Transmissible gastroenteritis virus(TGEV) is the causative agent of porcine Transmissible gastroenteritis(TGE), characterized by high mortality and severely retarded growth in piglets that dramatically affects the por...
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Transmissible gastroenteritis virus(TGEV) is the causative agent of porcine Transmissible gastroenteritis(TGE), characterized by high mortality and severely retarded growth in piglets that dramatically affects the porcine ***,we have identified two shRNA-expressing plasmids peGFP-U6/P1 and peGFP-U6/P2 that target RNA-dependent RNA polymerase (RdRP) gene of TGEV with more than 95%of virus inhibition in *** this study,inhibition of the TGEV replication by peGFP-U6/P1 and peGFP-U6/P2 was tested in *** mini-pigs at 25 days old were injected with the shRNA-expressing plasmids and then infected with *** results from the analyses of clinical signs,histopathology,indirect immunofluorescence(IIF) and RT-PCR show that the two shRNA-expressing plasmids could significantly decrease the quantity of TGEV in different organs and protect mini-pigs from TGEV *** findings illustrate the prospect for TGEV-specific shRNAs to be new anti-TGEV agents.
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