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Mid-term survival of the Optimys short stem: A prospective case series of 500 patients

World Journal of Orthopedics 2024年第3期15卷 257-265页

作者： Bryan Hamans Sheryl de Waard Sjoerd Kaarsemaker Esther R c Janssen Inger N Sierevelt Gino M M J Kerkhoffs Daniël Haverkamp Department of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Esther R c Janssen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands centre for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Department of Orthopaedic Surgery and Sports Medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BAcKGROUND In recent years,there has been an increase in the number of total hip arthroplasty procedures in the younger patient *** active group has higher expectations of their prosthesis in comparison to the older population,and there is a greater physical demand for the *** femoral stems were in-troduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific ***,the long-term survival and functional outcomes of various short stems are still being investigated in different *** To determine the 5-year survival of the Optimys hip *** This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the *** patients received the Optimys short stem(Mathys ltd,Bettl.c.,Switzerland).The primary outcome measure was survival of the hip stem,with revision as the *** secondary outcome measurements included patient-reported outcome measures(PROMs).Kaplan-Meier analysis was used to calculate the 5-year survival ***-minus-log transformation was performed to calculate the 95%confidence interval(95%cI).Mixed model analyses were performed to assess the course of the PROMs during the 1st 2 years after *** were modeled separately for the 1st and 2nd years to calculate the yearly change in PROMs during both follow-up periods with accompanying 95%*** The mean age of the total 500 patients was 62.3 years(standard deviation:10.6)and 202 were male(40%).At a median follow-up of 5.5 years(interquartile range:4.5-6.7),7 patients were deceased and 6 revisions were registered,for infection(n=3),subsidence(n=2)and malposition(n=1).This resulted in an overall 5-year survival of 98.8%(95%cI:97.3-99.5).If infection was left out as reason for revision,a stem survival of 99.4%(95%cI:98.1-99.8)was *** questionnaires were completed by 471 patients(94%),317 patients(63%)completed the 1-year follow-up questionna

关键词： Total hip arthroplasty Femoral stem Short stem Optimys Survival 5-year survival Revision PROMs

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Mulberry Biomass-Derived Nanomedicines Mitigate colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

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Research 2024年第1期2023卷 791-807页

作者： Wenjing Yang Ya Ma Haiting Xu Zhenhua Zhu Jiaxue Wu cheng Xu Wei Sun Erhu Zhao Min Wang Rui l.Reis Subhas c.Kundu Xiaoxiao Shi Bo Xiao State Key laboratory of Silkworm Genome Biology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China chongqing Key laboratory of Soft-Matter Material.c.emistry and Function Manufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal IcVS/3B’s-PT Government Associate laboratory BragaGuimarãesPortugal

The therapeutic outcomes of conventional oral medications against ulcerative colitis(Uc)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory ***,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MlNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MlNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MlNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes Biomass

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Unsynchronized butyrophilin mol.c.les dictate cancer cell evasion of Vγ9Vδ2 T-cell killing

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cellular & Mol.c.lar Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong lamao Meichao Gu Xuanxuan Jin Ying liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldrich catherine c.l Wong Wensheng Wei Biomedical Pioneering Innovation center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key laboratory for complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill.c.lls with altered pyrophosphate *** our effort to understand how cancer cells evade the cell-killing activity of Vγ9Vδ2 T cells,we performed a comprehensive genome-scale cRISPR screening of cancer *** found that four mol.c.les belonging to the butyrophilin(BTN)family,specifically BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critically important and play unique,nonoverlapping roles in facilitating the destruction of cancer cells by primary Vγ9Vδ2 T *** coordinated function of these BTN mol.c.les was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme called QPcTl was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in Vγ9Vδ2 T cell killing of cancer *** our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer cells escape Vγ9Vδ2 T ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-cell activity.

关键词： Butyrophilin Vγ9Vδ2 T-cell cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

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STcF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.c.Ai l.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.cai H.cai J.J.cao Q.H.cao X.cao Z.cao Q.chang K.T.chao D.Y.chen H.chen H.X.chen J.F.chen K.chen l.l.c.en P.chen S.l.c.en S.M.chen S.chen S.P.chen W.chen X.chen X.F.chen X.R.chen Y.chen Y.Q.chen H.Y.cheng J.cheng S.cheng T.G.cheng J.P.Dai l.Y.Dai X.c.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du l.M.Duan D.Epifanov Y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich c.Q.Feng X.Feng Y.T.Feng J.l.Fu J.Gao Y.N.Gao P.S.Ge c.Q.Geng l.S.Geng A.Gilman l.Gong T.Gong B.Gou W.Gradl J.l.Gu A.Guevara l.c.Gui A.Q.Guo F.K.Guo J.c.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou Y.R.Hou c.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.c.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.c.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.lei E.levichev c.H.li c.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.l.li J.M.li J.li l.li l.li l.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao l.Z.liao Y.liao c.X.lin D.X.lin X.S.lin B.J.liu c.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu l.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.l.liu Z.Q.liu Z.Y.liu Z.W.liu I.logashenko Y.long c.G.lu J.X.lu N.lu Q.F.lü Y.lu Y.lu Z.lu P.lukin F.J.luo T.luo X.F.luo Y.H.luo H.J.lyu X.R.lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.l.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian c.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.Rademacker c.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia cAS Key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom central.c.ina Normal University Wuhan 430079China central South University Changsha 410083China china University of Geosciences Wuhan 430074China china University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de lausanne(EPFl) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STcF)is an el.c.ron–positron collider proposed by the chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STcF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPcII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STcF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STcF,describes conceptual designs of the STcF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： el.c.ron–positron collider tau-charm region high luminosity STcF detector conceptual design

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Experimental implementation of phase tripl.c.tor gratings in a spatial light modulator

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chinese Optics letters 2024年第2期22卷 64-69页

作者：高尚 María del Mar Sánchez-lópez Ignacio Moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Física Apl.c.da Universidad Miguel HernándezElche 03202Spain Departamento de ciencia de Materiales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compare different methods for implementing a tripl.c.tor,a phase grating that generates three equiintense diffraction *** design with optimal efficiency features a continuous phase profile,which cannot be easily reproduced,and is typically affected by *** compare its performance with binary and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a random approach is adopted to eliminate the additional harmonic *** all.c.ses,a liquid-crystal-on-sil.c.n spatial light modulator is employed to experimentally verify and compare the different approaches.

关键词： diffraction gratings phase modulation tripl.c.tor spatial light modulators

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Imprints of a gravitational wave through the weak field defl.c.ion of photons

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chinese Physics c 2024年第8期48卷 240-245页

作者： Reggie c.Pantig AliÖvgün Physics Department Mapúa University658 Muralla St.IntramurosManila 1002Philippines Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkiye

In this study,we investigate the novel phenomenon of gravitational lensing experienced by gravitational waves traveling past a Schwarzschild bl.c. hole perturbed by a specific,first-order,polar gravitational *** apply the Gauss-Bonnet theorem,finding a topological.c.ntribution to the defl.c.ion of light rays passing near the bl.c. *** demonstrate that the defl.c.ion angle can be determined by analyzing a region entirely outside the path of the light ray,leading to a calculation based solely on the parameters of the perturbing wave(legendre polynomial order,l;frequency,σ).This approach offers a unique perspective on gravitational lensing and expands our understanding of bl.c. hole interactions with gravitational waves.

关键词： supermassive bl.c. holes gravitational waves chaos weak defl.c.ion angle Gauss-Bonnet theorem

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IgE-Mast cell mediated allergy: a sensor of food quality

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Signal Transduction and Targeted Therapy 2024年第1期9卷 8-9页

作者： christopher c.Udoye Rudolf A.Manz Institute for Systemic Inflammation Research University of LübeckLübeckGermany

In two recent studies published in Nature,Florsheim et *** Plum et *** that allergic-specific reactions induced by immunoglobulin(Ig)E mediated mast cell activation is crucial for the timely induction of antigen-avoidance behaviour.1,2 These studies prove the concept that allergic sensitization triggers the formation of avoidance behaviour and define the underlying mol.c.lar mechanism.

关键词： allergic mechanism

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Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)N-based layer for appl.c.tion as the el.c.ron bl.c.ing layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-cisneros carlos Alberto Hernández-Gutiérrez Enrique campos-González Máximo lópez-lópez Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with Mg by plasma-assisted mol.c.lar beam epitaxy(PAMBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoel.c.ron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInN layers were studied for use as the el.c.ron-bl.c.ing layer(EBl)in lED *** varied the Al.c.mposition in the EBl from 0.84 to 0.96 molar fraction to assess its theoretical effects on el.c.roluminescence,carrier concentration,and el.c.ric field,using SIlVAcO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInN layers through *** simulations suggest that an Al.c.ntent of 0.86 is optimal for achieving desired outcomes in el.c.roluminescence,carrier concentration,and el.c.ric field.

关键词： metal-modulated epitaxy AlInN DUV-lED EBl simulation

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Multi-aspect analysis of ureteral access sheath usage in retrograde intrarenal surgery: A RIRSearch group study

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Asian Journal of Urology 2024年第1期11卷 80-85页

作者： Oktay Özman Hacı M.Akgül.c.m Başataç Önder Çınar Eyüp B.Sancak cenk M.Yazıcı Bülent Önal Haluk Akpınar Gaziosmanpasa Training and Research Hospital Urology ClinicİstanbulTurkey TekirdağNamık Kemal University School of MedicineDepartment of UrologyTekirdağTurkey Group Florence Nightingale Hospitals Department of UrologyİstanbulTurkey Zonguldak Bulent Ecevit University School of MedicineDepartment of UrologyZonguldakTurkey Çanakkale Onsekiz Mart University School of MedicineDepartment of UrologyÇanakkaleTurkey İstanbul University-cerrahpaşa Cerrahpaşa Medical FacultyDepartment of UrologyİstanbulTurkey

Objective:To evaluate the effect of ureteral access sheath(UAS)use and calibration change on stone-free rate and compl.c.tions of retrograde intrarenal surgery(RIRS).Methods:Data from 568 patients undergoing RIRS for kidney or upper ureteral stones were retrospectively ***,patients were compared after 1:1 propensity score matching,according to UAS usage during RIRS(UAS used[+]87 and UAS non-used[−]87 patients).Then all UAS+patients(n=481)were subdivided according to UAS calibration:9.5-11.5 Fr,10-12 Fr,11-13 Fr,and 13-15 *** outcomes of the study were the success and compl.c.tions of ***:Stone-free rate of UAS+patients(86.2%)was significantly higher than UAS−patients(70.1%)after propensity score matching(p=0.01).Stone-free rate increased with higher caliber UAS(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;pcompl.c.tions of UAS+patients(11.5%)were significantly lower than UAS−patients(27.6%)(p=0.01).compl.c.tions(8.7%)with 9.5-11.5 Fr UAS was lower than thicker UAS(17.2%)but was not statistically significant(p=0.09).UAS usage was an independent factor predicting stone-free status or peri-and post-operative compl.c.tions(odds ratio[OR]3.654,95%confidence interval.c.]1.314-10.162;OR 4.443,95%cI 1.350-14.552;OR 4.107,95%cI 1.366-12.344,respectively).conclusion:Use of UAS in RIRS may increase stone-free rates,which also increase with higher caliber *** usage may reduce compl.c.tions;however,compl.c.tions seemingly increase with higher UAS calibration.

关键词： Stone Retrograde intrarenal surgery Ureteral access sheath Urolithiasis Kidney

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GRP7 phase separation as an interpreter of temperature cues

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Mol.c.lar Plant 2024年第6期17卷 842-844页

作者： Sunita Pathak l.c.a c.Strader Department of Biology Duke UniversityDurhamNCUSA

Plants are exposed to a range of daily and seasonal temperatures and thus are required to regulate their cellular processes under fl.c.uating temperature *** various temperature-responsive genes,Gl.c.NE-RIcH RNA BINDING PROTEIN7(GRP7)encodes a gl.c.ne-rich RNA-binding protein that provides freezing tolerance to plants(carpenter et al.,1994;Kim et al.,2008)by acting as an RNA chaperone(Kwak et al.,2011).

关键词： al. conditions. separation

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