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Solute transport and geochemical modeling of the coastal quaternary aquifer, delta dahab Basin, South Sinai, Egypt

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Acta Geochimica 2024年第1期43卷 16-39页

作者： Amira Samy Mustafa Eissa Seham Shahen Moustafa M.Said Rabab M.abou-shahaba division of Water Resources and Arid Land Department of HydrogeochemistryDesert Research CenterCairoEgypt Egypt desalination Research Center of Excellence Desert Research CenterCairoEgypt Center for Water Supply Studies S&E-Physical&Environmental SciencesTexas A&M University Corpus ChristiCorpus ChristiUSA department of Chemistry Faculty of Science(Girls)Al-Azhar UniversityYousef Abbas StrNasr CityP.O.Box:11754CairoEgypt

The wadi dahab delta is in a dry, arid coastal zone within Egypt’s south Sinai Peninsula’s eastern portion. The primary water source is the Quaternary coastal alluvial aquifer. The groundwater salinity varies from 890to 8213 mg/L, with a mean value of 3417 mg/L. The dissolved major ions have been used to calculate the seawater mixing index(SWMI) using a linear equation that discriminates the groundwater mostly affected by water–rock interaction(SWMI 1>) and other samples mixed with Seawater(SWMI n of groundwater for specifically chosen groundwater samples ranges from-0.645‰ to +5.212‰ for δ^(18)O and from-9.582‰ to + 22.778‰ for δ^(2)H, where the seawater represented by a Red Sea water sample(δ^(18)O + 1.64‰-δ^(2)H + 9.80‰) and reject brine water are considerably enriched the isotopic groundwater values. The geochemical nETPATH model constrained by the dissolved significant ions, isotopes, and the rock aquifer forming minerals as phases indicate the mixing percent with the seawater ranges from 9% to 97% of seawater from 91% to 3% of original recharge water. According to the SEAWAT 3-d flow models, seawater has penetrated the northeastern dahab delta aquifer, with the intrusion zone extending1500 m inland. The salt dissolution, upwelling of saline water, recharge from the upstream mountain block, and seawater encroachment are the primary aspects contributing to the deterioration of groundwater quality. These findings may have significance for effective groundwater withdrawal management in arid locations worldwide with similar hydrogeological systems.

关键词： Groundwater geochemistry Seawater intrusion Solute transport SEAWAT

Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.L-hashem Salah O.Bashir amal F.dawood Moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz M.Al-Garni Mohamed d.Morsy department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia department of Basic Medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia department of Medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological n rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the Morris Water Maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear nrf2 mRnA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective n rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective nrf2 gene oxidative stress vanillylacetone

Heavy metal pollution of river water and eco-friendly remediation using potent microalgal species

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Water Science and Engineering 2024年第1期17卷 41-50页

作者： Amudham Radha amal Raj Prabhakaran Mylsamy V.Sivasankar B.Sathish Kumar Kiyoshi Omine T.G.Sunitha Phycological Research Laboratory Research Department of BotanyPachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Research department of Chemistry Pachaiyappa's College(Affiliated to University of Madras)Chennai 600030India department of Botany Sri Vidya Mandir Arts&Science College(Autonomous)KatteriUthangarai 636902India department of Civil Engineering School of Engineering.Nagasaki UniversityNagasaki-Daigaku1-14 Bunkyo-machiNagasaki 8528521Japan

Pollution of rivers is mainly caused by anthropogenic activities such as discharge of effluent from industrial facilities,maintenance of sewage/effluent treatment plants,and dumping of solid waste on river *** study dealt with the pollution issues of the Cooum River in the well-known city of Chennai in South *** samples from 27 locations were collected and analyzed for 12 elements,including Ba,B,and Al,as well as heavy metals such as Pb,Cr,Mn,Fe,Co,ni,Cu,Zn,and *** samples showed levels of these elements that exceeded World Health Organization *** correlation analysis revealed the inter-dependency among elements,and the contribution of each element based on factor loadings showed its percentage contribution compared to *** samples from six significant locations were chosen for remediation with three algae:Chlorella vulgaris,Scenedesmus dimorphus,and Phormedium *** uptake of pollutants led to the continuous growth of algae during the incubation period of 15 d,effectively removing heavy metals from the river *** increasing levels of algal counts and the chlorophyll a content confirmed the algal growth during the incubation period,followed by a declining stage after the incubation *** scanning electron microscopic images of algae before and after the remediation showed no remarkable modification of morphological *** study showed that the uptake of heavy metals using algae is an effective water pollution remediation measure,making the process practicable in the field on a large scale in the near future.

关键词： Heavy metal Cooum river Phycoremediation Microalgae Factor analysis

Privacy-Preserving Information Fusion Technique for device to Server-Enabled Communication in the Internet of Things:A Hybrid Approach

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Computers, Materials & Continua 2024年第7期80卷 1305-1323页

作者： amal Al-Rasheed Rahim Khan Tahani Alsaed Mahwish Kundi Mohamad hanif Md.Saad Mahidur R.Sarker department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia department of Computer Science AbdulWali Khan University MardanMardan23200Pakistan Faculty of Computing and Informatics University Malaysia SabahKota KinabaluSabah88400Malaysia Applied College Taibah UniversityMadinah41477Saudi Arabia Maynooth International Engineering College Maynooth UniversityCo KildareW23 X021Irland department of Mechanical Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaBangiSelangor43600Malaysia Institute of Visual Informatics Universiti Kebangsaan MalaysiaBangiSelangor43600Malaysia University of design Innovation and Technology(UDIT)Av.Alfonso XIII97Madrid28016Spain

due to the overwhelming characteristics of the Internet of Things(IoT)and its adoption in approximately every aspect of our lives,the concept of individual devices’privacy has gained prominent attention from both customers,i.e.,people,and industries as wearable devices collect sensitive information about patients(both admitted and outdoor)in smart healthcare *** addition to privacy,outliers or noise are among the crucial issues,which are directly correlated with IoT infrastructures,as most member devices are resource-limited and could generate or transmit false data that is required to be refined before processing,i.e.,***,the development of privacy-preserving information fusion techniques is highly encouraged,especially those designed for smart IoT-enabled *** this paper,we are going to present an effective hybrid approach that can refine raw data values captured by the respectivemember device before transmission while preserving its privacy through the utilization of the differential privacy technique in IoT *** window,i.e.,δi based dynamic programming methodology,is implemented at the device level to ensure precise and accurate detection of outliers or noisy data,and refine it prior to activation of the respective transmission ***,an appropriate privacy budget has been selected,which is enough to ensure the privacy of every individualmodule,i.e.,a wearable device such as a smartwatch attached to the patient’s *** contrast,the end module,i.e.,the server in this case,can extract important information with approximately the maximum level of ***,refined data has been processed by adding an appropriate nose through the Laplace mechanism to make it useless or meaningless for the adversary modules in the *** proposed hybrid approach is trusted from both the device’s privacy and the integrity of the transmitted information *** and analytical results ha

关键词： Internet of things information fusion differential privacy dynamic programming Laplace function

从H1n1血凝素序列提取的沙门氏菌传递的COBRA-ha1抗原对甲型流感亚型产生广谱保护作用

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Engineering 2024年第1期32卷 41-56页

作者： Ram Prasad Aganja amal Senevirathne Chandran Sivasankar John Hwa Lee department of Veterinary Public Health College of Veterinary MedicineJeonbuk National UniversityIksan 54596Republic of Korea department of Preventive Medicine College of Veterinary MedicineChungnam National UniversityDaejeon 34134Republic of Korea

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza *** this study,a strategy called computationally optimized broadly reactive antigen(COBRA)was used to generate a consensus sequence of the hemagglutinin globular head portion(ha1)of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed *** carrying different ha1regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RnA-dependent RnApolymerase(RdRp)-based eukaryotic expression system,*** protein expression was confirmed by Western blot and immunofluorescence *** immunized with the designed constructs produced a humoral response,with a significant increase in immunoglobulin G(IgG)levels,and a cell-mediated immune response,including a 1.5-fold increase in Cd4^(+) and Cd8^(+)T ***,constructs #1 and #5 increased the production of interferon-γ(IFn-γ)producing Cd4^(+)and Cd8^(+)T cells,skewing the response toward the T helper type 1 cell(Th1)***,interleukin-4(IL-4)-producing T cells were upregulated *** efficacy was demonstrated,with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer>40 against the selected viral *** designed constructs conferred a broadly protective immune response,resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34,A/Brisbane/59/2007,A/California/07/2009,KBPV VR-92,and nCCP 43021 *** discovery revolutionizes influenza vaccine design and delivery;Salmonella-mediated COBRA-ha1 is a highly effective in vivo antigen presentation *** approach can effectively combat seasonal H1n1 influenza strains and potential pandemic outbreaks.

关键词： COBRA Influenza A Salmonella Vaccine Broad spectral protection

Optimization of Tin-doped Hybrid Perovskite Solar Cells

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Open Journal of Applied Sciences 2024年第3期14卷 687-706页

作者： Bakary Coulibaly abou Ahou Florentine Kokora desiré Meledje Boko Aka Bernabé Mari Soucase IREn (Institut de Recherche sur les Energies nouvelles Abidjan Cote d’Ivoire Unité de Formation et de Recherche des Sciences Fondamentales Appliquées (UFRSFA) Universite Nangui Abrogoua Abidjan Cote d’Ivoire Laboratoire de Physiques Fondamentales Appliquées (LPFA) Université Nangui Abrogoua Abidjan Cote d’Ivoire Institut de disseny i Fabricació Universitat Politècnica. València Spain

Perovskites are a category of materials with a unique crystal structure that allows them to absorb sunlight efficiently. This efficiency is particularly high in the case of CH3nH3Pb1-xSnxI3 mixed perovskites. The combination of lead (Pb) and tin (Sn) in this matrix provides a broad spectrum of sunlight absorption, enabling the generation of a larger voltage and, subsequently, increased power. The primary objective in solar cell development is to maximize the conversion of sunlight into electricity. Mixed perovskites like CH3nH3Pb1-xSnxI3 have demonstrated significant potential in this regard. Their tunable bandgap, courtesy of varying the Pb: Sn ratio, allows for the optimization of sunlight absorption. The result is solar cells that surpass many conventional counterparts in terms of energy efficiency. Another significant advantage of these mixed perovskite solar cells is their cost-effectiveness. They can be manufactured using solution-based processes, which are less expensive than the high-vacuum methods required for traditional silicon solar cells. While the prospects for mixed perovskite solar cells are undeniably promising, there are concerns about the toxicity of lead, a key component of these cells. Lead is known to have harmful effects on the environment and health. The aim of our work is to reduce or eliminate lead toxicity in the perovskite cell while maintaining its efficiency. Thus, in a theoretical and experimental approach, we obtained following efficiencies of samples: CH3nH3PbI3 (22.49%) CH3nH3Pb0.75Sn0.25I3 (22.72%), CH3nH3Pb0.5Sn0.5I3 (23.00%) CH3nH3Pb0.25Sn0.75I3 (22.61%), CH3nH3SnI3 (22.38%). doping with 50% tin

关键词： Cost Efficiency Lead/Tin Perovskite Toxicity

Local Criteria Used by Farmers to Evaluate the Agronomic Performance and the Fertilizing Capacity of Cowpea Varieties: diversity, Variability and Proximal Relation with Agronomic Measurements in Contrasted Sahelian Locations

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Agricultural Sciences 2024年第1期15卷 114-131页

作者： nouhou Salifou Jangorzo Abdoul-Aziz Saïdou abou-Soufianou Sadda Abdoulaye Moussa Mamoudou hassane Bil-Assanou Issoufou département des Sciences du Sol et Télédétection Université Dan Dicko Dankoulodo de Maradi Maradi Niger. Unité Mixte de Recherche “diversité et Adaptation des Plantes” (UMR dAP) Université Dan Dicko Dankoulodo de Maradi Maradi Niger Centre Imaan de Support en Recherche Transdisciplinaire (Imaan Research) Niamey Niger Institut de Recherche pour le développement Niamey Niger Université Boubacar BA de Tillabéri Tillabéri Niger département des Sciences et Techniques de Productions Végétales Université Dan Dicko Dankoulodo de Maradi Maradi Niger

When contributing to participatory research, farmers usually appreciate the performance of cowpea varieties using qualitative scores. The score they attribute to each variety are based on local knowledge. The specific criteria they individually use to attribute a score are not well described. The objectives of this work were to: 1) identify and describe exhaustively the local criteria used by farmers to measure the agronomic performance of cowpea;2) assess the variability and statistical structure of these farmer criteria across local contexts;3) and analyze the association between these farmer criteria and the classical agronomic measurement. To achieve these objectives, an augmented block design was implemented across fifteen locations in the regions of Maradi, dosso and Tillabéri, representing a diversity of local contexts. From a set of 36 cowpea varieties, fifteen varieties were sown per location, including five varieties (controls) common to all locations. In each location, two replicates were sown in randomized Fisher’s blocks. After agronomic measurement and participatory evaluation (scoring of varieties by farmers), a group survey (focus group) was conducted in each location to identify the criteria considered by farmers to found their discretional scoring of varieties during the participatory evaluation. The analysis of the data identified, across locations, thirteen criteria defined by farmers to characterize the agronomic performance of cowpea. Some of these criteria were different according to location. Farmers ranked the three varieties with the best performance for each agronomical trait (Top 3 varieties). A comparison of the farmer ranking with the ranking based on agronomic measurements revealed similarity and complementary between both methods. This study highlighted the importance of considering both local and scientific knowledge in local varietal evaluations.

关键词： Agronomic Performance Participatory Research Cowpea Farmers’ Criteria

Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani naseh Algehainy Mohammad A.Alanazi Abdul-Badi abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India department of Human Genetics-Precision Medicine in diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRnAs,miRnAs,dnA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

Modeling the Spatio-Temporal dynamics of Local Context for a Contextualized diffusion of Agroecological Intensification Options in niger

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International Journal of Geosciences 2024年第3期15卷 270-301页

作者： nouhou Salifou Jangorzo Maud Loireau abou-Souﬁanou Sadda Ousmane Sami Mari Abdoul-Aziz Saïdou hassane Bil-Assanou Issoufou département des Sciences du Sol et Télédétection Université Dan Dicko Dankoulodo de Maradi UMR DAP Maradi Niger Unité mixte de Recherche diversité et Adaptation des Plantes (UMR dAP) Université Dan Dicko Dankoulodo de Maradi Maradi Niger Institut de Recherche pour le développement UMR Espace-DEV Université de Perpignan Via Domitia (UPVD) Perpignan France Institut de Recherche pour le développement Représentation Niamey Niger Centre Imaan de Support en Recherche Transdisciplinaire UMR DAP/UDDM Niamey Niger département des Sciences et Techniques de Productions Végétales Université Dan Dicko Dankoulodo de Maradi UMR DAP Maradi Niger

Spatio-temporal variability and dynamics in Sahelian agro-pastoral zones make each local situation a special case. These specificities must be considered to guide the dissemination of agricultural options with a view to sustainable development. The territorial scale of municipalities is not sufficient for this necessary contextualization;the scale of the “village terroir” seems to be a better option. This is the hypothesis we put forward in the framework of the Global Collaboration for Resilient Food Systems program (CRFS), i.e. local context is spatially defined by village terroir. The study is based on data collected through participatory mapping and surveys in “village terroirs” in three regions of niger (Maradi, dosso and Tillabéri). Then the links between farm managers and their cultivated land, as well as the spatio-temporal dynamics of local context are analyzed. This study provides evidence of the existence and functional usefulness of the village terroir for farmers, their land management and their activities. It demonstrates the usefulness of contextualizing agricultural options at this scale. Their analysis elucidates the links between “terroirs village” and the specific functioning of the agrosocio-ecosystems acting on each of them, thus laying the systemic and geographical foundations for a model of the spatio- temporal dynamics of “village terroirs”. This initial work has opened up new perspectives in modeling and sustainable development.

关键词： niger Option by Context Local Condition Complex System Multiscale Conceptual Modeling