation *** Commencing anticoagulation<4days after stroke or TIA is associated with fewer ischaemic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑garcia Laura Morales‑Fernandez Javier garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

Anti-methanogenic potential of seaweeds and seaweed-derived compounds in ruminant feed:current perspectives,risks and future prospects

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Journal of Animal Science and Biotechnology 2024年第2期15卷 463-489页

作者： Ailbhe McGurrin Julie Maguire Brijesh K.Tiwari Marco garcia-Vaquero Section of Food and Nutrition School of Agriculture and Food ScienceUniversity College DublinDublin 4BelfieldIreland TEAGASC Food Research CentreDublin 15AshtownIreland Bantry Marine Research Station Ltd BantryCo.CorkP75 AX07GearhiesIreland

With methane emissions from ruminant agriculture contributing 17%of total methane emissions worldwide,there is increasing urgency to develop strategies to reduce greenhouse gas emissions in this *** of the proposed strategies is ruminant feed intervention studies focused on the inclusion of anti-methanogenic compounds which are those capable of interacting with the rumen microbiome,reducing the capacity of ruminal microorganisms to produce ***,seaweeds have been investigated for their ability to reduce methane in ruminants in vitro and in vivo,with the greatest methane abatement reported when using the red seaweed Asparagopsis taxiformis(attributed to the bromoform content of this species).From the literature analysis in this study,levels of up to 99%reduction in ruminant methane emissions have been reported from inclusion of this seaweed in animal feed,although further in vivo and microbiome studies are required to confirm these results as other reports showed no effect on methane emission resulting from the inclusion of seaweed to basal *** review explores the current state of research aiming to integrate seaweeds as anti-methanogenic feed additives,as well as examining the specific bioactive compounds within seaweeds that are likely to be related to these *** effects of the inclusion of seaweeds on the ruminal microbiome are also reviewed,as well as the future challenges when considering the largescale inclusion of seaweeds into ruminant diets as anti-methanogenic agents.

关键词： Asparagopsis Bromoform Methanogenesis Phlorotannin Saponin Tannin

Impact of surface roughness on the coefficient of friction of polymer-on-polymer contacts for deflection pulley-rope systems in the lift industry

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Friction 2024年第9期12卷 2126-2138页

作者： Ainhoa GUINEA Andrea AGINAGALDE Wilson TATO Iñigo LLAVORI Pablo garcia Leire ARRAIAGO Alaitz ZABALA Mechanical and Industrial Production Department Mondragon UnibertsitateaMondragon 20500Spain Orona EIC Orona IdeoHernani 20120Spain

The coefficient of friction(CoF)between the deflection pulley and rope in a lift strongly affects the life span of the *** surface roughness is a key factor affecting the metallic pulley–rope CoF,its effect on polymeric pulleys is *** present study analyses the effect of roughness and working conditions on cast polyamide 6(PA6G)deflection pulley–thermoplastic polyurethane(TPU)-coated rope *** statistical analysis revealed that the effect of surface roughness on the CoF for low-load tests was *** present study contributes significantly to parameter selection in deflection pulley machining to minimise friction between the pulley and rope.

关键词： polymer-on-polymer friction roughness dry sliding

Charting the course to solid-state dual-ion batteries

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Carbon Energy 2024年第3期6卷 132-177页

作者： Habtom D.Asfaw Antonia Kotronia Nuria garcia-Araez Kristina Edström Daniel Brandell Department of Chemistry Ångström LaboratoryUppsala UniversityUppsalaSweden Department of Chemistry University of SouthamptonSouthamptonUK

An electrolyte destined for use in a dual-ion battery(DIB)must be stable at the inherently high potential required for anion intercalation in the graphite electrode,while also protecting the Al current collector from anodic dissolution.A higher salt concentration is needed in the electrolyte,in comparison to typical battery electrolytes,to maximize energy density,while ensuring acceptable ionic conductivity and operational *** recent years,studies have demonstrated that highly concentrated organic electrolytes,ionic liquids,gel polymer electrolytes(GPEs),ionogels,and water-in-salt electrolytes can potentially be used in *** can help reduce the use of solvents and thus lead to a substantial change in the Coulombic efficiency,energy density,and long-term cycle life of ***,GPEs are suited to manufacture compact DIB designs without separators by virtue of their mechanical strength and electrical *** this review,we highlight the latest advances in the application of different electrolytes in DIBs,with particular emphasis on GPEs.

关键词： anion intercalation concentrated electrolytes dual-ion battery graphite ionic liquids polymer electrolyte

Thermoluminescence characterization of natural and synthetic irradiated Ce-monazites

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Journal of Rare Earths 2024年第4期42卷 643-650页

作者： V.Correcher C.Boronat J.garcia-Guinea J.F.Benavente T.Rivera-Montalvo CIEMAT Av.Complutense 4028040MadridSpain MNCN-CSIC J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The thermoluminescence(TL)emission of synthetic and natural Ce-monazites was characterized here to determine the potential application in the identification of microscopic defects from a qualitative point of view trying to link each TL peak to a chemical-physical *** kinetic parameters that lead the luminescence processes were calculated by means of variable heating rate and computing glow curve deconvolution methods and allow identifying three groups of components at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthetic CePO_(4):Nd_(0.20),La_(0.25)).The main differences appreciated in these complex TL curves are mainly due to(i)the content of impurities(natural sample contains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degree of crystallinity of the samples which is directly related to the type of impurities(synthetic monazite relies only on Nd and La).The behavior of the dose response in the range of 1-8 Gy is similar for both samples;the TL intensity increases linearly as the dose increases without changes in the position of the maxima,denoting first-order kinetic luminescence *** peak could be mostly associated with structural defects(i.e.,phase transitions),chemical reactions(i.e.,Ce3+?Ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic defects(i.e.,Frenkel defects,ODCs or NBOHCs).

关键词： Thermoluminescence Kineticparameters Phosphate Ce-monazite Defects Rare earths