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Tissue-specific Tregs in cancer metastasis:opportunities for precision immunotherapy

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Cellular & Molecular Immunology 2022年第1期19卷 33-45页

作者： Laura A.Huppert Michael D.Green Luke Kim Christine Chow Yan Leyfman Adil I.daud James C.Lee Division of Hematology/Oncology Department of MedicineUniversity of CaliforniaSan FranciscoSan FranciscoCAUSA Department of Radiation Oncology University of Michigan School of MedicineAnn ArborMIUSA Veterans Affairs Ann Arbor Healthcare System Ann ArborMIUSA University of California San Francisco School of MedicineSan FranciscoCAUSA Penn State College of Medicine HersheyPAUSA Parker Institute for Cancer Immunotherapy San FranciscoCAUSA

Decades of advancements in immuno-oncology have enabled the development of current immunotherapies,which provide longterm treatment responses in certain metastatic cancer ***,cures remain infrequent,and most patients ultimately succumb to treatment-refractory metastatic *** insights suggest that tumors at certain organ sites exhibit distinctive response patterns to immunotherapy and can even reduce antitumor immunity within anatomically distant tumors,suggesting the activation of tissue-specific immune tolerogenic mechanisms in some cases of therapy *** immune cells known as regulatory T cells(Tregs)are present within all tissues in the body and coordinate the suppression of excessive immune activation to curb autoimmunity and maintain immune *** the high volume of research on Tregs,the findings have failed to reconcile tissue-specific Treg functions in organs,such as tolerance,tissue repair,and regeneration,with their suppression of local and systemic tumor immunity in the context of immunotherapy *** improve the understanding of how the tissue-specific functions of Tregs impact cancer immunotherapy,we review the specialized role of Tregs in clinically common and challenging organ sites of cancer metastasis,highlight research that describes Treg impacts on tissue-specific and systemic immune regulation in the context of immunotherapy,and summarize ongoing work reporting clinically feasible strategies that combine the specific targeting of Tregs with systemic cancer *** knowledge of Tregs in the framework of their tissue-specific biology and clinical sites of organ metastasis will enable more precise targeting of immunotherapy and have profound implications for treating patients with metastatic cancer.

关键词： Tissue Tregs Immunotherapy Organ-specific tolerance Metastasis Cancer

A novel coordinated control strategy considering power smoothing for a hybrid photovoltaic/battery energy storage system

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Journal of Central South University 2016年第2期23卷 394-404页

作者： daud Muhamad Zalani MOHamED Azah HANNAN M A School of Ocean Engineering Universiti Malaysia Terengganu Department of Electrical Electronicand Systems EngineeringUniversiti Kebangsaan Malaysia

This work presents a novel coordinated control strategy of a hybrid photovoltaic/battery energy storage(PV/BES) system. Different controller operation modes are simulated considering normal, high fluctuation and emergency conditions. When the system is grid-connected, BES regulates the fluctuated power output which ensures smooth net injected power from the PV/BES system. In islanded operation, BES system is transferred to single master operation during which the frequency and voltage of the islanded microgrid are regulated at the desired level. PSCAD/EMTDC simulation validates the proposed method and obtained favorable results on power set-point tracking strategies with very small deviations of net output power compared to the power set-point. The state-of-charge regulation scheme also very effective with SOC has been regulated between 32% and 79% range.

关键词：协调控制策略储能系统 PSCAD/EMTDC 电池光伏混合输出功率 BES

Textural characteristics,surface chemistry and oxidation of activated carbon

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Journal of Natural Gas Chemistry 2010年第3期19卷 267-279页

作者： Wan Mohd Ashri Wan daud amir Hossein Houshamnd Department of Chemical Engineering Faculty of EngineeringUniversity of Malaya

Numerous researches were reviewed and interpreted to depict a comprehensive illustration of activated carbon and its behavior towards *** carbon as one of the most important adsorbents is tried to be described in this review paper by terms of its＂Textural Characteristics＂and＂Surface Chemistry＂.These two terms,coupled with each other,are responsible for behavior of activated carbon in adsorption processes and in catalytic *** as-prepared activated carbons are usually nonselective and their surfaces suffer from lack of enough reactive groups,their different aspects may be improved and developed by diverse types of *** is one of the most conventional modifications used for activated *** may be used as a final modification or as a pre-modification followed by further *** this paper,methods of oxidation of activated carbon and other graphene-layer carbon materials are introduced and wet oxidation as an extensively-used category of oxidation is discussed in more detail.

关键词： activated carbon graphene-layer carbon surface chemistry textural characteristics oxidation

An Innovative Approach Utilizing Binary-View Transformer for Speech Recognition Task

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Computers, Materials & Continua 2022年第9期72卷 5547-5562页

作者： Muham.ad Babar Kamal Arfat Ahmad Khan Faizan Ahmed Khan Malik Muham.ad Ali Shahid Chitapong Wechtaisong Muham.ad daud Kamal Muham.ad Junaid Ali Peerapong Uthansakul COMSATS University Islamabad Islamabad Campus45550Pakistan Suranaree University of Technology Nakhon Ratchasima30000Thailand COMSATS University Islamabad Lahore Campus54000Pakistan COMSATS University Islamabad Vehari Campus61100Pakistan National University of Sciences&Technology Islamabad45550Pakistan Virtual University of Pakistan Islamabad Campus45550Pakistan

The deep learning advancements have greatly improved the performance of speech recognition systems,and most recent systems are based on the Recurrent Neural Network(RNN).Overall,the RNN works fine with the small sequence data,but suffers from the gradient vanishing problem in case of large *** transformer networks have neutralized this issue and have shown state-of-the-art results on sequential or speech-related ***,in speech recognition,the input audio is converted into an image using Mel-spectrogram to illustrate frequencies and *** image is classified by the machine learning mechanism to generate a classification ***,the audio frequency in the image has low resolution and causing inaccurate *** paper presents a novel end-to-end binary view transformer-based architecture for speech recognition to cope with the frequency resolution ***,the input audio signal is transformed into a 2D image using ***,the modified universal transformers utilize the multi-head attention to derive contextual information and derive different speech-related ***,a feedforward neural network is also deployed for *** proposed system has generated robust results on Google’s speech command dataset with an accuracy of 95.16%and with minimal *** binary-view transformer eradicates the eventuality of the over-fitting problem by deploying a multiview mechanism to diversify the input data,and multi-head attention captures multiple contexts from the data’s feature map.

关键词： Convolution neural network multi-head attention multi-view RNN self-attention speech recognition transformer

CPEC Shows Ironclad Brotherhood Between China and Pakistan

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China News Release 2023年第10期 28-32页

作者： Dr.Hassan daud Butt the Center for BRI and Regional Studies in Beijing

The substantial disruption in global economic growth resulting from the COVID-19 pandemic and the conflict between Russia and Ukraine has made navigating the intricate global landscape,which is characterized by unpredictability and rapid changes,an arduous task for developing nations around the *** of how nations choose to address these emerging challenges,in the case of Pakistan,a notable source of optimism amid these crises lies in the China-Pakistan Economic Corridor(CPEC),a prominent project within the broader framework of the Belt and Road Initiative(BRI).

关键词： Pakistan landscape nations

A Time-Dependent Wavepacket Method for Photodissociation Dynamics of Triatomic Molecule

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Chinese Physics Letters 2009年第7期26卷 111-114页

作者： Moham.ad Noh daud Gabriel G. Balint-Kurti Department of Chemistry University of Malaya Kuala Lumpur 50603 Malaysia School of Chemistry University of Bristol Bristol BS8 1TS UK

We report a time-dependent quantum wavepacket theory employed to interpret the photoabsorption spectrum of the N20 molecule in terms of the nuclear motion on the upper 21A＇ and 11A＂ potential energy surfaces. The N2-O bond breaks upon excitation leading to dissociation. The total angular momentum is treated correctly taking into account the vector property of the electric field of the exciting radiation.

关键词： Atomic and molecular physics

Spatiotemporal Analysis of Meteorological Drought Using Standardized Precipitation Index (SPI) in Gabiley Region, Somaliland

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Journal of Geoscience and Environment Protection 2023年第5期11卷 47-59页

作者： Abdisamad Abib Omar Jie-Lun Chiang Bashir Hassan daud Department of Tropical Agriculture and International Cooperation National Pingtung University Science and Technology Taiwan Department of Soil and Water Conservation National Pingtung University Science and Technology Taiwan College of Engineering International Master Program on Natural Hazards Mitigation and Management National Cheng Kung University Taiwan

Drought is a common natural disaster worldwide, with varying durations, severity levels, and spatial extents. This study aimed to model the spatiotemporal variation of meteorological drought events in the Gabiley region of Somaliland. The study utilized primary data collected from the meteorological station in Gabiley and CHIRPS (Climate Hazards Group InfraRed Precipitation with Station) data to develop the standardized precipitation index (SPI) at a 3-month timescale. The results of the study revealed that the study area was characterized by drought and received inadequate precipitation, resulting in catastrophic droughts that negatively impacted the socioeconomic situation of the community. Mild-to-severe meteorological drought events occurred every two to three years, with the most severe droughts occurring in 1998, 2002, 2009, 2015, and 2017. Specifically, the year 2015 experienced the most severe meteorological drought in the region during the studied period. The predominant type of drought was a mild year in the study area. The SPI was found to potentially identify meteorological drought, making it a useful tool for policymakers as they develop drought adaptation and mitigation policies. This study provides valuable information that can benefit local authorities and policymakers in creating drought mitigation and adaptation strategies in the Gabiley region.

关键词： Meteorological Drought SPI CHRIPS Rainfall Gabiley

Enzymatic recovery of glycopeptides from different industrial grades edible bird’s nest and its by-products:nutrient,probiotic and antioxidant activities,and physicochemical characteristics

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Food Science and Human Wellness 2022年第6期11卷 1555-1564页

作者： Hidayati Syamimi Mohd Noor Rafi dah Mohd Ariff Lee Sin Chang Xin Yi Chai Hui Yan Tan Nur’Aliah daud Abdul Salam Babji Seng Joe Lim Faculty of Science and Technology Universiti Kebangsaan MalaysiaBangi 43600Malaysia International Institute for Halal Research and Training(INHART) International Islamic University Malaysia(IIUM)Jalan Gombak 53100Malaysia Faculty of Applied Sciences UCSI University Kuala LumpurCheras 56000Malaysia Faculty of Agriculture Science and Technology Universiti Putra Malaysia Bintulu CampusBintulu 97008Malaysia Innovative Centre for Confectionery Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600Malaysia

This study was conducted to recover edible bird’s nest(EBN)hydrolysates from different grades of EBN,including the industrial by-products,using enzymatic *** nutrient,physicochemical properties and antioxidant activities of the recovered hydrolysates at different hydrolysis times were *** showed that the recovery yield of enzymatic hydrolysis was above 89%for all grades of EBN and the degree of hydrolysis increased over *** content(0.321-0.433 mg/L)was below the permissible tolerance level for all ***,the antioxidant activities(DPPH and ABTS scavenging activities and ferric reducing antioxidant powder(FRAP)activity)were significantly higher(P≤0.05)in hydrolysates recovered from EBN by-products(EBNhC and EBNhD)as compared to the high grade EBN hydrolysates(EBNhA and EBNhB).The in-vitro probiotic activity of EBN and its hydrolysates were examined using the probiotic bacterium Lactobacillus ***,EBN by-products hydrolysate(EBNhD)recorded the highest number of ***(1.1×1011 CFU/mL),indicating that low grade EBN has the potential as prebiotic material that promotes probiotic *** study demonstrated the concept of using EBN by-products hydrolysates for various applications,such as functional ingredients with enhanced bioactivities,to improve its economic value.

关键词： Edible bird’s nest by-products Enzymatic hydrolysis Glycopeptides Lactobacillus plantarum Probiotic activity

Dynamic of ENSO towards upwelling and thermal front zone in the east coast of Peninsular Malaysia

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Acta Oceanologica Sinica 2019年第1期38卷 48-60页

作者： Nurul Rabitah daud Mohd Fadzil Akhir Aidy M Muslim Institute of Oceanography and Environment Universiti Malaysia Terengganu Faculty of Civil Engineering Universiti Teknologi MARA

The El Ni?o Southern Oscillation(ENSO) is a natural phenomenon that relates to the fluctuation of temperatures over the Pacific Ocean. The ENSO significantly affects the ocean dynamics including upwelling event and coastal front. A recent study discovered the seasonal upwelling in the east coast of Peninsular Malaysia(ECPM), which is significant to the fishery industry in this region. Thus, it is vital to have a better understanding of the influence of ENSO towards the coastal upwelling and thermal front in the ECPM. The sea surface temperature(SST) data achieved from moderate resolution imaging spectroradiometer(MODIS) aboard Aqua satellite are used in this study to observe the SST changes from 2005 to 2015. However, due to cloud cover issue, a reconstruction of data set is applied to MODIS data using the data interpolating empirical orthogonal function(DINEOF) to fill in the missing gap in the dataset based on spatial and temporal available data. Besides, a wavelet transformation analysis is done to determine the temperature fluctuation throughout the time series. The DINEOF results show the coastal upwelling in the ECPM develops in July and reaches its peak in August with a clear cold water patch off the coast. There is also a significant change of SST distribution during the El Ni?o years which weaken the coastal upwelling event along the ECPM. The wavelet transformation analysis shows the highest temperature fluctuation is in 2009–2010 which indicates the strongest El Ni?o throughout the time period. It is suggested that the El Ni?o is favourable for the stratification in water column thus it is weakening the upwelling and thermal frontal zone formation in ECPM waters.

关键词： ENSO thermal frontal zone coastal upwelling sea surface temperature South China Sea