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Review of natural products with hepatoprotective effects

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World Journal of Gastroenterology 2014年第40期20卷 14787-14804页

作者： Eduardo Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela álvarez-gonzález María Teresa Sumaya-Martínez José Gutiérrez-Salinas Mirandeli Bautista ángel Morales-gonzález Manuel García-Luna y gonzález-Rubio J Leopoldo Aguilar-Faisal José A Morales-gonzález Laboratorio Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Casco de Santo Tomás Del. Miguel Hidalgo México DF 11340 México Laboratorio de Genética Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Unidad profesional Adolfo López Mateos Col. Lindavista Delegación Gustavo A. Madero México DF 07738 México Secretaria de Investigación y Estudios de Posgrado Universidad Autónoma de Nayarit "Ciu-dad de la Cultura Amado Nervo" Nayarit 28000 México Laboratorio de Bioquímica y Medicina Experimental División de Investigación Biomédica Centro Médico Nacional "20 de Noviembre" ISSSTE México DF 03100 México área Académica de Farmacia Instituto de Ciencias de la Salud UAEH Pachuca Hidalgo 42000 México Escuela Superior de Cómputo Instituto Politécnico Nacional Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal Unidad Profesional Adolfo López Mateos México DF 07738 Mexico Facultad de Odontología UNAM México DF 04510 Mexico

The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are *** to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the *** enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic ***,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less *** use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called *** present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity.

关键词： Hepatoprotection Grapefruit Vaccinium spp Vitis vinifera L Opuntia ficus-indica Spirulina Propolis Glucans Alcoholic liver disease

Ecology and local knowledge of the Baird’s tapir (Tapirella bairdii) in the Sierra Madre de Oaxaca, Mexico

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Integrative Zoology 2016年第5期11卷 361-374页

作者： Mario César LAVARIEGA NOLASCO Miguel BRIONES-SALAS amado MAZAS-TEODOCIO Elvira DURÁN-MEDINA Interdisciplinary Research Center for Integral Development Oaxaca UnitNational Polytechnic InstituteOaxacaMexico

As well as being of global cultural importance(from local tribal folklore to being an iconic species for conservation),the tapir plays an important role in its ecosystem as a herbivore and seed ***,the ecology and ethnozoology of the endangered Baird’s tapir in the north of Oaxaca,Mexico is poorly *** used camera traps to estimate its relative abundance and density and to describe the activity patterns of the northernmost population of Baird’s tapir in the Sierra Madre de *** knowledge concerning the tapir was also documented,along with the conservation strategies undertaken by the 2 indigenous communities that own the land where the study site is *** adult tapirs were photographed,and these were active 14 h per day,but were mainly nocturnal and *** estimated relative abundance(12.99±2.24 events/1000 camera days)and density values(0.07-0.24 individuals/km2)were both similar to those found in another site in Mexico located within a protected ***-structured interviews revealed that people have a basic understanding of the eating habits,activity and main predators of the *** were reports of hunting,although not among those respondents who regularly consume bush ***,the relative abundance and density estimates of tapir at the study site could be related to the favorable condition of the forest and the absence of hunting and consumption of tapir ***,the local people are conducting initiatives promoting the conservation of this ungulate and its habitat that combine to constitute a regional trend of habitat and wildlife protection.

关键词： camera-trapping density estimation random encounter model tapir conservation

Cryopreservation of Cyrtopodium hatschbachii Pabst (Orchidaceae) immature seeds by encapsulation-dehydration

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BIOCELL 2012年第1期36卷 31-36页

作者： MAURO RODRIGO SURENCISKI EDUARDO ALBERTO FLACHSLAND GRACIELA TERADA LUIS amado MROGINSKI AND HEBE YOLANDA REY Instituto de Botánica del Nordeste(IBONE) CONICET–UNNEFacultad de Ciencias Agrarias(UNNE)C.C.209(3400)CorrientesArgentina

The aim of the present study was to investigate the efficiency of the encapsulation-dehydration technique for cryopreservation of Cyrtopodium hastchbachii Pabst *** seeds of this species were cryopreserved by an encapsulation-dehydration *** of five immature pods,120 days after pollination,were encapsulated in 3%calcium alginate matrix and pretreated in liquid medium supplemented with 0.08 M sucrose(24 h),0.15 M sucrose(24 h),0.25 M sucrose(48 h),0.5 M sucrose(24 h)and 0.75 M sucrose(24 h)in shaker at 60 *** beads were dehydrated 5 h in silicagel and immersed in liquid nitrogen for 12 *** beads were thawed at 30℃ for 1 min,rehydrated using the same liquid mediums[0.75 M sucrose(24 h),0.5 M sucrose(24 h),0.25 M sucrose(48 h)and 0.15 M sucrose(24 h)]and cultivated in half strength Murashige&Skoog medium(1962)with the addition of 2 g/L activated *** four percent of seeds survived and developed into acclimatized plants after being *** this work,the encapsulation-dehydration technique was employed for first time in Cyrtopodium hatschbachii.

关键词： cryoconservation liquid nitrogen calcium alginate activated charcoal sucrose

The Effectiveness of Diamel in the Treatment of Type 2 Diabetic Patients Receiving Insulin Therapy: A Randomized, Controlled Clinical Trial

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Open Journal of Endocrine and Metabolic Diseases 2012年第4期2卷 117-124页

作者： María Elena de la Uz Herrera Arturo Hernández Yero Reinaldo gonzález Iglesias Urbicio Reinoso Hernández Alfredo Novales amado María del Carmen Herrera de la Uz Marién García Otero Diabetic Care Centre Hospital Abel Santamaría Cuadrado Pinar del Río Cuba Endocrinology Service Instituto Nacional de Endocrinología Havana Cuba Internal Medicine Service Hospital Abel Santamaría Cuadrado Pinar del Río Cuba Medical University Physiology Department Pinar del Río Cuba Rehabilitation Service Hospital León Cuervo Rubio Pinar del Río Cuba

Aims/Introduction: Effectiveness of Diamel? on the biochemical variables: fasting blood glucose, postprandial glucose, cholesterol, triglycerides, and glycosylated haemoglobin [HbA1c] in type-2 diabetic patients receiving insulin terapy. Diamel is a natural product composed of trace elements: amino acids, vitamins, cranberry extract, and lettuce extract that have been activated by means of a magnetization process. Materials and methods: Randomized, doubleblind, comparator-controlled clinical trial. A central randomization centre used computer generated tables to allocate treatments. 116 patients suffering from type-2 diabetes mellitus treated with insulin at the Diabetes Care Centre in Pinar del Rio (Cuba), were recruited and randomly. The subjects were separated into two groups: Group A (n = 59), who were administered Diamel and Group B (n = 57) using placebo. The clinical and biochemical variables were assessed for 24 weeks. Results: Two subjects were excluded from the Diamel treatment group during the clinical trial. From the statistical point of view, a significant drop in the levels of the baseline glucose, postprandial glucose, glycated haemoglobin, and triglycerides was observed in the group taking Diamel (Group A). There was observed an increase in insulin requirements and in waist circumference in the subjects of Group B There was not reported any severe or serious adverse reactions during this clinical trial. Conclusion: Diamel (nutritional supplement) together with the administration of insulin in type-2 diabetic patients is useful to optimize the biochemical variables (baseline and postprandial glucose, Hb A1C, plus triglycerides), as well as to prevent the increase of insulin requirements at medium-term.

关键词： Diamel Dietary Supplement Type-2 Diabetes Clinical Trial Double-Blind

Inclusive housing program： The case of Oe-Cusse region in East Timor

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Frontiers of Architectural Research 2017年第1期6卷 74-88页

作者： Miguel P. amadoa Ines Ramalhete Antonio Ribeiro amado Joao C. Freitas CERIS - Civil Engineering Research and Innovation for Sustainability IST Universidade de Lisboa Lisboa 1049-001 Portugal GEOTPU LAB Instituto Superior Tecnico Universidude de Lisboo Lisboo 1049-001 Portugul CCIAUD Faculty of Architecture Universidude de Lisboo Lisboo 1049-001 Portugal

Housing development has become one of the main strategies to alleviate impoverished communities in developing countries. In the past, policies and programs focused on either economic or social aspects, and numerous imported solutions had failed to produce satisfactory results. At present, holistic approaches integrating all dimensions of human activity and environmental impact are gaining recognition as suitable alternatives for various experiences in developing nations. However, these approaches do not properly consider the local context, which is different for each case, thereby leading to inadequate models and unsuccessful implementations. This paper presents a context-driven and integrated approach for rural areas in developing nations for one of the most basic human endeavors, i.e., constructing a house. The self-building process utilized in constructing houses is a major strategy to help communities overcome poverty. Such a house must be capable of accommodating economic activities; must be durable yet flexible in layout and size; and must offer all basic services, including water, sanitation, and energy. Consequently, the Inclusive Housing Program is developed and employed in Oe-Cusse, a remote region of East Timor, as an integral part of the Regional Plan.

关键词： Developing countries Rural settlements Housing program Adaptive housing

Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

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World Journal of Gastroenterology 2009年第8期15卷 955-960页

作者： Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius amado Salvador Pea Coen DA Stehouwer Yvo M Smulders Department of Gastroenterology VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Department of Internal Medicine VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Laboratory of Immunogenetics Department of Pathology VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Department of Internal Medicine Academic Hospital Maastricht P. Debyelaan 25 6229 HX Maastricht The Netherlands

AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management.

关键词： Celiac disease Homocysteine Vitamin supplements

Hydroethanolic extract of Smallanthus sonchifolius leaves improves hyperglycemia of streptozotocin induced neonatal diabetic rats

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 420-424页

作者： Silmara Baroni Bruno Ambrosio da Rocha Juliana Oliveira de Melo Jurandir Fernando Comar Silvana Martins Caparroz-Assef Ciomar Aparecida Bersani-amado Department of Pharmacology and Therapeutic State University of MaringaParanaBrazil Department of Biochemistry State University of MaringaParanaBrazil

Objective: To evaluate the effect of hydroethanolic extract of yacon on the hyperglycemia induced by streptozotocin(STZ) in neonatal rats. Methods: Wistar rats aged two days old received an intraperitoneal injection of STZ(160 mg/kg); after seven weeks, glycosuria was determined and animals with glucose levels above 250 mg/d L were included in the study. Groups of diabetic and non-diabetic rats were treated orally with yacon extract at a dose of 400 mg/kg/d for 14 d. Tests were made for phytochemical characterization, glucose tolerance and toxicity. Results: The results showed that treatment with the extract reduced the glucose levels of fed diabetic rats and did not change the glucose levels of fasting diabetic and normal rats. Additionally, also it was observed that treatment with the extract reduced blood glucose levels of diabetic rats during the oral and intravenous glucose tolerance tests. There was no change in body weight, liver enzymes or mortality with yacon extract treatment. The phytochemical screening revealed the presence of caffeic acid, chlorogenic acid, ferulic acid and gallic acid. Conclusions: The data suggest that yacon extract reduces hyperglycemia, possibly by improving insulin sensibility through its phytochemicals constituents(phenolic compounds).

关键词： Yacon extract Hyperglycemia Insulin sensibility Streptozotocin

Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1080-1083页

作者： Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-amado Roberto Kenji Nakamura Cuman Department of Medicine Faculdade Uningá Department of Pharmacology and Therapeutics State University of Maringá Hospital Pharmacy at Santa Rita Hospital

Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal ***: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ***: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ***, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol.

关键词： Patent ductus arteriosus Premature neonatal Indomethacin Ibuprofen Paracetamol

Evaluation under Semi-Controlled Conditions of the Pathogenicity of Three Isolates of Phaeoisariopsis personata (Berk. & M.A Curt.)

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Agricultural Sciences 2023年第3期14卷 356-367页

作者： Bawomon Fidèle Neya amado Sawadogo Tounwendsida Abel Nana Kadidia Koita University Center of Gaoua Nazi BONI University Bobo Dioulasso Burkina Faso Life and Earth Sciences Unit Joseph KI-ZERBO University Ouagadougou Burkina Faso

Peanut (Arachis hypogaea L.) late leaf spot is an important disease caused by Phaeoisariopsis personata (Berk. Et M. A Curt.). This fungus is responsible for the most damaging leaf spots in peanut production. The present experiment was undertaken to evaluate the pathogenic variability of Phaeoisariopsis personata in Burkina Faso. To this end, detached leaves and healthy plants of three peanut varieties were inoculated. Isolates I3TF, I2TG and I1TK of the pathogen (105 conidia/ml), collected respectively in the western, central and eastern agroecological zones of country, were used. The inoculated leaves were kept in Petri dishes on moist blotting paper and stored in the laboratory during the experimental period. The inoculated plants were grown under glass in pots containing a mixture of sterilized sand and clay. The development of disease was monitored and severity was scored every 15 days using rating scale. The results obtained in the laboratory and in the greenhouse revealed that there is pathogenic variability in the isolates tested. Indeed, for each variety, the highest severity score was recorded in plants inoculated with isolate I3TF and the lowest severity score with isolate I1TG. In the laboratory the severity scores ranged from 6.76 to 8.80 in TS32-1, 6.18 to 8.29 in SH70P and 5.98 to 7.92 in PC79-79. In the greenhouse, the average severity scores ranged from 5.61 to 8.33 in TS32-1, from 5.19 to 8.00 in SH70P, from 4.90 to 7.50 in PC79-79. Thus, the variety TS32-1 was the most susceptible to all three isolates of the pathogen.

关键词： Peanut Late Leaf Spot Pathogenic Variability Severity Score Isolate