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Assessment of cognitive function in patients with myasthenia gravis

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Neuroimmunology and Neuroinflammation 2014年第1期1卷 141-146页

作者： Sherifa a.hamed Ahmad H.Youssef Mohamad A.Abd ElHameed Mohamed F.Mohamed amal M.Elattar Department of Neurology and Psychiatry Assiut University HospitalAssiut 71516AssiutEgypt Department of ENT Audiology UnitAssiut University HospitalAssiut 71516AssiutEgypt

Aim:During the past decade,there has been an increasing interest in the evaluation of cognitive function in myasthenia gravis(MG),neuromuscular transmission disorder caused by acetylcholine receptor ***,the results of previous studies on cognition and MG are inconsistent and *** study aimed to evaluate cognition in patients with mild/moderate grades of ***:This study included 20 patients with MG with a mean age of 28.45±8.89 years and duration of illness of 3.52±1.15 *** was tested using a sensitive battery of psychometric testing(Mini-mental State Examination[MMSE],Stanford-Binet Intelligence Scale 4^(th) edition[SBIS]and Wechsler Memory Scale-Revised[WMS-R])and by recording P300 component of event-related potentials(ERPs),a neurophysiological analog for cognitive ***:Compared with healthy subjects(n=20),patients had lower total scores of cognitive testing(MMSE,SBIS and WMS-R)(P=0.001),higher Beck Depression Inventory 2^(nd) edition scores(P=0.0001)and prolonged latencies(P=0.01)and reduced amplitudes(P=0.001)of P300 component of *** were identified between total scores of cognitive testing and age(r=-0.470,P=0.010),duration of illness(r=-0.788,P=0.001)and depression scores(r=-0.323,P=0.045).Using linear regression analysis and after controlling for age and depression scores,a significant correlation was identified between total scores of cognitive testing and duration of illness(β=-0.305,P=0.045).Conclusion:Patients with mild/moderate MG may have cognitive *** is important to determine prognosis and managing patients.

关键词： Cognition myasthenia gravis nicotinic acetylcholine receptors

Maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring;An Egyptian case-control study

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Genes & Diseases 2019年第2期6卷 193-200页

作者： Wesam A.Mokhtar amal Fawzy Reem M.Allam Rania M.Amer Mona S.hamed Pediatric Department Faculty of MedicineZagazig UniversityEgypt Medical Biochemistry Department Faculty of MedicineZagazig UniversityEgypt Clinical Pathology Department Faculty of MedicineZagazig UniversityEgypt Medical Microbiology and Immunology Department Faculty of MedicineZagazig UniversityEgypt Public Health and Community Medicine Faculty of MedicineZagazig UniversityEgypt

Vitamin D&vitamin D receptor(VDR)signaling play a very crucial role in early embryonic heart *** construct this case-control study to investigate the association between maternal serum vitamin D level&VDR gene Fok1 polymorphism and risk of congenital heart defects(CHD)in *** mothers who had term neonates with CHD were considered as *** age-comparable healthy mothers who had neonates without CHD were contemplated as *** serum 25 hydroxyvitamin D[25(OH)D]level was tested using *** VDR gene Fok1 polymorphism was analyzed using PCR-based *** was a significant decrease in maternal vitamin D level(P=0.002)and a significant increase in vitamin D deficient status(P=0.007)among cases when compared to *** gene Fok1 genotypes distribution frequency were in accordance with Hardy Weinberg equilibrium(HW)among controls.A significant increase in VDR gene Fok1 F/f&f/f genotypes and f allele were observed in cases compared to controls with estimated odds ratio(95%confidence interval)&P-value of 3(1e8)&P=0.006,11(1e97)&P=0.01 and 3(2e6)&P=0.001 *** was a significant decrease in maternal vitamin D level in neonates with cyanotic CHD(P=0.000)compared to those with a cyanotic CHD while there was no significant difference in VDR Fok1 genotype(P=0.18)&allele(P=0.05)distribution between two *** concluded that maternal vitamin D deficiency and VDR gene Fok1 F/f,f/f genotype and f allele were associated with increased risk of CHD in offspring.

关键词： Congenital heart disease FoK1 polymorphism Vitamin D Vitamin D receptor gene Maternal vitamin D

Optimal Bottleneck-Driven Deep Belief Network Enabled Malware Classification on IoT-Cloud Environment

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Computers, Materials & Continua 2023年第2期74卷 3101-3115页

作者： Mohammed Maray hamed Alqahtani Saud S.Alotaibi Fatma S.Alrayes Nuha Alshuqayran Mrim M.Alnfiai amal S.Mehanna Mesfer Al Duhayyim Department of Information Systems College of Computer ScienceKing Khalid UniversityAbhaSaudi Arabia Department of Information Systems College of Computer ScienceCenter of Artificial IntelligenceUnit of CybersecurityKing Khalid UniversityAbhaSaudi Arabia Department of Information Systems College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of information systems College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Systems College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic UniversitySaudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Digital Media Faculty of Computers and Information TechnologyFuture University in EgyptNew Cairo11845Egypt Department of Computer Science College of Sciences and Humanities-AflajPrince Sattam Bin Abdulaziz UniversitySaudi Arabia

Cloud Computing(CC)is the most promising and advanced technology to store data and offer online services in an effective *** such fast evolving technologies are used in the protection of computerbased systems from cyberattacks,it brings several advantages compared to conventional data protection *** of the computer-based systems that effectively protect the data include Cyber-Physical Systems(CPS),Internet of Things(IoT),mobile devices,desktop and laptop computer,and critical *** software(malware)is nothing but a type of software that targets the computer-based systems so as to launch cyberattacks and threaten the integrity,secrecy,and accessibility of the *** current study focuses on design of Optimal Bottleneck driven Deep Belief Network-enabled Cybersecurity Malware Classification(OBDDBNCMC)*** presentedOBDDBN-CMCmodel intends to recognize and classify the malware that exists in IoT-based cloud *** attain this,Zscore data normalization is utilized to scale the data into a uniform *** addition,BDDBN model is also exploited for recognition and categorization of *** effectually fine-tune the hyperparameters related to BDDBN model,GrasshopperOptimizationAlgorithm(GOA)is *** scenario enhances the classification results and also shows the novelty of current *** experimental analysis was conducted upon OBDDBN-CMC model for validation and the results confirmed the enhanced performance ofOBDDBNCMC model over recent approaches.

关键词： Malware detection security Internet of Things cloud computing machine learning parameter adjustment

Numerical Solutions of Finite Well in Two Dimensions Using the Finite Difference Time Domain Method

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Journal of Physical Science and Application 2022年第1期12卷 12-18页

作者： Huwaida K.Elgweri amal hamed Mohamed Mansor Faculty of Science Physics DepartmentUniversity of TripoliTripoliLibya Faculty of Education/Janzour Physics DepartmentUniversity of TripoliTripoliLibya

The higher excited states for two dimensional finite rectangular well potential are calculated numerically,by solving the Schrödinger equation using the finite difference time domain ***,this method is suitable to calculate the ground state of the quantum systems,it has been improved to calculate the higher excited states *** improvement is based on modifying the iterative process involved in this method to include two *** first is known as cooling steps and the second is known as a heating *** determining the required length of the cooling iteration steps using suitable excitation energy estimate,and repeating these two procedures using suitable initial guess function for sufficient *** modified iteration will lead automatically to the desired excited *** the two dimensional finite rectangular well potential problem both of the suitable excitation energy and the suitable initial guess wave function are calculated analytically using the separation of variables technique.

关键词： Finite difference time domain method diffusion equation separation of variables method finite well potential Schrödinger equation

Polymorphism of Human Organic Cationic Transporter1 (C480G) in Egyptian Chronic Myeloid Leukemia Patients on Imatinib

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American Journal of Molecular Biology 2018年第2期8卷 83-91页

作者： Nahla A. M. hamed Hashim Neanea amal M. Ghanem Maha M. A. Elgammal Yasmen Samir Hematology Department Faculty of Medicine Alexandria University Alexandria Egypt Hematology Department Medical Research Institute Faculty of Medicine Alexandria University Alex-andria Egypt

Background: Human organic cationic transporter1 (Hoct1) is a plasma membrane transporter responsible for the main influx of Imatinib into chronic myeloid leukemia (CML) cells. Single nucleotide polymorphisms (SNPs) in the gene coding for hOCT1 are important factors causing Imatinib resistance. We investigated the frequency of hOCT1 SNP C480G among Egyptian CML patients and its relation to early molecular response as an indicator of treatment outcome. Materials and Methods: Two groups of CML patients were included in this study. Group I consisted of 25 patients responding to Imatinib treatment (Imatinib responsive) and group II consisted of 25 patients resistant to Imatinib (Imatinib resistant). Response criteria were assessed according to the NCCN (National Comprehensive Cancer Network) guidelines 2017. Twenty healthy controls of matched age and sex were also included (group III). For all patients, we studied hOCT1 C480G at initial presentation using Taqman drug metabolism genotyping as well as BCR-ABL percent at diagnosis and after 3 months interval. Results: hOCT1 C480G was present in 32% of studied CML patients. CC (wild) was detected in 68% of group I and 64% of group II. CG (mutant heterozygous) was present in 28% of group I and 36% of group II while GG (mutant homozygous) was detected in only one case in group I. CG was also detected in 15% of control subjects There was no significant difference between hOCT1 C480G polymorphism and Early Molecular Response (χ2 = 0.089, p = 0.765). Conclusions: hOCT1 C480G polymorphism has no association with Imatinib resistance in Egyptian population. However, further studies on a larger number of patients are still needed to confirm this finding.

关键词： Chronic Myeloid Leukemia Imatinib Egyptian Resistance Human Organic Cationic Transporter1 C480G Polymorphism

Aminolysis of 1-(1-Hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-Hydroxybenzotriazolyl)-5-nitropyridine

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Open Journal of Physical Chemistry 2012年第3期2卷 156-168页

作者： Sherine N. Khattab Mohamed A. H. Kharaba amal El-Hawary Ayman El-Faham Ezzat A. hamed Department of Chemistry and Physics Faculty of Education Alexandria University Alexandria Egypt Department of Chemistry Faculty of Science Alexandria University Ibrahimia Egypt

The reaction 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene 1 and 2-(1-hydroxybenzotriazolyl)-5-nitro-pyridine 2 with amines undergoes amination followed by elimination of the 1-hydroxyl benzotriazolyl anion. The kinetic data for the reaction of 1 and 2 with Mo, CHA and An in MeOH and AN proceeded by uncatalysed mechanism in which the rate limiting step is the leaving group departure, whereas the reaction with Mo in toluene proceeded by uncatalysed mechanism in which the formation of the zwitterionic intermediate is the rate determining step. While the reactions of 1 with CHA and An and the reaction of 2 with CHA in toluene proceeded by SB mechanism in which the rate determining step is the proton transfer process. The reactions of 1 and 2 with Mo in the three solvents and with CHA and An in MeOH and AN is greatly depended on the stability of the zwitterionic intermediate. The effect of ring activation is due to the ground state stabilization and the more efficient delocalization of the negative charge with a nitro group than with a ring-nitrogen in the transition state. The low activation enthalpies ΔH# and the highly negative activation entropies ΔS# are due to the intramolecular hydrogen bonding with the ammonio hydrogen present in the transition state.

关键词： Nucleophilic Aromatic Substitution Reactions Kinetic Measurements 1-Hydroxybenzotriazole Solvent Effect Morpholine Cyclohexylamine and Aniline Uncatalyzed and Specific Base Catalyzed Mechanisms

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