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Combined and intraoperative risk modelling for oesophagectomy:A systematic review

World Journal of Gastrointestinal Surgery 2023年第7期15卷 1485-1500页

作者： James Paul Grantham amanda hii Jonathan Shenfine Department of General Surgery Modbury HospitalModbury 5092South AustraliaAustralia Department of General Surgical Unit Jersey General HospitalSaint Helier JE13QSJerseyUnited Kingdom

BACKGROUND Oesophageal cancer is the eighth most common malignancy worldwide and is associated with a poor *** remains the best prospect for a cure if diagnosed in the early disease ***,the procedure is associated with significant morbidity and mortality and is undertaken only after careful *** patient selection,counselling and resource allocation is *** risk models have been devised to guide surgeons in making these *** To evaluate which multivariate risk models,using intraoperative information with or without preoperative information,best predict perioperative oesophagectomy *** A systematic review of the MEDLINE,EMBASE and Cochrane databases was undertaken from *** search terms used were[(Oesophagectomy)AND(Model OR Predict OR Risk OR score)AND(Mortality OR morbidity OR complications OR outcomes OR anastomotic leak OR length of stay)].Articles were included if they assessed multivariate based tools incorporating preoperative and intraoperative variables to forecast patient outcomes after *** were excluded if they only required preoperative or any post-operative *** appraising univariate risk predictors such as preoperative sarcopenia,cardiopulmonary fitness and American Society of Anesthesiologists score were also *** review was conducted following the preferred reporting items for systematic reviews and meta-analyses *** captured risk models were appraised for clinical credibility,methodological quality,performance,validation and clinical *** Twenty published studies were identified which examined eleven multivariate risk *** of these combined preoperative and intraoperative data and the remaining three used only intraoperative *** two risk models were identified as promising in predicting mortality,namely the Portsmouth physiological and operative severity score for the enumeration o

关键词： Oesophagectomy Risk model Oesophageal cancer Preoperative Intraoperative Morbidity Mortality

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Preoperative risk modelling for oesophagectomy: A systematic review

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 450-470页

作者： James Paul Grantham amanda hii Jonathan Shenfine Department of General Surgery Modbury HospitalAdelaide 5092South AustraliaAustralia General Surgical Unit Jersey General HospitalSaint Helier JE13QSJerseyUnited Kingdom

BACKGROUND Oesophageal cancer is a frequently observed and lethal malignancy *** resection remains a realistic option for curative intent in the early stages of the ***,the decision to undertake oesophagectomy is significant as it exposes the patient to a substantial risk of morbidity and ***,appropriate patient selection,counselling and resource allocation is *** tools have been developed to aid surgeons in appropriate *** To examine all multivariate risk models that use preoperative and intraoperative information and establish which have the most clinical *** A systematic review of the MEDLINE,EMBASE and Cochrane databases was conducted from *** search terms applied were((Oesophagectomy)AND(Risk OR predict OR model OR score)AND(Outcomes OR complications OR morbidity OR mortality OR length of stay OR anastomotic leak)).The applied inclusion criteria were articles assessing multivariate based tools using exclusively preoperatively available data to predict perioperative patient outcomes following *** exclusion criteria were publications that described models requiring intra-operative or post-operative data and articles appraising only univariate predictors such as American Society of Anesthesiologists score,cardiopulmonary fitness or pre-operative *** that exclusively assessed distant outcomes such as long-term survival were excluded as were publications using cohorts mixed with other surgical *** articles generated from each search were collated,processed and then reported in accordance with PRISMA *** risk models were appraised for clinical credibility,methodological quality,performance,validation,and clinical *** The initial search of composite databases yielded 8715 articles which reduced to 5827 following the deduplication *** title and abstract screening,197 potentially relevant texts were

关键词： Oesophagectomy Risk model Oesophageal cancer Preoperative Morbidity Mortality

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Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases

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World Journal of Gastroenterology 2022年第18期28卷 1934-1945页

作者： Wynne Sim Wei-Meng Lim Ling-Wei hii Chee-Onn Leong Chun-Wai Mai School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia School of Pharmacy International Medical UniversityKuala Lumpur 57000Malaysia Center for Cancer and Stem Cell Research Institute for ResearchDevelopmentand InnovationInternational Medical UniversityKuala Lumpur 57000Malaysia AGTC Genomics Kuala Lumpur 57000Malaysia State Key Laboratory of Oncogenes and Related Genes Renji-Med X Clinical Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Pharmaceutical Chemistry Faculty of Pharmaceutical SciencesUCSI UniversityKuala Lumpur 56000Malaysia

The immune system plays a vital role in maintaining the delicate balance between immune recognition and tumor ***,it is not uncommon that cancerous cells can intelligently acquire abilities to bypass the antitumor immune responses,thus allowing continuous tumor growth and *** evasion has emerged as a significant factor contributing to the progression and immune resistance of pancreatic *** with other cancers,pancreatic cancer has a tumor microenvironment that can resist most treatment modalities,including emerging ***,the use of immunotherapy has yet to bring significant clinical breakthrough among pancreatic cancer patients,suggesting that pancreatic cancer has successfully evaded *** this review,we summarize the impact of genetic alteration and epigenetic modification(especially histone deacetylases,HDAC)on immune evasion in pancreatic *** overexpression significantly suppresses tumor suppressor genes,contributing to tumor growth and *** review the evidence on HDAC inhibitors in tumor eradication,improving T cells activation,restoring tumor immunogenicity,and modulating programmed death 1 *** provide our perspective in targeting HDAC as a strategy to reverse immune evasion in pancreatic cancer.

关键词： Histone acetylation Histone deacetylases inhibitors Immune evasion Pancreatic cancers Pancreatic ductal adenocarcinoma

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Quantification of Carpaine and Antioxidant Properties of Extracts from Carica Papaya Plant Leaves and Stalks

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Journal of Bioresources and Bioproducts 2021年第4期6卷 350-358页

作者： Jing Ying Yap Ching Lik hii Sze Pheng Ong Kuan Hon Lim Faridah Abas Kar Yong Pin Future Food Malaysia Department of Chemical and Environmental EngineeringFaculty of Science and EngineeringUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia School of Pharmacy Faculty of Science and Engineering University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Food Science Universiti Putra Malaysia43400 SerdangSelangor Darul EhsanMalaysia Forest Research Institute Malaysia 52109 Kuala LumpurSelangor Darul EhsanMalaysia

Significance increase in dengue cases have been recorded worldwide every year and South East Asian countries have been badly ***,antiviral drug to treat dengue is still not available but papaya leaves extract(PLE)have been successfully used in treating dengue *** in PLE is the major active compounds that contributes to the anti-thrombocytopenic activity(raising platelet count in patient’s blood).The PLE also contains polyphenols that contribute to antioxidant *** were carried out to extract and quantify carpaine from young leaves,old leaves and stalks of papaya *** crystalline powders were successfully purified and confirmed by ^(1)H and ^(13)C NMR(Nuclear Magnetic Resonance).Young papaya leaves recorded significantly higher amount of carpaine(P<0.05)as compared with old leaves and *** treatment showed significant effect(P<0.05)on the amount of carpaine extracted from the young and old leaves and blended young leaves showed significantly much higher amount of carpaine as compared with the unblended samples(P<0.05).In terms of total polyphenols content(TPC),young leaves(both unblended and blended samples)contained significantly higher amount of TPC(P<0.05)followed by the old leaves and *** also showed relationship between the TPC and the 1,1-diphenyl-2-picrylhydrazyl(DPPH)assay scavenging activities namely IC_(50)(R^(2)=0.9743)and acid equivalent antioxidant capacity(AEAC)(R^(2)=0.9581).Both young and old leaves also showed significantly higher(P<0.05)DPPH scavenging activities as compared with the stalks in both unblended and blended *** papaya leaves were recommended as source of material to extract carpaine for future development of drug in dengue treatment.

关键词： Antioxidants Carica papaya Carpaine Dengue Total polyphenols

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四川盆地金秋区块非常规天然气工厂化井作业设想

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天然气工业 2013年第6期33卷 54-59页

作者：李鹴 hii King-Kai Todd Franks 谢明华中国石油西南油气田公司金秋项目管理部壳牌中国勘探与生产有限公司

四川盆地上三叠统须家河组气藏经历了50多年的勘探开发,存在着"储量大、采出低"的难题。工厂化井作业是降低钻完井、井场建设成本,提高作业效率的重要手段。为此,基于北美地区工厂化钻完井作业成功实施的案例,综合分析了四川盆地金秋区... 详细信息

四川盆地上三叠统须家河组气藏经历了50多年的勘探开发,存在着"储量大、采出低"的难题。工厂化井作业是降低钻完井、井场建设成本,提高作业效率的重要手段。为此,基于北美地区工厂化钻完井作业成功实施的案例,综合分析了四川盆地金秋区块须家河组非常规天然气资源的特点,提出了以下工厂化井作业模式:①采用小井眼结构及单井场最多布36口井,井间地下间距650m的井眼数量优选方案;②采用单排、多井丛且有备用井眼(井丛)的丛式井布局模式;③采用3项交叉作业(钻井+完井+生产)模式,缩短井交付周期;④柔性井场布局设计可以有效地避开地形的限制;⑤选用定制钻机和修井机来完成特定作业目的;⑥作业过程中合理设计离线作业以提高钻完井效率;⑦采用批量完井压裂工厂化模式。这种工厂化井作业可为非常规天然气资源高效、低成本开发提供技术思路和实现手段。

关键词：四川盆地金秋区块工厂化钻井丛式井批量钻井交叉作业离线作业欠平衡钻井低成本开发

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基于生物可给性的某冶炼厂土壤重金属健康风险评价

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中国环境科学 2021年第1期41卷 442-450页

作者：冯康宏范缙 Lik Ung Stanley hii 罗启仕曹心德续晓云上海交通大学环境科学与工程学院上海200240 永清环保股份有限公司上海200051

为科学评价重金属污染场地的人体健康风险,以某冶炼厂土壤为研究对象,采用PBET(Physiologically-Based Extraction Test)和IVG(In-Vitro gastrointestinal)两种方法测定了As、Cd、Cu、Pb、Zn的生物可给性,并对比了只考虑重金属总量与基... 详细信息

为科学评价重金属污染场地的人体健康风险,以某冶炼厂土壤为研究对象,采用PBET(Physiologically-Based Extraction Test)和IVG(In-Vitro gastrointestinal)两种方法测定了As、Cd、Cu、Pb、Zn的生物可给性,并对比了只考虑重金属总量与基于生物可给性的人体健康风险.结果表明,场地土壤As、Cd、Pb的平均含量分别高达7063,691,3811mg/kg,严重超过国家环境质量标准.在PBET和IVG测试中,5种重金属的平均生物可给性介于1.81%~44.8%与1.78%~30.1%之间.As是PBET中生物可给性最高的重金属元素,而在IVG中Cd的生物可给性最高;含磷矿物的存在使Pb的生物可给性最低.提取液pH值及组成组分与重金属元素间的化学行为是造成两种方法结果差异的主要原因.在模型假设的条件下,土壤原有重金属的总危险商与总致癌系数为27.2与2.95×10^-3.考虑生物可给性使二者降低了59.9%~84.4%与55.6%~79.4%,且两个系数大小均呈现PBET胃液>PBET胃肠液>IVG胃液>IVG胃肠液的规律.调整后可以认为Pb不再具有健康风险,Cd仅具有致癌风险,只有As同时具有非致癌风险与致癌风险.尽管考虑重金属生物可给性后场地仍具有不可忽视的人体健康风险,但经过调整后能更准确地识别重金属的危害程度,避免场地的过度修复.

关键词：重金属生物可给性土壤风险评价

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High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

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Bioactive Materials 2022年第4期7卷 405-419页

作者： Xinkun Shen Kai Fang Kendrick hii Ru Yie Zixin Zhou Yiding Shen Shuyi Wu Yue Zhu Zhennan Deng Pingping Ma Jianfeng Ma Jinsong Liu School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou325027China

The excessive accumulation of reactive oxygen species(ROS)under osteoporosis precipitates a microenvironment with high levels of oxidative stress(OS).This could significantly interfere with the bioactivity of conventional titanium implants,impeding their early osseointegration with *** have prepared a series of strontium(Sr)-doped titanium implants via micro-arc oxidation(MAO)to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic(high OS levels)*** from the chemical composition,all groups exhibited similar physicochemical properties(morphology,roughness,crystal structure,and wettability).Among the groups,the low Sr group(Sr25%)was more conducive to osteogenesis under normal *** contrast,by increasing the catalase(CAT)/superoxide dismutase(SOD)activity and decreasing ROS levels,the high Sr-doped samples(Sr75% and Sr100%)were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells,thus enhancing early ***,the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples(especially Sr100%)had positive effects on osteoimmunomodulation under the OS ***,the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations.

关键词： Osteoporosis Oxidative stress Strontium Osteoimmunomodulation Osteogenesis

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Spatial variability of soil nutrients in Punta Fort William,Greenwich Island,maritime Antarctic

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Advances in Polar Science 2013年第4期24卷 273-280页

作者： Yii Siang hii Siti Aisyah Alias Monica Riofrío Nadia Ordóez Hernán Moreano Institute of Oceanography and Environment University Malaysia Terengganu Institute of Biological Science University Malaya Instituto Antártico Ecuatoriano Laboratorio de Biomedicina FIMCM Escuela Superior Politécnica del Litora (ESPOL) Guayaquil Instituto de Investigación Científica y Desarrollo Tecnológico Universidad Estatal Península de Santa ElenaLa LibertadEcuador

This study aims to report baseline soil nutrients, specifically the organic carbon, nitrogen and phosphorus profile, in soil samples collected from Puntta Fort William on Greenwich Island in maritime Antarctic. Samples were collected along two transect lines during the early summer of 2008. Ward＇s method of hierarchical agglomerative clustering was employed to group the sampling points based on their physico-chemical properties. In this context, the soil samples can be grouped into three major clus- ters：（1） Samples with intensive biological activities, （2） samples from the area recently exposed by glacial retreat and （3） samples from barren and dried areas. Nutrient contents in Punta Fort William are driven by the intensity of biological activities as well as melt water from the Qnito glacier.

关键词： soil nutrients Antarctic nitrogen phosphorus South Shetland Islands

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Optimization of Coral Video Transect Technique for Coral Reef Survey: Comparison with Intercept Transect Technique

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Open Journal of Marine Science 2015年第4期5卷 379-397页

作者： Mohd Safuan Wee Hin Boo hii Yi Siang Liew Hock Chark Zainudin Bachok Institute of Oceanography and Environment Universiti Malaysia Terengganu Kuala Terengganu Malaysia School of Fisheries and Aquaculture Sciences Universiti Malaysia Terengganu Kuala Terengganu Malaysia School of Marine Science and Environment Universiti Malaysia Terengganu Kuala Terengganu Malaysia

Variety in video sampling protocol for coral reef survey worldwide has prompted this study to?create an optimized protocol for Coral Video Transect (CVT) technique for coral reef survey in Malaysia. The effect of different vertical distance of the camera above the substrate during video recording, number of frames and points analyzed as well as time spent during field and analysis were examined to determine an optimal protocol for CVT technique at different coral reef conditions in Malaysia’s water. Video recording taken at 0.5 m camera distance was selected as optimize vertical distance above the substrate as it can identify more benthic categories than 1.0 m with lesser time taken as well as frames extracted than 0.2 m. Respectively, 80% of total frames extracted from 20 m transect and analyzed with 50 points per frames were chosen as an optimized sample size for its ability to precisely estimate percent cover and accurately identify benthic categories.?This optimized protocol was then compared with Line Intercept Transect (LIT) method. No clear difference in estimating percentage cover of major benthic categories between CVT and LIT method, but CVT recorded a significantly higher number of benthic categories with lesser time spent during field survey as compared to LIT method. This implied that the optimize CVT method can precisely estimate percent cover and accurately identify benthic categories in coral communities and are thus more suitable for scientific research and management purposes than LIT method. Other advantages of using this technique are by providing a permanent data that can be reassessed later on, lesser field time and wider survey area. Overall, this study showed that CVT technique is an acceptable alternative method of coral reef survey in Malaysia.

关键词： Coral Reef Survey Coral Video Transect Optimize Protocol

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数字电视系列(7) HDMI兼容性测试

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电子与电脑 2005年第9期5卷 75-79页

作者： Stevan Eidson Peter hii 美商晶像消费类电子产品部门不详

HDMI Licensing LLC目前授权两家HDMI授权测试中心(ATC),其中一家位于日本大阪,由Matsushita Electric Industries经营,另一家则位于美国加州Sunnyvale,由晶像公司(Silicon Image,Inc.)主持。HDM ILicensing LLC可能在日后授权其它ATC。

关键词： HDMI 兼容性测试数字电视 Electric Image 测试中心美国加州 LLC 授权

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