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Functional findings in irritable bowel syndrome

World Journal of Gastroenterology 2006年第18期12卷 2830-2838页

作者： Iris Posserud amanda ersryd Magnus Simrén Department of Internal Medicine Sahlgrenska University HospitalGteborgSweden

The pathophysiology of IBS is complex and still incompletely known. Both central and peripheral factors, including psychosocial factors, abnormal GI motility and secretion, and visceral hypersensitivity, are thought to contribute to the symptoms of IBS. Several studies have demonstrated altered GI motor function in IBS patients and the pattern differs between IBS subgroups based on the predominant bowel pattern. Few studies have so far addressed GI secretion in IBS, but there are some evidence supporting altered secretion in the small intestine of IBS patients. Visceral hypersensitivity is currently considered to be perhaps the most important pathophysiological factor in IBS. Importantly, several external and internal factors can modulate visceral sensitivity, as well as GI motility, and enhanced responsiveness within the GI tract to for instance stress and nutrients has been demonstrated in IBS patients. Today IBS is viewed upon as a disorder of dysregulation of the so-called brain-gut axis, involving abnormal function in the enteric, autonomic and/or central nervous systems, with peripheral alterations probably dominating in some patients and disturbed central processing of signals from the periphery in others.

关键词： IBS Gastrointestinal motility Visceral hypersensitivity Gastrointestinal secretion Intestinal gas Brain-gut axis Brain imaging Autonomic nervous system

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