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Changes in the Dynamics of a Rössler Oscillator by an External Forcing

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Chinese Physics Letters 2013年第3期30卷 22-25页

作者： amanda C.Mathias Paulo C.Rech Departamento de Física Universidade do Estado de Santa Catarina89219-710 JoinvilleBrazil

We report some results indicating changes in the observed dynamics of the Rössler model under the influence of external sinusoidal *** varying the control parameters of the external sinusoidal forcing,namely the amplitude and the angular frequency,we show,through numerical simulations which include parameter planes and Lyapunov exponents,that the external forcing can produce both chaos-order and order-chaos *** also show that the sinusoidal forcing may generate hyperchaos.

关键词： chaos sinusoidal transitions

Challenges and opportunities of machine learning control in building operations

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Building Simulation 2023年第6期16卷 831-852页

作者： Liang Zhang Zhelun Chen Xiangyu Zhang amanda Pertzborn Xin Jin The University of Arizona 1209 E 2nd StTucsonAZUSA Drexel University 3141 Chestnut StPhiladelphiaPAUSA National Renewable Energy Laboratory 15013 Denver W PkwyGoldenCOUSA National Institute of Standards and Technology 100 Bureau DrGaithersburgMDUSA

Machine learning control(MLC)is a highly flexible and adaptable method that enables the design,modeling,tuning,and maintenance of building controllers to be more accurate,automated,flexible,and *** research topic of MLC in building energy systems is developing rapidly,but to our knowledge,no review has been published that specifically and systematically focuses on MLC for building energy *** paper provides a systematic review of MLC in building energy *** review technical papers in two major categories of applications of machine learning in building control:(1)building system and component modeling for control,and(2)control process *** identify MLC topics that have been well-studied and those that need further research in the field of building operation *** also identify the gaps between the present and future application of MLC and predict future trends and opportunities.

关键词： machine learning building operation control building energy system reinforcement learning

Development of a Bias Compensating Q-Learning Controller for a Multi-Zone HVAC Facility

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IEEE/CAA Journal of Automatica Sinica 2023年第8期10卷 1704-1715页

作者： Syed Ali Asad Rizvi amanda J.Pertzborn Zongli Lin IEEE the Department of Electrical and Computer Engineering Tennessee Technological UniversityCookevilleTN 38505 USA the Mechanical Systems and Controls Group in the Building Energy and Environment Division at the National Institute of Standards and Technology(NIST) GaithersburgMD 20899 USA the Charles L.Brown Department of Electrical and Computer Engineering University of VirginiaCharlottesvilleVA 22904-4743 USA

We present the development of a bias compensating reinforcement learning(RL)algorithm that optimizes thermal comfort(by minimizing tracking error)and control utilization(by penalizing setpoint deviations)in a multi-zone heating,ventilation,and air-conditioning(HVAC)lab facility subject to unmeasurable disturbances and unknown *** is shown that the presence of unmeasurable disturbance results in an inconsistent learning equation in traditional RL controllers leading to parameter estimation bias(even with integral action support),and in the extreme case,the divergence of the learning *** demonstrate this issue by applying the popular Q-learning algorithm to linear quadratic regulation(LQR)of a multi-zone HVAC environment and showing that,even with integral support,the algorithm exhibits bias issue during the learning phase when the HVAC disturbance is unmeasurable due to unknown heat gains,occupancy variations,light sources,and outside weather *** address this difficulty,we present a bias compensating learning equation that learns a lumped bias term as a result of disturbances(and possibly other sources)in conjunction with the optimal control *** results show that the proposed scheme not only recovers the bias-free optimal control parameters but it does so without explicitly learning the dynamic model or estimating the disturbances,demonstrating the effectiveness of the algorithm in addressing the above challenges.

关键词： HVAC control optimal tracking Q-learning reinforcement learning(RL)

Multiresolution state-space discretization for Q-Learning with pseudorandomized discretization

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控制理论与应用（英文版） 2011年第3期9卷 431-439页

作者： amanda LAMPTON John VALASEK Mrinal KUMAR Systems Technology Inc.13766 S.Hawthorne BlvdHawthorneCA 90250U.S.A. Department of Aerospace Engineering Texas A&M University Department of Mechanical & Aerospace Engineering University of Florida

A multiresolution state-space discretization method with pseudorandom gridding is developed for the episodic unsupervised learning method of *** is used as the learning agent for closed-loop control of morphing or highly reconfigurable *** paper develops a method whereby a state-space is adaptively discretized by progressively finer pseudorandom grids around the regions of interest within the state or learning space in an effort to break the Curse of *** of the method is demonstrated with application to the problem of a morphing airfoil,which is simulated by a computationally intensive computational fiuid dynamics *** setting the multiresolution method to define the region of interest by the goal the agent seeks,it is shown that this method with the pseudorandom grid can learn a specific goal within ±0.001 while reducing the total number of state-action pairs needed to achieve this level of specificity to less than 3000.

关键词： Reinforcement learning Morphing Random grid

Effects of Yerba Mate Consumption (Ilex paraguariensis) on Cardiac Remodeling in Rats

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Food and Nutrition Sciences 2024年第8期15卷 827-845页

作者： Carlos Eduardo Brochini de Paiva Thaíssa Baptista Brochini de Paiva Isabelle Tiburcio Pecin Ferreira Sandra Cristina Genaro Danilo Silva Martins Santos Thaoan Bruno Mariano Robson Chacon Castoldi Rafael Stuani Floriano Julia amanda Rodrigues Fracasso Lucas Pires Guarnier Marina Politi Okoshi Francis Lopes Pacagnelli Postgraduate Program in Health Sciences Unoeste Presidente Prudente Brazil Faculty of Medicine Unoeste Presidente Prudente Brazil Department of Physiotherapy Unoeste Presidente Prudente Brazil Department of Nutrition Unoeste Presidente Prudente Brazil Postgraduate Program in Science and Movement Unesp Rio Claro Brazil Postgraduate Program in Health Promotion University of Northern Paran (UNOPAR) Londrina Brazil School of Dentistry So Paulo State University (UNESP) Araatuba Brazil Department of Genetics Ribeiro Preto Medical School University of So Paulo USP Ribeiro Preto Brazil Internal Medicine Department Botucatu Medical School So Paulo State University (UNESP) Botucatu Brazil

This study investigated the effects of yerba mate consumption, a South American beverage, on cardiac remodeling in rats. For this purpose, 24 male Wistar rats were divided into Control Group (CG) which received filtered water and a standard diet, and Yerba Mate Group (YM), 6 g of Ilex paraguariensis in 100 ml water and the same diet, for 30 days. The YM group showed a reduction in final body weight and food consumption without altering weight gain. Regarding cardiac remodeling, the YM group exhibited a decrease in the right ventricle weight/final body weight ratio, suggesting cardiac atrophy, without affecting the atria and left ventricle. There was no change in cardiomyocyte area or nuclear fractal dimension in both groups. However, animals that consumed yerba mate showed increased collagen deposition and a smaller fractal dimension in the left ventricle. The consumption of yerba mate at room temperature for 30 days induced changes in cardiac remodeling, as evidenced by increased collagen deposition and alterations in fractal dimension in the left ventricle.

关键词： Tereré Ilex paraguariensis Yerba Mate Cardiac Remodeling Fractal Dimension Hypertrophy

The new wave of p75 neurotrophin receptor targeted therapies

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Neural Regeneration Research 2022年第1期17卷 95-96页

作者： amanda M.Crooks Rick B.Meeker UNC School of Medicine University of North CarolinaChapel HillNCUSA(Crooks AM)Department of NeurologyUniversity of North CarolinaChapel HillNCUSA

Neurotrophins have been recognized for decades for their beneficial effects on growth,survival,and maintenance in the central nervous system,all of which suggest potential therapeutic *** understanding and harnessing the activity of neurotrophins has proven difficult,the past several years have seen significant strides in the development of deliverable therapies that modulate neurotrophin activity(Shen et al.,2019;Yang et al.,2020;Xie et al.,2021).These recent studies have primarily focused on the multifunctional p75 neurotrophin receptor(p75NTR)which is upregulated in central nervous system disease and injury,thus offering a unique target for intervention.

关键词： al. therapies p75

Updates in penile prosthesis infections

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Asian Journal of Andrology 2020年第1期22卷 28-33页

作者： amanda R Swanton Ricardo M Munarriz Martin S Gross Department of Surgery Section of UrologyDartmouth-Hitchcock Medical CenterLebanonNH 03766USA Department of Urology Boston Medical CenterBostonMA02118USA

Inflatable penile prostheses are an important tool in the treatment of medically refractory erectile *** of the major complications associated with these prostheses is infections,which ultimately require device explanation and placement of a new *** the past several decades,significant work has been done to reduce infection rates and optimize treatment strategies to reduce patient *** article reviews the current state of knowledge surrounding penile prosthesis infections,with attention to the evidence for methods to prevent infection and best practices for device reimplantation.

关键词： erectile dysfunction infection penile prosthesis

More forks on the road to replication stress recovery

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分子细胞生物学报:英文版 2011年第1期3卷 4-12页

作者： Chris Allen amanda K.Ashley Robert Hromas Jac A.Nickoloff Department of Environmental and Radiological Health Sciences Colorado State UniversityFt CollinsCO 80523USA University of New Mexico Cancer Center and Department of Internal Medicine University of New Mexico School of MedicineAlbuquerqueNM 87131USA

High-fidelity replication of DNA,and its accurate segregation to daughter cells,is critical for maintaining genome stability and suppressing *** replication forks are stalled by many DNA lesions,activating checkpoint proteins that stabilize stalled *** forks may eventually collapse,producing a broken DNA *** restart is typically mediated by proteins initially identified by their roles in homologous recombination repair of DNA double-strand breaks(DSBs).In recent years,several proteins involved in DSB repair by non-homologous end joining(NHEJ)have been implicated in the replication stress response,including DNA-PKcs,Ku,DNA Ligase IV-XRCC4,Artemis,XLF and *** is currently unclear whether NHEJ proteins are involved in the replication stress response through indirect(signaling)roles,and/or direct roles involving DNA end *** complexity in the replication stress response centers around RPA,which undergoes significant post-translational modification after stress,and RAD52,a conserved HR protein whose role in DSB repair may have shifted to another protein in higher eukaryotes,such as BRCA2,but retained its role in fork *** cancer therapeutic strategies create DNA replication ***,it is imperative to gain a better under-standing of replication stress response proteins and pathways to improve cancer therapy.

关键词： DNA repair genome instability cancer therapy

Investigating neurogenic bowel in experimental spinal cord injury: where to begin?

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Neural Regeneration Research 2019年第2期14卷 222-226页

作者： amanda R.White Gregory M.Holmes Department of Neural & Behavioral Sciences Penn State University College of Medicine

The devastating losses following traumatic spinal cord injury(SCI) encompass the motor, sensory and autonomic nervous systems. Neurogenic bowel is a slow transit colonic dysfunction marked by constipation, rectal evacuation difficulties, decreased anorectal sensation, fecal incontinence or some combination thereof. Furthermore, neurogenic bowel is one of the most prevalent comorbidities of SCI and is recognized by afflicted individuals and caregivers as a lifelong physical and psychological challenge that profoundly affects quality of life. The restoration of post-injury control of movement has received considerable scientific scrutiny yet the daily necessity of voiding the bowel and bladder remains critically under-investigated. Subsequently, physicians and caregivers are rarely presented with consistent, evidence-based strategies to successfully address the consequences of dysregulated voiding reflexes. Neurogenic bowel is commonly believed to result from the interruption of the supraspinal control of the spinal autonomic circuits regulating the colon. In this mini-review, we discuss the clinical challenges presented by neurogenic bowel and emerging pre-clinical evidence that is revealing that SCI also initiates functional remodeling of the colonic wall concurrent with a decrease in local enteric neurons. Since the enteric input to the colonic smooth muscle is the final common pathway for functional contractions of the colon, changes to the neuromuscular interface must first be understood in order to maximize the efficacy of therapeutic interventions targeting colonic dysfunction following SCI.

关键词： colon enteric nervous system parasympathetic sympathetic autonomic nervous system defecationreflexes gastrointestinal inflammation constipation incontinence