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A multi-shot target wheel assembly for high-repetition-rate, laser-driven proton acceleration

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High Power Laser science and Engineering 2024年第2期 91-98页

作者： J.Pe?as A.Bembibre d.Cortina-Gil L.martín A.Reija C.Ruiz m.seimetz A.Alejo J.Benlliure Instituto Galego de física de Altas Enerxías Universidade de Santiago de Compostela Laboratorio Láser de Aceleración y Aplicaciones RIAIDT Universidade de Santiago de Compostela Instituto Universitario de física fundamental y matemáticas y dpto.de didáctica de la matemática y de las Ciencias Experimentales Universidad de Salamanca Instituto de Instrumentación para Imagen molecular (I3m) CSIC-Universitat Politècnica de València

A multi-shot target assembly and automatic alignment procedure for laser–plasma proton acceleration at high repetition rate are introduced. The assembly is based on a multi-target rotating wheel capable of hosting more than 5000 targets,mounted on a 3d motorized stage to allow rapid replenishment and alignment of the target material between laser irradiations. The automatic alignment procedure consists of a detailed mapping of the impact positions at the target surface prior to the irradiation that ensures stable operation of the target, which alongside the purpose-built design of the target wheel, enables operation at rates up to 10 Hz. stable and continuous laser-driven proton acceleration at 10 Hz is demonstrated, with observed cut-off energy stability about 15%.

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A multi-shot target wheel assembly for high-repetition-rate, laser-driven proton acceleration

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High Power Laser science and Engineering 2024年第2期12卷 87-94页

作者： J.Penas A.Bembibre d.Cortina-Gil L.martin A.Reija C.Ruiz m.seimetz A.Alejo J.Benlliure Instituto Galego de fisica de Altas Enerxias Universidade de Santiago de CompostelaSantiago de CompostelaSpain Laboratorio Laser de Aceleracion y Aplicaciones RIAIDTUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Instituto Universitario de física fundamental y matematicas y dpto.de didactica de la matematica y de las Ciencias Experimentales Universidad de SalamancaSalamancaSpain Instituto de Instrumentación para Imagen molecular(I3m) CSIC-Universitat Politecnica de ValenciaValenciaSpain

A multi-shot target assembly and automatic alignment procedure for laser–plasma proton acceleration at high repetition rate are *** assembly is based on a multi-target rotating wheel capable of hosting more than 5000 targets,mounted on a 3d motorized stage to allow rapid replenishment and alignment of the target material between laser *** automatic alignment procedure consists of a detailed mapping of the impact positions at the target surface prior to the irradiation that ensures stable operation of the target,which alongside the purpose-built design of the target wheel,enables operation at rates up to 10 *** and continuous laser-driven proton acceleration at 10 Hz is demonstrated,with observed cut-off energy stability about 15%.

关键词： high repetition rate laser-plasma acceleration multi-shot operation proton source target assembly

Regularized quantile regression for sNP marker estimation of pig growth curves

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Journal of Animal science and Biotechnology 2017年第4期8卷 824-832页

作者： L.m.A.Barroso m.Nascimento A.C.C.Nascimento1 f.f.silva N.V.L.serao C.d.Cruz m.d.V.Resende f.L.silva C.f.Azevedo P.s.Lopes s.E.f.Guimaraes department of statistics Federal University of Vicosa Av. P H Rolfs s/nUniversity Campus Vicosa MG 36570-000 Brazil department of Animal science Federal University of Vicosa Av. P H Rolfs s/n University CampusVicosa MG 36570-000 Brazil department of Animal science Iowa State University Kildee Hall 50011 Ames Iowa USA department of General Biology Federal University of Vicosa Av. P H Rolfs s/n University CampusVicosa MG 36570-000 Brazil Embrapa forestry Estrada da Ribeira km 111Colombo PR Brazil. department of Plant science Federal University of Vicosa Av. P H Rolfs s/n University Campus Vicosa MG 36570-000 Brazil

Background: Genomic growth curves are general y defined only in terms of population mean; an alternative approach that has not yet been exploited in genomic analyses of growth curves is the Quantile Regression(QR). This methodology allows for the estimation of marker effects at different levels of the variable of interest. We aimed to propose and evaluate a regularized quantile regression for sNP marker effect estimation of pig growth curves, as well as to identify the chromosome regions of the most relevant markers and to estimate the genetic individual weight trajectory over time(genomic growth curve) under different quantiles(levels).Results: The regularized quantile regression(RQR) enabled the discovery, at different levels of interest(quantiles), of the most relevant markers al owing for the identification of QTL regions. We found the same relevant markers simultaneously affecting different growth curve parameters(mature weight and maturity rate): two(ALGA0096701 and ALGA0029483)for RQR(0.2), one(ALGA0096701) for RQR(0.5), and one(ALGA0003761) for RQR(0.8). Three average genomic growth curves were obtained and the behavior was explained by the curve in quantile 0.2, which differed from the ***: RQR allowed for the construction of genomic growth curves, which is the key to identifying and selecting the most desirable animals for breeding purposes. furthermore, the proposed model enabled us to find, at different levels of interest(quantiles), the most relevant markers for each trait(growth curve parameter estimates) and their respective chromosomal positions(identification of new QTL regions for growth curves in pigs). These markers can be exploited under the context of marker assisted selection while aiming to change the shape of pig growth curves.

关键词： Genome association Growth curve Pig QTL Regularized quantile regression

Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats

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World Journal of Gastroenterology 2009年第11期15卷 1373-1380页

作者： salim s Al-Rejaie Abdulaziz m Aleisa Abdulaziz A Al-Yahya saleh A Bakheet Abdulmalik Alsheikh amal G fatani Othman A Al-shabanah mohamed m sayed-Ahmed department of Pharmacology College of PharmacyKing Saud UniversityPO Box 2457Kingdom of Saudi Arabia department of Pathology College of MedicineKing Saud UniversityPO Box 2457 Kingdom of Saudi Arabia

AIm:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (dENA)-induced hepatic carcinogenesis. mETHOds:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each *** in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 *** in group 3(carnitine-depleted group)were given d-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 *** in group 4(dENA group)were injected with a single dose of dENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn *** in group 5(dENA-carnitine depleted group)received the same treatment as group 3 and group *** in group 6 (dENA-carnitine supplemented group)received the same treatment as group 2 and group ***:Administration of dENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARs)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GsH),glutathione peroxidase(GsHPx), catalase(CAT)and total carnitine content in liver *** the carnitine-depleted rat model,dENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver ***, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARs and NOx,and a decrease in total carnitine,GsH,GsHPx, and CAT induced by dENA,compared with the control *** examination of liver tissues confirmed the biochemical data,where L-carnitine prevented dENA-induced hepatic carcinogenesis while d-carnitine-mildronate aggravated dENA-

关键词： Carnitine deficiency d-carnitine L-carnitine diethylnitrosamine Hepatic carcinogenesis

friction and wear properties of nano-si3N4/nano-siC composite under nanolubricated conditions

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Journal of Advanced Ceramics 2016年第2期5卷 145-152页

作者： m.s.CHAROO m.f.WANI Centre for Tribology Mechanical Engineering Department National Institute of Technology Srinagar(J&K) 190006 India

friction and wear properties of nano-si3N4/nano-siC composite were studied under nanolubricated conditions. mineral oil mixed with nanoparticles of diamond was used as lubricant. A friction coefficient of 0.043 and a wear coefficient of 4.2×10-7 were obtained for nano-si3N4/nano-siC composite under normal load of 600 N with mineral oil + 0.5 wt% nanodiamond, whereas a friction coefficient of 0.077 and a wear coefficient of 10.3×10-7 were obtained for nano-si3N4/nano-siC composite under normal load of 600 N with mineral oil. 3d surface profilometer was used to study the surface morphology of wear scars. scanning electron microscopy (sEm) and X-ray diffraction (XRd) studies were conducted to illustrate reduction in friction and wear.

关键词： nano-ceramics nanolubrication nano-si3N4/nano-siC friction wear

Evaluation of stress concentration for planar tubular joints

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中国有色金属学会会刊：英文版 2006年第B1期16卷 1-10页

作者： m.f.GHANAmEH d.THE VENET A.ZEGHLOUL Laboratory of mechanics and Physics of materials - U.m.R.CNRs N° 7554 University of MetzLPMM57045 MetzFrance Laboratory of mechanics of Naval structures ENSIETA29806 BrestFrance Received 10 April 2006 accepted 25 April 2006

In offshore tubular structures, a typical tubular joint may be subjected to three different types of basic loadings: axial, in-plane bending and out-of-plane bending, through its brace members. Each type will cause a different stress distribution at the joint intersection of structures. moreover, the actual load condition of a tubular joint can be any combination of the above three basic load cases, for this reason, a combined loading was investigated in addition to these three basic loadings. This load is composed of an axial loading combined with a continuation of rotational bending loading obtained while rotate center of the brace around a circle. different types of planar joints such as T, Y, X, K, dT, dY, dX, TY, TK, dTX, dTdY, and dTdK, with braces subjected to combined loading, were numerically analyzed to study the effect of those different cases of loading and different types of joints, on the stress concentration zone and values.

关键词：管子接头焊接应力集中评价应力分布有限元法海洋平台

An integrated nanocarbon–cellulose membrane for solid-state supercapacitors

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science Bulletin 2016年第5期61卷 368-377页

作者： Huabo Liu Yuheng Tian Rose amal da-Wei Wang school of Chemical Engineering The University of New South Wales

In this work, we demonstrate the assembly of oxidised carbon nanohybrids(o CNHs) with a commercial cellulose membrane for solid-state supercapacitors. The o CNHs–cellulose membranes were prepared by filtering a water dispersion of o CNHs through the cellulose membrane. The o CNHs were derived from carbon nanotubes via a modified Hummer's method and contained both closed tubes and unzipped tubes, which indicated a hybrid geometrical structure. The solid-state supercapacitor based on the o CNHs–cellulose membranes showed a high areal capacitance of *75 m f/cm^2 at a low scan rate(5 m V/s)and excellent stability for 1,000 cycles.

关键词： solid-state supercapacitors Carbon nanotubes membrane

Nanostructured Graphene surfaces Promote different stages of Bone Cell differentiation

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Nano-micro Letters 2018年第3期10卷 103-114页

作者： f.f.Borghi P.A.Bean m.d.m.Evans T.van der Laan s.Kumar K.Ostrikov Plasma Nanoscience School of Physics The University of Sydney CsIRO manufacturing Brazilian Centre for Physics Research (CBPf) school of Chemistry Physics and Mechanical EngineeringQueensland University of Technology CsIRO-QUT Joint sustainable Processes and devices Laboratory Commonwealth Scientific and Industrial Research Organization

Nanostructured graphene films were used as platforms for the differentiation of saos-2 cells into bonelike cells. The films were grown using the plasma-enhanced chemical vapor deposition method, which allowed the production of both vertically and horizontally aligned carbon nanowalls(CNWs). modifications of the techniqueallowed control of the density of the CNWs and their orientation after the transfer process. The influence of two different topographies on cell attachment, proliferation,and differentiation was investigated. first, the transferred graphene surfaces were shown to be noncytotoxic and were able to support cell adhesion and growth for over 7 ***, early cell differentiation(identified by cellular alkaline phosphatase release) was found to be enhanced on the horizontally aligned CNW surfaces, whereas mineralization(identified by cellular calcium production), a later stage of bone cell differentiation, was stimulated by the presence of the vertical CNWs on the surfaces. These results show that the graphene coatings, grown using the presented method, are biocompatible. And their topographies have an impact on cell behavior, which can be useful in tissue engineering applications.

关键词： Carbon nanowalls Graphene films Bone cell Cell differentiation Plasma nanoscience

magnetic Configuration Effects on fast Ion Losses Induced by fast Ion driven Toroidal Alfvén Eigenmodes in the Large Helical device

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Plasma science and Technology 2012年第4期14卷 269-272页

作者： K.OGAWA m.IsOBE K.TOI f.WATANABE d.A.sPONG A.sHImIZU m.OsAKABE d.s.dARROW s.OHdACHI s.sAKAKIBARA LHd Experiment Group department of Energy science and Engineering Nagoya University National Institute for fusion science Graduate school of Energy science Kyoto University Oak Ridge National Laboratory Oak Ridge Princeton Plasma Physics Laboratory Princeton University

Beam-ion losses induced by fast-ion-driven toroidal Alfven eigenmodes （TAE） were measured with a scintillator-based lost fast-ion probe （sLIP） in the large helical device （LHd）. The sLIP gave simultaneously the energy E and the pitch angle X=arccos（v///v） distribution of the lost fast ions. The loss fluxes were investigated for three typical magnetic configurations of Rax-vac=3.60 m, 3.75 m. and 3.90 m, where Rax-vac is the magnetic axis position of the vacuum field. dominant losses induced by TAEs in these three configurations were observed in the E/X regions of 50-190 keV/40°, 40-170 keV/25°, and 30-190 keV/30°, respectively. Lost-ion fluxes induced by TAEs depend clearly on the amplitude of TAE magnetic fluctuations, Rax-vac and the toroidal field strength Bt. The increment of the loss fluxes has the dependence of （bTAE/Bt）s. The power s increases from s = 1 to 3 with the increase of the magnetic axis position in finite beta plasmas.

关键词： toroidal Alfven eigenmode fast ion loss the large helical device