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Matrix γ-carboxyglutamate protein and Fetuin-A, in wet type age-related macular degeneration

International Journal of Ophthalmology(English edition) 2015年第3期8卷 556-559页

作者： Alireza Javadzadeh am.r ghorbanihaghjo Ebadolah Heidari Nader Baharivand Karim Sadeghi rana Sorkhabi Mohammad Hossein Ahoor Tabriz University of Medical Science

AIM: To evaluate the high sensitivity C-reactive protein(hs CrP), Fetuin-A and matrix γ-carboxyglutamate protein(MGP) as the main factors for vascular calcification and inflammation in serum of patients with advanced age-related macular degeneration(ArMD) in comparison to healthy controls. METHODS: The subjects were 40 patients with choroidal neovascularization(CNV) having a mean age of70.9 ±9.1y and a matched group of 49 apparently healthy control subjects. The ArMD was diagnosed using a slitlamp with superfield lens, fundus photography and fluorescein angiography. Measurement of hs CrP was done by nephelometry method. Levels of Fetuin-A and MGP were measured by enzyme-linked immunosorbent assay(ELISA) ***: hs CrP [0.45(0.07-2.63) mg/L vs 0.25(0.03-1.2) mg/L, P =0.02)] and Fetuin-A levels(50.27 ±5.04 vs44.99±10.28 ng/m L, P =0.009) were higher in the patients than in the control groups. We could not find significant difference in MGP level between two groups(P =0.08).There was not a significant correlation between MGP with Fetuin-A and hs CrP among the patients(P =0.7, P =0.9respectively). A significant negative correlation of hs CrP with Fetuin-A was observed in both case and control groups(P =0.004, r =-0.33 and P =0.001, r =-0.54,respectively).CONCLUSION: Although our study shows that serum hs CrP and Fetuin-A is increased in CNV patients as well as negatively correlated with both study groups, their direct role on pathogenesis of ArMD required future studies.

关键词： high sensitivity C-reactive protein Fetuin-A matrix γ-carboxyglutamate protein age-related macular degeneration choroidal neovascularization

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