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Carotid Web as a Cause of Ischemic Stroke in Sub-Saharan Africa: A Preliminary Monocentric Descriptive Study of 6 Cases Collected at the Fann Teaching Hospital (Senegal)

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World Journal of Cardiovascular Diseases 2022年第3期12卷 133-139页

作者： Ndiaga Matar Gaye Alassane Mamadou diop Adjaratou Dieynabou Sow Abdoul Salam Soumaré Didier Smadja Moustapha Ndiaye Sokhna Ba amadou gallo diop Neurology Department Fann Teaching Hospital Dakar Senegal Stroke Unit Centre Hospitalier Sud-Francilien Corbeil-Essones France Radiology Department Fann Teaching Hospital Dakar Senegal

Introduction: Carotid web (CW), a rare and probably unknown arterial cause of ischemic stroke (IS), is commonly reported in young black patients, although most of the published cases resided in a non-African country. We describe the features of the first six Senegalese cases diagnosed at the Neurology Department of the Fann Teaching Hospital in Dakar. Patients and Method: It was a preliminary retrospective and prospective study conducted at the Neurology department of Fann teaching hospital (Dakar-Senegal). The symptomatic CW diagnosis was based on angioCT-scan of the neck arteries. The National Institute of Health Stroke Scale (NIHSS) and the modified-Rankin Scale (mRS) were used to assess the severity of the IS and the functional disability after the event, respectively. Results: CW was causing a left sylvian infarction in 4 patients. The mean age of the patients at the IS diagnosis was 41 ± 6 years with a sex ratio of 1. The mean time to diagnosis of CW was 13 months. Smoking (1/6), hypertension (1/6), and obesity (1/6) were the main vascular risk factors. The mean LDL cholesterol level was 1.52 g/L ± 0.49. The mean initial NIHSS was 15 ± 6 (8-22). Half of the patients had a severe infarction (NIHSS ≥ 15). For secondary prevention, half of the patients were treated with aspirin and the other half with acenocoumarol. After 18 months ± 17 of follow-up, the mean mRS score was 2 ± 1 (1-3). Conclusion: CW is an unknown cause of IS in young black patients. An early and appropriate multidisciplinary management could help to reduce the risk of recurrences.

关键词： Carotid Web Sub-Saharan Africa Senegal AngioCT-Scan Acenocoumarol

Peripheral Neuropathies Revealing Gougerot-Sjögren’s Syndrome: Description of 3 Cases

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Neuroscience & Medicine 2022年第3期13卷 120-125页

作者： Ndiaga Matar Gaye Alassane Mamadou diop Khalifa Ababacar Mbaye Serigne Abdou Aziz Fall Mamadou Ka Momo Banda Ndiaye Maouly Fall Moustapha Ndiaye amadou gallo diop Neuroscience Department Fann Hospital Dakar Senegal Neurology Department Pikine Hospital Dakar Senegal

Introduction: Sjögren’s syndrome is an autoimmune epithelitis with various extraglandular signs, among which are neurological, with a variable frequency according to studies. We report three cases of peripheral neuropathy revealing Gougerot-Sjögren’s syndrome, collected in the Neurology Department of the Fann University Hospital in Dakar (Senegal). Observations: The first patient, aged 48 years, presented with a length-dependent sensitivomotor polyneuropathy associated with retrobulbar optic neuritis, with dry eyes and dry mouth noticed by the patient for several years. The second patient, aged 28 years, was admitted to the hospital with chronic generalized paresthesia in the context of xerostomia and xerophthalmia. The results of the clinical examination and the electroeneuromyogram were in favour of pure sensory neuronopathy. The third patient was 32 years old female, with a history of thyroidectomy and acute inflammatory demyelinating polyneuropathy (AIDP), who was seen for acute ascending flaccid tetraplegia with facial diplegia, preceded by diffuse paresthesia. The diagnosis of recurrence of acute demyelinating polyradiculonueropathy was retained in view of the rapidly increasing character of the deficit, the hyperproteinorachy at the lumbar puncture, and the signs of demyelination at the ENMG. The diagnosis of Gougerot-Sjögren’s syndrome in our three patients was established on the basis of the 2016 ACR/EULAR criteria. Indeed, the anti-SSA antibodies (Ro) were positive in our 3 patients with a biopsy of the salivary glands which showed stage 3 in the first patient and stage 4 in the two others. Corticosteroid therapy and immunosuppressive treatment resulted in a favourable clinical evolution on the neurological and general levels. Conclusion: Gougerot-Sjögren’s syndrome is an autoimmune exocrinopathy that may present with peripheral neuropathy, which may precede the diagnosis of Sjögren’s syndrome, be concomitant or occur during the co

关键词： Sjögren’s Syndrome Peripheral Neuropathy Salivary Gland Biopsy Senegal

Creutzfeldt Jacob’s Disease: A Senegalese Observation

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Neuroscience & Medicine 2022年第1期13卷 43-48页

作者： Ahmadou Bamba Mbodji Alassane Mamadou diop Momo Banda Ndiaye Serigne Saliou Mbacke Khalifa Ababacar Mbaye Rokhaya Diagne Ibrahima Niang Ndiaga Matar Gaye Maouly Fall Adjaratou Sow Anna Basse Lala Bouna Seck Moustapha Ndiaye amadou gallo diop Department of Ibrahima Pierre Ndiaye Neuroscience Fann Hospital Dakar Sénégal Department of Neurology Pikine Hospital Dakar Sénégal Department of Radiology Fann Hospital Dakar Sénégal

Creuzfelt-Jakob Disease is a rare and progressive neurodegenerative disease that results in fatal, transmissible, subacute, spongiform encephalopathy characterized by rapidly progressive dementia and movement disorder. We present a 62-year-old male with no medical history who was admitted to our hospital because of gait and balance disturbance, language impairment and progressive motor deficit of the four limbs. A neurological examination found frontal lobe syndrome signs, myoclonic movements, pyramidal and extra-pyramidal signs. Brain Magnetic Resonance Imaging detected high intensity areas in the basal ganglia. EEG showed generalized triphasic sharp-wave complexes. A Cerebro Spinal Fluid examination found protein 14-3-3. Death occurred six months after onset. This is the first known case of Creuzfelt-Jakob Disease documented in Senegal.

关键词： Creutzfeldt-Jakob Disease Protein 14-3-3 Prion Disease Rapidly Progressive Dementia

Prognosis Factors of Urinary Quality of Life in Parkinson Disease

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Open Journal of Therapy and Rehabilitation 2024年第1期12卷 10-17页

作者： Ngor Side Diagne Sakhi Othman Ababacar Mamadou Gueye Marie Jeanne Sakho Fatou Dialo Mboup Amélie Ndeye Makarame Sy Papa Ndiouga Lo Ba Seydina Ousmane Anna Modji Basse Maouly Fall Adjaratou Dieynaba Sow Moustapha Ndiaye amadou gallo diop Physical Médicine and Rehabilitation Department Fann Teaching Hospital Dakar Senegal Neurology Department Pikine Hospital Dakar Senegal Physical Médicine and Rehabilitation Department Ibn Rochd Teaching Hospital Casablanca Morocco Physical Médicine and Rehabilitation Department Military Hospital Dakar Senegal Neurology Department Fann Teaching Hospital Dakar Senegal

Introduction: Quality of life in Parkinson disease is not necessary linked to motor symptoms. It’s correlated of overactive bladders and prostatic symptoms. Prognosis factors of urinary quality of life are unknown. Objectives: Our study aims to find prognosis factors of quality of life associated specifically of urinary disorders in PD. Patients and methods: We conducted a transversal, analytic and descriptive study in Physical Medicine, and Neurology departments, Fann Teaching Hospital, Dakar and included patients followed for treatment of PD. Urinary disorders, quality of life and functional autonomy were assessed respectively by Urinary Symptoms Profile (USP), Qualiven Short Form, Schwab and England Scale. Results: 38 patients presented PD, with a mean age of 60.89 ± 13.6 years and sex-ratio of 2.45. Mean duration of PD was 3.1 ± 2.9 years. Urinary disorders were found in 47.36% and dominated by incontinence (88.88%) and overactive bladders (88.88%) which were minor in more than 55%. Quality of life was impaired in 88.88% of cases. Minor forms (43.75%) were predominant and constraint dimension (50%) was the most severely altered. Prognosis factors for quality of life of urinary disorders were PD stages (0.046) and functional autonomy (0.042). Discussion and conclusion: Urinary disorders in PD are common, impaired quality of life, especially the constraint dimension, depends on stage of evolution of PD and functional autonomy of patients.

关键词： Urinary Quality of Life Parkinson Disease Dakar

Evaluation of Nutritional Composition of Two Fonio Ecotypes Grown in Casamance (Sénégal)

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Open Journal of Applied Sciences 2024年第2期14卷 533-544页

作者： amadou Bouye Seydi amadou diop Animal Physiology Laboratory Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal Analytical Chemistry and Bromatology Laboratory Faculty of Medicine Pharmacy and Odontology of Dakar Cheikh Anta Diop University Dakar Senegal

In order to better understand the cultural route, biochemical and nutritional composition of two ecotypes of fonio, a study was carried out in village of Tambananing located approximately 7 km from Sédhiou. The objective of studies was to determine nutritional composition of two ecotypes of fonio: the first called momo in short-cycle mandinka (75 - 90 days) and the other called medium-cycle dibong (90 - 110 days). For this, samples of two ecotypes were collected in an experimental field which was split into two equal parts, one sown with the momo ecotype and the other with the dibong ecotype. The nutritional composition (sugars, fats, proteins, minerals, ash, etc.) and the physicochemical properties (pH, humidity, water activity, color, etc.) of fonio’s were determined by appropriate physicochemical methods. The two ecotypes exhibited quite similar physicochemical properties. The levels of biochemical compounds were relatively close with protein contents of 7.05 ± 0.06 mg/100g for the momo ecotype and of 8.02 ± 0.04 mg/100g for the dibong ecotype, in carbohydrates (76.37 ± 1.2 mg/100g for momo and 78.7 ± 1.5 mg/100g for dibong) and in fat (2.92 ± 0.05 mg/100g for momo and 3.14 ± 0.004 mg/100g for dibong). Identical mineral element contents were found except for iron, an element for which the contents were 10.80 ± 0.008 mg/100g for the momo ecotype and 99.59 ± 0.005 mg/100g for the dibong ecotype. Thus, two ecotypes of fonio present a fairly interesting nutritional composition and their consumption deserves to be popularized and could contribute effectively to fight against the problems of malnutrition of certain vulnerable groups.

关键词： Biochemical Composition Ecotypes Fonio Casamance

Agro-Climatic Risks Analysis in Climate Variability Context in Ségou Region

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Open Journal of Statistics 2023年第1期13卷 170-193页

作者： diop amadou Barro Diakarya Université de Ségou République du Mali Région de Ségou Université Thomas Sankara Burkina Faso Ouagadougou

In the Sahel region, the population depends largely on rain-fed agriculture. In West Africa in particular, climate models turn out to be unable to capture some basic features of present-day climate variability. This study proposes a contribution to the analysis of the evolution of agro-climatic risks in the context of climate variability. Some statistical tests are used on the main variables of the rainy season to determine the trends and the variabilities described by the data series. Thus, the paper provides a statistical modeling of the different agro-climatic risks while the seasonal variability of agro-climatic parameters was analyzed as well as their inter annual variability. The study identifies the probability distributions of agroclimatic risks and the characterization of the rainy season was clarified.

关键词： Climate Variability Agro-Climatic Risks Seasonal Evolution Variability Parameters Tests

An Analysis of the Value of Additional Information Provided by Water Quality Measurement Network

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Journal of Water Resource and Protection 2016年第8期8卷 767-776页

作者： François Destandau amadou Pascal diop GESTE UMR MA 8101 Engees-Irstea Strasbourg France

European Community policy concerning water is placing increasing demands on the acquisition of information about the quality of aquatic environments. The cost of this information has led to a reflection on the rationalization of monitoring networks and, therefore, on the economic value of information produced by these networks. The aim of this article is to contribute to this reflection. To do so, we used the Bayesian framework to define the value of additional information in relation to the following three parameters: initial assumptions (prior probabilities) on the states of nature, costs linked to a poor decision (error costs) and accuracy of additional information. We then analyzed the impact of these parameters on this value, particularly the combined role of prior probabilities and error costs that increased or decreased the value of information depending on the initial uncertainty level. We then illustrated the results using a case study of a stream in the Bas-Rhin department in France.

关键词： Bayesian Decision Theory Eutrophication Value of Information Water Quality Monitoring Network Water Resource Management

Comparative Study of the Protein Contents of Local and Imported Rice Consumed in Senegal

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Open Journal of Applied Sciences 2024年第2期14卷 561-571页

作者： amadou Bouye Seydi Nadina Zuleika Leite Serigne Omar Sarr Yérim Mbagnick diop amadou diop Animal Physiology Laboratory Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal Analytical Chemistry and Bromatology Laboratory Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University Dakar Senegal

Protein is essential for the growth and maintenance of the body. They play a crucial role in different biological processes. This study focuses on comparing the protein contents of local rice grown in the Senegal River valley and rice imported from Asia. The objective is to evaluate the importance of the protein nutritional value of local rice compared to imported rice. Protein contents were determined using the Kjeldahl method. The results of the protein assays show that local rice varieties such as Sahel 108 and Sahel 134 grown in the Thilène basins had protein percentages comparable to those of imported rice. The protein percentages were 15.19% ± 0.91% for the Sahel 108 variety and 16.62% ± 0.01% for the Sahel 134 variety compared to 15.8% ± 0.01% on average for imported rice. Thus from the point of view of protein content, local rice has a nutritional value identical to that of imported rice which it can validly replace. It is important in Senegal to encourage local production, which would make it possible to reduce imports on the one hand and to make quality rice available to the local Senegalese market on the other. Sahel varieties with high protein contents deserve large-scale development to meet the country’s protein needs.

关键词： Proteins Rice Nutritional Value Kjeldahl Method River Valley Senegal

Subacute Hyperthyroidism Induced by Treatment with Lithium Salts

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Open Journal of Biophysics 2023年第2期13卷 29-33页

作者： Serigne Moussa Badiane Kalidou Gueye amadou diop Dia amadou Barro Biophysics and Nuclear Medicine Faculty of Health Sciences Gaston Berger University of Saint-Louis Senegal Department of Biophysics and Nuléaire Médicine Cheikh Anta Diop University Dakar Senegal ENT Department Cheikh Anta Diop University Dakar Senegal

Lithium treatment is usually indicated in bipolar disorder. It is associated with hypothyroidism and very rarely with hyperthyroidism. We report here the results of the exploration of a case of thyrotoxicosis occurring during treatment with lithium salts. This was a 16-year-old patient with ongoing lithium treatment for two and a half years who presented with a thyrotoxicosis syndrome without a context of iodine overload or an episode of anterior cervical pain that could suggest subacute thyroiditis or orthopathic sign. The assessment of the exploration of this patient reveals biological hyperthyroidism without anti-TSH receptor antibodies, a normal ultrasound, and white scintigraphy which makes it possible to evoke the diagnosis of subacute thyroiditis (absence of the context of iodine overload). Note the interest in a thyroid assessment before and during treatment with lithium salts. Moreover, scintigraphy occupies a place of choice in the exploration of hyperthyroidism, particularly in the context of normal thyroid ultrasound imaging.

关键词： Hyperthyroidism Lithium Scintigraphy