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Microbiome as an endocrine organ and its relationship with eye diseases:Effective factors and new targeted approaches

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World Journal of Gastrointestinal Pathophysiology 2024年第5期15卷 1-18页

作者： Leila Haghshenas Sara Banihashemi Yalda Malekzadegan Roberto Catanzaro Amir Moghadam Ahmadi Francesco marotta Department of Clinical Bioinformatics Harvard Medical SchoolBostonMA 02115United States Department of Bioscience School of Science and TechnologyNottingham Trend UniversityNottingham NG14FQUnited KingdomDepartment of BioscienceSchool of Science and TechnologyNottingham Trend UniversityNottingham NG14FQUnited Kingdom Department of Microbiology Saveh University of Medical SciencesSaveh ***Iran Department of Clinical and Experimental Medicine University of CataniaCatania 95123CataniaItaly Department of Neuroimmunology Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Department of Human Nutrition and Food Sciences Texas Women UniversityMilano 20154Italy

Microbiome is an endocrine organ that refers to both the complicated biological system of microbial species that colonize our bodies and their genomes and *** studies confirm the connection between the microbiome and eye diseases,which are involved in the pathogenesis of eye diseases,including age-related macular disorders,diabetic retinopathy,glaucoma,retinitis pigmentosa,dry eye,and *** aim of this review is to investigate the microbiome in relation to eye ***,a brief introduction of the characteristics of the gut microorganisms terms of composition and work,the role of dysbiosis,the gut microbiome and the eye microbiome in the progression of eye illnesses are highlighted,then the relationship among the microbiome and the function of the immune system and eye diseases,the role of inflammation and aging and the immune system,It has been reviewed and finally,the control and treatment goals of microbiome and eye diseases,the role of food factors and supplements,biotherapy and antibiotics in relation to microbiome and eye health have been reviewed.

关键词： Dysbiosis Gut microbiome Eye diseases Inflammation Diabetic retinopatyhy Aging Nutrient supplementation

How many subductions in the Variscan orogeny?Insights from numerical models

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Geoscience Frontiers 2020年第3期11卷 1025-1052页

作者： Alessandro Regorda Jean-Marc Lardeaux Manuel Roda Anna Maria marotta Maria Iole Spalla Universita Degli Studi di Milano Dipartimento di Scienze Della Terra'A.Desio’Via Mangiagalli 34I-20133MilanoItaly Universite Nice Sophia-Antipolis UMR Geoazur250 Rue A.EinsteinSophia-Antipolis06560ValbonneFrance

We developed a 2 D numerical model to simulate the evolution of two superposed ocean-continent-ocean subduction cycles with opposite vergence,both followed by continental collision,aiming to better understand the evolution of the Variscan *** models with different velocities of the first oceanic subduction have been *** differences in the thermo-mechanical evolution between the first subduction,which activates in an unperturbed system,and the second subduction,characterised by an opposite vergence,have been enlighten,in particular regarding the temperature in the mantle wedge and in the interior of the *** and temperature(P-T) conditions predicted by one cycle and two cycles models have been compared with natural P-T estimates of the Variscan metamorphism from the Alps and from the French Massif Central(FMC).The comparative analysis supports that a slow and hot subduction well reproduces the P-T conditions compatible with data from the FMC,while P-T conditions compatible with data of Variscan metamorphism from the Alps can be reproduced by either a cold or hot oceanic subduction *** the agreement of both double and single subduction models with natural P-T estimates,we observed that polycyclic models better describe the evolution of the Variscan orogeny.

关键词： Alps Double subduction French Massif Central Numerical modelling Variscan orogeny

Multilevel oblique corpectomies as an effective surgical option to treat cervical chordoma in a young girl

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World Journal of Clinical Cases 2014年第3期2卷 57-61页

作者： Roberto Delfini Daniele Marruzzo Roberto Tarantino Nicola marotta Alessandro Landi Department of Neurology and Psychiatry Division of Neurosurgery University of Rome "Sapienza"

Chordomas are malignant tumors arising from notochordal remnants. They are the most frequent tumors of the spine after plasmacytomas. Only 6% of chordomas are localized to the cervical level. In young patients, chordomas are rare and unpredictable. Despite this, the treatment of choice remains the total resection, as much as possible, followed by proton beam radiation. This case was managed using a precarotid and retrocarotid approach at the same time. The tumor was completely resected with the edges free from disease. The cervical spine was stabilized with an anterior plating C2-C4. Eighteen months after surgery the patient is still free from illness. Multilevel oblique corpectomies are an available and safe option for the treatment of upper cervical chordomas.

关键词： Cervical chordoma Multilevel oblique corpectomy Surgery RXT Retrocarotid approach

Lobular capillary hemangioma of the liver

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 323-325页

作者： Faisal Abaalkhail Mathieu Castonguay David K.Driman Jeremy Parfitt Paul marotta London Health Sciences Centre University of Western Ontario

BACKGROUND: Lobular capillary hemangioma (LCH) is a benign vascular tumor that is rare in adults and has never been reported in the liver. This vascular lesion usually presents on the skin or mucous membranes, and predominantly affects children. METHODS: LCH as a large asymptomatic hepatic mass was seen in a 35-year-old female. Imaging and pathologic characteristics of the mass are reviewed, and the relevant literature is also reviewed. RESULTS: A large vascular hepatic lesion was observed in an asymptomatic 35-year-old female. Pathologic examination after surgical resection revealed typical features of LCH. CONCLUSIONS: This is the first case of lobular capillary hemangioma seen as a liver lesion in an adult. Large vascular hepatic lesions pose significant difficulties in discerning benign from potentially malignant conditions. In this report we describe the pitfalls and radiological uncertainties with interpreting vascular lesions of the liver. (Hepatobiliary Pancreat Dis Int 2009; 8: 323-325)

关键词： lobular capillary hemangioma benign

Beneficial effect of refined red palm oil on lipid peroxidation and monocyte tissue factor in HCV-related liver disease： a randomized controlled study

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 165-172页

作者： Roberto Catanzaro Nicola Zerbinati Umberto Solimene Massimiliano Marcellino Dheeraj Mohania Angelo Italia Antonio Ayala Francesco marotta Department of Clinical and Experimental Medicine Gastroenterology Section University of Catania Catania Italy CMP-Medical Center & Laboratories Pavia Italy WHO-center for Traditional Medicine & Biotechnology University of Milano Milano Italy ReGenera Research Group for Aging-Intervention Milano Italy Department of Research Sir Ganga Ram Hospital Rajinder Nagar New Delhi India Biochemistry and Molecular Biology Seville University Sevilla Spain

BACKGROUND： A large amount of endotoxin can be detected in the peripheral venous blood of patients with liver cirrhosis, contributing to the pathogenesis of hepatotoxicity because of its role in oxidative stress. The present study aimed to test the effect of the supplementation with red palm oil（RPO）, which is a natural oil obtained from oil palm fruit（Elaeis guineensis） rich in natural fat-soluble tocopherols, tocotrienols and carotenoids, on lipid peroxidation and endotoxemia with plasma endotoxin-inactivating capacity, proinflammatory cytokines profile, and monocyte tissue factor in patients with chronic liver disease. METHODS： The study group consisted of sixty patients（34 males and 26 females; mean age 62 years, range 54-75） with Child A/B, genotype 1 HCV-related cirrhosis without a history of ethanol consumption, randomly enrolled into an 8-week oral daily treatment with either vitamin E or RPO. All patients had undergone an upper gastrointestinal endoscopy 8 months before, and 13 out of them showed esophageal ***： Both treatments significantly decreased erythrocyte malondialdehyde and urinary isoprostane output, only RPO significantly affected macrophage-colony stimulating factor and monocyte tissue factor. Liver ultrasound imaging did not show any change. CONCLUSIONS： RPO beneficially modulates oxidative stress and, not least, downregulates macrophage/monocyte inflammatory parameters. RPO can be safely advised as a valuable nutritional implementation tool in the management of chronic liver diseases.

关键词： endotoxin isoprostane macrophage-colony stimulating factor monocyte tissue factor oxidative stress red palm oil

Diagnostic accuracy of enhanced liver fibrosis test to assess liver fibrosis in patients with chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 500-507页

作者： Roberto Catanzaro Michele Milazzo Silvia Arona Chiara Sapienza Dario Vasta Domenico Arcoria Francesco marotta Department of Medical and Pediatric Sciences Institute of Internal Medicine "A. Francaviglia"Section of Gastro-enterologyUniversity of Catania"G. Rodolico" Hospital Laboratory analysis "MedLab-Analisi Cliniche" Specialist in diabetes and metabolic diseases ReGenera Research Group for Aging Intervention

BACKGROUND:The prognosis and clinical management of patients with chronic liver diseases are closely related to the severity of liver *** biopsy is considered the gold standard for the staging of liver ***,it is an invasive test sometimes related to *** study aimed to assess the diagnostic value of enhanced liver fibrosis(ELF) test to predict liver fibrosis in patients with chronic hepatitis ***:This study included 162 patients with liver disease and 67 healthy *** acid,tissue inhibitor of matrix metalloproteinase type 1,and amino-terminal propeptide type III procollagen were measured by enzymelinked immunosorbent assay with the ELF test ADVIA Centaur(Siemens Healthcare Diagnostics Inc.).Fibrosis stage was determined using the Metavir scoring ***:In our study,for the diagnosis of significant fibrosis(Metavir F≥2) a cut-off value >7.72 provides a sensitivity of 93.0% and a specificity of 83.0%.The areas under the receiver operator characteristic curve,sensitivity,specificity,and positive and negative predictive values were 0.94,93.3%,81.0%,93.3%,and 81.0%,respectively(P9.3 provides a sensitivity of 93.0% and a specificity of 86.0%.The areas under the receiver operator characteristic curve,sensitivity,specificity,and positive and negative predictive values were 0.94,79.1%,90.8%,75.6%,and 92.3%,respectively(P<0.001).CONCLUSIONS:The ELF test is a promising non-invasive method for assessing liver fibrosis in patients with chronic hepatitis *** is effective in the diagnosis of both fibrosis and cirrhosis.

关键词： enhanced liver fibrosis test non-invasive diagnosis liver fibrosis blood marker

Evaluation of the updated definition of early allograft dysfunction in donation after brain death and donation after cardiac death liver allografts

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 372-376页

作者： Kris P Croome William Wall Douglas Quan Sai Vangala Vivian McAlister Paul marotta Roberto Hernandez-Alejandro Multi-Organ Transplant Program London Health Sciences CentreThe University of Western OntarioLondonCanada Department of Surgery Division of General SurgeryThe University of Western OntarioLondonCanada Division of Gastroenterology The University of Western OntarioLondonCanada

BACKGROUND:An updated definition of early allograft dysfunction(EAD) was recently validated in a multicenter study of 300 deceased donor liver transplant *** analysis did not differentiate between donation after brain death(DBD) and donation after cardiac death(DCD) allograft ***:We reviewed our prospectively entered database for all DBD(n=377) and DCD(n=38) liver transplantations between January 1,2006 and October 30,*** incidence of EAD as well as its ability to predict graft failure and survival was compared between DBD and DCD ***:EAD was a valid predictor of both graft and patient survival at six months in DBD allograft recipients,but in DCD allograft recipients there was no significant difference in the rate of graft failure in those with EAD(11.5%) compared with those without EAD(16.7%)(P=0.664) or in the rate of death in recipients with EAD(3.8%) compared with those without EAD(8.3%)(P=0.565).The graft failure rate in the first 6 months in those with international normalized ratio ≥1.6 on day 7 who received a DCD allograft was 37.5% compared with 6.7% for those with international normalized ratio <1.6 on day 7(P=0.022).CONCLUSIONS:The recently validated definition of EAD is a valid predictor of patient and graft survival in recipients of DBD *** initial assessment,it does not appear to be a useful predictor of patient and graft survival in recipients of DCD allografts,however a study with a larger sample size of DCD allografts is needed to confirm these *** high ALT/AST levels in most recipients of DCD livers as well as the predisposition to biliary complications and early cholestasis make these parameters as poor predictors of graft *** alternative definition of EAD that gives greater weight to the INR on day 7 may be more relevant in this population.

关键词： donor risk index model for end-stage liver disease early allograft dysfunction donation after brain death

Bile duct hamartomas-the von Meyenburg complex

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 108-109页

作者： Valdemir José Alegre Salles Alexandre marotta Jorge Miguel Kather Netto Manlio Basílio Speranzini Marcos Roberto Martins University of Taubaté Department of Medicine So Paulo Brazil

: Hamartomas of the bile duct (von Meyenburg complex) are benign neoplasms of the liver, constituted histologically cystic dilatations of the bile duct, encompassed by fibrous stroma. We report a 42-year-old female patient with symptomatic cholecystitis, whose gross and ultrasonic appearance suggestive of multiple liver metastases. Magnetic resonance imaging and liver biopsy are the gold standards for diagnosis of this rare hepatobiliary condition.

关键词： bile duct hamartoma von Meyenburg complex nonparasitic hepatic cyst, surgery

Magnetic resonance diffusion tensor imaging and fibertracking diffusion tensor tractography in the management of spinal astrocytomas

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World Journal of Clinical Cases 2016年第1期4卷 1-4页

作者： Alessandro Landi Valeria Palmarini Alessandro D'Elia Nicola marotta Maurizio Salvati Antonio Santoro Roberto Delfini Department of Neurology and Psychiatry Division of NeurosurgeryUniversity of Rome "Sapienza"

Some specially imaging of magnetic resonance imaging,the diffusion-weighted imaging(DWI),the diffusion tensor imaging and fractional anisotropy(FA),are useful to described,detect,and map the extent of spinal cord *** measurements may are used to predicting the outcome of patients who have spinal cord *** tracking enable to visualizing the integrity of white matter tracts surrounding some lesions,and this information could be used to formulating a differential diagnosis and planning biopsies or *** this article,we will describe the current uses for DWI and fiber tracking and speculate on others in which we believe these techniques will be useful in the future.

关键词： Fiber tracking diffusion tensor imaging Surgery Magnetic resonance diffusion tensor imaging Intramedullary astrocytomas Spinal cord tumors Radiology