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Dynamical changes in hydration water accompanying lysozyme thermal denaturation

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Frontiers of physics 2015年第5期10卷 35-41页

作者： Francesco Mallamace Carmelo Corsaro Domenico Mallamace Nicola Cicero Sebastiano Vasi Giacomo Dugo H. Eugene stanley CNR-IPCF Messina Istituto per i Processi Chimico-Fisici Viale F. Stagno D'Alcontres 37 98158 Messina Italy Dipartimento di Fisica e Scienze della Terra Universitd di Messina Viale F. Stagno D'Alcontres 31 98166 Messina Italy Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA Dipartimento di Scienze dell'Ambiente della Sicurezza del Territorio degli Alimenti e della Salute Universita di Messina Viale F. Stagno d'Alcontres 31 98166 Messina Italy

We study the dynanfics of the first hydration shell of lysozyme to determine the role of hydra- tion water that accompanies lysozyme thermal denaturation. We use nuclear magnetic resonance spectroscopy to investigate both the translational and rotational contributions. Data on proton self-diffusion and reorentational correlation time indicate that the kinetics of the lysozyme fold- ing/unfolding process is controlled by the dynamics of the water molecules in the first hydration shell. When the hydration water dynamics change, because of the weakening of the hydrogen bond network, the three-dimensional structure of the lysozyme is lost and denaturation is triggered. Our data indicates that at temperatures above approximately 315 K, water behaves as a simple liquid and is no longer a good solvent.

关键词： lysozyme unfolding hydration water NMR correlation time solvent dynamics

Comparison of TRMM and Water District Rain Rates over New Mexico

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Advances in Atmospheric Sciences 2006年第1期23卷 1-13页

作者： Long S. CHIU Zhong LIU Jearanai VONGSAARD stanley.MORAIN Amy BUDGE Paul NEVILLE Chandra BALES NASA/Goddard Space Flight Center Distributed Active Archive Center Greenbelt Maryland 20771 USA Center for Earth Observing and Space Research School of Computational Sciences George Mason University Fairfax Virginia 22030-4444 USA Earth Data Analysis Center University of New Mexico Albuquerque New Mexico 87131 USA Thai Royal Military Academy Bangkok Thailand

This paper compares monthly and seasonal rain rates derived from the Version 5 （V5） and Version 6 （V6） TRMM Precipitation Radar （TPR, TSDIS reference 2A25）, TRMM Microwave Imager （TMI, 2A12）, TRMM Combined Instrument （TCI, 2B31）, TRMM calibrated IR rain estimates （3B42） and TRMM merged gauge and satellite analysis （3B43） algorithms over New Mexico （NM） with rain gauge analyses provided by the New Mexico water districts （WD）. The average rain rates over the NM region for 1998- 2002 are 0.91 mm d^-1 for WD and 0.75, 1.38, 1.49, 1.27, and 1.07 mm d^-1 for V5 3B43, 3B42, TMI, PR and TCA; and 0.74, 1.38, 0.87 and 0.97 mm d^-1 for V6 3B43, TMI, TPR and TCA, respectively. Comparison of V5 3B43 with WD rain rates and the daily TRMM mission index （TPR and TMI） suggests that the low bias of V5 3B43 for the wet months （summer to early fall） may be due to the non-inclusion of some rain events in the operational gauge analyses that. are used in the production of V5 3B43. Correlation analyses show that the WD rain rates vary in phase, with higher correlation between neighboring WDs. High temporal correlations （〉0.8） exist between WD and the combined algorithms （3B42, 3B43 and TCA for both V5 and V6） while satellite instrument algorithms （PR, TMI and TCI） are correlated best among themselves at the monthly scale. Paired t-tests of the monthly time series show that V5 3B42 and TMI are statistically different from the WD rain rates while no significant difference exists between WD and the other products. The agreements between the TRMM satellite and WD gauge estimates are best for the spring and fall and worst for winter and summer. The reduction in V6 TMI （-7.4%） and TPR （-31%） rain rates （compared to V5） results in better agreement between WD estimates and TMI in winter and TPR during summer.

关键词： satellite precipitation TRMM Water District New Mexico surface rain

Hepatitis B Vaccine and Immunoglobulin: Key Concepts

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 165-171页

作者： Saibal Das Kirubakaran Ramakrishnan Sapan Kumar Behera Mahalakshmi Ganesapandian Alphienes stanley.Xavier Sandhiya Selvarajan Department of Clinical Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)PuducherryIndia

Hepatitis B virus(HBV)immunization is safe and has been accepted worldwide as a routine *** target of such vaccination is to induce the immune response in the host,resulting in the prevention of replication of *** are several immunological and clinical factors which determine the clinical efficacy and safety of the HBV *** this article we have highlighted the response of the host immune system to HBV vaccination(immunogenicity),efficacy,and safety of the vaccine,issues with booster dosing,paths of development(preclinical and clinical)of the HBV vaccine,novel and upcoming strategies for improvement of HBV vaccination,and the concept of therapeutic HBV *** different aspects and regulatory recommendations pertaining to HBV vaccine development are also *** new strategies for improvement of HBV vaccination include pre-S1 and pre-S2 portions of the HBV surface antigen,increasing the antigen dose,accelerated vaccination schedules,alternative vaccination route,use of adjuvants like immunostimulatory DNA sequences,*** vaccination is being explored for initiation of a multifunctional and multispecific T cell response against the major HBV antigens and also effective activation of humoral immunity for viral control.

关键词： Antibody Development Immune response Immunoglobulin Vaccine

Determinants of moderate to vigorous physical activity and obesity in children:a structural equation modeling analysis

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世界儿科杂志:英文版 2016年第2期12卷 170-176页

作者： Daniel Chi-Shing Yeung Xin Yuan stanley.Sai-Chuen Hui Shingairai Aliifi na Feresu Department of Epidemiology and Biostatistics School of Public HealthIndiana UniversityUSA Department of Counseling and Educational Psychology School of EducationIndiana UniversityUSA Department of Sports Science and Physical Education The Chinese University of Hong KongShatinHong KongChina School of Health Systems and Public Health Biostatistics and EpidemiologyFaculty of MedicineUniversity of PretoriaSouth Africa

Background:The determinants of physical activity(PA)and body fatness in Chinese adolescents are rarely *** study aimed to investigate the effect of attitude toward PA,screen time,parents'socioeconomic status(SES),and exercise habit on PA and body fatness among Chinese children by using structural equation modeling(SEM)***:Data obtained from the second Community Fitness Survey in Hong Kong region were utilized,in which students from one secondary school of each of the 18 districts of Hong Kong were recruited.A total of 2517 questionnaires with physical fitness items were successfully distributed to students aged 13-19 years in these ***'SES,parents'exercise habit,children's intention to participate in PA,amount of moderate to vigorous PA(MVPA),screen time,children's attitude toward PA,and children's body fat percentage were measured and analyzed with *** structural equation model was composed of a measurement model and a structural *** model was tested with Mplus *** Chi-square test,root mean square error of approximation,comparative fi t index,and Tucker-Lewis index were calculated to evaluate model *** model was then modifi ed based on the model fi t ***:Children's intention to participate in PA was a strong predictor of their engagement in ***'exercise habit had both direct and indirect(via attitude)effects on their children's intention to participate in *** time was not a predictor of body ***'s intention to participate in PA directly affected their body ***'s attitude toward PA,parents'exercise habit,and SES had signifi cant effects on the children's intention to participate in ***,obesity had a negative effect on the children's attitude toward ***:To promote MVPA and prevent obesity in Chinese children of Hong Kong region,it is important to design intervention that enhances children's intention and attitude in PA,as well as pa

关键词： adolescent obesity behavior childhood obesity physical activity socioeconomic factors

Applying plant-based irrigation scheduling to assess water use efficiency of cotton following a high-biomass rye cover crop

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Journal of Cotton Research 2020年第2期3卷 134-145页

作者： MEEKS Calvin D SNIDER John L CULPEPPER stanley.HAWKINS Gary Division of Plant Sciences University of MissouriPortagevilleMO 63873USA Department of Crop and Soil Sciences University of GeorgiaTiftonGA 31793USA Department of Crop and Soil Sciences University of GeorgiaWatkinsvilleGA 30677USA.

Background:This study addressed the potential of combining a high biomass rye winter cover crop with predawn leaf water potential(ΨPD)irrigation thresholds to increase agricultural water use efficiency(WUE)in *** this end,a study was conducted near Tifton,Georgia under a manually-controlled,variable-rate lateral irrigation system using a Scholander pressure chamber approach to measure leaf water potential and impose varying irrigation scheduling treatments during the growing season.ΨPDthresholds were-0.4 MPa(T1),-0.5 MPa(T2),and-0.7 MPa(T3).A winter rye cover crop or conventional tillage were utilized for T1-T3 as ***:Reductions in irrigation of up to 10%were noted in this study for the driest threshold(-0.7 MPa)with no reduction in lint yield relative to the-0.4 MPa and-0.5 MPa *** conditions during flowering(2014)limited plant growth and node production,hastened cutout,and decreased yield and WUE relative to ***:We conclude thatΨPDirrigation thresholds between-0.5 MPa and-0.7 MPa appear to be viable for use in aΨPDscheduling system with adequate yield and WUE for cotton production in the southeastern *** cover positively impacted water potential at certain points throughout the growing season but not yield or WUE indicating the potential for rye cover crops to improve water use efficiency should be tested under longer-term production scenarios.

关键词： Cotton Irrigation management Water use efficiency Cover crops Cotton sustainability

Angiographic Profile and Treadmill Test Relationship of Women with Chest Pain Suggestive of Coronary Artery Disease

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World Journal of Cardiovascular Diseases 2017年第8期7卷 225-232页

作者： stanley.George Department of Cardiology Pariyaram Medical College Kannur India

Aim: The aim of present study was to analyze the prevalence and pattern of coronary artery disease (CAD) among women who underwent coronary angiography (CAG) and Treadmill Test (TMT). Methods: A total of 100 consecutive women patients for coronary angiogram were studied at Department of Cardiology, Government Medical College, Kottayam, Kerala, India on over a period of 6 months from February 2008. Total 65 women completed TMT stress test. The patients were subjected to CAG and TMT. Data were analyzed by using SPSS 20.0 software. Results: A total of 100 women patients were included. Among that 66% patients had hypertension and 47% patients had diabetes mellitus. The CAG revealed the presence of 17%, 13% and 15% of single vessel disease, double vessel disease, and triple vessel disease respectively. Vessel involvements were notably higher in positive TMT values during stress test. The sensitivity and specificity of TMT for detecting coronary artery disease in women were 61% and 69% respectively. Conclusion: It is concluded that, the findings of the present study effectively demonstrated higher predictive value of TMT in women with chest pain suggestive of CAD.

关键词： Coronary Angiography Coronary Artery Disease Treadmill Test

Sense of CommuniW Responsibility as a Determinant of Corporate Responsibility

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Sociology Study 2016年第10期6卷 653-662页

作者： Christopher Lowe Janet stanley.John stanley Bus Association Victoria Inc. Melbourne VictoriaAustralia University of Melbourne Melbourne Victoria Australia University of Sydney Sydney New South Wales Australia

Research on the social value of the bus industry in Australia revealed an inconsistency in findings between qualitative and quantitative results in relation to the nature of a bus operator＇s interaction with the community where they provide a transport service. As part of a larger research project that surveyed bus operators about their corporate social responsibility, bivariate analysis found that the responses to the embedded Sense of Community Index （SOCI） did not provide a predictor of the extent of a bus operator＇s community interaction or determinant of Corporate Responsibility （CR）. However, qualitative comments in the survey suggested that bus operators did display strong positive feelings about their community. Published after the data collection stage was completed, the Sense of Community Responsibility Index （SOCRI） appeared to be a better fit than SOCI to explain the nature of bus operator＇s interaction with their community. Rather than drawing on community resources, the interaction was shown to be one of leaderships on the part of the operator. Further examination of this relationship using the SOCR would test this finding.

关键词： Corporate responsibility sense of community sense of community responsibility leadership bus operators family business

Selective Sentinel Lymphadenectomy for Human Solid Cancer 1

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The stanley.Kubrick Archives

丛书名： Cancer Treatment and Research

2005年

作者： stanley.P. L. Leong Yuko Kitagawa Masaki Kitajima

来源：畅想之星图书光盘版（南... 评论

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