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Screening Programs for Cervical Cancer： Investigation ＂SWOT＂ in Calabria

Journal of Pharmacy and Pharmacology 2016年第6期4卷 279-282页

作者： Giuseppe Andrea de Biase Caterina Azzarito Carmela Bianchi amalia de luca Domenico Gulla Salvatore Lopresti Dario Macchione Domenica Mignuolo Liliana Rizzo Filomena Zappia Health Protection and Health Policy department Calabria Region Company Provincial Health of Cosenza 87100 Company Provincial Health of Reggio Calabria 89100

(Screening programs for cervical cancer: a "SWOT" investigation in the Calabria Region)—-The low adherence to screening programs for cervical cancer in Calabria, was analyzed by performing a SWOT analysis with concerned health professionals. The survey shows that screening organized in Calabria is active and well regulated, the human and financial resources are scarce and the healthcare management has paid little attention to the prevention of women"s cancers. In the perspective of a necessary improvement of the regional system of screening, it would be appropriate to enable promotion strategies and more effective communication, overcoming possible cultural factors hindering.

关键词： SWOT分析卡拉布里亚宫颈癌筛查程序资源稀缺区域系统文化因素

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Early onset versus late onset in Alzheimer’s disease: What is the reliable cut-off?

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Advances in Alzheimer's Disease 2013年第1期2卷 40-47页

作者： Gianfranco Spalletta Vincenzo de luca Alessandro Padovani luca Rozzini Roberta Perri amalia Bruni Vincenzo Canonico Alberto Trequattrini Giuseppe Bellelli Carla Pettenati Floriana Pazzelli Carlo Caltagirone Maria Donata Orfei Azienda Sanitaria Locale Città di Castello Perugia Italy Centro Regionale Alzheimer Azienda Ospedaliera Guido Salvini Passirana Italy Centro Regionale Di Neurogenetica Azienda Sanitaria Provinciale Catanzaro Lamezia Terme Italy department of Clinical and Behavioral Neurology IRCCS Santa Lucia Foundation Rome Italy department of Geriatrics University of Naples Naples Italy department of Neurology University of Brescia Brescia Italy department of Neuroscience Tor Vergata University of Rome Rome Italy department of Prevention and Clinical Medicine University of Milano-Bicocca Monza Italy department of Psychiatry University of Toronto Toronto Canada NESMOS department Sapienza University of Rome Rome Italy

Objective: As the literature on conventional criteria for discriminating early-onset (EO) from late-onset (LO) Alzheimer’s disease (AD) is sparse and controversial, the aim of this study was to establish a precise age at onset (AAO) criterion, by using a specific statistical procedure, and to describe the clinical characteristics of the two sub-groups. Methods: Admixture analysis was performed to establish the AAO cut-off in a multi-center study including 2000 AD patients consecutively recruited in eight Italian Memory Clinics. None of the patients were taking acetylcholinesterase inhibitors, antipsychoticor anti-depressant drugs. At the first diagnosticvisit, they were administered the Mini Mental StateExamination, the Basic and Instrumental Activities of Daily Living and the Neuropsychiatric Inventorytoassess clinical phenomenology. Results: Using a specific statistical procedure, we established that AAO that discriminated EO-from LO-AD was 66. Compared with the LO-AD group, the EO-AD group showed longer duration of illness and a higher educational level as well as less severe functional impairment and delusions. Conclusions: Differences in sociodemographic and clinical characteristics, such as duration of illness, education and delusion severity, suggested the involvement of different pathogenic processes. Additional studies are needed to further investigate the mechanisms underlying the disorder in the two sub-groups of AD patients.

关键词： Alzheimer’s Disease Onset Neuropsychiatric Symptoms Admixture Analysis Pathogenesis Cognitive Reserve

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Digital liver biopsy:Bio-imaging of fatty liver for translational and clinical research

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World Journal of Hepatology 2018年第2期10卷 231-245页

作者： Marcello Mancini Paul Summers Francesco Faita Maurizia R Brunetto Francesco Callea Andrea de Nicola Nicole Di Lascio Fabio Farinati amalia Gastaldelli Bruno Gridelli Peppino Mirabelli Emanuele Neri Piero A Salvadori Eleni Rebelos Claudio Tiribelli luca Valenti Marco Salvatore Ferruccio Bonino Institute of Biostructure and Bioimaging National Research CouncilNaples 80145Italy European Institute of Oncology(IEO)IRCCS Milan 20141Italy Institute of Clinical Physiology(IFC) National Research Council(CNR)Pisa 56124Italy Hepatology Unit Department of Clinical and Experimental MedicineUniversity Hospital of PisaPisa 56125Italy department of Pathology Children Hospital Bambino GesùIRCCSRome 00165Italy ASL 2 Abruzzo Policlinico SS AnnunziataChieti 66100Italy department of Gastroenterology Oncology and Surgical SciencesUniversity of PaduaPadua 35121Italy Cardio-metabolic Risk Laboratory Institute of Clinical Physiology(IFC)National Research Council(CNR)Pisa 56124Italy Institute for Health University of Pittsburgh Medical Center(UPMC)Chianciano Terme 53042Italy IRCCS SDN SpA Naples 80143Italy Diagnostic Radiology 3 Department of Translational ResearchUniversity of Pisa and“Ospedale S.Chiara”AOUPPisa 56126Italy Fondazione Italiana Fegato(FIF) Area Science ParkCampus BasovizzaTrieste 34012Italy department of Pathophysiology and Transplantation Universitàdegli Studi di Milano and Department of Internal Medicine and Metabolic DiseasesFondazione IRCCS Ca’Granda Ospedale PoliclinicoMilan 20122Italy

The rapidly growing field of functional, molecular and structural bio-imaging is providing an extraordinary new opportunity to overcome the limits of invasive liver biopsy and introduce a "digital biopsy" for in vivo study of liver pathophysiology. To foster the application of bio-imaging in clinical and translational research, there is a need to standardize the methods of both acquisition and the storage of the bio-images of the liver. It can be hoped that the combination of digital, liquid and histologic liver biopsies will provide an innovative synergistic tri-dimensional approach to identifying new aetiologies, diagnostic and prognostic biomarkers and therapeutic targets for the optimization of personalized therapy of liver diseases and liver cancer. A group of experts of different disciplines(Special Interest Group for Personalized Hepatology of the Italian Association for the Study of the Liver, Institute for Biostructures and Bio-imaging of the National Research Council and Bio-banking and Biomolecular Resources Research Infrastructure) discussed criteria, methods and guidelines for facilitating the requisite application of data collection. This manuscript provides a multi-Author review of the issue with special focus on fatty liver.

关键词： Biobank Bio-imaging Fatty liver Genomics Liver biopsy Liver cancer Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Magnetic resonance Radiomics Ultrasound

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