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A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3221-3224页

作者： JoséManuel García-Heredia Marco Pérez Eva M.Verdugo-Sivianes María M.Martínez-Ballesteros Sara M.Ortega-Campos amancio carnero Instituto de Biomedicina de Sevilla(IBIS)/HUVR/Universidad de Sevilla/CSIC SevillaSpain Departamento de Bioquímica Vegetal y Biología Molecular Universidad de SevillaSevillaSpain CIBERONC IS Carlos IIIMadridSpain Departamento de Anatomía Patológica HUVRSevillaSpain Departamento de Lenguajes y Sistemas Informáticos Escuela Superior de Ingeniería InformáticaUniversidad de SevillaSevillaSpain

Dear Editor Sarcomas are a group of heterogeneous mesodermic rare tumors with high incidence in children,reaching up to 20%of *** treatment for sarcomas is surgical resection,and only some patients are treated with ch... 详细信息

关键词： neoplasms chemotherapy treatment

NAD+ metabolism, sternness, the immune response, and cancer

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Signal Transduction and Targeted Therapy 2021年第2期6卷 257-276页

作者： Lola ENavas amancio carnero Instituto de Biomedicina de Sevilla(IBIS) Hospital Universitario Virgen del RocioUniversidad de SevillaConsejo Superior de Investigaciones CientificasSevillaSpain CIBER de Cancer SevillaSpain

NAD+was discovered during yeast fermentation,and since its discovery,its important roles in redox metabolism,aging,and longevity,the immune system and DNA repair have been highlighted.A deregulation of the NAD+levels has been associated with metabolic diseases and aging-related diseases,including neurodegeneration,defective immune responses,and ***+acts as a cofactor through its interplay with NADH,playing an essential role in many enzymatic reactions of energy metabolism,such as glycolysis,oxidative phosphorylation,fatty acid oxidation,and the TCA ***+also plays a role in deacetylation by sirtuins and ADP ribosylation during DNA damage/repair by PARP ***,different NAD hydrolase proteins also consume NAD+while converting it into ADP-ribose or its cyclic *** of these proteins,such as CD38,seem to be extensively involved in the immune *** NAD cannot be taken directly from food,NAD metabolism is essential,and NAMPT is the key enzyme recovering NAD from nicotinamide and generating most of the NAD cellular *** of the complex network of pathways in which NAD+is essential,the important role of NAD+and its key ge nerating enzyme,NAMPT,in cancer is *** the present work,we review the role of NAD+and NAMPT in the ways that they may influence cancer metabolism,the immune system,stemness,aging,and ***,we review some ongoing research on therapeutic approaches.

关键词： metabolism cancer diseases

Sarcoma stratification by combined pH2AX and MAP17(PDZK1IP1)levels for a better outcome on doxorubicin plus olaparib treatment

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Signal Transduction and Targeted Therapy 2020年第1期5卷 697-709页

作者： Marco Perez JoséManuel García-Heredia Blanca Felipe-Abrio Sandra Muñoz-Galván Javier Martín-Broto amancio carnero Instituto de Biomedicina de Sevilla(IBIS) Hospital Universitario Virgen del RocíoUniversidad de SevillaConsejo Superior de Investigaciones CientíficasSevillaSpain Ciber de Cancer IS Carlos IIIMadridSpain Departamento de Bioquímica Vegetal y Biología Molecular Universidad de SevillaSevillaSpain Departamento de Anatomía Patológica Hospital Universitario Virgen del RocíoSevillaSpain

Sarcomas constitute a rare heterogeneous group of tumors,including a wide variety of histological *** advances in our understanding of the pathophysiology of the disease,first-line sarcoma treatment options are still limited and new treatment approaches are *** H2AX phosphorylation is a sensitive marker for double strand breaks and has recently emerged as biomarker of DNA damage for new drug *** this study,we explored the role of H2AX phosphorylation at Ser139 alone or in combination with MAP17 protein,an inducer of DNA damage through ROS increase,as prognostic biomarkers in sarcoma ***,we proposed doxorubicin and olaparib combination as potential therapeutic strategies against sarcomas displaying high level of both *** evaluate retrospectively the levels of pH2AX(Ser139)and MAP17 in a cohort of 69 patients with different sarcoma types and its relationship with clinical and pathological *** found that the levels of pH2AX and MAP17 were related to clinical features and poor ***,we pursued PARP1 inhibition with olaparib to potentiate the antitumor effect of DNA damaging effect of the DNA damaging agent doxorubicin to achieve an optimal synergy in *** demonstrated that the combination of olaparib and doxorubicin was synergistic in vitro,inhibiting cell proliferation and enhancing pH2AX intranuclear accumulation,as a result of DNA *** synergism was corroborated in patient-derived xenografts(PDX)where the combination was effective in tumors with high levels of pH2AX and MAP17,suggesting that both biomarkers might potentially identify patients who better benefit from this combined therapy.

关键词： H2AX doxorubicin treatment

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo Martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez amancio carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

Determination of the density of zinc powders for alkaline battery

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电池 2007年第1期37卷 36-37页

作者： Beatriz Ares Tejero David Guede carnero Cegasa S.A.Celaya Emparanza Galdos S.A.01013 Vitoria-GasteizSpain

The density of zinc powder for alkaline battery was determined using a *** results showed that powders made before the end of 2003 could reach relative densities above 99% of the theoretical *** the relative volume sw... 详细信息

关键词：碱性电池锌粉密度测定方法

Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain

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World Journal of Pediatrics 2020年第6期16卷 629-632页

作者： Pan Roses-Gibert Javier Gimeno Castillo Amaia Saenz Aguirre Francisco Javier De la Torre Gomar Lucia carnero Gonzalez Zurine Martinez de Lagran Alvarez de Arcaya Ricardo Gonzalez-Perez Araba University Hospital Francisco Leandro de Viana Street01009 VitoriaSpain

Background To describe the cutaneous acral findings in a pediatric population noticed during this *** A retrospective descriptive study was performed collecting data on 36 patients under 14 years old,presenting suspicious acral skin manifestations for coronavirus disease 2019(COVID-19).Results Patients were mostly male(63.8%).The mean age was 11.11 years.66.67%of patients showed erythematous papules,and 44.44%purpuric *** were aifected in 97.22%of patients and hands in 5.55%.Lesions were asymptomatic in 50%of patients.30.55%of patients showed extracutaneous findings,preceding skin lesions in 12.62 *** patients underwent specific severe acute coronavirus 2(SARS-CoV-2)testing;all of these patients tested *** The association between these symptoms and SARS-CoV-2 remains *** recommend using these manifestations as a sign of SARS-CoV-2 infection in *** could lead to the examination of asymptomatic and mildly symptomatic children so that contagions may be avoided.

关键词： Acral lesions Acute acro-ischemia Chilblain-like COVID-19

The Beneficial Effect of Trichoderma spp. in Seed Treatment of Four Maize (Zea mays L.) Genotypes

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American Journal of Plant Sciences 2023年第6期14卷 625-637页

作者： José Luis Arispe-Vázquez Abiel Sánchez-Arizpe Daniel Alejandro Cadena-Zamudio Ma. Elizabeth Galindo-Cepeda David Heriberto Noriega-Cantú Oscar Guadalupe Barrón-Bravo Leslie carnero-Avilés Juan Mayo-Hernández Susana Elizabeth Ramírez-Sánchez Adriana Antonio-Bautista Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Iguala de la Independencia Guerrero México Departamento de Parasitología Universidad Autónoma Agraria Antonio Narro Saltillo México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Altamira México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Delicias México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Tepatitlán de Morelos Jalisco México Departamento de Fitomejoramiento Universidad Autónoma Agraria Antonio Narro Saltillo México

Maize is the main crop for Mexicans;however, it is affected by species of fungi causing ear rot. This research aimed to evaluate the effect of T. asperellum T11, T. harzianum T1 4 y T. longibrachiatum T1 40 on some agronomic variables of four maize genotypes. The seeds of the genotypes H-515, Zapata 7, and H-507 were treated with a suspension of Trichoderma spp. to 1 × 108 spores mL-1, using a control (untreated seed), and Benomyl as chemical control. The planting was in Morelos, in a completely random block design with a factorial arrangement. The ear rot was natural. Data were obtained at the end of the crop cycle and processed in SAS 9.4®. H-515 genotype had the greatest effect on the treatment of maize seeds with Trichoderma spp. (5.562 kg);T. asperellum T11 was the strain that stood out with a mean yield of 50 ears in an area of 16 m2 of 4.904 kg, and control of 4.448 kg. Our results are an economic option for farmers to contemplate the use of Trichoderma and obtain its benefits.

关键词： Seeds Treatment Trichoderma asperellum Ear Rot Yield

Trends in Global and Mexico Research in Wildfires: A Bibliometric Perspective

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Open Journal of Forestry 2023年第2期13卷 182-199页

作者： Daniel Alejandro Cadena Zamudio Betsabé Ruiz Guerra José Luis Arispe Vázquez José German Flores Garnica Leslie carnero Avilés Rocío Toledo Aguilar David Heriberto Noriega Cantú Adriana Antonio Bautista Juan Mayo Hernandez David Castillo Quiroz Norma Tolama Nava Roger Guevara Hernández Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Iguala de la Independencia Guerrero México Instituto de Ecología A.C Xalapa Veracruz México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Tepatitlán Guadalajara México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Delicias Chihuahua México Universidad Autónoma Agraria Antonio Narro Saltillo Coahuila México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Saltillo Coahuila México

In the last two decades, unprecedented changes have taken place in the frequency and severity of wildfires;in different regions of the world, some fires were even classified as megafires. Although there are studies about the diverse effects of fire, which have made significant theoretical contributions, a comprehensive review of the changes in fire research is required to understand worldwide patterns, particularly in those countries where fire activity is on the rise, such is the case of Mexico. The objective of this study was to analyze the trends in the research on wildfires published in Mexico and worldwide over a 40-year timescale. For this purpose, the Web of Science database, bibliometric tools, and the keywords TI = Forest fire* OR TI = Wildfire* were used to extract as many articles as possible related to fires from 1980 to 2020, without being restricted to those studies whose title included any of the variants of the keywords. There were 8458 publications about fires in the vegetation cover, with a notable increase in the frequency of studies in the previous decade;52% of the studies were concentrated in five countries and 20% of the articles focused on the study of different aspects of the soil. Mexico ranks thirteenth in volume of scientific production and studies in the country have focused mainly on the description of the quantitative relationship between the size of the affected area and the number of occurrences in the landscape, meanwhile, studies on fires and the consequences on the biotic interactions have been little explored.

关键词： Global Warming Fire Regime Forest Ecosystems Biotic Interactions Anthropogenic Activities