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＂RADIOTRANSCRIPTOMICS＂： A synergy of imaging and transcriptomics in clinical assess- ment

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Frontiers of Electrical and Electronic Engineering in China 2016年第1期4卷 1-12页

作者： amal Katrib William Hsu alex Bui Yi Xing Department of Microbiology Immunology and Molecular Genetics University of California Los Angeles Los Angeles CA_ 90095 USA Department of Radiological Sciences University of California Los Angeles Los Angeles CA 90095 USA

Recent advances in quantitative imaging and ＂omics＂ technology have generated a wealth of mineable biological ＂big data＂. With the push towards a P4 ＂predictive, preventive, personalized, and participatory＂ approach to medicine, researchers began integrating complementary tools to further tune existing diagnostic and therapeutic models. The field of radiogenomics has long pioneered such multidisciplinary investigations in neuroscience and oncology, correlating genotypic and phenotypic signatures to study structural and functional changes in relation to altered molecular behavior. Given the innate dynamic nature of complex disorders and the role of environmental and epigenetic factors in pathogenesis, the transcriptome can further elucidate serial modifications undetected at the genome level. We therefore propose ＂radiotranscriptomics＂ as a new member of the P4 medicine initiative, combining transcriptome information, including gene expression and isoform variation, and quantitative image annotations.

关键词： quantitative imaging transcriptomics RNA-seq genomics image genomics radiogenomics systems biology precision medicine

Computerized Detection of Limbal Stem Cell Deficiency from Digital Cornea Images

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Computer Systems Science & Engineering 2022年第2期40卷 805-821页

作者： Hanan A.Hosni Mahmoud Doaa S.Khafga amal H.alharbi Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11047KSA

Limbal Stem Cell Deficiency(LSCD)is an eye disease that can cause corneal opacity and *** its advanced stage it can lead to a degree of visual *** involves the changing in the semispherical shape of the cornea to a drooping shape to downwards *** is hard to be diagnosed at early *** color and texture of the cornea surface can provide significant information about the cornea affected by *** such as shape and texture are very crucial to differentiate normal from LSCD *** several medical approaches exist,most of them requires complicated procedure and medical ***,in this paper,we pursued the development of a LSCD detection technique(LDT)utilizing image processing *** diagnosis of LSCD is very crucial for physicians to arrange for effective *** the proposed technique,we developed a method for LSCD detection utilizing frontal eye images.A dataset of 280 eye images of frontal and lateral LSCD and normal patients were used in this ***,the cornea region of both frontal and lateral images is segmented,and the geometric features are extracted through the automated active contour model and the spline *** the texture features are extracted using the feature selection *** experimental results exhibited that the combined features of the geometric and texture will exhibit accuracy of 95.95%,sensitivity of 97.91% and specificity of 94.05% with the random forest classifier of n=*** a result,this research developed a Limbal stem cell deficiency detection system utilizing features’fusion using image processing techniques for frontal and lateral digital images of the eyes.

关键词： Feature extraction corneal opacity geometric features computerized detection image processing

Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

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Nano-Micro Letters 2024年第6期16卷 127-179页

作者： amal George Kurian Rajendra K.Singh Varsha Sagar Jung‑Hwan Lee Hae‑Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

Wafer-scale quasi-layered tungstate-doped polypyrrole film with high volumetric capacitance

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Nano Research 2023年第4期16卷 4895-4900页

作者： Huabo Liu Jiaxing Liang John Watt Richard D.Tilley Rose amal Da-Wei Wang School of Chemical Engineering University of New South WalesSydneyNSW 2052Australia 2 Center for Integrated NanotechnologiesLos Alamos National LaboratoryLos AlamosNW 87545USA 3 School of ChemistryUniversity of New South WalesSydneyNSW 2052Australia

Layered materials are particularly attractive for supercapacitors because of their unique physical,electrical and chemical ***,we demonstrate a facile and scalable electrochemical deposition method for wafer-scale synthesis of quasilayered tungstate-doped polypyrrole films(named TalPy)with controllable thickness and *** as-prepared TalPy film exhibits a high gravimetric density and excellent volumetric capacitance,exceeding many high-performing carbon-and polymerbased film *** on combined results of ex-situ X-ray diffraction(XRD),Raman and X-ray photoelectron spectroscopy(XPS),it is determined that TalPy stores charge through an ion intercalation process accompanied by change in oxidation states of polypyrrole backbone,which is referred as intercalation *** these results suggest the great promise of electrochemical deposition as a scalable and controllable bottom-up approach for synthesizing quasi-layered conductive organic-inorganic hybrid films for electrochemical energy storage applications with high volumetric performance.

关键词： electrochemical deposition conductive polymer polypyrrole organic-inorganic hybrid supercapacitor intercalation pseudocapacitance

A digital assistant for shading paper sketches

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Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 152-167页

作者： amal Dev Parakkat Hari Hara Gowtham Sarang Joshi Ramanathan Muthuganapathy Indian Institute of Technology Madras Chennai 600036India Indian Institute of Technology Guwahati Assam 781039India

We present a mixed reality-based assistive system for shading paper *** a paper sketch made by an artist,our interface helps inexperienced users to shade it ***,using a simple Delaunaytriangulation based inflation algorithm,an approximate depth map is *** system then highlights areas(to assist shading)based on a rendering of the 2.5-dimensional inflated model of the input *** the help of a mixed reality system,we project the highlighted areas back to aid *** hints given by the system are used for shading and are smudged appropriately to apply an artistic shading to the *** user is given flexibility at various levels to simulate conditions such as height and light *** show that the proposed system aids novice users in creating sketches with impressive shading.

关键词： Shading Paper sketch Mixed reality Iso-contours Delaunay triangulation Digital art

Emerging material engineering strategies for amplifying photothermal heterogeneous CO_(2)catalysis

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Journal of Energy Chemistry 2021年第8期30卷 108-125,I0004页

作者： Bingqiao Xie Emma Lovell Tze Hao Tan Salina Jantarang Mengying Yu Jason Scott Rose amal Particles and Catalysis Research Group School of Chemical EngineeringThe University of New South Wales2052 SydneyAustralia Department of Chemistry Faculty of Science Kyushu UniversityMoto-oka744 Nishi-ku819-0395 FukuokaJapan

Closing the carbon loop,through CO_(2)capture and utilization,is a promising route to mitigate climate *** energy is a sustainable energy source which can be exploited to drive catalytic reactions for utilizing CO_(2),including converting the CO_(2)into useful *** energy can be harnessed through a range of different pathways to valorize CO_(2).Whilst using solar energy to drive CO_(2)reduction has vast potential to promote catalytic CO_(2)conversions,the progress is limited due to the lack of understanding of property-performance relations as well as feasible material engineering ***,we outline the various driving forces involved in photothermal CO_(2)*** heat from solar energy can be utilized to induce CO_(2)catalytic reduction reactions via the photothermal ***,solar energy can act to modify reaction pathways through light-matter ***-induced chemical functions have demonstrated the ability to regulate intermediary reaction steps,and thus control the reaction *** catalyst structures and specific catalyst design strategies are discussed in this *** review provides a comprehensive understanding of the heat-light synergy and guidance for rational photothermal catalyst design for CO_(2)utilization.

关键词： CO_(2)reduction Photothermal catalysis Material engineering strategies Plasmonic photocatalysis

Radial Hahn Moment Invariants for 2D and 3D Image Recognition

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International Journal of Automation and computing 2018年第3期15卷 277-289页

作者： Mostafa El Mallahi amal Zouhri Anass El Affar Ahmed Tahiri Hassan Qjidaa Sidi Mohamed Ben Abdellah University Faculty of Sciences Dhar el MahrazCED-ST Center of Doctoral Studies in Sciences and Technologies

Recently, orthogonal moments have become efficient tools for two-dimensional and three-dimensional（2D and 3D） image not only in pattern recognition, image vision, but also in image processing and applications engineering. Yet, there is still a major difficulty in 3D rotation invariants. In this paper, we propose new sets of invariants for 2D and 3D rotation, scaling and translation based on orthogonal radial Hahn moments. We also present theoretical mathematics to derive them. Thus, this paper introduces in the first case new 2D radial Hahn moments based on polar representation of an object by one-dimensional orthogonal discrete Hahn polynomials, and a circular function. In the second case, we present new 3D radial Hahn moments using a spherical representation of volumetric image by one-dimensional orthogonal discrete Hahn polynomials and a spherical function. Further 2D and 3D invariants are derived from the proposed 2D and 3D radial Hahn moments respectively, which appear as the third case. In order to test the proposed approach, we have resolved three issues： the image reconstruction, the invariance of rotation, scaling and translation, and the pattern recognition. The result of experiments show that the Hahn moments have done better than the Krawtchouk moments, with and without noise. Simultaneously, the mentioned reconstruction converges quickly to the original image using 2D and 3D radial Hahn moments, and the test images are clearly recognized from a set of images that are available in COIL-20 database for 2D image, and Princeton shape benchmark（PSB） database for 3D image.

关键词： Orthogonal moments two-dimensional and three-dimensional (2D and 3D) radial Hahn moments Hahn polynomials image reconstruction 2D and 3D rotation invariants.

Kumaraswamy Inverted Topp–Leone Distribution with Applications to COVID-19 Data

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Computers, Materials & Continua 2021年第7期68卷 337-358页

作者： amal S.Hassan Ehab M.almetwally Gamal M.Ibrahim Faculty of Graduate Studies for Statistical Research Cairo UniversityGiza12613Egypt Faculty of Business Administration Delta University of Science and TechnologyMansoura35511Egypt High Institute for Management Sciences Belqas35511Egypt

In this paper, an attempt is made to discover the distributionof COVID-19 spread in different countries such as;Saudi Arabia, Italy,Argentina and Angola by specifying an optimal statistical distribution for analyzing the mortality rate of COVID-19. A new generalization of the recentlyinverted Topp Leone distribution, called Kumaraswamy inverted Topp–Leonedistribution, is proposed by combining the Kumaraswamy-G family and theinverted Topp–Leone distribution. We initially provide a linear representationof its density function. We give some of its structure properties, such as quantile function, median, moments, incomplete moments, Lorenz and Bonferronicurves, entropies measures and stress-strength reliability. Then, Bayesian andmaximum likelihood estimators for parameters of the Kumaraswamy invertedTopp–Leone distribution under Type-II censored sample are *** estimator is regarded using symmetric and asymmetric loss functions. As analytical solution is too hard, behaviours of estimates have beendone viz Monte Carlo simulation study and some reasonable comparisonshave been presented. The outcomes of the simulation study confirmed theefficiencies of obtained estimates as well as yielded the superiority of Bayesianestimate under adequate priors compared to the maximum likelihood *** to COVID-19 in some countries showed that the new distributionis more appropriate than some other competitive models.

关键词： Kumaraswamy-G family maximum likelihood Bayesian method COVID-19 moments quantile function stress-strength reliability

Education in War:A Case Study of the Education Quality of Public Primary School in al-Thorah District,Amant alasimah Sana’a,Yemen

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Education in War:A Case Study of the Education Quality of Pu...

作者： amal AHMED HASAN SUWAID 浙江师范大学

学位级别：硕士

Education in general and primary education in particular can bring about the advancement of a *** is traumatizing by war this study was conducted to investigate the factors and forces influencing the quality of public primary education,the challenges and the solutions needed to improve the effectiveness of reform and development of the basic education system in al Thaorah district Amanat al Asimah,Sana’a,YemenA case study was conducted in al Thaorah district in Amanat al Asimah in *** schools were taken from the al Thaorah Directorate for this case *** data was collected through interviews with the principals and administrators from each school,five teachers from each school and three parents from the Parents Council in each ***,articles and topics related to the field of research were analyzed so that a comprehensive idea of the issue could be *** results of this study were as follows:In terms of factors and important forces affecting the quality of education,the war had a major role in the decline in the quality of education due to the destruction of the infrastructure of some *** deteriorating economic situation,the emergence of sub-forces and the politicization and division of education have also significantly affected the quality of educationThe study also found that there are many challenges facing the quality of public primary education in Yemen,including the limited number of teachers in government *** is a direct result of the salary cuts many teachers face and the promotion of some teachers to supervisors and ***,an increase in the number of students within the classes has contributed to the low quality of *** one semester,there were one hundred students due to the displacement of citizens to the capital,Sanaa,from other *** number of students exceeded the number of teachers *** problem is compounded by the fact that the teachers lack motivation due to poor sala

关键词：公立小学教育质量教师素质